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1. 发明申请

WO0179189A3 "AMIDES OF R-2-(AMINOARYL)-PROPIONIC ACIDS FOR USE IN THEPREVENTION OF LEUCOCYTE ACTIVATION" 审中-公开
标题翻译： “用于预防胆固醇激活的R-2-（氨基） - 丙酸的用途”
公开(公告)号：WO0179189A3
公开(公告)日：2003-10-09
申请号：PCT/EP0104137
申请日：2001-04-11
申请人： DOMPE SPA , ALLEGRETTI MARCELLO , BERTINI RICCARDO , BIZZARRI CINZIA , SABBATINI VILMA , CASELLI GIANFRANCO , CESTA MARIA CANDIDA , GANDOLFI CARMELO , COLOTTA FRANCESCO
发明人： ALLEGRETTI MARCELLO , BERTINI RICCARDO , BIZZARRI CINZIA , SABBATINI VILMA , CASELLI GIANFRANCO , CESTA MARIA CANDIDA , GANDOLFI CARMELO , COLOTTA FRANCESCO
IPC分类号： A61P17/06 , C07D207/20 , C07D209/18 , C07D213/75 , C07D215/12 , C07D239/42 , C07D241/20 , C07D277/46 , C07D295/155 , C07D401/12 , C07D403/12 , C07D521/00 , A61K31/47 , C07D215/38
CPC分类号： C07D213/75 , C07D207/20 , C07D209/18 , C07D215/12 , C07D231/12 , C07D233/56 , C07D239/42 , C07D241/20 , C07D249/08 , C07D277/46 , C07D295/155 , C07D401/12 , C07D403/12
摘要： N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.
摘要翻译：描述了式（1）的N-（2-氨基芳基 - 丙酰基） - 酰胺。还描述了其制备方法及其制备药物。本发明的酰胺可用于预防和治疗由于炎性部位多形核嗜中性粒细胞（白细胞PMN）的加剧引起的组织损伤。特别地，本发明涉及用于抑制IL-8诱导的嗜中性粒细胞趋化性的式（1）的2-（氨基芳基） - 丙酰基酰胺的R对映异构体。本发明的化合物用于治疗牛皮癣，溃疡性胆管炎，肾小球性肾炎，急性呼吸功能不全，特发性纤维化和类风湿性关节炎。

2. 发明申请

WO0158852A3 (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8-INDUCED CHEMIOTAXIS OF NEUTROPHILS 审中-公开
标题翻译：（R）-2-亚甲基 - 丙酸，用于抑制IL-8诱导的中性粒细胞减少症
公开(公告)号：WO0158852A3
公开(公告)日：2002-03-14
申请号：PCT/EP0101285
申请日：2001-02-06
申请人： DOMPE SPA , ALLEGRETTI MARCELLO , BERTINI RICCARDO , CINZIA BIZZARRI , SABBATINI VILMA , CASELLI GIANFRANCO , CESTA MARIA CANDIDA , GANDOLFI CARMELO , COLOTTA FRANCESCO
发明人： ALLEGRETTI MARCELLO , BERTINI RICCARDO , CINZIA BIZZARRI , SABBATINI VILMA , CASELLI GIANFRANCO , CESTA MARIA CANDIDA , GANDOLFI CARMELO , COLOTTA FRANCESCO
IPC分类号： A61K31/12 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/221 , A61K31/223 , A61K31/4035 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K38/00 , A61P1/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/06 , A61P19/02 , A61P21/02 , A61P29/00 , C07C51/353 , C07C57/42 , C07C59/52 , C07C69/157 , C07C233/11 , C07C233/22 , C07C233/51 , C07C233/52 , C07C235/34 , C07C235/78 , C07C237/20 , C07C259/06 , C07C271/64 , C07D209/46 , C07D213/75 , C07D233/61 , C07D239/42 , C07D241/28 , C07D409/12 , C07K5/06 , A61K31/395 , C07D241/20 , C07K5/062
CPC分类号： C07D213/75 , A61K38/00 , C07B2200/07 , C07C233/11 , C07C233/22 , C07C233/51 , C07C233/52 , C07C235/34 , C07C235/78 , C07C237/20 , C07C271/64 , C07C2601/14 , C07D239/42 , C07K5/06026
摘要： N-(2-aryl-propionyl)-amides of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of N-(2-aryl-propionyl)amides of formula (I) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.
摘要翻译：描述了式（I）的N-（2-芳基 - 丙酰基） - 酰胺。还描述了其制备方法及其制备药物。本发明的酰胺可用于预防和治疗由于炎性部位多形核嗜中性粒细胞（白细胞PMN）的加剧引起的组织损伤。特别地，本发明涉及用于抑制IL-8诱导的嗜中性粒细胞趋化性的式（I）的N-（2-芳基 - 丙酰基）酰胺的R对映异构体。本发明的化合物用于治疗牛皮癣，溃疡性胆管炎，肾小球性肾炎，急性呼吸功能不全，特发性纤维化和类风湿性关节炎。

3. 发明申请

WO9938967A3 RECOMBINANT PROTEINS DERIVED FROM HGF AND MSP 审中-公开
标题翻译： HGF和MSP衍生的重组蛋白
公开(公告)号：WO9938967A3
公开(公告)日：1999-09-16
申请号：PCT/EP9900478
申请日：1999-01-27
申请人： DOMPE SPA , MEDICO ENZO , MICHIELI PAOLO , COLLESI CHIARA , CASELLI GIANFRANCO , COMOGLIO PAOLO
发明人： MEDICO ENZO , MICHIELI PAOLO , COLLESI CHIARA , CASELLI GIANFRANCO , COMOGLIO PAOLO
IPC分类号： C12N15/09 , A61K38/00 , A61P39/02 , C07K14/47 , C07K14/475 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , A61K38/18
CPC分类号： C07K14/4753 , A61K38/00 , C07K2319/02 , C12N2799/026
摘要： Recombinant proteins deriving from recombination of structural domains deriving from the alpha subunits of HGF and/or MSP growth factors. The recombinant proteins of the present invention have biological activity, and protect cells from death (apoptosis) induced by chemotherapeutic drugs. These molecules can conveniently be used to prevent or to treat the toxic side effects of chemotherapeutic agents used in cancer therapy.
摘要翻译：衍生自HGF和/或MSP生长因子的α亚基的结构域的重组的重组蛋白质。本发明的重组蛋白质具有生物活性，保护细胞免受化疗药物诱导的死亡（凋亡）。这些分子可以方便地用于预防或治疗癌症治疗中使用的化学治疗剂的毒副作用。

4. 发明专利

ITMI931330D0 未知
公开(公告)号：ITMI931330D0
公开(公告)日：1993-06-21
申请号：ITMI931330
申请日：1993-06-21
申请人： GANDOLFI CARMELO A , COTINI LORELLA , MANTOVANINI MARCO , CASELLI GIANFRANCO
发明人： GANDOLFI CARMELO A , COTINI LORELLA , MANTOVANINI MARCO , CASELLI GIANFRANCO
IPC分类号： A61K20060101 , C07C20060101 , C07C

5. 发明专利

JPH10204025A GEMINAL CARBOXYLIC ACID USEFUL FOR THERAPY OF BONE DISBOLISM AND PHARMACEUTICAL PREPARATION CONTAINING THE ESTER 失效
公开(公告)号：JPH10204025A
公开(公告)日：1998-08-04
申请号：JP5710497
申请日：1997-02-26
申请人： DOMPE SPA
发明人： ALLEGRETTI MARCELLO , MANTOVANINI MARCO , CASELLI GIANFRANCO , FIORENTINO SIMONETTA , CLAVENNA GAETANO , GANDOLFI CARMELO A
IPC分类号： C07D295/08 , A61K31/19 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/385 , A61K31/40 , A61K31/42 , A61K31/44 , A61K31/4406 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P19/10 , A61P43/00 , C07C57/13 , C07C69/708 , C07C69/712 , C07C69/734 , C07C323/51 , C07C335/32 , C07D207/16 , C07D211/22 , C07D211/34 , C07D211/42 , C07D211/46 , C07D213/30 , C07D213/32 , C07D213/55 , C07D213/65 , C07D213/68 , C07D233/42 , C07D239/10 , C07D239/26 , C07D261/08 , C07D295/14 , C07D295/15 , C07D307/46 , C07D309/06 , C07D309/12 , C07D333/24 , C07D333/26 , C07D333/32 , C07D333/34 , C07D335/02 , C07D339/06 , C07D401/12
摘要： PROBLEM TO BE SOLVED: To obtain the new compound capable of maintaining the normal activity of osteoclasts even in the hyperreactive syndromes of the osteoclasts and capable of being used for the treatments of osteoporosis, bone dispolism, malignant hyderpcalcemia, and Paget's disease. SOLUTION: A compound of formula I Ra , Rb are each H, an alkali metal cation, etc.; ϕ is a group of the formula: (Y)q -(CH2 )r (Y is CH2 , O, S); B is 2-propyl, a heterocyclic group of formula II (Z is HC, etc.; X is a single bond, CH2 , O, etc.), etc.; R is β-pyridyl, a group of formula III (when R is H and R is H, a 1-7C alkyl, etc., R is H, a 1-4C alkyl, etc., and can form a five or six-membered heterocyclic ring or a five to seven-membered saturated nitrogen-containing heterocyclic ring), etc.; (m) is 0, 1, 2, 3; (n) is 0.1 to 6; (q) is 0,1; (r) is an integer of 0, 1-3}, e.g. 5-BOC-amino-2-[2-(ethoxy)-ethoxy]-2- carboxy-pentanoic acid lithium salt. The compound of formula I is obtained by a substitution method at the methine group C-H of a malonic acid ester of formula IV (R'a , R'b are each a 1-4C alkyl, etc.).

6. 发明申请

WO2009040331A2 AMIDINE, THIOUREA AND GUANIDINE DERIVATIVES OF 2-AMINOBENZOTHIAZOLES AND AMINOBENZOTHIAZINES, NOVEL PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE PATHOLOGIES 审中-公开
标题翻译：用于治疗神经病变病理学的新型药物代谢产物的氨基酸，硫脲和胍衍生物2-氨基苯并噻唑和氨苄青霉素
公开(公告)号：WO2009040331A2
公开(公告)日：2009-04-02
申请号：PCT/EP2008062636
申请日：2008-09-22
申请人： ROTTAPHARM SPA , ANZINI MAURIZIO , GIORDANI ANTONIO , MAKOVEC FRANCESCO , CAPPELLI ANDREA , VOMERO SALVATORE , CASELLI GIANFRANCO , ROVATI LUCIO CLAUDIO
发明人： ANZINI MAURIZIO , GIORDANI ANTONIO , MAKOVEC FRANCESCO , CAPPELLI ANDREA , VOMERO SALVATORE , CASELLI GIANFRANCO , ROVATI LUCIO CLAUDIO
IPC分类号： C07D277/82 , C07D279/16
CPC分类号： C07D277/82 , C07D279/16
摘要： The present invention relates to novel amidine, thiourea and guanidine derivatives of appropriately substituted 2-aminobenzothiazoles, 2-amino-3,l-4H-benzothiazines and 3- amino-l,4-3H-benzothiazines, as understood from formula (I), the related pharmaceutically acceptable salts and solvates thereof: Formula (I): and the use of said products and the corresponding pharmaceutical formulations for the treatment of neurodegenerative pathologies such as cerebral ischemia, neurodegeneration induced by cranial trauma, Alzheimer's disease, Multiple Sclerosis and Amyotrophic Lateral Sclerosis.
摘要翻译：本发明涉及由式（I）可以理解的适当取代的2-氨基苯并噻唑，2-氨基-3,1H-苯并噻嗪和3-氨基-1,4-苯并噻嗪的新型脒，硫脲和胍衍生物，，其相关的药学上可接受的盐和溶剂化物：式（I）：以及所述产品和相应的药物制剂用于治疗神经变性病理学如脑缺血，由颅外伤，阿尔茨海默氏病，多发性硬化症和肌萎缩症引起的神经变性的用途侧脑硬化

7. 发明申请

WO2007039869A3 USE OF NEBOGLAMINE IN THE TREATMENT OF TOXICODEPENDENCY 审中-公开
标题翻译： NEBOGLAMINE在治疗有毒性中的应用
公开(公告)号：WO2007039869A3
公开(公告)日：2007-07-05
申请号：PCT/IB2006053603
申请日：2006-10-03
申请人： ROTTAPHARM SPA , MAKOVEC FRANCESCO , CASELLI GIANFRANCO , ROVATI LUCIO CLAUDIO , GIORDANI ANTONIO
发明人： MAKOVEC FRANCESCO , CASELLI GIANFRANCO , ROVATI LUCIO CLAUDIO , GIORDANI ANTONIO
IPC分类号： A61K31/16 , A61P25/30 , A61P25/32 , A61P25/36
CPC分类号： A61K31/16
摘要： Use of neboglamine, (S)-4-amino-N (4, 4-dimethyl-cyclohexyl) glutamic acid (CR 2249) (CAS Registry Number 163000-63-3) , the racemic mixture thereof or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in the treatment of toxicodependency induced by drugs such as CNS sedatives such as opiates, barbiturates, benzodiazepines, alcohol, stimulants such as amphetamines and cocaine, and hallucinogens such as LSD, mescalin, cannabis (marijuana) or fencyclidine.
摘要翻译：（S）-4-氨基-N（4,4-二甲基 - 环己基）谷氨酸（CR 2249）（CAS登记号163000-63-3），其外消旋混合物或其药学上可接受的盐的使用，用于制备用于治疗由诸如阿片类药物，巴比妥类，苯并二氮杂类，酒精，兴奋剂如苯丙胺和可卡因的CNS镇静剂等药物诱导的毒性依赖性药物，以及迷幻药如LSD，mescalin，大麻（大麻）或 fencyclidine。

8. 发明专利

ES2336301T3 (R)-2-ARIL-PROPIONAMIDAS UTILES EN LA INHIBICION DE LA QUIMIOTAXIS DE NEUTROFILOS INDUCIDA POR IL-8. 未知
公开(公告)号：ES2336301T3
公开(公告)日：2010-04-12
申请号：ES01916976
申请日：2001-02-06
申请人： DOMPE SPA
发明人： ALLEGRETTI MARCELLO , BERTINI RICCARDO , CINZIA BIZZARRI , SABBATINI VILMA , CASELLI GIANFRANCO , CESTA MARIA CANDIDA
IPC分类号： C07C233/51 , A61K31/12 , A61K31/16 , A61K31/165 , A61K31/197 , A61K31/221 , A61K31/223 , A61K31/395 , A61K31/4035 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K38/00 , A61P1/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/06 , A61P19/02 , A61P21/02 , A61P29/00 , C07C51/353 , C07C57/42 , C07C59/52 , C07C69/157 , C07C233/11 , C07C233/22 , C07C233/52 , C07C235/34 , C07C235/78 , C07C237/20 , C07C259/06 , C07C271/64 , C07D209/46 , C07D213/75 , C07D233/61 , C07D239/42 , C07D241/20 , C07D241/28 , C07D409/12 , C07K5/06 , C07K5/062
摘要： Uso de enantiómeros (R) de amidas 2-arilpropiónicas de fórmula (I) **(Ver fórmula)** y sales farmacéuticamente aceptables de las mismos, en la que: Arilo es un grupo fenilo opcionalmente sustituido con de uno a tres sustituyentes, que son iguales o diferentes seleccionados de átomos de halógeno, alquilo C1-C4, alcoxi C1-C4, hidroxi, aciloxi C1-C7, ciano, nitro, amino, acilamino C1-C3, haloalquilo C1-C3, hidroxialquilo C1-C3, haloalcoxi C1-C3, hidroxialquilarilo C1-C3, benzoílo, 4-(2,2-dimetil)vinilfenilo, (CH3)2C=CH-C6H4-, 3-fenoxifenilo, 3-bencilfenilo, 3-C6H5-CH(OH)-fenilo, 5-benzoil-tien2-ilo, 1-oxo-2-isoindolinilfenilo, 2-fluoro-4-bifenililo, 6-metoxinaftilo, 3-α-metilbencil-fenilo, o arilo es el resto conocido de ácidos 2-arilpropiónicos antiinflamatorios seleccionados de suprofeno, pirprofeno, fenoprofeno: R representa H, alquilo C1-C4, alilo, propargilo, CH2-CO2H r (CH2)2-CO2H; R'' es: - un residuo de aminoácido compuesto de alquilo C1-C6 lineal o ramificado, alquenilo, cicloalquilo, fenilaquilo sustituido con uno o más grupos carboxi CO2H; - un residuo de aminoácido compuesto de alquilo C1-C6 lineal o ramificado, alquenilo, cicloalquilo, fenilaquilo sustituido con uno o más grupos carboxi CO2H y con un heteroátomo seleccionado de oxígeno o azufre; - o un residuo de aminoácido seleccionado de ácido γ-aminobutírico, ácido δ-aminovalérico, ácido cis-4-amino-ciclohexanocarboxílico, ácido trans-4-ciclohexanocarboxílico, ácido 3-amino-1,5-pentanodioico, L-alanil-glicina, histidina y glutamina; - un residuo de fórmula -CH2-CH2X-(CH2-CH2O)nR, en la que R es como se ha definido en la presente memoria descriptiva en lo que antecede; siendo n un número entero de 0 a 5, mientras que X es oxígeno o azufre; - un residuo de fórmula (R) o (S)-CH-(CH3)-CH2-O-CH2-CH2-OH; - un residuo de fórmula OR, en la que R es como se ha definido en la presente memoria descriptiva en lo que antecede; - un residuo de fórmula (III). **(Ver fórmula)** en la que Φ representa 2-(1-metil-pirrolidilo), 2-piridilo, 4-piridilo, 1-imidazolilo, 4-imidazolilo, 1-metil-4-imidazolilo, 1-metil-5-imidazolilo o un grupo NRaRb, en el que cada Ra y Rb, que pueden ser iguales o diferentes, representa alquilo C1-C6, 1-(4-difenilmetil)-piperacinilo, 1-(4-(4'',4''''-difluorodifenil)-metil)-piperacinilo o -(CH2)m-OH hidroxialquilo en la que m es un número entero de 2 a 3, y, como alternativa, Ra y Rb junto con el átomo de N al que están unidos constituyen un heterociclo de 3 a 7 miembros de fórmula (IV). **(Ver fórmula)** en la que - Y representa un enlace simple, CH2, O, S o N-Rc, siendo RC H, alquilo C1-C6, (CH2)m-OH-hidroxialquilo, un - residuo (CH2)m-Ar'', en el que Ar'' es un arilo, heteroarilo, residuo cicloalifático y/o heterocicloalifático, m'' es cero o un número entero de 1 a 3, p y q son, cada uno de forma independiente, un número entero de 1 a 3; - un heteroarilo seleccionado del grupo constituido por 2-piridilo o 4-piridilo, 2-pirimidinilo o 4-pirimidinilo; 2-piracinilo, 5-metil-2-piracinilo; 2-1,3-tiazolidinilo; 2-1,3-tiazolilo, 1,3-oxazolilo, 3-isoxazolilo, 4-dihidro-3-oxo-isoxazolilo, 5-metil-isoxazol-4-ilo, 2-imidazolilo, 4-imidazolil-5-carboxiamida y 2-imidazolil-4,5-dicarbonitrilo, 5-indanilo, 5-indazolilo, 7-aza-indol-3-ilo, 2- o 3- o 4-quinolinilo; en la preparación de un medicamento para el tratamiento de enfermedades que implican la quimiotaxis de neutrófilos inducida por la interleuquina-8.

9. 发明专利

EE04912B1 未知
公开(公告)号：EE04912B1
公开(公告)日：2007-10-15
申请号：EEP200100233
申请日：1999-10-14
申请人： DOMPE SPA
发明人： BERTINI RICCARDO , BIZZARRI CINZIA , SABBATINI VILMA , PORZIO STEFANO , CASELLI GIANFRANCO , ALLEGRETTI MARCELLO , CESTA MARIA CANDIDA , GANDOLFI CARMELO A , MANTOVANINI MARCO , COLOTTA FRANCESCO
IPC分类号： A61K31/16 , A61P9/08 , A01N37/18 , A61K20060101 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/275 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/445 , A61K31/497 , A61K31/537 , A61P11/00 , A61P13/12 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , C07C20060101 , C07C221/00 , C07C233/11 , C07C311/03 , C07C311/04 , C07C311/05 , C07C311/45 , C07C311/47 , C07C311/50 , C07C311/51 , C07D213/82 , C07D295/08 , C07D333/20
摘要： The compounds of formula 1 wherein R and R 2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN leukocytes) at the inflammatory sites.

10. 发明专利

PL366698A1 OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS 未知
公开(公告)号：PL366698A1
公开(公告)日：2005-02-07
申请号：PL36669802
申请日：2002-02-25
申请人： DOMPE SPA
发明人： ALLEGRETTI MARCELLO , BERTINI RICCARDO , BERDINI VALERIO , BIZZARRI CINZIA , CESTA MARIA CANDIDA , DI CIOCCIO VITO , CASELLI GIANFRANCO , COLOTTA FRANCESCO , GANDOLFI CARMELO
IPC分类号： C07D295/12 , A61K31/165 , A61K31/198 , A61K31/439 , A61K31/445 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61P1/04 , A61P9/10 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P29/00 , A61P37/06 , A61P43/00 , C07C231/02 , C07C231/16 , C07C233/40 , C07C233/44 , C07C233/51 , C07C235/34 , C07C235/70 , C07C237/22 , C07C279/12 , C07C281/16 , C07D211/58 , C07D233/24 , C07D233/46 , C07D295/13 , C07D295/14 , C07D451/04 , C07C233/34 , C07D211/06 , A61K31/16
摘要： (R)-2-Arylpropionamide compounds of formula (I), pharmaceutical preparations of the compounds and a process for making the compounds are described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonuclear leukocytes and monocytes at inflammatory sites. In particular, the invention relates to the R enantiomers of omega-aminoalkylamides of 2-aryl propionic acids, of formula (I), for use as inhibitors of chemotaxis of neutrophils and monocytes induced by the C5a fraction of complement and by other chemotactic proteins whose biological activity is associated with activation of a 7-TD receptor. Selected compounds of formula (I) are dual inhibitors of both the C5a-induced chemotaxis of neutrophils and monocytes and the IL-8-induced chemotaxis of polymorphonuclear leukocytes.

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