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1. 发明申请

WO2006038027A3 SINGLE DOMAIN ANTIBODIES AGAINST TNFRl AND METHODS OF USE THEREFOR 审中-公开
标题翻译：针对TNFR1的单一抗体抗体及其使用方法
公开(公告)号：WO2006038027A3
公开(公告)日：2007-01-04
申请号：PCT/GB2005003873
申请日：2005-10-07
申请人： DOMANTIS LTD , BREWIS NEIL D , WOOLVEN BENJAMIN P , HOLMES STEVE , TOMLINSON IAN M , LEE JENNIFER , ENEVER CAROLYN , BASRAN AMRIK , JONES KATE , WILDT RUUD DE , TUNA MIHRIBAN
发明人： BREWIS NEIL D , WOOLVEN BENJAMIN P , HOLMES STEVE , TOMLINSON IAN M , LEE JENNIFER , ENEVER CAROLYN , BASRAN AMRIK , JONES KATE , WILDT RUUD DE , TUNA MIHRIBAN
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C07K16/28 , C07K16/40 , C12N15/13 , C12N15/62 , C12N15/63
CPC分类号： C07K16/18 , A61K47/60 , A61K2039/505 , C07K16/241 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/40 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12N2799/021
摘要： The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
摘要翻译：本发明提供了治疗炎性疾病（例如慢性炎性疾病）的方法，其包括施用肿瘤坏死因子受体1拮抗剂。本发明还提供了含有结合肿瘤坏死因子的免疫球蛋白单可变结构域（结构域抗体，dAb）单体的配体受体1以及使用配体的方法。还提供了编码配体的核酸，重组宿主细胞和制备配体的方法。

2. 发明申请

WO2010007376A3 COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 审中-公开
标题翻译： CD28结合的组合物单一使用方法和使用方法
公开(公告)号：WO2010007376A3
公开(公告)日：2010-05-27
申请号：PCT/GB2009001762
申请日：2009-07-17
申请人： DOMANTIS LTD , ENEVER CAROLYN , GRANT STEVEN , SANSOM DAVID , HOLMES STEVE
发明人： ENEVER CAROLYN , GRANT STEVEN , SANSOM DAVID , HOLMES STEVE
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06
CPC分类号： C07K16/2818 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76
摘要： The disclosure relates to a monovalent polypeptide domain which specifically binds CD28, as well as to an antagonist of CD28, where the antagonist comprises a monovalent polypeptide domain which specifically binds CD28. This disclosure encompasses monovalent polypeptide domains comprising an antibody single variable domain that monovalently binds CD28. An antibody single variable domain that is monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a monovalent anti-CD28 antibody single variable domain consists of or comprises an antibody single variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the monovalent anti-CD28 antibody single variable domain is a human antibody single variable domain. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a monovalent anti-CD28 antibody single variable domain to the individual.
摘要翻译：本公开涉及特异性结合CD28的单价多肽结构域以及CD28拮抗剂，其中拮抗剂包含特异性结合CD28的单价多肽结构域。本公开内容涵盖包含单价结合CD28的抗体单可变结构域的单价多肽结构域。用于结合CD28的单价抗体单可变区可抑制CD28活性。在一个方面，单价抗CD28抗体单可变结构域由一个方面组成或包含特异性结合和拮抗CD28的活性的抗体单可变结构域，而不具有实质上激动的CD28活性。另一方面，单价抗CD28抗体单可变结构域是人抗体单可变结构域。本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及CD80和/或CD86与CD28相互作用的疾病或病症的方法，涉及向单克隆抗CD28抗体单可变结构域施用的方法个人。

3. 发明申请

WO2010063818A3 METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES 审中-公开
标题翻译：选择抗蛋白酶多肽的方法
公开(公告)号：WO2010063818A3
公开(公告)日：2010-08-12
申请号：PCT/EP2009066395
申请日：2009-12-04
申请人： GLAXO GROUP LTD , ENEVER CAROLYN , JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN M
发明人： ENEVER CAROLYN , JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN M
IPC分类号： C07K16/00 , C12Q1/37
CPC分类号： G01N33/6857 , C12Q1/37 , C40B40/10 , G01N33/6845 , G01N2500/02
摘要： The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g. for treating disease in humans.
摘要翻译：本发明涉及用于从文库或肽和多肽（例如展示系统）库中选择，分离和/或回收肽或多肽的方法，所述肽和多肽抗蛋白酶如蛋白酶血清。一般而言，该方法包括提供肽或多肽的文库或库，在适合蛋白酶活性的条件下将文库或所有组成成分与蛋白酶一起孵育，并选择，分离和/或回收抗蛋白酶降解的肽或多肽并具有期望的生物活性。选定的肽和多肽可用作治疗剂，例如治疗剂。用于治疗人类疾病。

4. 发明申请

WO2008149150A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149150A3
公开(公告)日：2009-06-25
申请号：PCT/GB2008050407
申请日：2008-06-04
申请人： DOMANTIS LTD , STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
发明人： STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
摘要翻译：本发明涉及抗蛋白酶降解的抗VEGF多肽和抗体单可变结构域（dAb），以及包含这些的拮抗剂。多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺并递送至患者的胃肠道，以及用于治疗癌症和炎性疾病如关节炎。

5. 发明申请

WO2008149144A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149144A3
公开(公告)日：2009-04-02
申请号：PCT/GB2008050400
申请日：2008-06-03
申请人： DOMANTIS LTD , SEPP ARMIN , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT
发明人： SEPP ARMIN , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译：本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道，以及用于治疗炎性疾病，例如关节炎或COPD。

6. 发明申请

WO2010136508A3 STEM CELL TARGETING 审中-公开
标题翻译：干细胞靶向
公开(公告)号：WO2010136508A3
公开(公告)日：2011-02-24
申请号：PCT/EP2010057283
申请日：2010-05-26
申请人： GLAXO GROUP LTD , BALLARD VICTORIA , BATUWANGALA THIL DINUK , COULSTOCK EDWARD , DE ANGELIS ELENA , EDELBERG JAY , ENEVER CAROLYN , HOLMES STEVE , JAWAD-ALAMI ZAHRA
发明人： BALLARD VICTORIA , BATUWANGALA THIL DINUK , COULSTOCK EDWARD , DE ANGELIS ELENA , EDELBERG JAY , ENEVER CAROLYN , HOLMES STEVE , JAWAD-ALAMI ZAHRA
IPC分类号： A61K38/19 , A61K39/395 , A61P9/00 , A61P21/00 , C07K16/18 , C07K16/46 , C12N5/00
CPC分类号： A61K38/1866 , A61K38/1793 , A61K38/1825 , A61K38/195 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/569 , C07K2317/60 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The present invention describes an antigen-binding construct comprising a first agent which binds to a stem cell specific marker molecule and a second agent which binds to a tissue specific marker molecule. In particular, the invention describes a construct wherein the tissue specific marker is a muscle specific marker molecule. Such a construct may be used in a pharmaceutical composition for use in muscle regeneration or heart disease.
摘要翻译：本发明描述了一种抗原结合构建体，其包含结合干细胞特异性标志物分子的第一药剂和与组织特异性标志物分子结合的第二药剂。特别地，本发明描述了其中组织特异性标记物是肌肉特异性标记分子的构建体。这种构建体可以用于用于肌肉再生或心脏病的药物组合物中。

7. 发明申请

WO2008149146A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149146A3
公开(公告)日：2009-06-11
申请号：PCT/GB2008050403
申请日：2008-06-03
申请人： DOMANTIS LTD , STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
发明人： STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-VEGF pol ypeptides and antibody single variable domains (dAbs) that are resi stant to degradation by a prot ease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
摘要翻译：本发明涉及抗VEGF多肽和抗体单可变结构域（dAb），其通过抗原降解，以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺部并递送至患者胃肠道，以及治疗癌症和炎性疾病如关节炎。

8. 发明申请

WO2008149149A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149149A3
公开(公告)日：2009-04-02
申请号：PCT/GB2008050406
申请日：2008-06-04
申请人： DOMANTIS LTD , JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN
发明人： JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-IL-1R1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译：本发明涉及抗蛋白酶降解抗体的抗IL-1R1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道，以及用于治疗炎性疾病，例如关节炎或COPD。

9. 发明申请

WO2008149147A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149147A3
公开(公告)日：2009-06-11
申请号：PCT/GB2008050404
申请日：2008-06-03
申请人： DOMANTIS LTD , STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
发明人： STEWARD MICHAEL , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN , JESPERS LAURENT , BATUWANGALA THIL DINUK
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/2878 , C07K16/22 , C07K16/244 , C07K16/2866 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要： The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.
摘要翻译：本发明涉及抗蛋白酶降解的抗VEGF多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用于肺部给药，口服给药，递送至肺部并递送至患者胃肠道，以及治疗癌症和炎性疾病如关节炎。

10. 发明申请

WO2008149148A3 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 审中-公开
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：WO2008149148A3
公开(公告)日：2009-04-02
申请号：PCT/GB2008050405
申请日：2008-06-04
申请人： DOMANTIS LTD , JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN
发明人： JESPERS LAURENT , PUPECKA MALGORZATA , TOMLINSON IAN , ENEVER CAROLYN
IPC分类号： C07K16/00 , C07K16/22 , C07K16/28
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译：本发明涉及抗蛋白酶降解的抗TNFR1多肽和抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用作治疗剂和/或预防剂，当施用于患者时可能遇到蛋白酶，例如用于肺部施用，口服施用，递送至肺并递送至患者的胃肠道，以及用于治疗炎性疾病如关节炎或COPD。

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