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1. 发明专利

CA2906574C IMAGEABLE EMBOLIC MICROSPHERE 未知
公开(公告)号：CA2906574C
公开(公告)日：2021-08-31
申请号：CA2906574
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LENNARD , TANG YIQING , THE US NATIONAL INSTITUTES OF HEALTH A COMPONENT OF THE UNITED STATES DEPARTMENT OF HEALTH AND HUMAN
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LENNARD , TANG YIQING
IPC分类号： A61K49/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

2. 发明专利

CA2906574A1 IMAGEABLE EMBOLIC MICROSPHERE 未知
公开(公告)号：CA2906574A1
公开(公告)日：2014-09-25
申请号：CA2906574
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K49/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.

3. 发明申请

WO2014152488A3 IMAGEABLE EMBOLIC MICROSPHERE 审中-公开
标题翻译：可塑胶囊微胶囊
公开(公告)号：WO2014152488A3
公开(公告)日：2015-03-05
申请号：PCT/US2014027395
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译：本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。珠子通过将预形成的氢键珠活化成亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备。不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。

4. 发明申请

WO2014152488A8 IMAGEABLE EMBOLIC MICROSPHERE 审中-公开
标题翻译：可塑胶囊微胶囊
公开(公告)号：WO2014152488A8
公开(公告)日：2014-12-04
申请号：PCT/US2014027395
申请日：2014-03-14
申请人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K49/04
CPC分类号： A61K49/0442 , A61K49/0438 , A61K49/0476 , A61K49/0485 , B82Y5/00 , C08F116/06 , C08L29/04
摘要： This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hvdrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
摘要翻译：本发明涉及可成像的不透射线的栓塞珠，其特别适用于监测栓塞过程。珠粒包含共价掺入到预先形成的水凝胶珠的聚合物网络中的含碘化合物。珠子通过将预形成的氢键珠活化成亲核攻击然后将碘化化合物共价连接到聚合物网络中来制备。不透射线珠可以装载化学治疗剂并用于栓塞增生组织或实体瘤的方法。

5. 发明专利

HK1220119A1 可成像栓塞微球未知
公开(公告)号：HK1220119A1
公开(公告)日：2017-04-28
申请号：HK16108169
申请日：2016-07-12
申请人： DREHER MATTHEW R
发明人： DREHER MATTHEW R , WOOD BRADFORD J , NEGUSSIE AYELE H , LEWIS ANDREW LEONARD , TANG YIQING
IPC分类号： A61K20060101

6. 发明申请

WO0203873A3 RADIOFREQUENCY PROBES FOR TISSUE TREATMENT AND METHODS OF USE 审中-公开
标题翻译：用于组织治疗的无线电探测和使用方法
公开(公告)号：WO0203873A3
公开(公告)日：2002-05-10
申请号：PCT/US0120632
申请日：2001-06-28
申请人： US HEALTH , WOOD BRADFORD J
发明人： WOOD BRADFORD J
IPC分类号： A61B18/14 , A61B19/00
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61B2090/3925
摘要： A device and method for radiofrequency treatment of tissue is disclosed. The device includes an introducer, a plurality of RF electrodes positionable in a nondeployed state within the introducer, and an electrode advancement element. In the nondeployed state, the RF electrodes are contained within the introducer, and separated from the subject's tissue by a plug which substantially occludes the distal end of the introducer. In the method for RF tissue treatment, the introducer is introduced into the tissue of a subject. The RF electrodes are then positioned in the deployed state when the electrode advancement element advances the RF electrodes through the distal end of the introducer, thereby displacing the plug. The electrode advancement element may be a spring-loaded element, and may be actuated by a triggering device on the introducer. The introducer and the RF electrodes may be scored to enhance their visibility in medical imaging studies such as ultrasound, thereby helping to ensure optimal placement of the introducer and the RF electrodes.
摘要翻译：公开了一种用于组织射频治疗的装置和方法。该装置包括导引器，可在导引器内以非部署状态定位的多个RF电极和电极前进元件。在非部署状态下，RF电极被包含在导引器内，并且通过基本上封闭导引器的远端的插塞与被检者的组织分离。在用于RF组织处理的方法中，引入器被引入到受试者的组织中。然后当电极前进元件使RF电极通过引导器的远端前进时，RF电极被定位在展开状态，从而移位插头。电极推进元件可以是弹簧加载元件，并且可以由导引器上的触发装置来致动。可以对导引器和RF电极进行刻痕以增强其在诸如超声的医学成像研究中的可见性，从而有助于确保导引器和RF电极的最佳放置。

7. 发明申请

WO2005077303A2 VENOUS FILTERS 审中-公开
标题翻译： VENOUS过滤器
公开(公告)号：WO2005077303A2
公开(公告)日：2005-08-25
申请号：PCT/US2005004076
申请日：2005-02-08
申请人： US GOV HEALTH & HUMAN SERV , NEEMAN ZIV , WOOD BRADFORD J
发明人： NEEMAN ZIV , WOOD BRADFORD J
IPC分类号： A61F2/00 , A61F2/01 , A61F2/02 , A61F2/06
CPC分类号： A61F2/01 , A61F2002/016 , A61F2002/8483 , A61F2210/0004 , A61F2210/0014 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61F2250/003 , A61F2250/0059 , A61F2250/0071
摘要： Venous filters having at least two struts each having a connected end and a non-connected end, wherein each of the struts includes a strut portion and an anchor portion, and wherein the strut portion and the anchor portion are attached via an electrolytically active thread; and a head that connects the connected ends of the struts, wherein the strut portion can be separated from the anchor portion at least in part by the application of an electrical current. The invention also includes a venous filter having at least two struts, wherein each of the struts includes a temperature sensitive portion and an anchor portion; wherein the anchor portion is separated from the temperature sensitive portion at least in part by changing the temperature around at least the temperature sensitive portion. Also included is a venous filter having a web of dissolvable material; and at least two anchors, wherein the at least two anchors are configured to retain the web within a mammalian blood vessel.
摘要翻译：具有至少两个支柱的静脉过滤器，每个支柱具有连接端和非连接端，其中每个支柱包括支柱部分和锚定部分，并且其中所述支柱部分和所述锚定部分经由电解活动螺纹附接; 以及连接支柱的连接端的头部，其中支柱部分可以至少部分地通过施加电流而与锚定部分分离。本发明还包括具有至少两个支柱的静脉过滤器，其中每个支柱包括温度敏感部分和锚定部分; 其中所述锚定部分至少部分地通过改变至少所述温度敏感部分周围的温度与所述温度敏感部分分离。还包括具有可溶解材料纤维网的静脉过滤器; 和至少两个锚，其中所述至少两个锚定构造成将所述腹板保持在哺乳动物血管内。

8. 发明申请

WO2004016155A3 APPARATUS FOR MULTIFOCAL DEPOSITION AND ANALYSIS AND METHODS FOR ITS USE 审中-公开
标题翻译：多功能沉积装置及其分析及其使用方法
公开(公告)号：WO2004016155A3
公开(公告)日：2004-08-12
申请号：PCT/US0325575
申请日：2003-08-14
申请人： GOVERNMENT OF US SECRETARY OF , BETH ISRAEL HOSPITAL , WOOD BRADFORD J , GORBACH ALEXANDER M , PERELMAN LEV T , HVIZDA JULIE , NEEMAN ZIV
发明人： WOOD BRADFORD J , GORBACH ALEXANDER M , PERELMAN LEV T , HVIZDA JULIE , NEEMAN ZIV
IPC分类号： A61B20060101 , A61B1/018 , A61B5/00 , A61B6/00 , A61B18/22 , A61B18/24
CPC分类号： A61B18/24 , A61B1/00167 , A61B1/018 , A61B5/0075 , A61B5/0084 , A61B2018/2211
摘要： An multifocal apparatus for delivering an agent to and/or gathering information about a biological tissue. The apparatus includes a catheter (24) having a catheter lumen extending longitudinally at least partially therethrough and a deployment port within the distal portion of the catheter. A plurality of extendable-retractable needles (15) are housed within the catheter lumen and, when deployed, extend through the deployment port. A needle may be solid or hollow and may deliver an agent to the tissue, include a mechanism for gathering information about the tissue, or both.
摘要翻译：一种用于将药剂递送到和/或收集有关生物组织的信息的多焦点装置。该装置包括导管（24），其具有至少部分地穿过其纵向延伸的导管内腔和在导管的远端部分内的展开口。多个可伸缩针（15）容纳在导管内腔内，并且当展开时延伸穿过展开口。针可以是固体或中空的并且可以将药剂递送到组织，包括用于收集关于组织的信息的机构，或两者。

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