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1. 发明申请

WO2006042245A1 NOVEL ISOXAZOLE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
标题翻译：具有PPAR激动剂活性的新型异丙唑化合物
公开(公告)号：WO2006042245A1
公开(公告)日：2006-04-20
申请号：PCT/US2005/036474
申请日：2005-10-11
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , MADHAVAN, Gurram Ranga , IQBAL, Javed , BHUNIYA, Debnath , DAS, Saibal Kumar , SHARMA, Sudhir Kumar , CHAKRABARTI, Ranjan
发明人： MADHAVAN, Gurram Ranga , IQBAL, Javed , BHUNIYA, Debnath , DAS, Saibal Kumar , SHARMA, Sudhir Kumar , CHAKRABARTI, Ranjan
IPC分类号： C07D261/08
CPC分类号： C07D275/02 , C07D261/08 , C07D413/12
摘要： The present invention relates to novel isoxazole compounds of formula (I) having (PPAR) agonist activity, pharmaceutical compositions containing such compounds and methods for their use.
摘要翻译：本发明涉及具有（PPAR）激动剂活性的式（I）的异恶唑化合物，含有这些化合物的药物组合物及其用途。

2. 发明申请

WO2003048116A2 NEW COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新化合物及其在医药中的应用，其制备方法和含有它们的药物组合物
公开(公告)号：WO2003048116A2
公开(公告)日：2003-06-12
申请号：PCT/IB2002/005064
申请日：2002-12-02
申请人： DR. REDDY'S LABORATORIES LTD. , BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan , VIKRAMADITHYAN, Reeba, Kannimel
发明人： BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan , VIKRAMADITHYAN, Reeba, Kannimel
IPC分类号： C07C309/00
CPC分类号： A61K31/353 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C309/66 , C07C309/73 , C07C311/53
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to compounds of the general formula (I) which are predominantly PPAR alpha agonists, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them The present invention also relates to processes for the preparation of novel compounds of formula (I), novel intermediates, processes for their preparation, use of the novel intermediates in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.
摘要翻译：本发明涉及式（I）的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和药学上可接受的组合物，其含有他们。更具体地说，本发明涉及通式（I）的化合物，其主要是PPARα激动剂，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和药学上可接受的溶剂合物含有它们的可接受的组合物本发明还涉及式（I）的新型化合物的制备方法，新型中间体，其制备方法，新型中间体在制备上述化合物中的用途及其作为抗糖尿病，降血脂，抗肥胖和低胆固醇血症化合物。

3. 发明申请

WO2003033456A1 NOVEL β-PHENYL-α-OXYSUBSTITUTED PROPIONIC DERIVATIVES: PROCESS FOR ITS PREPARATION AND THEIR USE IN THE PREPARATION OF PHARMACEUTICALLY IMPORTANT COMPOUNDS 审中-公开
标题翻译：新型β-苯基-α-衍生化的衍生物：其制备方法及其在制备药物重要化合物中的应用
公开(公告)号：WO2003033456A1
公开(公告)日：2003-04-24
申请号：PCT/IB2002/004274
申请日：2002-10-15
申请人： DR. REDDY'S LABORATORIES LTD. , BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
发明人： BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
IPC分类号： C07C229/34
CPC分类号： C07C229/42 , C07C229/34 , C07D265/36 , C07D279/16
摘要： The present invention relates to novel propionic acid derivatives. More particularly, the present invention relates to beta-phenyl alpha-oxysubstituted propionic acids of the general formula (I). The present invention also relates to processes for the preparation of compounds of the formula (I) and their use in the preparation of compounds of formula (II).
摘要翻译：本发明涉及新型丙酸衍生物。更具体地说，本发明涉及通式（I）的β-苯基α-氧代取代丙酸。本发明还涉及制备式（I）化合物及其在制备式（II）化合物中的用途的方法。

4. 发明申请

WO2005040104A1 NOVEL COMPOUNDS AND THEIR USE IN MEDICINE: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新化合物及其在医药中的应用：其制备及其含有药物组合物的方法
公开(公告)号：WO2005040104A1
公开(公告)日：2005-05-06
申请号：PCT/IB2004/000208
申请日：2004-01-29
申请人： DR. REDDY'S LABORATORIES LTD. , GURRAM, Ranga, Madhavan , BHUNIYA, Debnath , DAS, Saibal, Kumar , CHAKRABARTI, Ranjan , IQBAL, Javed , SHARMA, Sudhir, Kumar
发明人： GURRAM, Ranga, Madhavan , BHUNIYA, Debnath , DAS, Saibal, Kumar , CHAKRABARTI, Ranjan , IQBAL, Javed , SHARMA, Sudhir, Kumar
IPC分类号： C07C323/09
CPC分类号： C07C69/757 , C07B2200/07 , C07C33/28 , C07C59/68 , C07C67/30 , C07C67/31 , C07C69/712 , C07C217/84 , C07C309/66 , C07C323/52 , C07C2601/08 , C07C2603/18 , C07D233/64 , C07D265/38 , C07D279/22
摘要： The present invention relates to novel hypolipidemic, antiobesity, hypocholesterolemic and antidiabetic compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their stereoisomers, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them where all symbols are as defined in the description.
摘要翻译：本发明涉及新型降血脂，抗肥胖，低胆固醇血症和抗糖尿病化合物。更具体地，本发明涉及通式（I）的新型烷基羧酸，其立体异构体，其药学上可接受的盐和含有它们的药物组合物，其中所有符号如说明书中所定义。

5. 发明申请

WO2003053974A1 NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新化合物及其在医药中的应用，其制备方法和含有它们的药物组合物
公开(公告)号：WO2003053974A1
公开(公告)日：2003-07-03
申请号：PCT/IB2002/005442
申请日：2002-12-17
申请人： DR. REDDY'S LABORATORIES LTD. , DAS, Saibal, Kumar , BHUNIYA, Debnath , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
发明人： DAS, Saibal, Kumar , BHUNIYA, Debnath , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07C69/734 , C07C229/18 , C07C229/34 , C07C233/47 , C07C323/52
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
摘要翻译：本发明涉及新型抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。更具体地，本发明涉及通式（I）的新型烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和药学上可接受的组合物，其含有他们。

6. 发明申请

WO2006029075A3 FIBRATE COMPOUNDS HAVING PPAR AGONIST ACTIVITY 审中-公开
公开(公告)号：WO2006029075A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031532
申请日：2005-09-06
申请人： DR. REDDY'S LABORATORIES LTD. , DR. REDDY'S LABORATORIES, INC. , DAS, Saibal Kumar , SINGH, Sunil Kumar , MADHAVAN, Gurram, Ranga , BHUNIYA, Debnath , IQBAL, Javed , SHARMA, Sudhir, Kumar , CHAKRABARTI, Ranjan
发明人： DAS, Saibal Kumar , SINGH, Sunil Kumar , MADHAVAN, Gurram, Ranga , BHUNIYA, Debnath , IQBAL, Javed , SHARMA, Sudhir, Kumar , CHAKRABARTI, Ranjan
IPC分类号： C07D487/04 , C07D239/90 , A61K31/519 , A61K31/517 , C07D231/14 , C07D231/38 , C07C59/48 , C07C59/01 , C07C69/003 , C07C43/205
摘要： There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARα agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARα agonist activity and a PPARα agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.

7. 发明申请

WO2003048116A3 ESTERS AND AMIDES AS PPAR-ALPHA AGONISTS____________ 审中-公开
公开(公告)号：WO2003048116A3
公开(公告)日：2003-06-12
申请号：PCT/IB2002/005064
申请日：2002-12-02
申请人： DR. REDDY'S LABORATORIES LTD. , BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan , VIKRAMADITHYAN, Reeba, Kannimel
发明人： BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan , VIKRAMADITHYAN, Reeba, Kannimel
IPC分类号： C07C309/66
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to compounds of the general formula (I) which are predominantly PPAR alpha agonists, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them The present invention also relates to processes for the preparation of novel compounds of formula (I), novel intermediates, processes for their preparation, use of the novel intermediates in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.

8. 发明申请

WO2003033481A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：苯并噻嗪和苯并噻嗪衍生物及其包含它们的组合物
公开(公告)号：WO2003033481A1
公开(公告)日：2003-04-24
申请号：PCT/IB2002/004275
申请日：2002-10-15
申请人： DR. REDDY'S LABORATORIES LTD. , BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
发明人： BHUNIYA, Debnath , DAS, Saibal, Kumar , MADHAVAN, Gurram, Ranga , IQBAL, Javed , CHAKRABARTI, Ranjan
IPC分类号： C07D265/36
CPC分类号： C07C229/42 , C07C229/34 , C07D265/36 , C07D279/16
摘要： The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. More particularly, the present invention relates to novel alkyl carboxylic acids of the general, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, to a process for preparing such compounds. The present invention also relates to processes for the preparation of the compounds of formula (I), novel intermediates, processes for their preparation, their use in the preparation of the above said compounds and their use as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds.
摘要翻译：本发明涉及式I的新型抗糖尿病，降血脂，抗胆固醇和低胆固醇血症的衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物，制备这种化合物的方法。更具体地说，本发明涉及通用的衍生物，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物的新型烷基羧酸，制备此类化合物的方法。本发明还涉及制备式I化合物的方法，新型中间体，其制备方法，它们在制备上述化合物中的用途及其作为抗糖尿病，降血脂症，抗肥胖症和低胆固醇血症化合物的用途。

9. 发明申请

WO2002081454A1 DERIVATIVES OF ARYL ACIDS, THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： ARYLACID的衍生物，其在医药中的应用，其制备方法和含有它们的药物组合物
公开(公告)号：WO2002081454A1
公开(公告)日：2002-10-17
申请号：PCT/IB2002/001104
申请日：2002-04-08
申请人： DR. REDDY'S LABORATORIES LTD.
发明人： IQBAL, Javed , GURRAM, Ranga, Madhavan , DAS, Saibal, Kumar , BHUNIYA, Debnath , CHAKRABARTI, Ranjan , RAMANUJAM, Rajagopalan
IPC分类号： C07D239/36
CPC分类号： C07D239/36 , A61K45/06 , C07C323/60
摘要： The present invention relates to novel hypolipidemic, antihyperglycemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel b-aryl-a-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. (Formula I).
摘要翻译：本发明涉及新型降血脂，抗高血糖化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂化物和含有它们的药学上可接受的组合物。更具体地，本发明涉及通式（I）的新型b-芳基-α-氧代烷基羧酸，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的盐溶剂合物和含有它们的药学上可接受的组合物。（式I）。

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