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1. 发明申请

WO9942477A2 TRANSPORTER FOR SACCHARIDE-COUPLED MEDICAMENTS 审中-公开
标题翻译：用于糖精联合药物的转运蛋白
公开(公告)号：WO9942477A2
公开(公告)日：1999-08-26
申请号：PCT/DE9900535
申请日：1999-02-18
申请人： DEUTSCHES KREBSFORSCH , KOEPSELL HERMANN , WIESSLER MANFRED
发明人： KOEPSELL HERMANN , WIESSLER MANFRED
IPC分类号： G01N33/48 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/68 , C07K14/00
CPC分类号： C07K14/47 , A61K48/00 , C07K16/18 , C07K2317/11
摘要： The invention relates to a nucleic acid molecule from a sugar transporter family. Said nucleic acid codes for a protein with the biological activity of a transporter for saccharide-coupled medicaments. The invention also relates to vectors containing these nucleic acid molecules. In a preferred form, these vectors are suitable for the expression of the transporter in prokaryotes or eukaryotes and for gene therapy. The invention also relates to proteins which are coded by the nucleic acid and to antibodies which specifically recognise these proteins. The objects of the invention can be used to test cells, especially tumour cells, for the presence of a transporter of this kind. In the event that said transporter is not present in cells, it can be introduced by gene therapy. In this way, tumour cells can be made accessible to chemotherapy much more effectively than previously possible.
摘要翻译：描述了来自糖转运蛋白家族的核酸分子，其中所述核酸编码具有糖偶联药物转运蛋白生物学活性的蛋白质。此外，描述了含有核酸分子的这些载体，其中在一个优选的实施方案中，这些载体适于在原核生物或真核生物中表达转运蛋白以及用于基因治疗。它还声称编码的蛋白质和特异性识别这些蛋白质的抗体。利用这些发明目的，可以检查细胞，优选肿瘤细胞中是否存在这种转运蛋白。在细胞中不存在所述转运蛋白时，这可以通过基因治疗来引入。肿瘤细胞可以更容易接受化疗比目前可能。

2. 发明申请

WO9942477A8 TRANSPORTER FOR SACCHARIDE-COUPLED MEDICAMENTS 审中-公开
标题翻译：转运FOR糖偶联药物
公开(公告)号：WO9942477A8
公开(公告)日：1999-11-04
申请号：PCT/DE9900535
申请日：1999-02-18
申请人： DEUTSCHES KREBSFORSCH , KOEPSELL HERMANN , WIESSLER MANFRED
发明人： KOEPSELL HERMANN , WIESSLER MANFRED
IPC分类号： G01N33/48 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/68 , C07K14/00
CPC分类号： C07K14/47 , A61K48/00 , C07K16/18 , C07K2317/11
摘要： The invention relates to a nucleic acid molecule from a sugar transporter family. Said nucleic acid codes for a protein with the biological activity of a transporter for saccharide-coupled medicaments. The invention also relates to vectors containing these nucleic acid molecules. In a preferred form, these vectors are suitable for the expression of the transporter in prokaryotes or eukaryotes and for gene therapy. The invention also relates to proteins which are coded by the nucleic acid and to antibodies which specifically recognise these proteins. The objects of the invention can be used to test cells, especially tumour cells, for the presence of a transporter of this kind. In the event that said transporter is not present in cells, it can be introduced by gene therapy. In this way, tumour cells can be made accessible to chemotherapy much more effectively than previously possible.
摘要翻译：公开的是由糖转运蛋白家族的核酸分子，其中所述核酸具有用于糖偶联药物编码的转运蛋白的生物活性的蛋白质。此外，这些核酸分子描述了含有载体，这些载体适于在原核生物或真核生物中转运的表达，以及用于在一个优选实施例中的基因治疗。此外，编码的蛋白质和抗体的要求保护的特异性识别这些蛋白质。根据本发明的细胞中的这些目的可以，优选地，待分析用于这种转运肿瘤细胞的存在。在不存在在这些细胞中所描述的转运可以引入到基因治疗方法。肿瘤细胞可以成为可能访问化疗比这样过去更有效。

3. 发明专利

DE19806803A1 未知
公开(公告)号：DE19806803A1
公开(公告)日：1999-11-25
申请号：DE19806803
申请日：1998-02-18
申请人： KOEPSELL HERMANN , DEUTSCHES KREBSFORSCH
发明人： WIESLER MANFRED , KOEPSELL HERMANN
IPC分类号： G01N33/48 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/68 , C07K16/00 , C07H21/00 , C07K14/245 , C12N1/00 , C12N15/11 , C12N15/63

4. 发明专利

DE60325689D1 未知
公开(公告)号：DE60325689D1
公开(公告)日：2009-02-26
申请号：DE60325689
申请日：2003-02-05
申请人： KOEPSELL HERMANN
发明人： KOEPSELL HERMANN , LANG FLORIAN , OSSWALD CHRISTINA
IPC分类号： A01K67/027 , A61K38/00 , A61K38/17 , A61K48/00 , C07K14/47 , C12N15/85 , C12Q1/68 , G01N33/50 , G01N33/53

5. 发明申请

WO2004018512A3 POLYMORPHISMS IN THE HUMAN GENES FOR OCT1 AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS 审中-公开
标题翻译： OCT1基因多态性及其在诊断和治疗应用中的应用
公开(公告)号：WO2004018512A3
公开(公告)日：2004-07-01
申请号：PCT/EP0309356
申请日：2003-08-22
申请人： EPIDAUROS BIOTECHNOLOGIE AG , KERB REINHOLD , KOEPSELL HERMANN , BRINKMANN ULRICH
发明人： KERB REINHOLD , KOEPSELL HERMANN , BRINKMANN ULRICH
IPC分类号： A01K67/027 , A61K38/00 , A61K38/17 , A61K48/00 , C07K14/47 , C07K16/18 , C12N15/12 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C12Q1/6883
摘要： The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
摘要翻译：本发明涉及多态性OCT1多核苷酸。此外，本发明涉及包含本发明的多核苷酸的基因或载体以及用本发明的多核苷酸或基因进行基因工程改造的宿主细胞。此外，本发明涉及产生分子变体多肽或其片段的方法，产生能表达分子变异多肽的细胞的方法，以及由本发明的多核苷酸或基因编码的多肽或其片段，方法或由本发明的方法产生的细胞。此外，本发明涉及特异性结合本发明多肽的抗体。此外，本发明涉及转基因非人类动物。本发明还涉及包含一种或多种上述多核苷酸，基因，载体，多肽，抗体或宿主细胞的固体支持物。此外，鉴定多态性，鉴定和获得前药或药物或抑制剂的方法也包括在本发明中。另外，本发明涉及生产药物组合物的方法和诊断疾病的方法。此外，本发明涉及检测本发明多核苷酸的方法。此外，本发明包含诊断和药物组合物。甚至更多地，本发明涉及本发明的多核苷酸，基因，载体，多肽或抗体的用途。最后，本发明涉及一种诊断试剂盒。

6. 发明申请

WO2006105912A3 PEPTIDES THAT DOWN REGULATE THE ACTIVITY OF PLASMA MEMBRANE TRANSPORTERS INCLUDING SODIUM-D-GLUCOSE COTRANSPORTER SGLT1 审中-公开
标题翻译：降低血浆膜转运蛋白活性的肽，包括钠-D-葡萄糖酸转运蛋白SGLT1
公开(公告)号：WO2006105912A3
公开(公告)日：2006-12-14
申请号：PCT/EP2006002980
申请日：2006-03-31
申请人： UNIV WUERZBURG J MAXIMILIANS , KOEPSELL HERMANN , VERNALEKEN ALEXANDRA
发明人： KOEPSELL HERMANN , VERNALEKEN ALEXANDRA
IPC分类号： A61K38/08 , A61P3/00 , A61P3/08
CPC分类号： A61K38/08
摘要： The present invention relates to the use of a regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of a pharmaceutical composition for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, wherein said RS1 fragment is characterized in comprising at least 3 consecutive amino acid residues as comprised in the amino acid sequence S-D-S-D-R-I-E-P (Serine-Aspartic acid-Serine-Aspartic acid-Arginine- Isoleucine-Glutamic acid-Proline) or derivatives thereof. Furthermore, the present invention relates to a method for the amelioration, prevention and/or treatment of a metabolic disease or a secondary disorder caused by a (pathological) modification of homeostasis, said method comprising administering to a patient in need of such amelioration, prevention and/or treatment a pharmaceutically active amount of said regulatory protein RS1 fragment as defined herein or a nucleic acid molecule encoding said regulatory protein RS1 fragment. Moreover, the present invention relates to the use of said regulatory protein RS1 fragment or a nucleic acid molecule encoding said regulatory protein RS1 fragment for the preparation of food, feed and/or food supplements.
摘要翻译：本发明涉及调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子在制备用于改善，预防和/或治疗由以下引起的代谢疾病或继发性疾病的药物组合物中的用途：（病理学）修饰，其中所述RS1片段的特征在于包含至少3个连续的氨基酸残基，其包含在氨基酸序列SDSDRIEP（丝氨酸 - 天冬氨酸 - 丝氨酸 - 天冬氨酸 - 精氨酸 - 异亮氨酸 - 谷氨酸 - 脯氨酸）或其衍生物。此外，本发明涉及用于改善，预防和/或治疗由体内平衡（病理）改变引起的代谢疾病或继发性疾病的方法，所述方法包括向需要这种改善，预防和/或治疗药学活性量的如本文所定义的所述调节蛋白RS1片段或编码所述调节蛋白RS1片段的核酸分子。此外，本发明涉及所述调控蛋白RS1片段或编码所述调控蛋白RS1片段的核酸分子在制备食物，饲料和/或食物补充物中的用途。

7. 发明专利

AT419747T 未知
公开(公告)号：AT419747T
公开(公告)日：2009-01-15
申请号：AT03002465
申请日：2003-02-05
申请人： KOEPSELL HERMANN
发明人： KOEPSELL HERMANN , LANG FLORIAN , OSSWALD CHRISTINA
IPC分类号： A01K67/027 , A61K38/00 , A61K38/17 , A61K48/00 , C07K14/47 , C12N15/85 , C12Q1/68 , G01N33/50 , G01N33/53

8. 发明专利

DE10006887A1 Modulators of regulatory protein RS1, useful for treating diabetes or tumors and for increasing drug transport, control concentration of transport proteins in plasma membranes 未知
公开(公告)号：DE10006887A1
公开(公告)日：2001-09-06
申请号：DE10006887
申请日：2000-02-16
申请人： KOEPSELL HERMANN
发明人： KOEPSELL HERMANN , KORN THOMAS , KUEHLKAMP THOMAS , TRACK CHRISTINA , VEYHL MAIKE
IPC分类号： A61K38/00 , A61P3/10 , A61P35/00 , C07K14/47 , C07K16/18 , C12N15/113 , C12N15/12 , C07K16/00 , A61K39/395 , C12N5/10 , C12N15/79
摘要： Compound (I) for regulating the concentration of transport proteins (TP) in the plasma membrane of cells that acts by modifying the activity or concentration of the regulatory protein RS1. Independent claims are also included for the following: (1) expression vector containing a nucleic acid (II) that (i) encodes a ribozyme or antisense RNA, directed against mRNA of RS1, or an antibody against RS1, or (ii) encodes RS1 or its fragments; and (2) cells that contain the vector of (1) or in which the RS1-encoding gene has been inactivated or deleted.

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