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    • 1. 发明申请
    • COMPOUNDS AND METHODS FOR CONTROLLING FUNGI
    • 用于控制真菌的化合物和方法
    • WO2010135070A1
    • 2010-11-25
    • PCT/US2010/033327
    • 2010-05-03
    • DOW AGROSCIENCES LLCDAVIS, GeorgeLO, WilliamRENGA, JamesTISDELL, FrancisYAP, MauriceYOUNG, David
    • DAVIS, GeorgeLO, WilliamRENGA, JamesTISDELL, FrancisYAP, MauriceYOUNG, David
    • C07D239/30A01N43/54A01P3/00
    • A61K31/505A01N43/54C07D239/30
    • Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula (I), wherein, X 1 is N or C-R 3 ; X 2 is N or C-R 4 provided that X 1 and X 2 are not both N; R 1 -R 7 are H, CN, CHO, -SCN, NO 2 , F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, Cl-C4-alkoxy-amino, C1-C4-alkyl-S(O)=NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO 2 , CHO, -SCN, S(0)n-C1-C4-alkyl (where n = 0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-thioalkyl, halo-C1-C4-thioalkyl, C1-C4-alkylacyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-imino, hydroxy- imino; C1-C4-alkyl-S(O)=NH; and Q is a substituted or unsubstituted aryl, substituted or unsubstituted heterocycle wherein the substituents of Q are taken from R 1 -R 7 .
    • 本文公开的各个方面涉及根据式(I)的芳基取代的氨基嘧啶,其中,X 1是N或C-R 3; X2是N或C-R4,条件是X1和X2不同时为N; R 1 -R 7是H,CN,CHO,-SCN,NO 2,F,Cl,Br,I,取代或未取代的C 1 -C 4 - 烷基,取代或未取代的卤代-C 1 -C 4烷基,取代或未取代的C 1 -C 4 - 烷氧基,取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的C 1 -C 4 - 硫代烷基,取代或未取代的卤代C 1 -C 4 - 硫代烷基,取代或未取代的C 3 -C 7 - 环烷基,取代或未取代的C 2 -C 4 烯基,C 2 -C 4 - 炔基,取代或未取代的C 1 -C 4酰基烷基,C 1 -C 4酰氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基 - 氨基,C 1 -C 4烷基-S(O) 取代或未取代的芳基,取代或未取代的杂环,其中取代基是以下F,Cl,Br,OH,CN,NO 2,CHO,-SCN,S(O)n-C 1 -C 4烷基中的一种或多种 n = 0-2),C 1 -C 4 - 烷基,卤代-C 1 -C 4 - 烷基,C 1 -C 4烷基胺,C 1 -C 4 - 烷氧基,卤代-C 1 -C 4 - 烷氧基,C 1 -C 4 - C 1 -C 4烷氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基亚氨基,羟基亚氨基; C1-C4烷基-S(O)= NH; 并且Q是取代或未取代的芳基,取代或未取代的杂环,其中Q的取代基取自R 1 -R 7。
    • 4. 发明公开
    • COMPOUNDS AND METHODS FOR CONTROLLING FUNGI
    • 用于控制真菌的化合物和方法
    • EP2432767A1
    • 2012-03-28
    • EP10720212.9
    • 2010-05-03
    • Dow AgroSciences LLC
    • DAVIS, GeorgeLO, WilliamRENGA, JamesTISDELL, FrancisYAP, MauriceYOUNG, David
    • C07D239/30A01N43/54A01P3/00
    • A61K31/505A01N43/54C07D239/30
    • Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula (I), wherein, X
      1 is N or C-R
      3 ; X
      2 is N or C-R
      4 provided that X
      1 and X
      2 are not both N; R
      1 -R
      7 are H, CN, CHO, -SCN, NO
      2 , F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, Cl-C4-alkoxy-amino, C1-C4-alkyl-S(O)=NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO
      2 , CHO, -SCN, S(0)n-C1-C4-alkyl (where n = 0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-thioalkyl, halo-C1-C4-thioalkyl, C1-C4-alkylacyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-imino, hydroxy- imino; C1-C4-alkyl-S(O)=NH; and Q is a substituted or unsubstituted aryl, substituted or unsubstituted heterocycle wherein the substituents of Q are taken from R
      1 -R
      7 .
    • 本文公开的各个方面涉及根据式(I)的芳基取代的氨基嘧啶,其中X 1是N或C-R 3; X 2是N或C-R 4,条件是X 1和X 2不都是N; R 1 -R 7是H,CN,CHO,-SCN,NO 2,F,Cl,Br,I,取代或未取代的C 1 -C 4烷基,取代或未取代的卤代C 1 -C 4烷基, 取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的C 1 -C 4 - 硫代烷基,取代或未取代的C 3 -C 7 - C2-C4-链烯基,C2-C4-炔基,取代的或未取代的C1-C4-酰基烷基,C1-C4-酰氧基,C1-C4-烷氧基羰基,C1- = NH,取代或未取代的芳基,取代或未取代的杂环,其中取代基为以下一个或多个F,Cl,Br,OH,CN,NO 2,CHO,-SCN,S(O)n -C 1 -C 4 (其中n = 0-2),C 1 -C 4烷基,卤代C 1 -C 4烷基,C 1 -C 4烷基胺,C 1 -C 4烷氧基,卤代C 1 -C 4烷氧基,C 1 -C 4硫代烷基 卤代-C 1 -C 4硫代烷基,C 1 -C 4烷基酰基,C 1 -C 4酰氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基亚氨基,羟基亚氨基; C1-C4烷基-S(O)= NH; Q是取代或未取代的芳基,取代或未取代的杂环,其中Q的取代基取自R 1 -R 7。