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1. 发明申请

WO2008110283A2 METHOD FOR PREVENTION OF AGE-RELATED MACULAR DEGENERATION (AMD) 审中-公开
标题翻译：预防年龄相关性变性的方法（AMD）
公开(公告)号：WO2008110283A2
公开(公告)日：2008-09-18
申请号：PCT/EP2008/001688
申请日：2008-03-04
申请人： DSM IP ASSETS B.V. , BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
发明人： BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
CPC分类号： C12Q1/6886 , C12Q2600/172
摘要： A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.
摘要翻译：预防年龄相关性黄斑变性（AMD）的方法涉及在第一步中从个体取样并检测多形性（rs1200638或rs10490924，或与（或高温要求）丝氨酸蛋白酶）。在第二步中，个体被提供可以预防AMD的物质，或者可以减轻或缓解AMD的症状。该物质是包含叶黄素和/或玉米黄质的药物和/或某些抗氧化剂（或其混合物）适合于该个体。本发明还提供了一种确定要给予个体的物质的方法，该个体可能通过检测多态性的存在并鉴定其可能具有年龄相关性黄斑变性（或年龄相关性黄斑变性相关病症）能够预防或治疗该个体年龄相关性黄斑变性的物质。该方法可以另外包括向个体提供（例如管理或通信）物质（或其身份）。

2. 发明申请

WO2008110828A1 METHOD FOR PREVENTION OF AGE-RELATED MACULAR DEGENERATION (AMD) 审中-公开
标题翻译：预防与年龄相关的黄斑变性（AMD）的方法
公开(公告)号：WO2008110828A1
公开(公告)日：2008-09-18
申请号：PCT/GB2008/000925
申请日：2008-03-14
申请人： DSM IP ASSETS B.V. , WRIGHT, Simon, Mark , BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
发明人： BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/172
摘要： A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.
摘要翻译：预防年龄相关性黄斑变性（AMD）的方法包括，在第一步中，从个体取样品并检测多态性（rs1112638或rs10490924或与（高温需求）丝氨酸蛋白酶相关或相关的SNP）。在第二步中，向个体提供能够预防AMD的物质，或者可以缓解或缓解AMD的症状。该物质是含有叶黄素和/或玉米黄质和/或某种抗氧化剂（或其混合物）的个体的药物。本发明还提供了测定待施用于个体的物质的方法，所述个体可能通过检测多态性的存在并鉴定出与年龄相关的黄斑变性（或与年龄相关的黄斑变性有关的病症）能够预防或治疗该个体的年龄相关性黄斑变性的物质。该方法可以另外包括向个体提供（例如给予或传递）物质（或其身份）。

3. 发明申请

WO2008110824A2 DIAGNOSTIC TEST FOR AGE-RELATED MACULAR DEGENERATION (AMD) 审中-公开
标题翻译：与年龄相关的恶性肿瘤的诊断测试（AMD）
公开(公告)号：WO2008110824A2
公开(公告)日：2008-09-18
申请号：PCT/GB2008/000917
申请日：2008-03-14
申请人： DSM IP ASSETS B.V. , WRIGHT, Simon, Mark , BENDIK, Igor , SANCAK, Ozgür , SCHALCH, Wolfgang , WITTWER, Jonas
发明人： BENDIK, Igor , SANCAK, Ozgür , SCHALCH, Wolfgang , WITTWER, Jonas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/172
摘要： A method of prevention of age-related macular degeneration (AMD) is provided where a sample is taken from an individual and the presence of a polymorphism associated with a dehydrogenase, oxygenase, acyltransferase, dismutase or a macular or retinal pigment, or an SNP as shown in Table 1 of the specification, is detected. The individual can then be provided with a substance that can prevent or treat AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual.
摘要翻译：提供了一种预防年龄相关性黄斑变性（AMD）的方法，其中取自个体的样品和与脱氢酶，加氧酶，酰基转移酶，岐化酶或黄斑或视网膜色素或SNP相关的多态性的存在或作为检测了表1中所示的规格。然后可以向个体提供可以预防或治疗AMD的物质，或者可以减轻或缓解AMD的症状。该物质是包含叶黄素和/或玉米黄质的药物和/或某些抗氧化剂（或其混合物）适合于该个体。

4. 发明申请

WO2012146651A1 PROTEIN HYDROLYSATES AS AGENTS FOR OVERCOMING ADDICTION 审中-公开
标题翻译：蛋白质水解剂作为替代物的代理
公开(公告)号：WO2012146651A1
公开(公告)日：2012-11-01
申请号：PCT/EP2012/057638
申请日：2012-04-26
申请人： DSM IP ASSETS B.V. , FERNANDEZ-REUMANN, Guillen Santiago Eusebio , GORALCZYK, Regina , KLOEK, Joris , KROES, Marijn Christoffel Waander , MOHAJERI, Hasan , WINGEN VAN, Guido Alexander , WITTWER, Jonas
发明人： FERNANDEZ-REUMANN, Guillen Santiago Eusebio , GORALCZYK, Regina , KLOEK, Joris , KROES, Marijn Christoffel Waander , MOHAJERI, Hasan , WINGEN VAN, Guido Alexander , WITTWER, Jonas
IPC分类号： A61K35/54 , A61K38/47 , A23L1/305 , A61P25/30 , A61P25/18
CPC分类号： A61K38/47 , A23K20/147 , A23K20/189 , A23L33/18 , A23L33/30 , A61K9/0056 , A61K35/57 , C12Y302/01017 , G09B19/00
摘要： This invention is directed to the use of a protein hydrolysate, and in particular an egg lysozyme hydrolysate to assist an animal, including a human in overcoming an addiction, or by breaking an unwanted habit.
摘要翻译：本发明涉及蛋白质水解物，特别是卵溶解酶水解产物的用途，以帮助动物，包括人类克服成瘾，或通过破坏不想要的习惯。

5. 发明申请

WO2010094761A2 OREGANO EXTRACT FOR ALERTNESS 审中-公开
标题翻译： OREGANO萃取物为警觉
公开(公告)号：WO2010094761A2
公开(公告)日：2010-08-26
申请号：PCT/EP2010/052115
申请日：2010-02-19
申请人： DSM IP Assets B.V. , GORALCZYK, Regina , WITTWER, Jonas , MOHAJERI, Hasan
发明人： GORALCZYK, Regina , WITTWER, Jonas , MOHAJERI, Hasan
IPC分类号： A23L1/00
CPC分类号： A23L33/105
摘要： Oregano extract can act as a stimulant, yet it does not interfere with sleep patterns or induce nervousness the way many stimulants such as caffeine can. It also has the benefits of promoting improved vigilance, improving attention and ability to focus on a task, and improving general alertness.
摘要翻译：牛至提取物可以起到兴奋剂的作用，但它不会干扰睡眠模式或引起紧张情绪，如咖啡因等许多兴奋剂。它还具有提高警惕性，提高注意力和专注于任务的能力以及提高普遍警觉性的优势。

6. 发明公开

EP2398340A2 OREGANO EXTRACT FOR ALERTNESS 审中-公开
标题翻译：牛至提取物用于增加警觉
公开(公告)号：EP2398340A2
公开(公告)日：2011-12-28
申请号：EP10705337.3
申请日：2010-02-19
申请人： DSM IP Assets B.V.
发明人： GORALCZYK, Regina , WITTWER, Jonas , MOHAJERI, Hasan
IPC分类号： A23L1/00
CPC分类号： A23L33/105
摘要： Oregano extract can act as a stimulant, yet it does not interfere with sleep patterns or induce nervousness the way many stimulants such as caffeine can. It also has the benefits of promoting improved vigilance, improving attention and ability to focus on a task, and improving general alertness.

7. 发明公开

EP2701716A1 PROTEIN HYDROLYSATES AS AGENTS FOR OVERCOMING ADDICTION 有权
标题翻译：蛋白酶组合酶联免疫吸附试验
公开(公告)号：EP2701716A1
公开(公告)日：2014-03-05
申请号：EP12717282.3
申请日：2012-04-26
申请人： DSM IP Assets B.V.
发明人： FERNANDEZ-REUMANN, Guillen Santiago Eusebio , GORALCZYK, Regina , KLOEK, Joris , KROES, Marijn Christoffel Waander , MOHAJERI, Hasan , WINGEN VAN, Guido Alexander , WITTWER, Jonas
IPC分类号： A61K35/54 , A61K38/47 , A23L1/305 , A61P25/30 , A61P25/18
CPC分类号： A61K38/47 , A23K20/147 , A23K20/189 , A23L33/18 , A23L33/30 , A61K9/0056 , A61K35/57 , C12Y302/01017 , G09B19/00
摘要： This invention is directed to the use of a protein hydrolysate, and in particular an egg lysozyme hydrolysate to assist an animal, including a human in overcoming an addition, or by breaking an unwanted habit.
摘要翻译：本发明涉及蛋白质水解物，特别是蛋清溶解酶水解产物的用途，以帮助动物，包括人克服添加，或通过破坏不需要的习惯。

8. 发明授权

EP2701716B1 PROTEIN HYDROLYSATES AS AGENTS FOR OVERCOMING ADDICTION 有权
标题翻译：蛋白质水解物作为抑制成瘾的药物
公开(公告)号：EP2701716B1
公开(公告)日：2017-11-01
申请号：EP12717282.3
申请日：2012-04-26
申请人： DSM IP Assets B.V.
发明人： FERNANDEZ-REUMANN, Guillen Santiago Eusebio , GORALCZYK, Regina , KLOEK, Joris , KROES, Marijn Christoffel Waander , MOHAJERI, Hasan , WINGEN VAN, Guido Alexander , WITTWER, Jonas
IPC分类号： A61K35/57 , A23L33/18 , G09B19/00 , A23K20/147 , A23K20/189 , A61K38/47
CPC分类号： A61K38/47 , A23K20/147 , A23K20/189 , A23L33/18 , A23L33/30 , A61K9/0056 , A61K35/57 , C12Y302/01017 , G09B19/00
摘要： This invention is directed to the use of a protein hydrolysate, and in particular an egg lysozyme hydrolysate to assist an animal, including a human in overcoming an addition, or by breaking an unwanted habit.

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