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1. 发明申请

WO2014195522A2 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有渗透酶活性的多肽
公开(公告)号：WO2014195522A2
公开(公告)日：2014-12-11
申请号：PCT/EP2014/063070
申请日：2014-06-20
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel , DRIESSEN, Arnold Jacob Mattieu , NIJLAND, Jeroen Gerben , SHIN, Hyun Yong
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution corresponding to T89C/Y, V187M/Q/C/G/Y, A191 l/K/D/C/E/N/W/R/P, Y214L/P, Q215D/E/S/M/L/C/F/A, 1218W, T219V/L/R/E, I222G/Y/M/P/S/W, Y226M/T/P/Q, Q338R/I/D/E/F/G/P, M339Y/E/N, Q341V/Y/S/H, Q342N/H/R/C/F/G/I/K/L/P/S/T/W, L343Y/Q/I/C/E/K/N/P/S, N346G/I, N347S/L/K/G/TA/, Y350E/S/Q, G373R/K/L/IWY, N376K/Q/A/C/D/E/I/M/P, T380Y/G/M/A/S/D/E/I/K/L/W, S383Y/WA//C/E/I/L/Q/R, F446H/D/I, T448/R/K/H/D/E/W, T449F/H/A/G/I/L/P/QA/, T451W/Y/S, W455D/K/E/P/Q, N478Q/I/F/G, or W479S/I/F/D/E/H/M/N/R/T/Y of SEQ ID NO:59 wherein the polypeptide is member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及具有一个或多个对应于T89C / Y，V187M / Q / C / G / Y，A1911 / K / D / C / E / N / W / Y / Y / M / P / S / W，Y226M / T / Y214L / Q338R / I / D / E / F / G / P，M339Y / E / N，Q341V / Y / S / H，Q342N / H / R / C / F / G / I / K / L / P / S / T / W，L343Y / Q / I / C / E / K / N / P / S，N346G / I，N347S / L / K / G / TA /，Y350E / S / Q，G373R / K / L / IWY，N376K / Q / A / C / D / E / I / M / P，T380Y / G / M / A / S / D / E / I / K / L / W，S383Y / WA // C / E / I / L / Q / R，F446H / D / I，T448 / R / K / H / D / E / W，T449F / H / A / G / I / L / P / QA / / Y / S，W455D / K / E / P / Q，N478Q / I / F / G或W479S / I / F / D / E / H / M / N / R / T / 其中该多肽是主要促进剂超家族（MFS）的成员。

2. 发明申请

WO2018073107A1 EUKARYOTIC CELL COMPRISING XYLOSE ISOMERASE 审中-公开
标题翻译：包含木糖异构酶的真核细胞
公开(公告)号：WO2018073107A1
公开(公告)日：2018-04-26
申请号：PCT/EP2017/076148
申请日：2017-10-13
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
发明人： VERHOEVEN, Maarten D , LEE, Misun , VAN DEN BROEK, Marel , JANSSEN, Dirk Barend , DARAN, Jean-Marc Georges , VAN MARIS, Antonius Jeroen Adriaan , PRONK, Jacobus Thomas , BRACHER, Jasmine Melanie , DE WAAL, Paulus Petrus , DE BRUIJN, Hans Marinus Charles Johannes
IPC分类号： C07K14/395 , C12N9/92 , C12P7/06
CPC分类号： C07K14/395 , C12N1/18 , C12N1/22 , C12N1/38 , C12N9/14 , C12N9/92 , C12P7/06 , C12P7/10 , C12Y306/03008 , C12Y503/01005 , Y02E50/16 , Y02E50/17
摘要： Eukaryotic cell comprising a heterologous xylose isomerase, wherein the xylose isomerase is loaded with Mn and wherein the Mn metal loading is at least 0.10 mol Mn (mol XylA subunit) -1 , preferably about 0.30 mol Mn (mol XylA subunit) -1 .
摘要翻译：包含异源木糖异构酶的真核细胞，其中所述木糖异构酶负载有Mn，并且其中所述Mn金属负载量为至少0.10mol Mn（mol XylA亚基）-1，，优选约0.30摩尔Mn（摩尔XylA亚基）-1 。

3. 发明申请

WO2014195520A2 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195520A2
公开(公告)日：2014-12-11
申请号：PCT/EP2014/063068
申请日：2014-06-20
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel , DRIESSEN, Arnold Jacob Mattieu , NIJLAND, Jeroen Gerben , SHIN, Hyun Yong
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Y of SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及一种对F85T / A / C / H / M / N，T89H / D / C / A / N，V187T / C / D / E / F / G / H / K / M / Q / R / S / W / Y，A191N / G / P / C / D / F / H / I / K / Q / V / W / Y，Y214V / Q / G / L / M / N / P / R / S，Q215L / M / I / A / C / D / F / S，I218K / N / A / C / D / E / H / L，T219G / F / D / N，I222D / C / H / E / G / P / S / V / Y，Y226D / M / R / C / G / H / I / L / P / Q / T / W，Q338C / E / F / D / G / / P / R / S / T / V / W / Y，M339N / V / D / E / H / K / P / Q / R / Y，Q341T / M / N / S / Y，Q342Y / S / C / A / D / F / G / H / I / K / L / N / P / R / T / V / W，L343K / R / P / C / D / E / G / H / I / M / N / Q / S / T / Y，N346W / Y / F / G / H / K / L / M / R / T，N347A / I / E / H / L，Y350R / L / T / D / K / M / N / V，G373L / E / N / F / K / M / R / V / W / Y，N376I / T / M / A / C / E / F / H / K / L / P / Q / R / V / W / Y，T380M / F / H / N / P / Q / R / S / V，S383Q / T / C / D / E / F / I / K / L / M / R / V / W / Y，F444Y / D / E / H / K / N / P / Q / R / W，F446Q / L / H / D / E / I / M / N，T448M / H / D / E / F / K / R / W / Y，T449F / M / N / S / D / E / G / H / I / K / L / P / Q / R / V / W / Y，T451I / E / C / D / F / H / K / L / M / N / Q / R / S / T / V / W / Y，W455T / N / A / C / E / L / P / Q / T，N478P / F / V / G / I / K / R / W，或SEQ ID NO：59的W479T / S / Q / D / E / F / G / H / I / M / N / P / R / V / Y，主要辅导员超家庭成员（MFS）的成员。

4. 发明申请

WO2014195521A2 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195521A2
公开(公告)日：2014-12-11
申请号：PCT/EP2014/063069
申请日：2014-06-20
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel , DRIESSEN, Arnold Jacob Mattieu , NIJLAND, Jeroen Gerben , SHIN, Hyun Yong
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å 3 and a side chain hydrophobicity of 10 to 100 Δt R .
摘要翻译：本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中所述多肽是主要促进剂超家族（MFS）的成员。在一个实施方案中，取代位于对应于376的位置，并且其中该位置处的氨基酸被具有范德华体积为80至138 3的氨基酸和10至100重量％的侧链疏水性。

5. 发明申请

WO2014195381A2 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195381A2
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061640
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the aminoacid at that position is replaced by an aminoacid that has a van der Waals volume of 80 to 138Å 3 and a side chain hydrophobicity of 10 to 100 ∆t R .
摘要翻译：本发明涉及在对应于SEQ ID NO：59的位置339或376的位置具有一个或多个取代的多肽，其中多肽是主要促进剂超家族（MFS）的成员。在一个实施方案中，取代位于对应于376的位置，其中该位置的氨基酸被具有范德华体积为80至138埃的氨基酸和10至100ΔtR的侧链疏水性所取代。

6. 发明申请

WO2014195377A2 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
公开(公告)号：WO2014195377A2
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061635
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel , DRIESSEN, Arnold Jacob Mattieu , NIJLAND, Jeroen Gerben , SHIN, Hyun Yong
IPC分类号： C07K14/395
CPC分类号： C07K14/395 , C12P19/02
摘要： The invention relates to a polypeptide having one or more substitution corresponding to T89C/Y, V187M/Q/C/G/Y, A191 l/K/D/C/E/N/W/R/P, Y214L/P, Q215D/E/S/M/L/C/F/A, 1218W, T219V/L/R/E, I222G/Y/M/P/S/W, Y226M/T/P/Q, Q338R/I/D/E/F/G/P, M339Y/E/N, Q341V/Y/S/H, Q342N/H/R/C/F/G/I/K/L/P/S/T/W, L343Y/Q/I/C/E/K/N/P/S, N346G/I, N347S/L/K/G/TA/, Y350E/S/Q, G373R/K/L/IWY, N376K/Q/A/C/D/E/I/M/P, T380Y/G/M/A/S/D/E/I/K/L/W, S383Y/WA//C/E/I/L/Q/R, F446H/D/I, T448/R/K/H/D/E/W, T449F/H/A/G/I/L/P/QA/, T451W/Y/S, W455D/K/E/P/Q, N478Q/I/F/G, or W479S/I/F/D/E/H/M/N/R/T/Y of SEQ ID NO:59 wherein the polypeptide is member of the Major Facilitator Superfamily (MFS).

7. 发明申请

WO2014195376A3 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
公开(公告)号：WO2014195376A3
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061632
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel , DRIESSEN, Arnold Jacob Mattieu , NIJLAND, Jeroen Gerben , SHIN, Hyun Yong
IPC分类号： C07K14/395
摘要： The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 A 3 and a side chain hydrophobicity of 10 to 100 Δt R .

8. 发明申请

WO2020212376A1 PHAGE TEST KIT 审中-公开
公开(公告)号：WO2020212376A1
公开(公告)日：2020-10-22
申请号：PCT/EP2020/060513
申请日：2020-04-15
申请人： DSM IP ASSETS B.V.
发明人： DE WAAL, Paulus Petrus , HANEMAAIJER, Laurens Leendert
IPC分类号： C12Q1/689
摘要： The present invention relates to a kit suitable for detection and quantification of phage DNA from a lactic acid bacteria infecting phage in a dairy sample. The invention provides a quantitative polymerase chain reaction (qPCR) kit for detection and quantification of phage DNA from a lactic acid bacteria infecting phage in a dairy sample, said kit comprising a first primer pair and wherein said first primer pair has a robustness of a delta Cq lower than 1.0 cycle when tested in a temperature range of 55.0 - 70.0, preferably 55.0 - 68.0, more preferably 58.6 -65.6 degrees Celsius and wherein said first primer pair is directed to a lactic acid bacteria infecting phage which is a lactococcal phage from the subgroup 9362, c2 or P335 or a streptococcal phage from the subgroup pac.

9. 发明申请

WO2020127144A1 PHAGE RESISTANT LACTIC ACID BACTERIA 审中-公开
公开(公告)号：WO2020127144A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/085483
申请日：2019-12-17
申请人： DSM IP ASSETS B.V.
发明人： DE WAAL, Paulus Petrus , HANEMAAIJER, Laurens Leendert
IPC分类号： C12N15/01 , C12N1/20 , C12R1/46 , C07K14/005 , C07K14/315 , C12N7/00 , A23C9/123 , A23C19/032
摘要： The present invention relates to a method for obtaining a bacteriophage insensitive mutant (BIM) of a lactic acid bacterium parent strain suitable for food and feed fermentation. Further, the present invention relates to a method for the construction of a bacteriophage insensitive lactic acid bacterium whereby the phage resistance is conferred by a mechanism other than CRISPR. A preferred lactic acid bacterium is Streptococcus thermophilus. The invention provides a method for obtaining a non-CRISPR bacteriophage-insensitive mutant (BIM) from a lactic acid bacterium parent strain comprising exposing said parent strain to at least one virulent bacteriophage which expresses a gene encoding an anti- CRISPR protein, growing surviving lactic acid bacteria for at least one cycle in milk in the presence of said at least one bacteriophage which expresses a gene encoding an anti-CRISPR protein, isolating BIMs resulting therefrom, characterizing and selecting a BIM which when compared to the parent strain is insensitive to more bacteriophages, has an improved stability of the acquired bacteriophage resistance, and has an acidification profile in milk which is at least comparable to or improved when compared to said parent strain.

10. 发明申请

WO2014195380A1 POLYPEPTIDES WITH PERMEASE ACTIVITY 审中-公开
标题翻译：具有过氧化物酶活性的多糖
公开(公告)号：WO2014195380A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061639
申请日：2014-06-04
申请人： DSM IP ASSETS B.V.
发明人： KLAASSEN, Paul , DE WAAL, Paulus Petrus , DE JONG, René Marcel
IPC分类号： C07K14/395
CPC分类号： C07K14/395
摘要： The invention relates to Polypeptide having one or more substitution corresponding to F85T/A/C/H/M/N, T89H/D/C/A/N, V187T/C/D/E/F/G/H/K/M/Q/R/S/W/Y, A191N/G/P/ C/D/F/H/I/K/Q/V/W/Y, Y214V/Q/G/L/M/N/P/R/S, Q215L/M/I/A/C/D/F/S, I218K/N/A/C/D/E/H/L, T219G/F/D/N, I222D/C/H/E/G/P/S/V/Y, Y226D/M/R/C/G/H/I/L/P/Q/T/W, Q338C/E/F/D/G/I/P/R/S/T/V/W/Y, M339N/V/D/E/H/K/P/Q/R/Y, Q341T/M/N/S/Y, Q342Y/S/C/A/D/F/G/H/I/K/L/N/P/R/T/V/W, L343K/R/P/C/D/E/G/H/I/M/N/Q/S/T/Y, N346W/Y/F/G/H/K/L/M/R/T, N347A/I/E/H/L, Y350R/L/T/D/K/M/N/V, G373L/E/N /F/K/M/R/V/W/Y, N376I/T/M/A/C/E/F/H/K/L/P/Q/R/V/W/Y, T380M/F/H/N/P/Q/R/S/V, S383Q/T/C/D/E/F/I/K/L/M/R/V/W/Y, F444Y/D/E/H/K/N/P/Q/R/W, F446Q/L/H/D/E/I/M/N, T448M/H/D/E/F/K/R/W/Y, T449F/M/N/S/D/E/G/H/I/K/L/P/Q/R/V/W/Y, T451I/E/C/D/F/H/K/L/M/N/Q/R/S/T/V/W/Y, W455T/N/A/C/E/L/P/Q/T, N478P/F/V/G/I/K/R/W, or W479T/S/Q/D/E/F/G/H/I/M/N/P/R/V/Yof SEQ ID NO:59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS).
摘要翻译：本发明涉及具有一个或多个对应于F85T / A / C / H / M / N，T89H / D / C / A / N，V187T / C / D / E / F / G / H / K / M / Q / R / S / W / Y，A191N / G / P / C / D / F / H / I / K / Q / V / W / Y，Y214V / Q / G / L / M / P / R / S，Q215L / M / I / A / C / D / F / S，I218K / N / A / C / D / E / H / L，T219G / F / D / N，I222D / C / H / E / G / P / S / V / Y，Y226D / M / R / C / G / H / I / L / P / Q / T / W，Q338C / E / F / D / G / P / R / S / T / V / W / Y，M339N / V / D / E / H / K / P / Q / R / Y，Q341T / M / N / S / Y，Q342Y / S / A / D / F / G / H / I / K / L / N / P / R / T / V / W，L343K / R / P / C / D / E / G / H / I / Q / S / T / Y，N346W / Y / F / G / H / K / L / M / R / T，N347A / I / E / H / L，Y350R / L / T / D / K / N / V，G373L / E / N / F / K / M / R / V / W / Y，N376I / T / M / A / C / E / F / H / K / L / P / Q / V / W / Y，T380M / F / H / N / P / Q / R / S / V，S383Q / T / C / D / E / F / I / K / L / M / R / V / Y，F444Y / D / E / H / K / N / P / Q / R / W，F446Q / L / H / D / E / I / M / N，T448M / H / D / E / R / W / Y，T449F / M / N / S / D / E / G / H / I / K / L / P / Q / R / V / W / Y，T451I / E / C / D / H / K / L / M / N / Q / R / S / T / V / W / Y，W455T / N / A / C / E / L / P / Q / T，N478P / F / V / I / K / R / W或SEQ ID NO：59的W479T / S / Q / D / E / F / G / H / I / M / N / P / R / V / Y，其中多肽是成员的主要辅导员超家庭（MFS）。

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