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1. 发明申请

WO2004092338A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO CANCER SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，SPLICE变量和与癌症特异性基因和蛋白质相关的方法
公开(公告)号：WO2004092338A3
公开(公告)日：2005-09-29
申请号：PCT/US2004011104
申请日：2004-04-12
申请人： DIADEXUS INC , MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , TAM ALBERT
发明人： MACINA ROBERTO A , TURNER LEAH R , SUN YONGMING , TAM ALBERT
IPC分类号： C07K14/82 , C12N20060101 , C12N15/11 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/82 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, colon, lung, ovarian or prostate, identifying breast, colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered normal or cancerous breast, colon, lung, ovarian or prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺，结肠，肺，卵巢或前列腺中的乳腺癌，结肠癌，肺癌，卵巢癌或前列腺癌和非癌性疾病状态，鉴别乳腺癌，结肠癌，肺癌，卵巢癌或卵巢癌前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生，以及生产工程化的正常或癌性乳腺癌，结肠癌，肺癌，卵巢癌或前列腺组织用于治疗和研究。

2. 发明申请

WO2005044977A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物，群体变异和方法
公开(公告)号：WO2005044977A3
公开(公告)日：2009-03-26
申请号：PCT/US2004020678
申请日：2004-06-25
申请人： DIADEXUS INC , VARTANIAN STEFFAN F , TURNER LEAH R , MACINA ROBERTO A , CHEN HUEI-MEI , TAM ALBERT
发明人： VARTANIAN STEFFAN F , TURNER LEAH R , MACINA ROBERTO A , CHEN HUEI-MEI , TAM ALBERT
IPC分类号： C07H21/02 , A61K31/70 , C07H21/04 , C12N20060101 , C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/47 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

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