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1. 发明申请

WO2007131767A3 NOVEL ACTIVES AGAINST PROSTATE CARCINOMA 审中-公开
标题翻译：对前瞻性癌症的新兴活动
公开(公告)号：WO2007131767A3
公开(公告)日：2008-04-03
申请号：PCT/EP2007004302
申请日：2007-05-15
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , SILER ULRICH , WERTZ KARIN
发明人： GORALCZYK REGINA , SILER ULRICH , WERTZ KARIN
IPC分类号： A61K31/01 , A61K31/353 , A61K31/355 , A61P13/08 , A61P35/00
CPC分类号： A61K31/01 , A61K31/353 , A61K31/355 , A61K2300/00
摘要： The present invention relates to the use of a composition comprising lycopene and genistein in the prevention and coadjuvant treatment of prostate carcinoma. The present invention is also directed to the use of a composition comprising lycopene and epigallocatechin gallate in the prevention and coadjuvant treatment of prostate carcinoma. More specifically, the present invention relates to the use of one of these compositions in the primary prevention (i.e., the prophylactic supplementation of healthy subjects) of the onset of prostate carcinoma, in the coadjuvant treatment (i.e. the supplementation accompanying a running therapy of prostate carcinoma) and in the secondary prevention (i.e., the supplementation after a successful therapy for the prevention of relapse) of prostate carcinoma. Furthermore, the present invention is also directed to the reduction/decrease of the PSA plasma level in the blood of subjects to whom either a composition comprising lycopene and genistein or to whom either a composition comprising lycopene and epigallocatechin gallate are administered. Further compounds that may preferably also be present in the composition of the present invention are vitamin E, resveratrol and polyunsaturated fatty acid (derivative)s.
摘要翻译：本发明涉及包含番茄红素和染料木素的组合物在预防和辅助治疗前列腺癌中的用途。本发明还涉及包含番茄红素和表没食子儿茶素没食子酸酯的组合物在预防和辅助治疗前列腺癌中的用途。更具体地说，本发明涉及这些组合物中的一种在辅助治疗中的一级预防（即健康受试者的预防性补充）前列腺癌发作的用途（即伴随前列腺的运行治疗的补充）癌症）和前列腺癌的二次预防（即成功治疗预防复发后的补充）。此外，本发明还涉及给予包含番茄红素和染料木素的组合物或包含番茄红素和表没食子儿茶素没食子酸酯的组合物的受试者的血液中PSA血浆水平的降低/降低。还可以存在于本发明组合物中的其它化合物是维生素E，白藜芦醇和多不饱和脂肪酸（衍生物）。

2. 发明专利

AU2003294778A1 NOVEL USE OF LYCOPENE 未知
公开(公告)号：AU2003294778A1
公开(公告)日：2004-06-30
申请号：AU2003294778
申请日：2003-12-04
申请人： DSM IP ASSETS BV
发明人： WERTZ KARIN , BARELLA LUCA , GORALCZYK REGINA , SILER ULRICH
IPC分类号： A61K31/01 , A61K31/07 , A61K31/353 , A61K31/355 , A61K31/375
摘要： Lycopene can be used in the primary prevention and incidence risk reduction of non-cancerous symptoms and/or pathologies (i.e., the prophylactic supplementation of the healthy subjects), in the treatment or the coadjuvant treatment of non-can-cerous symptoms and/or pathologies (i.e. the supplementation as therapy or accompanying a running therapy) and in the secondary prevention of non-cancerous symptoms and/or pahtologies (i.e., the supplementation after a successful therapy for the prevention of the relapse), which are associated with, favored by or caused by androgen signalling or which are sensitive to a reduction of androgen signalling.

3. 发明专利

ES2329238T3 NUEVO USO DE LICOPENO PARA EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON LA SEÑALIZACION DE ANDROGENOS. 未知
公开(公告)号：ES2329238T3
公开(公告)日：2009-11-24
申请号：ES03785727
申请日：2003-12-04
申请人： DSM IP ASSETS BV
发明人： BARELLA LUCA , GORALCZYK REGINA , SILER ULRICH , WERTZ KARIN
IPC分类号： A61K31/01 , A61K31/07 , A61K31/353 , A61K31/355 , A61K31/375 , A61P5/00
摘要： El uso de licopeno en la fabricación de una composición para la prevención primaria y secundaria, la reducción del riesgo de incidencia, el tratamiento coadyuvante o el tratamiento de síntomas y/o patologías no cancerosos, que están asociados con, favorecidos o causados por señalización de andrógenos, o que son sensibles a una reducción de la señalización de andrógenos, en donde los síntomas y/o patologías se seleccionan del grupo constituido por: síndrome de ovario poliquístico, anovulación crónica hiperandrogénica, infertilidad femenina, síndrome de hiperestimulación ovárica, amenorrea, oligomenorrea, obesidad, acumulación de grasa abdominal, hirsutismo, trastorno menstrual, hiperandrogenismo, hiperplasia suprarrenal congénita (CAH) y desequilibrio de la señalización de andrógenos inducido por estrés.

4. 发明专利

DE60328517D1 未知
公开(公告)号：DE60328517D1
公开(公告)日：2009-09-03
申请号：DE60328517
申请日：2003-12-04
申请人： DSM IP ASSETS BV
发明人： BARELLA LUCA , GORALCZYK REGINA , SILER ULRICH , WERTZ KARIN
IPC分类号： A61K31/01 , A61K31/07 , A61K31/353 , A61K31/355 , A61K31/375 , A61P5/00
摘要： Lycopene can be used in the primary prevention and incidence risk reduction of non-cancerous symptoms and/or pathologies (i.e., the prophylactic supplementation of the healthy subjects), in the treatment or the coadjuvant treatment of non-can-cerous symptoms and/or pathologies (i.e. the supplementation as therapy or accompanying a running therapy) and in the secondary prevention of non-cancerous symptoms and/or pahtologies (i.e., the supplementation after a successful therapy for the prevention of the relapse), which are associated with, favored by or caused by androgen signalling or which are sensitive to a reduction of androgen signalling.

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