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1. 发明专利

CA2321961A1 NOVEL DISULFIDES AND THIOL COMPOUNDS 未知
公开(公告)号：CA2321961A1
公开(公告)日：1999-08-26
申请号：CA2321961
申请日：1999-02-24
申请人： HAUSER CHEMICAL RES INC , DOVETAIL TECHNOLOGIES INC
发明人： MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J , TAUB FLOYD
IPC分类号： A61K38/00 , A23L1/30 , A61K31/00 , A61K31/16 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/66 , A61K31/675 , A61K45/06 , A61P39/06 , A61P43/00 , C07C323/41 , C07K5/00 , C07K5/06 , C07K5/08
摘要： The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example is a compound of the formula (1): A-B-C-S-S-D-E-F, wherein A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy group, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.

2. 发明专利

AU7461896A Low molecular weight cell, bone marrow and immune stimulants 未知
公开(公告)号：AU7461896A
公开(公告)日：1997-05-07
申请号：AU7461896
申请日：1996-10-17
申请人： DOVETAIL TECHNOLOGIES INC , HAUSER CHEMICAL RES INC
发明人： TAUB FLOYD , PERUN THOMAS J , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J , LEDNICER DANIEL
IPC分类号： A61K31/66 , A01N37/20 , A01N41/02 , A01N41/04 , A01N57/12 , A01N57/20 , A61K31/00 , A61K31/16 , A61K31/255 , A61K31/661 , A61K31/662 , A61K39/39 , A61P7/00 , A61P7/06 , A61P35/00 , A61P37/00 , A61P37/04 , C07C309/15 , C07C323/41 , C07F9/09 , C07F9/143 , C07F9/38 , C07F9/40 , A01N37/34 , A61K45/00 , A61K45/05 , A61K47/00 , A61K39/00 , A61K39/38
摘要： The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

3. 发明专利

CA2235245A1 LOW MOLECULAR WEIGHT CELL, BONE MARROW AND IMMUNE STIMULANTS 未知
公开(公告)号：CA2235245A1
公开(公告)日：1997-04-24
申请号：CA2235245
申请日：1996-10-17
申请人： DOVETAIL TECHNOLOGIES INC , HAUSER CHEMICAL RES INC
发明人： PERUN THOMAS J , TAUB FLOYD , DAUGHENBAUGH RANDALL J , LEDNICER DANIEL , MURRAY CHRISTOPHER K
IPC分类号： A61K31/66 , A01N37/20 , A01N41/02 , A01N41/04 , A01N57/12 , A01N57/20 , A61K31/00 , A61K31/16 , A61K31/255 , A61K31/661 , A61K31/662 , A61K39/39 , A61P7/00 , A61P7/06 , A61P35/00 , A61P37/00 , A61P37/04 , C07C309/15 , C07C323/41 , C07F9/09 , C07F9/143 , C07F9/38 , C07F9/40 , A61K39/00 , C07C305/04 , C07D295/15 , A61K31/185 , A61K31/27 , A61K31/395
摘要： The present invention relates to peptide-like compounds, e.g. aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

4. 发明专利

AU718140B2 Low molecular weight cell, bone marrow and immune stimulants 未知
公开(公告)号：AU718140B2
公开(公告)日：2000-04-06
申请号：AU7461896
申请日：1996-10-17
申请人： DOVETAIL TECHNOLOGIES INC , HAUSER CHEMICAL RES INC
发明人： TAUB FLOYD , PERUN THOMAS J , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J , LEDNICER DANIEL
IPC分类号： A61K31/66 , A01N37/20 , A01N41/02 , A01N41/04 , A01N57/12 , A01N57/20 , A61K31/00 , A61K31/16 , A61K31/255 , A61K31/661 , A61K31/662 , A61K39/39 , A61P7/00 , A61P7/06 , A61P35/00 , A61P37/00 , A61P37/04 , C07C309/15 , C07C323/41 , C07F9/09 , C07F9/143 , C07F9/38 , C07F9/40 , A01N37/34 , A61K45/00 , A61K45/05 , A61K47/00 , A61K39/00 , A61K39/38
摘要： The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

5. 发明专利

AU2874199A Novel disulfides and thiol compounds 未知
公开(公告)号：AU2874199A
公开(公告)日：1999-09-06
申请号：AU2874199
申请日：1999-02-24
申请人： DOVETAIL TECHNOLOGIES INC , HAUSER CHEMICAL RES INC
发明人： TAUB FLOYD , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J
IPC分类号： A61K38/00 , A23L1/30 , A61K31/00 , A61K31/16 , A61K31/195 , A61K31/215 , A61K31/275 , A61K31/66 , A61K31/675 , A61K45/06 , A61P39/06 , A61P43/00 , C07C323/41 , C07K5/00 , C07K5/06 , C07K5/08
摘要： The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A-B-C-S-S-D-E-F, wherein: A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy groups, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.

6. 发明公开

EP1018877A4 LOW MOLECULAR WEIGHT CELL, BONE MARROW AND IMMUNE STIMULANTS 失效
标题翻译：细胞，骨髓和低分子量的免疫调节剂
公开(公告)号：EP1018877A4
公开(公告)日：2000-08-09
申请号：EP96936784
申请日：1996-10-17
申请人： DOVETAIL TECHNOLOGIES INC , HAUSER CHEMICAL RES INC
发明人： TAUB FLOYD , PERUN THOMAS J , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J , LEDNICER DANIEL
IPC分类号： A61K31/66 , A01N37/20 , A01N41/02 , A01N41/04 , A01N57/12 , A01N57/20 , A61K31/00 , A61K31/16 , A61K31/255 , A61K31/661 , A61K31/662 , A61K39/39 , A61P7/00 , A61P7/06 , A61P35/00 , A61P37/00 , A61P37/04 , C07C309/15 , C07C323/41 , C07F9/09 , C07F9/143 , C07F9/38 , C07F9/40 , A01N37/34 , A61K39/00 , A61K39/38 , A61K45/00 , A61K47/00 , A61K45/05
CPC分类号： C07F9/091 , A61K39/39 , A61K2039/55511 , C07C309/15 , C07C323/41 , C07F9/3808 , Y10S514/885 , A61K2300/00 , A61K31/16
摘要： The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.

7. 发明公开

EP0815096A4 CEPHALOMANNINE EPOXIDE, ITS ANALOGUES AND A METHOD FOR PREPARING THE SAME 失效
标题翻译： CEPHALOMANNIN-EPOXID，DESSEN ANALOGON UND EIN VERFAHREN ZU DESSEN HERSTELLUNG
公开(公告)号：EP0815096A4
公开(公告)日：1998-07-08
申请号：EP96909628
申请日：1996-03-08
申请人： HAUSER CHEMICAL RES INC
发明人： ZHENG QUN Y , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J
IPC分类号： A61K31/335 , A61K31/337 , A61P35/00 , C07D305/14 , C07D407/12
CPC分类号： C07D407/12 , C07D305/14
摘要： An antitumor compound of formula (5), in which R = Ac or H, and R1 = R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 = H; R1 = R2 = R3 = H; R1 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2 = R3 = H; R1 = R3 = H, R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = H, R2 = R3 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = R2 = R3 = an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one-step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.
摘要翻译：（5）的抗肿瘤化合物，其中R = Ac或H，并且R1 = R2 =烷基如Me，Et，Pr，i-Pr，n-Bu或t-Bu，R3 = H; R1 = R2 = R3 = H; R1 =烷基如Me，Et，Pr，i-Pr，n-Bu或t-Bu，R2 = R3 = H; R1 = R3 = H，R2 =烷基如Me，Et，Pr，i-Pr，n-Bu或t-Bu; R 1 = H，R 2 = R 3 =烷基如Me，Et，Pr，i-Pr，n-Bu或t-Bu; R1 = R2 = R3 =烷基Me，Et，Pr，i-Pr，n-Bu或t-Bu。 Me是甲基的缩写，Et是乙基，Pr是丙基，i-Pr是异丙基，n-Bu是正丁基，并且t-Bu是叔丁基。本发明还提供了制备式（5）化合物的一步法，其中将具有连接至侧链的惕酸酯基的紫杉烷与氧化剂接触，导致形成具有抗肿瘤活性的环氧化物。

8. 发明专利

CA2214993A1 CEPHALOMANNINE EPOXIDE, ITS ANALOGUES AND A METHOD FOR PREPARING THE SAME 未知
公开(公告)号：CA2214993A1
公开(公告)日：1996-09-19
申请号：CA2214993
申请日：1996-03-08
申请人： HAUSER CHEMICAL RES INC
发明人： ZHENG QUN Y , DAUGHENBAUGH RANDALL J , MURRAY CHRISTOPHER K
IPC分类号： A61K31/335 , A61K31/337 , A61P35/00 , C07D305/14 , C07D407/12
摘要： An antitumor compound of formula (5), in which R = Ac or H, and R1 = R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 = H; R1 = R2 = R3 = H; R1 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2 = R3 = H; R1 = R3 = H, R2 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = H, R2 = R3 = an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 = R2 = R3 = an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and tBu is tert-butyl. Also provided by the invention is a one-step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.

9. 发明专利

AU5305796A Cephalomannine epoxide, its analogues and a method for preparing the same 未知
公开(公告)号：AU5305796A
公开(公告)日：1996-10-02
申请号：AU5305796
申请日：1996-03-08
申请人： HAUSER CHEMICAL RES INC
发明人： ZHENG QUN Y , MURRAY CHRISTOPHER K , DAUGHENBAUGH RANDALL J
IPC分类号： A61K31/335 , A61K31/337 , A61P35/00 , C07D305/14 , C07D407/12

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