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    • 6. 发明申请
    • USES OF IL-12 IN HEMATOPOIESIS
    • IL-12在HEMATOPOIESIS中的应用
    • WO2005007093A2
    • 2005-01-27
    • PCT/US2004/021710
    • 2004-07-06
    • ZHAO, YiCHEN, TingchaoANDERSON, French, W.
    • ZHAO, YiCHEN, TingchaoANDERSON, French, W.
    • A61K
    • A61K38/208
    • Embodiments of the present invention are directed to uses of Interleukin-12 (IL­12) in enhancing or stimulating hematopoietis to yield hematopoietic recovery in a mammal in need. Particular embodiments of the invention are directed to uses of IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other embodiments include uses of IL-12 to ameliorate various hematopoietic deficiencies. Still other embodiments are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed embodiments are directed to uses of I1-12 for bone marrow preservation or recovery.
    • 本发明的实施方案涉及白细胞介素-12(IL12)在增强或刺激造血发生中以在需要的哺乳动物中产生造血恢复的用途。 本发明的具体实施方案涉及IL-12用作辅助治疗以减轻与用于对抗疾病状态的一种或多种治疗方案相关的造血毒性的用途。 其它实施方案包括IL-12的用途来改善各种造血缺陷。 其它实施方案涉及IL-12用于造血再生细胞,造血祖细胞和造血干细胞的体内增殖的用途。 其他公开的实施方案涉及I1-12用于骨髓保存或恢复。