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1. 发明申请

WO2012023031A2 METHOD AND SYSTEM FOR INCREASING THE DYNAMIC RANGE OF ION DETECTORS 审中-公开
标题翻译：提高离子检测器动态范围的方法和系统
公开(公告)号：WO2012023031A2
公开(公告)日：2012-02-23
申请号：PCT/IB2011/001905
申请日：2011-08-18
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , GUNA, Mircea , COLLINGS, Bruce
发明人： GUNA, Mircea , COLLINGS, Bruce
IPC分类号： H01J49/02
CPC分类号： H01J49/0031 , H01J49/025 , H01J49/06 , H01J49/061
摘要： A mass spectrometer system can include a mass analyzer operable to mass transmit streams of ions to a detector in a mass dependent fashion for measurement of ion flux intensity. An ion attenuator can be located in the extraction region between the mass analyzer and detector, downstream of the mass analyzer, and can be operable to provide selective attenuation of the ion beam by attenuating ion flux intensity also in mass dependent fashion. Higher concentration ions can be selected and attenuated, while other lower concentration ions can be left unattenuated. Different ions can be attenuated to different degrees. Locating the ion attenuator downstream of the mass analyzer so that the ion beam is already mass differentiated when attenuated can avoid mass discriminatory effects associated with ion beam attenuators. Selective attenuation of only certain ions but not others can extend the dynamic range of the detector without necessarily sacrificing detector sensitivity.
摘要翻译：质谱仪系统可以包括质量分析仪，该质量分析仪可操作以质量依赖的方式将质量流传送到检测器以测量离子流强度。离子衰减器可位于质量分析器和检测器之间的提取区域中，位于质量分析器的下游，并且可用于通过以质量依赖的方式衰减离子流强度来提供离子束的选择性衰减。较高浓度的离子可以被选择并减弱，而其他较低浓度的离子可以不被减弱。不同的离子可以被不同程度地衰减。将质量分析仪下游的离子衰减器定位，使得离子束在衰减时已经质量分辨，可避免与离子束衰减器相关的质量鉴别效应。选择性衰减只有某些离子而非其他离子可以扩大检测器的动态范围，而不必牺牲检测器的灵敏度。

2. 发明申请

WO2009094762A1 METHODS FOR FRAGMENTING IONS IN A LINEAR ION TRAP 审中-公开
标题翻译：用于在线性离子阱中去除离子的方法
公开(公告)号：WO2009094762A1
公开(公告)日：2009-08-06
申请号：PCT/CA2009/000090
申请日：2009-01-26
申请人： MDS ANALYTICAL TECHNOLOGIES, a business unit of MDS INC., doing business through its SCIEX DIVISION , LIFE TECHNOLOGIES CORPORATION , GUNA, Mircea , COLLINGS, Bruce
发明人： GUNA, Mircea , COLLINGS, Bruce
IPC分类号： H01J49/10 , H01J49/26
CPC分类号： H01J49/005 , H01J49/063 , H01J49/4225
摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5 x 10 -4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.
摘要翻译：描述了保留在离子阱中的分离离子的方法。在各种实施例中，使用小于约5×10 -4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅用于将大于约 80％的碎片效率。在各种实施例中，离子激发的持续时间大于约25ms。

3. 发明申请

WO2009036569A1 COLLISION CELL FOR MASS SPECTROMETER 审中-公开
标题翻译：大量光谱仪的碰撞细胞
公开(公告)号：WO2009036569A1
公开(公告)日：2009-03-26
申请号：PCT/CA2008/001654
申请日：2008-09-19
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC. DOING BUSINESS THROUGH ITS SCIEX DIVISION , APPLIED BIOSYSTEMS INC. , COLLINGS, Bruce , GUNA, Mircea
发明人： COLLINGS, Bruce , GUNA, Mircea
IPC分类号： H01J49/02 , H01J49/26
CPC分类号： H01J49/0045 , H01J49/063
摘要： A novel curved collision cell for a mass spectrometer is described. The collision cell includes a straight section having a length that is selected to cause a precursor ion entering the straight section to lose a desired amount of kinetic energy such that when the precursor ion enters the curved section of the collision cell the precursor ion will tend to neither escape nor contact the collision cell, and thereby tending to survive its passage within the curved portion.
摘要翻译：描述了用于质谱仪的新型弯曲碰撞池。碰撞单元包括具有选择的长度的直线段，以使前体离子进入直线段以失去所需量的动能，使得当前体离子进入碰撞池的弯曲部分时，前体离子将倾向于既不逃逸也不接触碰撞室，从而趋于在弯曲部分内通过。

4. 发明申请

WO2019012367A1 APPARATUS AND METHODS FOR REDUCED NEUTRAL CONTAMINATION IN A MASS SPECTROMETER 审中-公开
公开(公告)号：WO2019012367A1
公开(公告)日：2019-01-17
申请号：PCT/IB2018/054874
申请日：2018-06-29
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： COLLINGS, Bruce , MARTIN, Pascal
IPC分类号： H01J49/14 , H01J49/16 , G01N27/62
CPC分类号： H01J49/067
摘要： Apparatus and methods for controlling contamination of components contained within the high- vacuum chambers of mass spectrometer systems are provided. The apparatus and methods employ a beam of neutral gas injected in a contra-flow configuration to incoming particle stream from the ionization chamber. The contra-flow can be in the directly opposite counter-flow direction (e.g., 180 degrees) or at a cross-flow angle to the incoming ion stream (e.g., flowing at an angle between about 10 degrees and 170 degrees). The contra-flow disrupts the axial gas flow and diverts neutral molecules and other undesirable contaminants before they reach the high vacuum stages (e.g., beyond the IQ0 orifice) of the spectrometer. By reducing the transmission of contaminants into the sensitive components housed deep within the mass spectrometer, the present invention can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.

5. 发明申请

WO2022269414A1 A TECHNIQUE TO NEUTRALIZE CHARGE ON A DIFFERENTIAL PUMPING APERTURE 审中-公开
公开(公告)号：WO2022269414A1
公开(公告)日：2022-12-29
申请号：PCT/IB2022/055554
申请日：2022-06-15
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： COLLINGS, Bruce
IPC分类号： H01J49/00 , H01J49/0031 , H01J49/0095
摘要： In one aspect, a method for performing mass spectrometry is disclosed, which comprises passing a plurality of ions from an upstream ion guide to a downstream ion guide through an aperture of an ion lens disposed between the ion guides, and depositing a plurality of charged particles having an electric charge with opposite polarity relative to an electric charge of said plurality of ions on at least a portion of a surface of the ion lens, e.g., a surface facing the ions, so as to reduce an effect of a plurality of said ions, if any, deposited on said ion lens surface on a trajectory of the ions passing through the lens aperture, as ions pass from the upstream ion guide to the downstream ion guide.

6. 发明申请

WO2020121257A1 EFFECTIVE POTENTIAL MATCHING AT BOUNDARIES OF SEGMENTED QUADRUPOLES IN A MASS SPECTROMETER 审中-公开
公开(公告)号：WO2020121257A1
公开(公告)日：2020-06-18
申请号：PCT/IB2019/060729
申请日：2019-12-12
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： COLLINGS, Bruce
IPC分类号： H01J49/42
摘要： Methods and apparatus are disclosed for reducing ion reflections between multipole segments in a mass spectrometer by matching the effective potential between the two segments. Mass spectrometers having at least two multipole segments separated from each other along a longitudinal axis of the mass spectrometer such that a boundary region exists through which ions are drawn from an upstream segment to a downstream segment, and wherein each multipole segment further includes a set of spaced-apart rod-shaped electrodes disposed around the longitudinal axis and having a field radius defined by an inscribed circle between the innermost portions of each electrode. Effective potential matching can be achieved by either supplying RF signals of different amplitudes to each segment and/or by modifying the field strength of the segments. In one embodiment, the multipole segments are configured such that the upstream multipole segment has a smaller field radius than the downstream segment.

7. 发明申请

WO2022107026A2 METHOD OF PERFORMING MS/MS OF HIGH INTENSITY ION BEAMS USING A BANDPASS FILTERING COLLISION CELL TO ENHANCE MASS SPECTROMETRY ROBUSTNESS 审中-公开
公开(公告)号：WO2022107026A2
公开(公告)日：2022-05-27
申请号：PCT/IB2021/060677
申请日：2021-11-17
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： COLLINGS, Bruce , HAGER, James W. , KANG, Yang , SCHNEIDER, Bradley B.
IPC分类号： H01J49/00 , H01J49/42 , H01J49/0031 , H01J49/004 , H01J49/421
摘要： A mass spectrometer comprises a first mass filter for receiving a plurality of ions and having a transmission bandwidth configured to allow transmission of ions having m/z ratios within a desired range, and a second mass filter that is disposed downstream of the first mass filter for selecting ions having a target m/z value within a transmission window thereof for mass analysis. The transmission bandwidth of the first mass filter encompasses at least two m/z ratios of interest such that one of said m/z ratios corresponds to said target m/z value within the transmission window of said second mass filter.

8. 发明申请

WO2021014390A1 INCREASED DYNAMIC RANGE FOR THE ATTENUATION OF AN ION BEAM 审中-公开
公开(公告)号：WO2021014390A1
公开(公告)日：2021-01-28
申请号：PCT/IB2020/056924
申请日：2020-07-22
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： COLLINGS, Bruce , MARTIN, Pascal
IPC分类号： H01J49/42 , H01J49/06 , H01J49/00 , H01J49/02
摘要： In one aspect, a method of modulating transmission of ions in a mass spectrometer is disclosed, which comprises generating an ion beam comprising a plurality of ions, directing the ion beam to an ion optic positioned in the path of the ion beam, wherein the ion optic includes at least one opening through which the ions can pass, and applying one or more voltage pulses at a selected duty cycle to said ion optic so as to obtain a desired attenuation of brightness of the ion beam passing through the ion optic, where a pulse width of said voltage pulses at said selected duty cycle is determined by identifying a pulse width on a calibration normalized ion intensity versus pulse width relation for said ions that corresponds to said desired attenuation on an ideal normalized ion intensity versus pulse width relation for said ions.

9. 发明公开

EP4004967A1 INCREASED DYNAMIC RANGE FOR THE ATTENUATION OF AN ION BEAM 审中-实审
公开(公告)号：EP4004967A1
公开(公告)日：2022-06-01
申请号：EP20747140.0
申请日：2020-07-22
申请人： DH Technologies Development Pte. Ltd.
发明人： COLLINGS, Bruce , MARTIN, Pascal
IPC分类号： H01J49/42 , H01J49/06 , H01J49/00 , H01J49/02

10. 发明公开

EP2606504A2 METHOD AND SYSTEM FOR INCREASING THE DYNAMIC RANGE OF ION DETECTORS 审中-公开
标题翻译：方法和系统用于提高离子检测器的动态范围
公开(公告)号：EP2606504A2
公开(公告)日：2013-06-26
申请号：EP11764288.4
申请日：2011-08-18
申请人： DH Technologies Development Pte. Ltd.
发明人： GUNA, Mircea , COLLINGS, Bruce
IPC分类号： H01J49/02
CPC分类号： H01J49/0031 , H01J49/025 , H01J49/06 , H01J49/061
摘要： A mass spectrometer system can include a mass analyzer operable to mass transmit streams of ions to a detector in a mass dependent fashion for measurement of ion flux intensity. An ion attenuator can be located in the extraction region between the mass analyzer and detector, downstream of the mass analyzer, and can be operable to provide selective attenuation of the ion beam by attenuating ion flux intensity also in mass dependent fashion. Higher concentration ions can be selected and attenuated, while other lower concentration ions can be left unattenuated. Different ions can be attenuated to different degrees. Locating the ion attenuator downstream of the mass analyzer so that the ion beam is already mass differentiated when attenuated can avoid mass discriminatory effects associated with ion beam attenuators. Selective attenuation of only certain ions but not others can extend the dynamic range of the detector without necessarily sacrificing detector sensitivity.

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