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1. 发明公开

EP3157921A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：替加利米咪唑[1,2-A]吡啶 - 维生素ZUR BEHANDLUNG VON SCHMERZEN
公开(公告)号：EP3157921A1
公开(公告)日：2017-04-26
申请号：EP15735808.6
申请日：2015-06-23
申请人： Dr. Reddy's Laboratories Ltd. , Sasmal, Pradip Kumar , Ahmed, Shahadat , Tehim, Ashok , Paradkar, Vidyadhar
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： A61K31/437 , A61K31/4025 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D471/04 , C07K5/06 , Y02A50/414
摘要： The present application relates to a series of substituted imidazo[1,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及式（I）的一系列取代的咪唑并[1,2-a]吡啶化合物，其药学上可接受的盐，药学上可接受的溶剂合物或立体异构体，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，制备方法和包含这些化合物的药物组合物。

2. 发明申请

WO2015200341A1 SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开
标题翻译：用于治疗疼痛的替代咪达唑[1,2-A]吡啶化合物
公开(公告)号：WO2015200341A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/037214
申请日：2015-06-23
申请人： DR. REDDY'S LABORATORIES LTD. , SASMAL, Pradip, Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： A61K31/437 , A61K31/4025 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D471/04 , C07K5/06 , Y02A50/414
摘要： The present application relates to a series of substituted imidazo[l,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的式（I）咪唑并[1,2-a]吡啶化合物，其药学上可接受的盐，药学上可接受的溶剂合物或立体异构体，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，制备方法和包含这些化合物的药物组合物。

3. 发明申请

WO2013088257A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS 审中-公开
标题翻译：作为TROMOOSIN受体激酶A（TRKA）抑制剂的取代的杂环化合物
公开(公告)号：WO2013088257A1
公开(公告)日：2013-06-20
申请号：PCT/IB2012/003022
申请日：2012-12-12
申请人： DR. REDDY'S LABORATORIES LTD.
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , PRABHU, Ganesh , TEHIM, Ashok , PARADKAR, Vidyadhar , DATTATREYA, Marahanakuli, Prasanna , MAVINAHALLI, Nanjegowda, Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[l,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的吡唑并[1,5-a]吡啶化合物，其用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，制备方法和包含这些化合物的药物组合物。

4. 发明申请

WO2013088256A1 SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS 审中-公开
标题翻译：取代的吡唑并[1,5-A]吡啶作为TROMOMOSOS受体激酶（TRK）抑制剂
公开(公告)号：WO2013088256A1
公开(公告)日：2013-06-20
申请号：PCT/IB2012/003012
申请日：2012-12-12
申请人： DR. REDDY'S LABORATORIES LTD.
发明人： SASMAL, Pradip Kumar , AHMED, Shahadat , TEHIM, Ashok , PRADKAR, Vidyadhar , DATTATREYA, Prasanna M. , MAVINAHALLI, Nanjegowda Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors., method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的吡唑并[1,5-a]吡啶化合物，它们用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，其制备方法和包含这些化合物的药物组合物。

5. 发明公开

EP2791139A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS 有权
标题翻译：替加利异丁烯酸酯VERBINDUNGEN ALS TROPOMYOSIN-REZEPTOR-KINASE-A（TRKA）-INHIBITOREN
公开(公告)号：EP2791139A1
公开(公告)日：2014-10-22
申请号：EP12834589.9
申请日：2012-12-12
申请人： Dr. Reddy's Laboratories Ltd.
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , PRABHU, Ganesh , TEHIM, Ashok , PARADKAR, Vidyadhar , DATTATREYA, Marahanakuli, Prasanna , MAVINAHALLI, Nanjegowda, Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的吡唑并[1,5-a]吡啶化合物，它们用作原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂，制备方法和包含这些化合物的药物组合物。

6. 发明授权

EP2791139B1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS 有权
标题翻译：作为肌动蛋白受体激酶A（TRKA）抑制剂的取代的杂环化合物
公开(公告)号：EP2791139B1
公开(公告)日：2017-11-08
申请号：EP12834589.9
申请日：2012-12-12
申请人： Dr. Reddy's Laboratories Ltd.
发明人： SASMAL, Pradip, Kumar , AHMED, Shahadat , PRABHU, Ganesh , TEHIM, Ashok , PARADKAR, Vidyadhar , DATTATREYA, Marahanakuli, Prasanna , MAVINAHALLI, Nanjegowda, Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

7. 发明公开

EP2791138A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS 有权
标题翻译：取代的吡唑并[1,5-A]吡啶作为肌钙蛋白受体激酶（TRK）抑制剂
公开(公告)号：EP2791138A1
公开(公告)日：2014-10-22
申请号：EP12832784.8
申请日：2012-12-12
申请人： Dr. Reddy's Laboratories Ltd.
发明人： SASMAL, Pradip Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar , DATTATREYA, Prasanna M. , MAVINAHALLI, Nanjegowda Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.
摘要翻译：本申请涉及一系列取代的吡唑并[1,5-a]吡啶化合物，它们作为原肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂的用途，制备方法和包含此类化合物的药物组合物。

8. 发明授权

EP2791138B1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS 有权
公开(公告)号：EP2791138B1
公开(公告)日：2018-06-06
申请号：EP12832784.8
申请日：2012-12-12
申请人： Dr. Reddy's Laboratories Ltd.
发明人： SASMAL, Pradip Kumar , AHMED, Shahadat , TEHIM, Ashok , PARADKAR, Vidyadhar , DATTATREYA, Prasanna M. , MAVINAHALLI, Nanjegowda Jagadeesh
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/635 , C07D519/00 , Y02A50/414
摘要： The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

9. 发明申请

WO2010142934A1 INDOLE DERIVATIVES AS LIGANDS OF CRTH2 RECEPTORS 审中-公开
标题翻译：作为CRTH2受体配体的衍生物
公开(公告)号：WO2010142934A1
公开(公告)日：2010-12-16
申请号：PCT/GB2009/050671
申请日：2009-06-12
申请人： PULMAGEN THERAPEUTICS (ASTHMA) LIMITED , HYND, George , MONTANA, John Gary , FINCH, Harry , ARIENZO, Rosa , AHMED, Shahadat
发明人： HYND, George , MONTANA, John Gary , FINCH, Harry , ARIENZO, Rosa , AHMED, Shahadat
IPC分类号： C07D209/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , A61P37/00 , A61K31/4439 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/404
CPC分类号： C07D417/14 , C07D209/10 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The following compounds are CRTH2 antagonists, useful in treatment of respiratory disease: {3-[3-chloro-4-(pyridine-2-sulfonyl)isothiazol-5-ylmethyl]-5-fluoro-2- methylindol-1-yl}acetic acid, [3-(5-benzenesulfonyl-3-methyl-3H-imidazol-4-ylmethyl)-5-fluoro-2- methylindol-1-yl]acetic acid, [3-(5-benzenesulfonyloxazol-4-ylmethyl)-5-fluoro-2-methylindol-1-yl]acetic acid, [3-(3-benzenesulfonyl-4-met ylthiophen-2-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, {5-fluoro-2-methyl-3-[2-(pyridin-2-ylsulfamoyl)benzyl]indol-1-yl}acetic acid, {5-fluoro-2-methyl-3-[4-methyl-3-(pyridine-2-sulfonyl)thiophen-2- ylmethyl]indol-1-yl}acetic acid, {5-fluoro-2-methyl-3-[3-methyl-5-(pyridine-2-sulfonyl)-3H-imidazol-4- ylmethyl]indol-1-yl}acetic acid, {5-fluoro-3-[2-(3-fluorophenylsulfamoyl)pyridin-3-ylmethyl]-2-methylindol-1- yl}acetic acid, [3-(4-benzenesulfonyloxazol-5-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, {3-[2-(3-cyanophenylsulfamoyl)benzyl]-5-fluoro-2-methylindol-1-yl}acetic acid, [3-(4-benzenesulfonylthiazol-5-ylmethyl)-5-chloro-2-methyl-indol-1-yl]acetic acid, [3-(4-benzenesulfonyl-2-methylthiazol-5-ylmethyl)-5-fluoro-2-methylindol-1- yl]acetic acid, and [3-(4-benzenesulfonyl-3-methylisothiazol-5-ylmethyl)-5-fluoro-2- methylindol-1-yl]acetic acid.
摘要翻译：以下化合物是可用于治疗呼吸系统疾病的CRTH2拮抗剂：{3- [3-氯-4-（吡啶-2-磺酰基）异噻唑-5-基甲基] -5-氟-2-甲基吲哚-1-基} 乙酸，[3-（5-苯磺酰基-3-甲基-3H-咪唑-4-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸[3-（5-苯磺酰基恶唑-4-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸，[3-（3-苯磺酰基-4-甲基噻吩-2-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸， {5-氟-2-甲基-3- [2-（吡啶-2-基氨磺酰基）苄基]吲哚-1-基}乙酸{5-氟-2-甲基-3- [4-甲基-3- （吡啶-2-磺酰基）噻吩-2-基甲基]吲哚-1-基}乙酸{5-氟-2-甲基-3- [3-甲基-5-（吡啶-2-磺酰基）咪唑-4-基甲基]吲哚-1-基}乙酸，{5-氟-3- [2-（3-氟苯基氨磺酰基）吡啶-3-基甲基] -2-甲基吲哚-1-基}乙酸[3 - （4-苯磺酰氧基-5-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸{3- [2-（3-氰基苯基氨磺酰基）苄基] -5-氟-2-甲基吲哚-1-基] 乙酸，[3- （4-苯磺酰基噻唑-5-基甲基）-5-氯-2-甲基 - 吲哚-1-基]乙酸[3-（4-苯磺酰基-2-甲基噻唑-5-基甲基）-5-氟-2- 甲基吲哚-1-基]乙酸和[3-（4-苯磺酰基-3-甲基异噻唑-5-基甲基）-5-氟-2-甲基吲哚-1-基]乙酸。

10. 发明申请

WO2006051408A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS 审中-公开
标题翻译：奥沙利汀衍生物作为抗生素
公开(公告)号：WO2006051408A1
公开(公告)日：2006-05-18
申请号：PCT/IB2005/003390
申请日：2005-11-10
申请人： RANBAXY LABORATORIES LIMITED , DAS, Biswajit , YADAV, Ajay, Singh , AHMED, Shahadat , GUJRATI, Arti , GHOSH, Soma , RATTAN, Ashok
发明人： DAS, Biswajit , YADAV, Ajay, Singh , AHMED, Shahadat , GUJRATI, Arti , GHOSH, Soma , RATTAN, Ashok
IPC分类号： C07D413/12 , C07D413/14 , C07D263/32 , A61K31/422 , A61P31/04
CPC分类号： C07D413/14 , C07D263/32 , C07D413/06
摘要： Provided herein are novel substituted phenyloxazolidinones and to processes for the synthesis thereof. Also provided are pharmaceutical compositions comprising one or more compounds described herein. The compounds described can be useful antimicrobial agents, which can be effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria, such as multiple-resistant staphylococci, streptococci and enterococci, as well as, anaerobic organisms, such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms, such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本文提供新的取代的苯基恶唑烷酮及其合成方法。还提供了包含本文所述的一种或多种化合物的药物组合物。所描述的化合物可以是有用的抗微生物剂，其可以对许多人和兽医病原体有效，包括革兰氏阳性需氧细菌，如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧生物，如细菌属。和梭菌属（Clostridia spp。）物种和酸性快速生物，如结核分枝杆菌，鸟分枝杆菌和分枝杆菌。

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