专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005030258A3 SMALL MOLECULE COMPOSITIONS AND METHODS FOR INCREASING DRUG EFFICIENCY USING COMPOSITIONS THEREOF 审中-公开
标题翻译：小分子组合物和使用其组合物来提高药物效率的方法
公开(公告)号：WO2005030258A3
公开(公告)日：2005-09-22
申请号：PCT/US2004031147
申请日：2004-09-22
申请人： DIHEDRON CORP , CASTELLINO ANGELO JOHN , ASPLAND SIMON ERIC , BALLATORE CARLO , DESHARNAIS JOEL , NEWMAN MICHAEL JAMES , SUN CHENGZAO , WIRSCHING PETER
发明人： CASTELLINO ANGELO JOHN , ASPLAND SIMON ERIC , BALLATORE CARLO , DESHARNAIS JOEL , NEWMAN MICHAEL JAMES , SUN CHENGZAO , WIRSCHING PETER
IPC分类号： A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K49/04 , C07K7/08 , A61K47/48 , C07H21/00
CPC分类号： C07K7/08 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K49/0404
摘要： In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula (1): D - L - S or formula (2): D-L-S' wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S' is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.
摘要翻译：在某些实施方案中，本文提供了用于提高药物效率的组合物和方法。在某些实施方案中，提供的缀合物用于治疗各种疾病的组合物和方法，并具有式（1）：D-L-S或式（2）：D-L-S'，其中D是药物部分; 可能存在或不存在的L是非释放连接体部分; S是除己糖激酶，蛋白激酶或脂质激酶以外的激酶的底物; 和S'是除己糖激酶，蛋白激酶或脂质激酶之外的磷酸转移酶的底物。

2. 发明申请

WO2006002895A2 COMPOSITIONS AND METHODS FOR DELIVERY OF ANTITUMOR AGENTS 审中-公开
标题翻译：用于递送抗菌剂的组合物和方法
公开(公告)号：WO2006002895A2
公开(公告)日：2006-01-12
申请号：PCT/EP2005007007
申请日：2005-06-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , SCRIPPS RESEARCH INST , JANDA KIM D , WIRSCHING PETER , BOGER DALE L
发明人： JANDA KIM D , WIRSCHING PETER , BOGER DALE L
IPC分类号： A61K47/48 , C07D403/14 , C07D487/04 , C07D487/10
CPC分类号： C07D487/10 , A61K47/6849 , C07D403/06 , C07D403/14 , C07D487/04
摘要： Methods for treating a neoplastic disease with an antibody-cytotoxin conjugate molecule, methods of synthesizing an antibody-cytotoxin conjugate molecule are provided. Compounds that are useful as antibody-cytotoxin conjugate molecule or useful in the synthesis of these molecules are also provided.
摘要翻译：提供了用抗体 - 细胞毒素偶联物分子治疗肿瘤疾病的方法，合成抗体 - 细胞毒素偶联物分子的方法。还提供了可用作抗体 - 细胞毒素缀合物分子或可用于合成这些分子的化合物。

3. 发明申请

WO0246234A8 COCAINE HAPTENS 审中-公开
公开(公告)号：WO0246234A8
公开(公告)日：2003-04-24
申请号：PCT/US0147471
申请日：2001-12-07
申请人： SCRIPPS RESEARCH INST , JANDA KIM D , WIRSCHING PETER
发明人： JANDA KIM D , WIRSCHING PETER
IPC分类号： C07K16/44 , G01N33/94 , C07K16/00
CPC分类号： C07K16/44 , A61K2039/505 , G01N33/946
摘要： The development of a catalytic monoclonal antibody (mAb) provides the means for not only binding, but also degrading cocaine, which offers a broad-based therapy for cocaine addition. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analog phosphonate haptens are shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.
摘要翻译：催化单克隆抗体（mAb）的开发提供了不仅结合，而且降解可卡因的方法，可卡因为可卡因添加提供了广泛的治疗。 Hapten设计是编程抗体催化的核心要素。在经典的过渡态类似物膦酸盐半抗原中使用的接头的特征显示出对于获得水解可卡因的苯甲酸酯的mAb是重要的。

4. 发明申请

WO2005040338A3 CONSTRAINED ALKALOID IMMUNOGENS AND ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：受限制的生物碱免疫原和抗体及其用途
公开(公告)号：WO2005040338A3
公开(公告)日：2005-10-27
申请号：PCT/US2004016040
申请日：2004-05-20
申请人： SCRIPPS RESEARCH INST , JANDA KIM D , WIRSCHING PETER
发明人： JANDA KIM D , WIRSCHING PETER
IPC分类号： A61K31/4745 , A61K35/14 , A61K39/00 , A61K39/385 , C07D401/04 , C07K1/13 , C07K16/44 , C07K17/02 , C07K17/06 , C12N20060101 , G01N33/53 , G01N33/531
CPC分类号： A61K39/385 , A61K31/4745 , A61K39/00 , A61K2039/505 , C07D471/04 , C07K16/44
摘要： Immunogens useful in the production of anti-nicotine antibodies are provided. Anti-nicotine antibodies that immunoreact with the immunogens and nicotine and uses of the immunogens and antibodies in treating nicotine addiction are also provided. Also provided are methods for enhancing the immunogenicity of a hapten by introducing a modification to constrain its conformation.
摘要翻译：提供了用于生产抗尼古丁抗体的免疫原。还提供了与免疫原和尼古丁免疫反应的抗尼古丁抗体以及免疫原和抗体在治疗尼古丁成瘾方面的用途。还提供了通过引入修饰以约束其构象来增强半抗原的免疫原性的方法。

5. 发明申请

WO2009036340A3 MPZP: A SMALL MOLECULE CORTICOTROPIN-RELEASING FACTOR TYPE 1 RECEPTOR (CRF1) ANTAGONIST 审中-公开
标题翻译： MPZP：小分子释放促凋亡因子1型受体（CRF1）拮抗剂
公开(公告)号：WO2009036340A3
公开(公告)日：2009-12-30
申请号：PCT/US2008076257
申请日：2008-09-12
申请人： SCRIPPS RESEARCH INST , KOOB GEORGE F , ZORRILA ERIC P , MASON BARBARA , JANDA KIM , WIRSCHING PETER
发明人： KOOB GEORGE F , ZORRILA ERIC P , MASON BARBARA , JANDA KIM , WIRSCHING PETER
IPC分类号： C07D417/14 , A61K31/513
CPC分类号： A61K31/519
摘要： A method for treating or preventing a host mammal that exhibits aversive signs and symptoms present during protracted abstinence or extended discontinuation syndromes as seen after cessation of compulsive activity, behaviors, or substance use is disclosed. That method comprises administering to a host mammal in need a pharmaceutical composition containing an aversive sign and symptom lessening amount a compound of Formula I or a pharmaceutically acceptable salt thereof dissolved or dispersed in a physiologically acceptable diluent, and repeating the administration as needed, wherein W, X, Y and Z, R1 and Ar are defined within. Data are provided in rats as host mammals using behavioral models dependent on the CRFi system: defensive burying, alcohol dependence, cocaine dependence and nicotine dependence. A contemplated method also is useful for inhibiting relapse of such a behavior. A contemplated method also is useful for treating substance -related or substance- induced psychiatric disorders that include aversive signs and symptoms.
摘要翻译：公开了一种用于治疗或预防宿主哺乳动物的方法，所述宿主哺乳动物在停止强迫活动，行为或物质使用之后看到的在持续禁欲或延长中断综合征期间呈现厌恶症状和症状。该方法包括向需要的宿主哺乳动物施用含有厌恶症状和症状减轻量的药物组合物，溶解或分散于生理上可接受的稀释剂中的式I化合物或其药学上可接受的盐，并且根据需要重复施用，其中W ，X，Y和Z，R1和Ar定义在其中。使用依赖于CRFI系统的行为模型：大鼠作为宿主哺乳动物提供数据：防御性掩埋，酒精依赖，可卡因依赖和尼古丁依赖。预期的方法也可用于抑制这种行为的复发。所考虑的方法也可用于治疗包括厌恶症状和症状的物质相关的或物质诱导的精神病症。

6. 发明申请

WO02058635A3 NICOTINE IMMUNOGENS AND ANTIBODIES AND USES THEREOF 审中-公开
标题翻译： NICOTINE免疫原和抗体及其用途
公开(公告)号：WO02058635A3
公开(公告)日：2003-03-20
申请号：PCT/US0202146
申请日：2002-01-25
申请人： SCRIPPS RESEARCH INST , JANDA KIM D , WIRSCHING PETER
发明人： JANDA KIM D , WIRSCHING PETER
IPC分类号： A61K39/00 , A61P25/08 , C07D207/06 , C07D207/26 , C07D207/263 , C07D207/27 , C07D401/04 , C07K16/16 , C12P21/08 , A61K31/405 , A61K31/44 , A61K39/385 , A61K39/395 , C07D207/16 , C07K16/44
CPC分类号： C07D207/27 , A61K39/00 , A61K2039/505 , C07D207/06 , C07D401/04 , C07K16/16
摘要： Immunogens useful in the production of anti-nicotine antibodies are provided. Anti-nicotine antibodies that immunoreact with the immunogens and nicotine and uses of the immunogens and antibodies in treating nicotine addiction are also provided.
摘要翻译：提供了可用于生产抗尼古丁抗体的免疫原。还提供了与免疫原和尼古丁免疫反应的抗尼古丁抗体以及免疫原和抗体在治疗尼古丁成瘾中的用途。

7. 发明专利

AU2004275770A1 Small molecule compositions and methods for increasing drug efficiency using compositions thereof 未知
公开(公告)号：AU2004275770A1
公开(公告)日：2005-04-07
申请号：AU2004275770
申请日：2004-09-22
申请人： DIHEDRON CORP
发明人： CASTELLINO ANGELO JOHN , BALLATORE CARLO , NEWMAN MICHAEL JAMES , WIRSCHING PETER , SUN CHENGZAO , DESHARNAIS JOEL , ASPLAND SIMON ERIC
IPC分类号： C07K7/08 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K49/04

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式