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1. 发明授权

US10172659B2 Bone treatment systems and methods 有权
公开(公告)号：US10172659B2
公开(公告)日：2019-01-08
申请号：US15477678
申请日：2017-04-03
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61F2/44 , A61B17/70 , A61B17/56
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

2. 发明授权

US10136934B2 Bone treatment systems and methods 有权
公开(公告)号：US10136934B2
公开(公告)日：2018-11-27
申请号：US14741864
申请日：2015-06-17
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B90/00
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

3. 发明申请

US20170333103A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170333103A1
公开(公告)日：2017-11-23
申请号：US15477678
申请日：2017-04-03
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88 , A61F2/44 , A61B17/56 , A61B17/00 , A61B17/70
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

4. 发明授权

US09610110B2 Bone treatment systems and methods 有权
公开(公告)号：US09610110B2
公开(公告)日：2017-04-04
申请号：US14683506
申请日：2015-04-10
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61F2/44 , A61B17/88 , A61B17/00 , A61B17/70 , A61B17/56
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.

5. 发明申请

US20150282852A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20150282852A1
公开(公告)日：2015-10-08
申请号：US14683506
申请日：2015-04-10
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.
摘要翻译：本发明在某些实施例中涉及用于治疗脊椎压缩性骨折的医疗装置。更具体地，本发明的实施例涉及通过控制骨水泥进入椎骨内部并且由水泥流引起的力的施加来可控地恢复椎体高度的仪器和方法。一个示例性系统利用Rf能量组合导电骨水泥，用于选择性聚合流入羽流以增加水泥的粘度。在本发明的一个方面，该系统利用控制器来控制骨水泥流动参数以允许或不允许水泥交叉指向松质骨。本发明的方法包括脉动骨粘固剂的流动，其中流动脉冲的高加速度可以施加穿过水泥羽流表面的膨胀力，以减少椎骨骨折。

6. 发明申请

US20140163519A1 MEDICAL SYSTEM AND METHOD OF USE 有权
标题翻译：医疗系统及其使用方法
公开(公告)号：US20140163519A1
公开(公告)日：2014-06-12
申请号：US13955769
申请日：2013-07-31
申请人： DFINE, INC.
发明人： John H. Shadduck , Andrew Kohm
IPC分类号： A61B17/88 , A61L24/04
CPC分类号： A61L24/043 , A61B17/3472 , A61B17/8822 , A61B17/8827 , A61B17/8833 , A61B17/8836 , A61B2017/8838 , A61F2002/3009 , A61F2002/465 , A61F2002/4653 , A61F2002/4685 , A61F2250/0091
摘要： A medical system and method can used to treat a bone. The system and method can include the preparation of bone cement to be used in the treatment. A non-liquid component and a liquid component can be combined to form a bone cement. A vacuum system can be used to saturate the non-liquid component with the liquid component. The bone cement and/or components can be heated and/or cooled.
摘要翻译：医疗系统和方法可用于治疗骨骼。该系统和方法可以包括用于治疗的骨水泥的制备。非液体组分和液体组分可以组合以形成骨水泥。真空系统可用于使液体组分的非液体组分饱和。骨水泥和/或组分可以被加热和/或冷却。

7. 发明申请

US20160106489A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：骨治疗系统和方法
公开(公告)号：US20160106489A1
公开(公告)日：2016-04-21
申请号：US14887030
申请日：2015-10-19
申请人： DFINE, Inc.
发明人： Csaba Truckai , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88
摘要： Systems and methods for treating vertebral compression fractures are provided. A kit can include at least one body containing a bone cement precursor to be mixed with at least one other bone cement precursor to form a bone cement. The body or a package containing the body can include at least one sensor. In some embodiments the sensor can be a temperature sensor. In some methods, data from the sensor can be used to determine certain parameters related to a treatment interval involving the bone cement.
摘要翻译：提供了治疗椎体压缩性骨折的系统和方法。试剂盒可以包括至少一个含有待与至少一种其他骨水泥前体混合以形成骨粘固剂的骨水泥前体的主体。身体或包含身体的包装可以包括至少一个传感器。在一些实施例中，传感器可以是温度传感器。在一些方法中，可以使用来自传感器的数据来确定与涉及骨水泥的治疗间隔相关的某些参数。

8. 发明授权

US09005210B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US09005210B2
公开(公告)日：2015-04-14
申请号：US13734829
申请日：2013-01-04
申请人： DFINE, Inc.
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61F2/00 , A61B17/88 , A61B17/00 , A61F2/44
CPC分类号： A61B17/8805 , A61B17/70 , A61B17/8822 , A61B17/8827 , A61B17/8836 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61B2017/564 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the flow of bone cement into the interior of a vertebra and the application of forces causes by the cement flow. An exemplary system utilizes Rf energy in combination a conductive bone cement for selectively polymerizing the inflow plume to increase the viscosity of the cement. In one aspect of the invention, the system utilizes a controller to control bone cement flow parameters to either allow or disallow cement interdigitation into cancellous bone. A method of the invention includes pulsing the flows of bone cement wherein high acceleration of the flow pulses can apply expansion forces across the surface of the cement plume to reduce a vertebral fracture.
摘要翻译：本发明在某些实施例中涉及用于治疗脊椎压缩性骨折的医疗装置。更具体地，本发明的实施例涉及通过控制骨水泥进入椎骨内部并且由水泥流引起的力的施加来可控地恢复椎体高度的仪器和方法。一个示例性系统利用Rf能量组合导电骨水泥，用于选择性聚合流入羽流以增加水泥的粘度。在本发明的一个方面，该系统利用控制器来控制骨水泥流动参数以允许或不允许水泥交叉指向松质骨。本发明的方法包括脉动骨粘固剂的流动，其中流动脉冲的高加速度可以施加穿过水泥羽流表面的膨胀力，以减少椎骨骨折。

9. 发明授权

US11672579B2 Bone treatment systems and methods 有权
公开(公告)号：US11672579B2
公开(公告)日：2023-06-13
申请号：US16200176
申请日：2018-11-26
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/00 , A61B90/00
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

10. 发明申请

US20190167328A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20190167328A1
公开(公告)日：2019-06-06
申请号：US16200176
申请日：2018-11-26
申请人： DFINE, INC.
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/88
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.

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