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1. 发明申请

WO2014096386A1 ANTI-HDAC11 ANTIBODIES 审中-公开
标题翻译： ANTI-HDAC11抗体
公开(公告)号：WO2014096386A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/077750
申请日：2013-12-20
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
发明人： SCHIER, Marie Catherine , DEUBZER, Hedwig , WITT, Olaf
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K2317/34
摘要： The present invention relates to an antibody specifically recognizing histone deacetylase 11 (HDAC11), wherein said antibody recognizes native HDAC11 or native and denatured HDAC11. The present invention also relates to a cell line producing said antibody. It further relates to methods for identifying a subject afflicted with cancer as being susceptible to treatment with an HDAC11 inhibitor, for identifying HDAC11 recruitment sites, for identifying a subject afflicted with cancer, for identifying an inhibitor of HDAC11 recruitment, and for identifying an HDAC11 binding compound, said methods making use of the antibody of the present invention. The invention further relates to the use of the antibody of the present invention in said methods and to devices and kits comprising the antibody of the present invention.
摘要翻译：本发明涉及特异性识别组蛋白脱乙酰酶11（HDAC11）的抗体，其中所述抗体识别天然HDAC11或天然和变性的HDAC11。本发明还涉及产生所述抗体的细胞系。它进一步涉及用于识别患有癌症的受试者易于用HDAC11抑制剂治疗，用于鉴定HDAC11募集位点，用于鉴定患有癌症的受试者，用于鉴定HDAC11募集抑制剂以及鉴定HDAC11结合的方法化合物，所述方法利用本发明的抗体。本发明还涉及本发明的抗体在所述方法中的用途以及包含本发明抗体的装置和试剂盒的用途。

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