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1. 发明申请

WO2011060327A1 LIQUID JET APPARATUS AND METHODS FOR DENTAL TREATMENTS 审中-公开
标题翻译：液体喷射装置和牙科治疗方法
公开(公告)号：WO2011060327A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056620
申请日：2010-11-12
申请人： DENTATEK CORPORATION , BERGHEIM, Bjarne , GHARIB, Morteza , KHAKPOUR, Mehrzad , PHAM, Michele , TEBBS, Richard, S.
发明人： BERGHEIM, Bjarne , GHARIB, Morteza , KHAKPOUR, Mehrzad , PHAM, Michele , TEBBS, Richard, S.
IPC分类号： A61C5/02
CPC分类号： A61C5/62 , A61C5/40 , A61C17/02 , A61C17/028
摘要： Systems and methods for using a liquid jet apparatus for dental treatments are disclosed. In one implementation, the liquid jet apparatus may include a handpiece configured to deliver a high velocity liquid jet to a desired location in the mouth of a patient. The handpiece may include a positioning member having a channel through or along which the jet can propagate. The positioning member may have a distal end portion configured to be at least partially disposed in a pulp cavity, canal space, or opening in the tooth under treatment. During operation, the jet may impact an impingement surface of the distal end portion of the positioning member and be deflected as a spray through one or more openings in the distal end portion. The liquid jet apparatus may be used for root canal treatments.
摘要翻译：公开了用于牙科治疗的液体喷射装置的系统和方法。在一个实施方案中，液体喷射装置可以包括构造成将高速液体射流输送到患者口腔中的期望位置的手持件。手持件可以包括定位构件，该定位构件具有通过喷射器可以传播的通道。定位构件可以具有远端部分，其构造成至少部分地设置在纸浆腔，运河空间或处理的牙齿中的开口处。在操作期间，射流可以冲击定位构件的远端部分的冲击表面，并且通过远端部分中的一个或多个开口作为喷射而偏转。液体喷射装置可用于根管治疗。

2. 发明申请

WO2012054905A2 APPARATUS, METHODS, AND COMPOSITIONS FOR ENDODONTIC TREATMENTS 审中-公开
标题翻译：装置，方法和组合物用于内切治疗
公开(公告)号：WO2012054905A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/057401
申请日：2011-10-21
申请人： SONENDO, INC. , BERGHEIM, Bjarne , KHAKPOUR, Mehrzad , PHAM, Michele , GHARIB, Morteza , TEBBS, Richard, S.
发明人： BERGHEIM, Bjarne , KHAKPOUR, Mehrzad , PHAM, Michele , GHARIB, Morteza , TEBBS, Richard, S.
IPC分类号： A61C5/02 , C12N15/85
CPC分类号： A61C5/44 , A61C5/40 , A61C5/50 , A61C17/20
摘要： Examples of apparatus, methods, and compositions for endodontic treatments are described. The apparatus can include a fluid platform configured to substantially retain fluid in a tooth chamber during treatment. The fluid platform can help maintain fluid circulation in the tooth chamber as fluid flows into and out of the tooth chamber. The apparatus can also include a pressure wave generator configured to generate acoustic waves that can be used for cleaning root canals and tooth surfaces in the tooth chamber. Examples of pressure wave generators include a liquid jet, an electromagnetic energy delivery device, and an ultrasonic device. The fluid can include antiseptic or antibacterial solutions to assist in tooth cleaning. The fluid may be degassed to have a reduced dissolved gas content (compared to non- degassed fluids used in endodontic treatments), which may improve the effectiveness of the pressure wave generation or the cleaning.
摘要翻译：描述了用于牙髓治疗的装置，方法和组合物的实例。该装置可以包括流体平台，该流体平台构造成在处理期间基本上将流体保持在齿室中。当流体流入和流出齿室时，流体平台可帮助保持在齿室中的流体循环。该装置还可以包括压力波发生器，该压力波发生器被配置为产生可用于清洁牙槽中的根管和齿表面的声波。压力波发生器的实例包括液体射流，电磁能量输送装置和超声装置。流体可以包括消毒或抗菌溶液以帮助牙齿清洁。流体可以被脱气以具有降低的溶解气体含量（与用于牙髓治疗中的非脱气流体相比），这可以提高压力波产生或清洁的有效性。

3. 发明申请

WO2008092125A2 APPARATUS AND METHODS FOR MONITORING A TOOTH 审中-公开
标题翻译：用于监测牙齿的装置和方法
公开(公告)号：WO2008092125A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/052122
申请日：2008-01-25
申请人： DENTATEK CORPORATION , GHARIB, Morteza , ADAMS, Joshua , BERGHEIM, Bjarne , PIOTROWSKI, Adam, E.
发明人： GHARIB, Morteza , ADAMS, Joshua , BERGHEIM, Bjarne , PIOTROWSKI, Adam, E.
IPC分类号： A61C17/032
CPC分类号： A61B5/4547 , A61B5/113 , A61B8/08 , A61C5/40 , A61C19/04 , A61C19/042
摘要： Apparatus and methods for monitoring a tooth may include sensing acoustic energy propagating from regions (such as a root canal system) in and/or near a tooth. The apparatus and methods may be used with root canal cleaning treatments to determine the efficacy of the treatment and/or to reduce risk of post- treatment complications. An acoustic source (e.g., an acoustic transducer and/or a high-speed liquid jet) may be used to transmit energy into a tooth and/or regions near a tooth. An acoustic receiver may be used to detect acoustic signatures of acoustic events (e.g., acoustic echoes and/or acoustic cavitation) occurring in the tooth. The acoustic signatures may be used, for example, to determine the progress of a root canal cleaning treatment and/or the presence or movement of material toward a periapical region of the tooth. Apparatus and methods for monitoring a tooth may include detecting impact of a first jet on a tooth and actuating a second jet in response to detection of the impact.
摘要翻译：用于监测牙齿的装置和方法可包括感测从牙齿中和/或牙齿附近的区域（例如根管系统）传播的声能。该设备和方法可与根管清洁治疗一起使用以确定治疗的功效和/或降低治疗后并发症的风险。可以使用声源（例如声学换能器和/或高速液体喷射器）将能量传输到牙齿附近的牙齿和/或区域。可以使用声学接收器来检测在牙齿中发生的声学事件（例如声学回声和/或声学空化）的声学标记。例如，可以使用声学特征来确定根管清洁处理的进展和/或材料朝向牙齿的根尖区域的存在或运动。用于监测牙齿的装置和方法可以包括检测第一射流对牙齿的冲击并且响应于检测到冲击而致动第二射流。

4. 发明申请

WO2007124038A2 APPARATUS AND METHODS FOR TREATING ROOT CANALS OF TEETH 审中-公开
标题翻译：用于处理牙根的装置和方法
公开(公告)号：WO2007124038A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009633
申请日：2007-04-19
申请人： DENTATEK CORPORATION , GHARIB, Morteza , ADAMS, Joshua , HARS, Erik , BERGHEIM, Bjarne , STOCKS, Karl , DOHERTY, Lance
发明人： GHARIB, Morteza , ADAMS, Joshua , HARS, Erik , BERGHEIM, Bjarne , STOCKS, Karl , DOHERTY, Lance
IPC分类号： A61C5/02
CPC分类号： A61C17/02 , A61C5/40 , A61C5/50 , A61C17/0202 , A61C17/16
摘要： Apparatus and methods for endodontic treatment of teeth provide effective cleaning of organic material (such as pulp and diseased tissue) from the root canal system. In an embodiment, a compressor system generates high pressure liquid (e.g., water) that flows through an orifice to produce a high-velocity collimated jet of liquid. The high-velocity jet is directed toward a surface of a tooth, for example, an exposed dentinal surface, and impingement of the jet onto the surface generates an acoustic wave that propagates throughout the tooth. The acoustic wave effectively detaches organic material from dentinal surfaces and tubules. The detached organic material is flushed from the root canal system by the liquid jet and/or by additional irrigation.
摘要翻译：用于牙齿治疗牙齿的装置和方法提供了从根管系统有效清洁有机材料（例如纸浆和病变组织）。在一个实施例中，压缩机系统产生流过孔口的高压液体（例如水），以产生高速准直的液体射流。高速射流被引导到牙齿的表面，例如暴露的牙质表面，并且喷射到表面上的冲击产生在整个齿上传播的声波。声波有效地从牙本质表面和小管分离有机材料。分离的有机材料通过液体喷射从根管系统冲洗和/或通过额外的灌溉冲洗。

5. 发明申请

WO2009137815A1 APPARATUS AND METHODS FOR ROOT CANAL TREATMENTS 审中-公开
标题翻译：根管治疗的装置和方法
公开(公告)号：WO2009137815A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/043386
申请日：2009-05-08
申请人： DENTATEK CORPORATION , GHARIB, Morteza , BERGEHIM, Bjarne , PIOTROWSKI, Adam, E. , PHAM, Michele , GOUSHCHA, Oleg
发明人： GHARIB, Morteza , BERGEHIM, Bjarne , PIOTROWSKI, Adam, E. , PHAM, Michele , GOUSHCHA, Oleg
IPC分类号： A61C5/02
CPC分类号： A61C17/02 , A61C5/40
摘要： Apparatus and methods for root canal treatments are provided. In some embodiments, an aiming element may be used to position a high-velocity liquid jet near a desired location in the tooth. Embodiments of the aiming element may include an interrupter that deflects or impedes the liquid jet when it is not desirable for the jet to propagate from the aiming element. Embodiments of the aiming element may include an elongated member that permits passage of the liquid jet through a channel. The elongated member may include one or more openings, for example, on sides and/or ends of the member. Some root canal cleaning techniques include one or more applications of the liquid jet followed by application of a disinfectant such as. for example, an aqueous solution of sodium hypochlorite.
摘要翻译：提供了根管治疗的装置和方法。在一些实施例中，瞄准元件可用于将高速液体射流定位在牙齿中所需位置附近。瞄准元件的实施例可以包括当不期望射流从瞄准元件传播时偏转或阻止液体射流的中断器。瞄准元件的实施例可以包括允许液体射流通过通道的细长构件。细长构件可以包括例如在构件的侧面和/或端部上的一个或多个开口。一些根管清洗技术包括液体喷射器的一个或多个应用，然后施加消毒剂，例如。例如，次氯酸钠的水溶液。

6. 发明申请

WO2007139809A3 ROOT CANAL FILLING MATERIALS AND METHODS 审中-公开
公开(公告)号：WO2007139809A3
公开(公告)日：2007-12-06
申请号：PCT/US2007/012254
申请日：2007-05-23
申请人： DENTATEK CORPORATION , GHARIB, Morteza , HARS, Erik
发明人： GHARIB, Morteza , HARS, Erik
IPC分类号： A61C5/02 , A61C5/08
摘要： In various embodiments of a method for filling root canal spaces, the root canal spaces are cleaned and irrigated, for example, by any suitable endodontic procedure, and the irrigating liquid is not removed from the canal spaces prior to filling. In some embodiments, a hydrophobic filler material is introduced into the root canal spaces while they are filled with liquid. As the canal spaces are filled, the hydrophobic filler material displaces the liquid and drives it out of the canal spaces, towards the crown of the tooth, where it can be removed. The hydrophobic filler material may comprise magnetically responsive particles having a hydrophobic surface coating that are compacted into the root canal spaces by application of a magnetic force field. In other embodiments, hydrophilic filler material in a flowable phase is introduced into the canal spaces where it partly displaces and partly absorbs the irrigating liquid before solidifying.

8. 发明申请

WO2014018456A1 MULTI-LAYERED LIQUID-DIODE FABRIC AND PRODUCTS 审中-公开
标题翻译：多层液体二极体织物和产品
公开(公告)号：WO2014018456A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/051518
申请日：2013-07-22
申请人： GHARIB, Morteza , GAT, Amir , VAHDANI, Aria
发明人： GHARIB, Morteza , GAT, Amir , VAHDANI, Aria
IPC分类号： D06M17/00 , A41D31/02 , A43B1/00
CPC分类号： B32B5/02 , A41B11/005 , A41D27/00 , A41D31/0016 , A41D2400/22 , A43B1/00 , A43B7/125 , A43B19/00 , A43B23/022 , F16K15/14 , Y10T137/7879 , Y10T428/249921 , Y10T428/249962 , Y10T428/2835
摘要： Multi-layer fabrics and products incorporating the same are described in which the fabrics are configured to provide asymmetric resistance to liquid flow from one side of the fabric to the other. In garments or other products worn by a user, the effect can be utilized to prevent penetration of liquids (e.g., rain droplets) and contact of liquids from the exterior with the user's skin while allowing for extraction of droplets (e.g., sweat) in contact with an inner layer of the fabric out of contact with the skin and accelerating their evaporation. Medical and industrial applications of the fabric are contemplated as well.
摘要翻译：描述了包含其的多层织物和产品，其中织物被配置为对从织物的一侧到另一侧的液体流提供不对称的阻力。在用户佩戴的服装或其他产品中，可以利用该效果来防止液体（例如，雨滴）的渗透和来自外部的液体与使用者的皮肤的接触，同时允许提取接触中的液滴（例如汗液）织物的内层与皮肤接触并加速它们的蒸发。也可以考虑织物的医疗和工业应用。

9. 发明申请

WO2011008986A2 A METHOD APPLYING HEMODYNAMIC FORCING AND KLF2 TO INITIATE THE GROWTH AND DEVELOPMENT OF CARDIAC VALVES 审中-公开
标题翻译：应用血液动力学和KLF2的方法来启动心脏瓣膜的生长和发育
公开(公告)号：WO2011008986A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/042176
申请日：2010-07-15
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
发明人： GHARIB, Morteza , RINDERKNECHT, Derek , FOROUHAR, Arian , VERMOT, Julien , FRASER, Scott, E.
IPC分类号： C12N5/071 , C12N5/02 , A61F2/06 , A61F2/24 , C12M3/00
CPC分类号： A61L27/3625 , A61F2/2415 , A61L27/3834 , A61L27/507 , A61L2430/20 , C12M21/08 , C12M25/14 , C12M29/12 , C12M35/04 , C12N5/0657 , C12N2501/15 , C12N2501/165 , C12N2521/00
摘要： A method for forming a cardiovascular structure in culture is provided. The method includes applying mechanical force to a cell population in culture such that a cardiovascular structure is formed. In some embodiments, the mechanical force is produced in culture medium by a pulsatile liquid flow with a retrograde component. The cell population can include stem cells or differentiated cells, or combinations of both. In particular embodiments, a cardiovascular valve is formed. Scaffolds for the support and growth of the cell population, and bioreactors including the scaffolds, are also provided.
摘要翻译：提供了一种在培养中形成心血管结构的方法。该方法包括对培养物中的细胞群体施加机械力，从而形成心血管结构。在一些实施方案中，通过具有逆行组分的脉动液体流在培养基中产生机械力。细胞群可包括干细胞或分化细胞，或两者的组合。在特定实施例中，形成心血管瓣膜。还提供了用于支持和生长细胞群体的支架，以及包括支架的生物反应器。

10. 发明申请

WO2008133957A1 SINGLE-LENS, SINGLE-SENSOR 3-D IMAGING DEVICE WITH A CENTRAL APERTURE FOR OBTAINING CAMERA POSITION 审中-公开
标题翻译：单镜头，单传感器3-D成像装置，带有用于获取相机位置的中央光圈
公开(公告)号：WO2008133957A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/005311
申请日：2008-04-23
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , GRAFF, Emilio , PEREIRA, Francisco , LU, Jian
发明人： GHARIB, Morteza , GRAFF, Emilio , PEREIRA, Francisco , LU, Jian
IPC分类号： H04N13/00
CPC分类号： H04N13/254 , G01B11/2509 , G02B5/005 , G02B2207/129 , G03B15/12 , G03B35/02 , G06T7/50 , H04N13/204 , H04N13/207
摘要： A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an entire image of a target object, at least one defocusing aperture located off of the optical axis, a sensor operable for capturing electromagnetic radiation transmitted from an object through the lens and the central aperture and the at least one defocusing aperture, and a processor communicatively connected with the sensor for processing the sensor information and producing a 3-D image of the object. Different optical filters can be used for the central aperture and the defocusing apertures respectively, whereby a background image produced by the central aperture can be easily distinguished from defocused images produced by the defocusing apertures.
摘要翻译：公开了一种使用散焦技术进行三维（3-D）成像的装置和方法。该装置包括透镜，沿着光轴定位的中心孔，用于投影目标物体的整个图像，位于光轴外的至少一个散焦孔;可操作用于捕获从物体透过透镜的电磁辐射的传感器以及与所述传感器通信地连接的处理所述传感器信息并产生所述对象的3D图像的处理器。可以分别使用不同的光学滤光器用于中心孔和散焦孔，由此可以容易地区分由中心孔产生的背景图像与由散焦孔产生的散焦图像。

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