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1. 发明申请

WO2008006547A3 PYRROLOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物的吡咯并吡啶
公开(公告)号：WO2008006547A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007006109
申请日：2007-07-10
申请人： DEVELOGEN AG , JAEKEL STEFAN , REUTER TANJA , MURFIN STEPHEN , COULTER THOMAS STEPHEN , TAYLOR STEVEN
发明人： JAEKEL STEFAN , REUTER TANJA , MURFIN STEPHEN , COULTER THOMAS STEPHEN , TAYLOR STEVEN
IPC分类号： C07D487/04 , A61K31/519 , A61P3/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel pyrrolopyrimidine compounds of the general formula (1) and pharmaceutical compositions comprising said pyrrolopyrimidine compounds. Moreover, the present invention relates to the use of the pyrrolopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译：本发明涉及通式（1）的新型吡咯并嘧啶化合物和包含所述吡咯并嘧啶化合物的药物组合物。此外，本发明涉及本发明的吡咯并嘧啶化合物用于制备药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a）激酶活性的疾病的用途或Mnk2b）和/或其变体。

2. 发明申请

WO2006066937A2 NOVEL USE OF PYRAZOLOPYRIMIDINES 审中-公开
标题翻译：新型使用吡唑并嘧啶
公开(公告)号：WO2006066937A2
公开(公告)日：2006-06-29
申请号：PCT/EP2005013907
申请日：2005-12-22
申请人： DEVELOGEN AG , EVOTEC AG , COULTER THOMAS STEPHEN , TAYLOR STEVEN , MURFIN STEPHEN , THAMMALAKSA VALERY , AICHER BABETTE , JAEKEL STEFAN , REUTER TANJA
发明人： COULTER THOMAS STEPHEN , TAYLOR STEVEN , MURFIN STEPHEN , THAMMALAKSA VALERY , AICHER BABETTE , JAEKEL STEFAN , REUTER TANJA
CPC分类号： A61K31/519
摘要： The present invention relates to the use of pyrazolopyrimidine compounds for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnkl and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.
摘要翻译：本发明涉及吡唑并嘧啶化合物用于生产药物组合物用于预防和/或治疗可受到抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b）的激酶活性和/或其变体。

3. 发明申请

WO2007059905A9 THIENOPYRIMIDINES TREATING INFLAMMATORY DISEASES 审中-公开
标题翻译：治疗炎性疾病的三苯甲酰嘧啶
公开(公告)号：WO2007059905A9
公开(公告)日：2007-11-01
申请号：PCT/EP2006011081
申请日：2006-11-17
申请人： DEVELOGEN AG , TAYLOR STEVEN , MURFIN STEVEN , COULTER THOMAS STEPHEN , JAEKEL STEFAN , AICHER BABETTE , KELTER ARNDT-RENE , KRAEMER JOACHIM , KIRCHHOFF CHRISTIAN , SCHEEL ANDREAS , WOELKE JULIAN
发明人： TAYLOR STEVEN , MURFIN STEVEN , COULTER THOMAS STEPHEN , JAEKEL STEFAN , AICHER BABETTE , KELTER ARNDT-RENE , KRAEMER JOACHIM , KIRCHHOFF CHRISTIAN , SCHEEL ANDREAS , WOELKE JULIAN
IPC分类号： A61K31/519 , A61P11/06 , A61P17/06 , A61P29/00
CPC分类号： A61K31/519
摘要： The present invention relates to the use of thienopyrimidine compounds for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
摘要翻译：本发明涉及噻吩并嘧啶化合物在制备用于治疗炎性疾病的药物组合物中的用途。

4. 发明申请

WO2007059905A2 NOVEL USE OF THIENOPYRIMIDINES 审中-公开
标题翻译：新型使用三烯酰基嘧啶
公开(公告)号：WO2007059905A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006011081
申请日：2006-11-17
申请人： DEVELOGEN AG , TAYLOR STEVEN , COULTER THOMAS STEPHEN , JAEKEL STEFAN , AICHER BABETTE , KELTER ARNDT-RENE , KRAEMER JOACHIM , KIRCHHOFF CHRISTIAN , SCHEEL ANDREAS , WOELKE JULIAN
发明人： TAYLOR STEVEN , COULTER THOMAS STEPHEN , JAEKEL STEFAN , AICHER BABETTE , KELTER ARNDT-RENE , KRAEMER JOACHIM , KIRCHHOFF CHRISTIAN , SCHEEL ANDREAS , WOELKE JULIAN
IPC分类号： A61K31/519 , A61P11/06 , A61P17/06 , A61P29/00
CPC分类号： A61K31/519
摘要： The present invention relates to the use of thienopyrimidine compounds for the production of pharmaceutical compositions for the treatment of inflammatory diseases.
摘要翻译：本发明涉及噻吩并嘧啶化合物在制备用于治疗炎性疾病的药物组合物中的用途。

5. 发明专利

AU8790598A Clothes peg 未知
公开(公告)号：AU8790598A
公开(公告)日：1998-11-19
申请号：AU8790598
申请日：1998-10-06
申请人： TAYLOR STEVEN
发明人： TAYLOR STEVEN
IPC分类号： D06F55/00

6. 发明专利

AU6364798A Clothes peg 未知
公开(公告)号：AU6364798A
公开(公告)日：1998-10-29
申请号：AU6364798
申请日：1998-04-28
申请人： TAYLOR STEVEN
发明人： TAYLOR STEVEN
IPC分类号： D06F55/00

7. 发明专利

BRPI0712882A2 未知
公开(公告)号：BRPI0712882A2
公开(公告)日：2012-10-09
申请号：BRPI0712882
申请日：2007-07-10
申请人： DEVELOGEN AG
发明人： JOKEL STEFAN , REUTER TANJA , MURFIN STEPHEN , COULTER THOMAS STEPHEN , TAYLOR STEVEN
IPC分类号： C07D487/04 , A61K31/519 , A61P3/00
摘要： The present invention relates to novel pyrrolopyrimidine compounds of the general formula (1) and pharmaceutical compositions comprising said pyrrolopyrimidine compounds. Moreover, the present invention relates to the use of the pyrrolopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

8. 发明专利

CO6150162A2 PIRROLOPIRIMIDINAS PARA COMPOSICIONES FARMACEUTICAS 未知
公开(公告)号：CO6150162A2
公开(公告)日：2010-04-20
申请号：CO09001490
申请日：2009-01-08
申请人： DEVELOGEN AG
发明人： JAKEL STEFAN , REUTER TANJA , MURFIN STEPHEN , COULTER THOMAS STEPHEN , TAYLOR STEVEN
IPC分类号： C07D487/04
摘要： Un compuesto de la fórmula general (1)en la que X es un enlace sencillo, O, S, SO2, CH2, CHR1a, CR1aR1b, CH(halógeno), C(halógeno)2, C=O, C(O)NR1a, NH o NR1a, donde R1a y R1b son alquilo C1-6, alquil C1-6-cicloalquilo C3-10, cicloalquilo C3-10, alquil C1-6-heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, donde R1a y R1b están opcionalmente sustituidos con uno o más R9; R1 es hidrógeno, alquilo C1-6, alquil C1-6-cicloalquilo C3-10, cicloalquilo C3-10, alquil C1-6-heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, arilo C6-10, alquil C1-6-arilo C6-10, heteroarilo C5-10 que comprende al menos un heteroátomo seleccionado entre N, S y O, alquil C1-6-heteroarilo C5-10 que comprende al menos un heteroátomo seleccionado entre N, S y O, donde R1 está opcionalmente sustituido con uno o más R9; o si X es NR1a, CHR1a, C(O)NR1a o CR1aR1b, R1 puede formar un anillo carbocíclico o heterocíclico con R1a y el átomo de N o C al que están unidos, que puede contener uno o más heteroátomos adicionales seleccionados entre N, S y O, que puede estar opcionalmente sustituido con uno o más R9; R2 y R3 son iguales o diferentes y se seleccionan independientemente entre hidrógeno, alquilo C1-6, alquil C1-6-cicloalquilo C3-10, cicloalquilo C3-10, arilo C6-10, alquil C1-6-arilo C3-10, heteroarilo C3-10 que comprende al menos un heteroátomo seleccionado entre N, S y O, alquil C1-6-heteroarilo C5-10 que comprende al menos un heteroátomo seleccionado entre N, S y O, alquil C1-6-heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, heterocicloalquilo de 3 a 10 miembros que comprende al menos un heteroátomo seleccionado entre N, S y O, o junto con los átomos de C a los que están unidos forman un grupo cicloalquilo C3-7 o ...

9. 发明专利

AU2007271928A1 Pyrrolopyrimidines for pharmaceutical compositions 未知
公开(公告)号：AU2007271928A1
公开(公告)日：2008-01-17
申请号：AU2007271928
申请日：2007-07-10
申请人： DEVELOGEN AG
发明人： MURFIN STEPHEN , TAYLOR STEVEN , JAKEL STEFAN , COULTER THOMAS STEPHEN , REUTER TANJA
IPC分类号： A61K31/519 , A61P3/00 , C07D487/04
摘要： The present invention relates to novel pyrrolopyrimidine compounds of the general formula (1) and pharmaceutical compositions comprising said pyrrolopyrimidine compounds. Moreover, the present invention relates to the use of the pyrrolopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

10. 发明申请

WO0069855A3 FURANONE DERIVATIVES AS INHIBITORS OF CATHEPSIN S 审中-公开
标题翻译：呋喃酮衍生物作为CATHEPSIN S的抑制剂
公开(公告)号：WO0069855A3
公开(公告)日：2001-02-08
申请号：PCT/GB0001894
申请日：2000-05-18
申请人： MEDIVIR UK LTD , PEPTIMMUNE INC , QUIBELL MARTIN , TAYLOR STEVEN
发明人： QUIBELL MARTIN , TAYLOR STEVEN
IPC分类号： C07D307/64 , A61K31/00 , A61K31/341 , A61K31/381 , A61P7/02 , A61P9/12 , A61P37/02 , A61P43/00 , C07D307/22 , C07D307/32 , C07D307/68 , C07D307/85 , C07D309/14 , C07D309/30 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , A61K31/365 , A61K31/40 , A61K31/4015
CPC分类号： C07D307/32 , C07D307/22 , C07D307/68 , C07D307/85 , C07D309/14 , C07D309/30 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： Cathepsin S is a highly active cysteine protease belonging to the papain superfamily. It is found mainly in lymph nodes, spleen, and macrophages and this limited occurrence suggests the potential involvement of this enzyme in the pathogenesis of degenerative disease. The invention relates to novel protease inhibitors, particularly inhibitors of the cysteine proteases of the papain superfamily and more particularly to Cathepsin S. The inhibitors are Furanone derivatives of Formula (II) which have a characteristic non-hydrogen substituent R5. They are selective over other members of the family and in particular show selectivity over other members of the Cathepsin family such as L and K.
摘要翻译：组织蛋白酶S是属于木瓜蛋白酶超家族的高活性半胱氨酸蛋白酶。主要发现在淋巴结，脾脏和巨噬细胞，这种有限的发生表明该酶潜在地参与退行性疾病的发病机制。本发明涉及新型蛋白酶抑制剂，特别是木瓜蛋白酶超家族的半胱氨酸蛋白酶的抑制剂，更具体地涉及组织蛋白酶S.抑制剂是具有特征性非氢取代基R5的式（II）的呋喃酮衍生物。它们对家族的其他成员具有选择性，并且特别地显示出组织蛋白酶家族的其他成员如L和K的选择性。

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