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1. 发明申请

WO2011054899A1 TALAROMYCES TRANSFORMANTS 审中-公开
标题翻译： TALAROMYCES变性剂
公开(公告)号：WO2011054899A1
公开(公告)日：2011-05-12
申请号：PCT/EP2010/066796
申请日：2010-11-04
申请人： DSM IP ASSETS B.V. , LOS, Alrik, Pieter , VONK, Brenda , BERG, VAN DEN, Marco, Alexander , DAMVELD, Robbertus, Antonius , SAGT, Cornelis, Maria, Jacobus , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus , SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise
发明人： LOS, Alrik, Pieter , VONK, Brenda , BERG, VAN DEN, Marco, Alexander , DAMVELD, Robbertus, Antonius , SAGT, Cornelis, Maria, Jacobus , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus , SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise
IPC分类号： C12N1/14 , C12N9/14 , C12N9/24 , C12N9/42 , C12N15/52
CPC分类号： C12N15/80 , C12N9/2437 , C12N9/2445 , C12N9/2477 , C12P21/02 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/343
摘要： The invention relates to a Talaromyces transformant comprising one or more recombinant gene, capable of producing cellulase in the absence of cellulase inducer in a glucose medium, having a cellulase activity of 2 WSU/ml or more, in 16 times or more diluted supernatant or broth.
摘要翻译：本发明涉及一种含有一种或多种重组基因的塔拉霉菌转化体，其在16倍或更多稀释的上清液或肉汤中能够在葡萄糖培养基中不存在纤维素酶诱导剂产生纤维素酶活性为2WUU / ml以上的纤维素酶。

2. 发明申请

WO2006084710A2 NOVEL GENE VCS 02 审中-公开
标题翻译：新基因VCS 02
公开(公告)号：WO2006084710A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001205
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , GELDER VAN, Marina , HAUK, Corina , KOEKMAN, Bertus, Pieter , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
发明人： CHEVREUX, Bastien , GELDER VAN, Marina , HAUK, Corina , KOEKMAN, Bertus, Pieter , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
IPC分类号： C12N15/09 , C07K14/195
CPC分类号： C12N9/0004 , C12N9/0034 , C12Y105/03001
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

3. 发明申请

WO2016050917A1 METHODS FOR GENOMIC MODIFICATION 审中-公开
标题翻译：基因修饰方法
公开(公告)号：WO2016050917A1
公开(公告)日：2016-04-07
申请号：PCT/EP2015/072710
申请日：2015-10-01
申请人： DSM IP ASSETS B.V.
发明人： VOLLEBREGT, Adrianus, Wilhelmus, Hermanus , VONDERVOORT, VAN DE, Peter, Jozef, Ida , MEIJRINK, Bernard , ROUBOS, Johannes, Andries , TOUW-RIEL, Hesselien , BERG, VAN DEN, Marco, Alexander
IPC分类号： C12N15/63 , C12N15/65 , C12N15/80 , C12N15/90
CPC分类号： C12N15/80 , C12N9/22 , C12N15/102
摘要： A method for the modification of the genome of a fungal host cell at a target locus, the method comprises: (a) providing a fungal host cell comprising in its chromosome a target locus, the target locus comprising a recognition site for a nuclease; and (b) introducing into said cell the nuclease protein or mRNA encoding a nuclease protein which cleaves DNA at the recognition site such that recombination occurs at the target locus, thereby to modify the genome of the host cell at the target locus.
摘要翻译：一种用于在目标基因座处修饰真菌宿主细胞的基因组的方法，所述方法包括：（a）提供在其染色体中包含靶基因座的真菌宿主细胞，所述靶基因座包含核酸酶的识别位点; 和（b）向所述细胞中引入编码核酸酶蛋白的核酸酶蛋白或mRNA，所述核酸酶蛋白在识别位点切割DNA，使得在靶基因座处发生重组，从而修饰靶基因座上宿主细胞的基因组。

4. 发明申请

WO2006084719A1 FERMENTIVE VITAMIN C PRODUCTION 审中-公开
标题翻译：维生素C生产
公开(公告)号：WO2006084719A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001214
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , BEUZELIN OLLIVIER, Marie-Gabrielle , CHEVREUX, Bastien , DALLUEGE, Manuela , GELDER VAN, Marina , GOESE, Markus , HAUK, Corina , KOEKMAN, Bertus, Pieter , LEE, Connie , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , TOEPFER, Christine , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
发明人： BEUZELIN OLLIVIER, Marie-Gabrielle , CHEVREUX, Bastien , DALLUEGE, Manuela , GELDER VAN, Marina , GOESE, Markus , HAUK, Corina , KOEKMAN, Bertus, Pieter , LEE, Connie , MAYER, Anne, Françoise , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , TOEPFER, Christine , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
IPC分类号： C12N9/04 , C12P7/60 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0008
摘要： The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及能够直接生产L-抗坏血酸（以下也称为维生素C）的新鉴定的微生物。本发明还涉及包含参与维生素C合成的蛋白质的基因的多核苷酸序列。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸和片段编码的新多肽以及它们的功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明申请

WO2006084713A2 NOVEL GENE VCS 03 审中-公开
标题翻译：新基因VCS 03
公开(公告)号：WO2006084713A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001208
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , GELDER VAN, Marina , HAUK, Corina , KOEKMAN, Bertus, Pieter , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
发明人： CHEVREUX, Bastien , GELDER VAN, Marina , HAUK, Corina , KOEKMAN, Bertus, Pieter , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
IPC分类号： C12N9/02
CPC分类号： C12P17/04 , C12N9/0034 , C12Y105/03001
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其直接生产维生素C的用途。

6. 发明公开

EP2496686A1 TALAROMYCES TRANSFORMANTS 审中-公开
标题翻译：转化的Talaromyces
公开(公告)号：EP2496686A1
公开(公告)日：2012-09-12
申请号：EP10773095.4
申请日：2010-11-04
申请人： DSM IP Assets B.V.
发明人： LOS, Alrik, Pieter , VONK, Brenda , BERG, VAN DEN, Marco, Alexander , DAMVELD, Robbertus, Antonius , SAGT, Cornelis, Maria, Jacobus , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus , SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise
IPC分类号： C12N1/14 , C12N9/14 , C12N9/24 , C12N9/42 , C12N15/52
CPC分类号： C12N15/80 , C12N9/2437 , C12N9/2445 , C12N9/2477 , C12P21/02 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/343
摘要： The invention relates to a Talaromyces transformant comprising one or more recombinant gene, capable of producing cellulase in the absence of cellulase inducer in a glucose medium, having a cellulase activity of 2 WSU/ml or more, in 16 times or more diluted supernatant or broth.

7. 发明公开

EP1848797A2 NOVEL GENE VCS 03 审中-公开
标题翻译：新基因VCS 03
公开(公告)号：EP1848797A2
公开(公告)日：2007-10-31
申请号：EP06706836.1
申请日：2006-02-10
申请人： DSM IP Assets B.V.
发明人： CHEVREUX, Bastien , GELDER VAN, Marina , HAUK, Corina , KOEKMAN, Bertus, Pieter , MEURY, Anja , MOUNCEY, Nigel, John , SCHIPPER, Dick , SHINJOH, Masako , VOLLEBREGT, Adrianus, Wilhelmus, Hermanus
IPC分类号： C12N9/02
CPC分类号： C12P17/04 , C12N9/0034 , C12Y105/03001
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成的蛋白质（以下也称为维生素C）的新鉴定的基因。本发明的特征还在于包含新基因及其片段的全长多核苷酸序列的多核苷酸，由该多核苷酸及其片段编码的新多肽以及它们的功能等价物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在由微生物生产维生素C中的用途，由此修饰所述多核苷酸和/或编码的多肽对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/过程。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

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