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    • 4. 发明申请
    • AFFINITY DOMAIN FOR ANALYTE SENSOR
    • 分析传感器的AFFINITY域
    • WO2005052543A2
    • 2005-06-09
    • PCT/US2004038726
    • 2004-11-17
    • DEXCOM INCBURD JOHNTAPSAK MARKRHODES RATHBUN
    • BURD JOHNTAPSAK MARKRHODES RATHBUN
    • A61B5/00C12M1/34C12Q1/00G01N20060101G01N
    • C12Q1/002A61B5/14532A61B5/14865
    • The preferred embodiments provide a membrane system (16), particularly for use on an electrochemical sensor (10a), wherein the membrane system includes an affinity domain that dampens the effects of target interferant(s) on the sensor. The affinity domain can be layer, surface, region, and/or portion of the membrane system formed using sorbents that have an affinity for the target interferant. The sorbents can be adapted to adsorb the interferants, for example using adsorbents such as chromatography packing materials. The sorbents can also be adapted to absorb the interferants by imprinting a molecular structure on the material that forms the affinity domain such that target interferants bind to the imprinted surfaces at the molecular level.
    • 优选的实施方案提供了一种特别用于电化学传感器(10a)的膜系统(16),其中膜系统包括抵消目标干扰物对传感器的影响的亲和结构域。 亲和结构域可以是使用对目标干扰物具有亲和力的吸附剂形成的膜系统的层,表面,区域和/或部分。 吸附剂可以适于吸附干扰剂,例如使用吸附剂如色谱填充材料。 吸附剂也可适用于通过在形成亲和结构域的材料上印记分子结构来吸收干扰物,使得靶分子在分子水平上与印迹表面结合。
    • 5. 发明申请
    • SENSOR HEAD FOR MONITORING GLUCOSE FOR USE WITH IMPLANTABLE DEVICES
    • 用于监视葡萄糖的传感器头用于可移植设备
    • WO03011131A3
    • 2003-08-21
    • PCT/US0223903
    • 2002-07-26
    • DEXCOM INCBRAUKER JAMES HSHULTS MARK CTAPSAK MARK ARHODES RATHBUN
    • BRAUKER JAMES HSHULTS MARK CTAPSAK MARK ARHODES RATHBUN
    • G01N27/416A61B5/00A61B5/145A61B5/1473A61B5/1486C12Q1/00G01N27/327
    • G01N27/3272A61B5/14532A61B5/14865C12Q1/002C12Q1/006G01N33/48707G01N33/48785
    • The present invention provides a sensor head (10) for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode (21), a reference electrode (20) and a counter electrode (22), wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode (22) is greater than the surface area of the working electrode (21); and a multi-region membrane having a first region (33), a second region (31), and a third region (32), wherein the membrane is affixed to the nonconductive body and covering the working electrode (21), reference electrode (20) and counter electrode (22). In addition, the present application provides an implantable device including at least one of the sensor heads (10). A method of monitoring glucose levels in a host utilizing the implantable device is also disclosed.
    • 本发明提供一种在可植入装置中使用的传感器头(10),其用于测量生物流体中的分析物的浓度,其包括:非导电体; 工作电极(21),参比电极(20)和对电极(22),其中电极通过非导电体,在身体的一个位置形成电化学反应性表面,并在另一位置形成电子连接 其中所述对电极(22)的电化学反应性表面大于所述工作电极(21)的表面积; 以及具有第一区域(33),第二区域(31)和第三区域(32)的多区域膜,其中所述膜固定到所述非导电体并覆盖所述工作电极(21),参考电极 20)和对电极(22)。 此外,本申请提供了包括至少一个传感器头(10)的可植入装置。 还公开了利用可植入装置监测主机中的葡萄糖水平的方法。