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1. 发明专利

CA2687534A1 METHOD FOR PRODUCTION OF DENDRITIC CELL 未知
公开(公告)号：CA2687534A1
公开(公告)日：2008-11-27
申请号：CA2687534
申请日：2008-05-12
申请人： DNAVEC CORP , UEDA YASUJI
发明人： INOUE MAKOTO , HASEGAWA MAMORU , YONEMITSU YOSHIKAZU , HARADA YUI
IPC分类号： C12N5/0784 , A61K38/14 , A61K38/19
摘要： Disclosed are: a method for producing a dendritic cell (DC), which involves the step of culturing a DC precursor cell in the presence of two or more cytokines; a DC produced by the method; and use of the DC. The method can produce a large quantity of a DC precursor cell which is highly capable of being differentiated into a DC. The method can also produce a large quantity of a DC from a small quantity of a DC precursor cell. Therefore, it becomes possible to readily increase the number of DCs to be administered in the anti-tumor immunotherapy or the treatment of an infectious disease utilizing a DC, resulting in the enhancement of the efficacy of a DC vaccine.

2. 发明公开

EP2351599A4 METHOD FOR PRODUCING DENDRITIC CELLS 审中-公开
标题翻译：用于生产树突状细胞
公开(公告)号：EP2351599A4
公开(公告)日：2013-05-08
申请号：EP09826146
申请日：2009-11-13
申请人： DNAVEC CORP , UEDA YASUJI
发明人： UEDA YASUJI , YONEMITSU YOSHIKAZU , HARADA YUI
IPC分类号： A61P35/00 , A61K39/00
CPC分类号： C12N5/0639 , A61K39/00 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/23 , C12N2501/26

3. 发明公开

EP2154243A4 METHOD FOR PRODUCTION OF DENDRITIC CELL 有权
标题翻译：一种用于生产树突状细胞
公开(公告)号：EP2154243A4
公开(公告)日：2011-07-06
申请号：EP08752599
申请日：2008-05-12
申请人： DNAVEC CORP , UEDA YASUJI
发明人： INOUE MAKOTO , HASEGAWA MAMORU , YONEMITSU YOSHIKAZU , HARADA YUI
IPC分类号： C12N5/0784 , C12N5/06
CPC分类号： C12N5/0639 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/26

4. 发明申请

WO2006112553A3 HIGHLY SAFE INTRANASALLY ADMINISTRABLE GENE VACCINES FOR TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：高度安全的管理基因疫苗治疗阿尔茨海默病
公开(公告)号：WO2006112553A3
公开(公告)日：2007-02-22
申请号：PCT/JP2006308913
申请日：2006-04-20
申请人： DNAVEC CORP , JAPAN GOVERNMENT , HARA HIDEO , TABIRA TAKESHI , YONEMITSU YOSHIKAZU , INOUE MAKOTO , TOKUSUMI YUMIKO , HASEGAWA MAMORU
发明人： HARA HIDEO , TABIRA TAKESHI , YONEMITSU YOSHIKAZU , INOUE MAKOTO , TOKUSUMI YUMIKO , HASEGAWA MAMORU
IPC分类号： C12N15/09
CPC分类号： C12N15/86 , A61K2039/5256 , A61K2039/543 , A61K2039/57 , C07K14/4711 , C12N2760/18843 , C12N2800/30
摘要： An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.
摘要翻译：本发明的目的是为阿尔茨海默病提供安全有效的疫苗疗法。构建携带淀粉样蛋白基因的负链RNA病毒载体，鼻内给予24至25个月大的APP转基因小鼠。测定血清抗-A42抗体水平，显示明显高于对照组。组织学研究结果表明，施用本发明的载体显着降低了所有额叶，顶叶和海马中的老年斑。脑A水平也明显降低。此外，本发明的载体的施用不会导致中枢神经系统中的淋巴细胞浸润。

5. 发明专利

JP2008105946A Method of reconstructing blood cell from gene-transfer hematopoietic cell 审中-公开
标题翻译：从基因转移HEMATOPOIETIC细胞重建血液细胞的方法
公开(公告)号：JP2008105946A
公开(公告)日：2008-05-08
申请号：JP2005032205
申请日：2005-02-08
申请人： Dnavec Corp , ディナベック株式会社
发明人： YOSHIDA HISAMI , OKANO SHINJI , YONEMITSU YOSHIKAZU , SUEISHI KATSUO , HASEGAWA MAMORU
IPC分类号： A61K35/28 , A61K48/00 , A61P43/00 , C12N15/09
CPC分类号： C12N7/00 , A61K48/00 , C12N5/0647 , C12N2510/02 , C12N2760/18852
摘要： PROBLEM TO BE SOLVED: To provide a method of producing a hematopoietic cell transplantation composition containing gene-transfer hematopoietic cells by using chromosome non-integration virus vector, and a method of reconstructing blood cells from the gene-transfer hematopoietic cells by using the chromosome non-integration virus vector. SOLUTION: The method of producing the hematopoietic transplantation composition enables to reconstruct blood cells expressing transferred gene by transferring a minus chain RNA virus vector into hematopoietic cells and hematopoietic cell-transplanting these cells. The gene-transfer hematopoietic cells can be differentiated into leucocytes, erythrocytes and thrombocytes in the body to which the hematopoietic cells are transplanted. Furthermore, a safe gene-transferring system causing no danger of damaging host chromosomes in gene therapy in hematopoietic cell transplantation. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过使用染色体非整合病毒载体制备含有基因转移造血细胞的造血细胞移植组合物的方法，以及通过使用从基因转移造血细胞重建血细胞的方法染色体非整合病毒载体。解决方案：造血移植组合物的制备方法能通过将负链RNA病毒载体转移到造血细胞和造血细胞移植这些细胞中来重建表达转移基因的血细胞。基因转移造血细胞可以分化成移植造血细胞的体内的白细胞，红细胞和血小板。此外，一种安全的基因转移系统在造血细胞移植的基因治疗中不会造成损害宿主染色体的危险。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2010263859A Dendritic cell and anticancer agent 审中-公开
标题翻译： DENDRITIC CELL AND ANTICANCER AGENT
公开(公告)号：JP2010263859A
公开(公告)日：2010-11-25
申请号：JP2009119333
申请日：2009-05-15
申请人： Dnavec Corp , Kyushu Univ , ディナベック株式会社 , 国立大学法人九州大学
发明人： YONEMITSU YOSHIKAZU , SUGIYAMA MASAHIKO , YOSHIDA HISAMI , MAEHARA YOSHIHIKO , INOUE MAKOTO , HASEGAWA MAMORU
IPC分类号： C12N5/10 , A61K35/12 , A61K35/76 , A61K38/00 , A61K48/00 , A61P35/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide an anticancer agent to adenocarcinoma, having a potent anti-tumor effect by a specific immune response, inhibiting the function of VEGF (vascular endothelial growth factor), and treating peritoneal dissemination.
SOLUTION: The dendritic cell is characterized by including a recombinant paramyxoviral vector introduced with an Flt-1 gene, and the anticancer agent is characterized by containing the dendritic cells, inhibiting the production of the VEGF, contracting the tumor, inhibiting the body weight increase and the production of ascites by a cancer, and further increasing the survival rate of peritoneal dissemination model mice to be able to extend the surviving number of days.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供抗癌剂，其具有通过特异性免疫应答有效的抗肿瘤作用，抑制VEGF（血管内皮生长因子）的功能和治疗腹膜传播的腺癌。解决方案：树突状细胞的特征在于包含引入Flt-1基因的重组副粘病毒载体，抗癌剂的特征在于含有树突状细胞，抑制VEGF的产生，收缩肿瘤，抑制身体体重增加和腹水由癌症产生，并进一步提高腹膜传播模型小鼠的存活率，以延长生存天数。版权所有（C）2011，JPO＆INPIT

7. 发明公开

EP2322611A4 METHOD FOR PRODUCTION OF REPROGRAMMED CELL USING CHROMOSOMALLY UNINTEGRATED VIRUS VECTOR 有权转让
标题翻译：制造方法重新编程小区是基于染色体非整合病毒载体
公开(公告)号：EP2322611A4
公开(公告)日：2012-04-18
申请号：EP09797978
申请日：2009-07-16
申请人： DNAVEC CORP
发明人： FUSAKI NOEMI , BAN HIROSHI , HASEGAWA MAMORU , YONEMITSU YOSHIKAZU
IPC分类号： C12N15/09 , C12N5/074 , C12N5/10
CPC分类号： C12N15/86 , C07K14/4702 , C12N5/0696 , C12N7/00 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18645 , C12N2760/18662 , C12N2760/18822 , C12N2760/18843

8. 发明专利

CA2605957A1 HIGHLY SAFE INTRANASALLY ADMINISTRABLE GENE VACCINES FOR TREATING ALZHEIMER'S DISEASE 未知
公开(公告)号：CA2605957A1
公开(公告)日：2006-10-26
申请号：CA2605957
申请日：2006-04-20
申请人： DNAVEC CORP , JAPAN GOVERNMENT
发明人： HARA HIDEO , HASEGAWA MAMORU , TABIRA TAKESHI , INOUE MAKOTO , TOKUSUMI YUMIKO , YONEMITSU YOSHIKAZU
IPC分类号： C12N15/09
摘要： An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.

9. 发明专利

AT447018T 未知
公开(公告)号：AT447018T
公开(公告)日：2009-11-15
申请号：AT06732451
申请日：2006-04-20
申请人： DNAVEC CORP , JAPAN GOVERNMENT
发明人： HARA HIDEO , TABIRA TAKESHI , YONEMITSU YOSHIKAZU , INOUE MAKOTO , TOKUSUMI YUMIKO , HASEGAWA MAMORU
IPC分类号： C12N15/09

10. 发明专利

DE602006010064D1 未知
公开(公告)号：DE602006010064D1
公开(公告)日：2009-12-10
申请号：DE602006010064
申请日：2006-04-20
申请人： DNAVEC CORP , JAPAN GOVERNMENT
发明人： HARA HIDEO , TABIRA TAKESHI , YONEMITSU YOSHIKAZU , INOUE MAKOTO , TOKUSUMI YUMIKO , HASEGAWA MAMORU
IPC分类号： C12N15/09
摘要： An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.

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