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1. 发明申请

WO2009112703A1 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译： 2-氨基-2-苯基卡诺醇衍生物及其制备方法和含有该组合物的药物组合物
公开(公告)号：WO2009112703A1
公开(公告)日：2009-09-17
申请号：PCT/FR2009000106
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22
CPC分类号： C07C271/16 , A61K9/2054 , C07C219/22 , C07C271/22 , C07C271/48 , C07C333/04 , C07D213/80 , C07D213/82 , C07D317/40
摘要： Esters derived from 2-amino-2-phenylalkanol of general formula (I) in which: R1 is H, straight or branched C1 to C4 alkyl, straight or branched C2 to C4 alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a -CO-R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or else R2 is a -CO-Y-R4 radical for which Y is -O-, -S-, -NH-, or -Nalk- for which alk is straight or branched (C1 to C4) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, which may be substituted by one or more halogen atoms or OH radicals, straight or branched (C1 to C4) alkyl radicals, or straight or branched (C1 to C4) alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino radicals, or oxo radicals, or which may be substituted by R5COO- in which R5 is an alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by the residue of an amino acid, or represents a heterocycle, or else R2 is a (C2 to C4) alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5-or 6-membered heterocycle optionally bearing another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least C2 between >N-R2 and the substituent; and R3 is a straight or branched (C1 to C4) alkyl unless specifically mentioned, alkyl or acyl are straight or branched (C1 to C7), in their R or S forms or mixtures thereof, and also the pharmaceutically acceptable salts thereof when they exist.
摘要翻译：衍生自通式（I）的2-氨基-2-苯基烷醇的酯，其中：R 1是H，直链或支链C 1 -C 4烷基，被OH取代的直链或支链C 2 -C 4烷基，烷氧基，烷硫基，酰氧基，NH 2，烷基氨基，二烷基氨基，烷基氨基甲酰氧基，烷氧基羰基氨基，脲基或烷基脲基，R 2为其中R为H，烷基，芳基，杂环基，苄基或杂环基甲基或其中R 2为-CO-Y- Y是-O - ， - S - ， - NH-或-Nalk-，其中alk是直链或支链（C1-C4）烷基，R4是烷基，芳基，芳烷基或杂环基烷基，（C 1 -C 4）烷基或直链或支链（C 1 -C 4）烷氧基，烷硫基，酰氨基烷硫基，烷氧羰基或酰氨基，或氧代基，或可被R 5 COO- 其中R5是任选被苄氧羰基氨基，酰氨基或氨基酸残基取代的烷基，或者代表a 杂环，或者R 2是被OH，烷氧基，烷硫基，酰氧基，NH 2，烷基氨基，二烷基氨基取代的（C 2 -C 4）烷基，其任选地与它们所连接的氮原子一起形成5-或6-元杂环带有另一个杂原子（O或N），或被烷基氨基甲酰氧基，烷氧基羰基氨基，脲基或烷基脲基取代，应理解为所述直链或支链取代的烷基包含> N-R2与取代基之间的至少C2; 除非特别提及，R 3是直链或支链（C 1 -C 4）烷基，烷基或酰基是直链或支链（C 1 -C 7），它们的R或S形式或其混合物，以及它们存在时的药学上可接受的盐。

2. 发明专利

PL2252575T3 POCHODNE 2-AMINO-2-FENYLOALKANOLU, ICH WYTWARZANIE I KOMPOZYCJE FARMACEUTYCZNE, KTÓRE JE ZAWIERAJĄ 未知
公开(公告)号：PL2252575T3
公开(公告)日：2013-05-31
申请号：PL09720924
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22

3. 发明专利

PT2252575E DERIVADOS DE 2-AMINO-2-FENILALCANOL, SUA PREPARAÇÃO E COMPOSIÇÕES FARMACÊUTICAS QUE OS CONTÊM 未知
公开(公告)号：PT2252575E
公开(公告)日：2013-03-05
申请号：PT09720924
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22

4. 发明专利

DK2252575T3 2-amino-2-phenylalkanolderivater, fremstilling deraf og farmaceutiske sammensætninger, som indeholder disse 未知
公开(公告)号：DK2252575T3
公开(公告)日：2013-02-18
申请号：DK09720924
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22

5. 发明专利

ZA201005316B 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：ZA201005316B
公开(公告)日：2011-10-26
申请号：ZA201005316
申请日：2010-07-26
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C20060101 , A61K20060101
摘要： 2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a —CO—R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2 is a —CO—Y—R4 radical for which Y is —O—, —S—, —NH—, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO— in which R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2 is alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between >N—R2 and the substituent; and R3 is alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist.

6. 发明专利

AU2009224558A1 2-amino-2-phenylalkanol derivatives, preparation thereof and pharmaceutical compositions containing same 未知
公开(公告)号：AU2009224558A1
公开(公告)日：2009-09-17
申请号：AU2009224558
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DINI CHRISTOPHE , DENIS ALEXIS , PACHOT JEAN
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22
摘要： 2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a —CO—R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2 is a —CO—Y—R4 radical for which Y is —O—, —S—, —NH—, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO— in which R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2 is alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between >N—R2 and the substituent; and R3 is alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist.

7. 发明专利

TN2010000328A1 DERIVES DE 2 AMINO -2- PHENYL-ALKANOL, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENENT 未知
公开(公告)号：TN2010000328A1
公开(公告)日：2011-12-29
申请号：TN2010000328
申请日：2010-07-16
申请人： DENIS ALEXIS , OROXCELL
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： A61K31/135 , A61K31/24 , C07C217/48 , C07C219/22
摘要： Esters dérivés de 2-amino-2-phényl-alkanol de formule générale (I) dans laquelle : R1 est H, alkyle 1 à 4C droit ou ramifié, alkyle 2 à 4C droit ou ramifié substitué par OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, uréido ou alkyluréido, R2 est un radical -CO-R dans lequel R est H, alkyle, aryle, hétérocyclyle, benzyle ou hétérocyclylméthyle, ou bien R2 est un radical -CO- Y-R4 pour lequel Y est -O-, -S-, -NH-, -NaIk- pour lequel alk est alkyle droit ou ramifié (1 à 4C), et R4 est alkyle, aryle, aralkyle ou hétérocyclylalkyle, pouvant être substitués par un ou plusieurs atomes d'halogène ou radicaux OH, alkyle (1 à 4C) droit ou ramifié, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyle ou acylamino (1 à 4C) droits ou ramifiés, ou oxo, ou pouvant être substitués par R5COO- dans lequel R5 est alkyle éventuellement substitué par benzyloxycarbonylamino, acylamino ou par le reste d'un aminoacide, ou représente un hétérocycle, ou bien R2 est alkyle (2 à 4C) substitué par OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino formant éventuellement avec l'atome d'azote auquel elles sont attachées, un hétérocycle à 5 ou 6 chaînons portant éventuellement un autre hétéroatome (O ou N), ou substitué par alkylcarbamoyloxy, alkoxycarbonylamino, uréido ou alkyluréido, étant entendu que ledit radical alkyle substitué droit ou ramifié, comporte au moins 2C entre >N-R2 et le substituant; et R3 est alkyle (1 à 4C) droit ou ramifié sauf mention spéciale, alkyle ou acyle sont droits ou ramifiés (1 à 7C), sous leurs formes R ou S ou leurs mélanges, ainsi que leurs sels pharmaceutiquement acceptables lorsqu'ils existent.

8. 发明专利

HK1147090A1 未知
公开(公告)号：HK1147090A1
公开(公告)日：2011-07-29
申请号：HK11101187
申请日：2011-02-08
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： A61K20060101 , C07C20060101
摘要： 2-amino-2-phenyl-alkanol ester derivatives of general formula (I) in which: R1 is H, straight or branched 1 to 4C alkyl, straight or branched 2 to 4C alkyl substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, R2 is a —CO—R radical in which R is H, alkyl, aryl, heterocyclyl, benzyl or heterocyclylmethyl, or R2 is a —CO—Y—R4 radical for which Y is —O—, —S—, —NH—, -Nalk- for which alk is straight or branched (1 to 4C) alkyl, and R4 is alkyl, aryl, aralkyl or heterocyclylalkyl, capable of being substituted by one or more halogen atoms or OH radicals, straight or branched (1 to 4C) alkyl, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyl or acylamino (1 to 4C) straight or branched, or oxo, or capable of being substituted by R5COO— in which R5 is alkyl optionally substituted by benzyloxycarbonylamino, acylamino or by an amino acid residue, or represents an heterocyclyl radical, or R2 is alkyl (2 to 4C) substituted by OH, alkoxy, alkylthio, acyloxy, NH2, alkylamino, dialkylamino optionally forming, with the nitrogen atom to which they are attached, a 5- or 6-member heterocycle optionally having another heteroatom (O or N), or substituted by alkylcarbamoyloxy, alkoxycarbonylamino, ureido or alkylureido, it being understood that said straight or branched substituted alkyl radical comprises at least 2C between >N—R2 and the substituent; and R3 is alkyl (1 to 4C) straight or branched unless specifically mentioned, alkyl or acyl are straight or branched (1 to 7C), in their R or S forms or their mixtures, as well as their pharmaceutically acceptable salts when these exist.

9. 发明专利

ES2400080T3 Derivados de 2-amino-2-fenil-alcanol, su preparación y composiciones farmacéuticas que los contienen 未知
公开(公告)号：ES2400080T3
公开(公告)日：2013-04-05
申请号：ES09720924
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22
摘要： Un éster derivado de 2-amino-2-fenil-alcanol de fórmula general: en la que: R1 es un átomo de hidrógeno, un radical alquilo que contiene de 1 a 4 átomos de carbono en cadena recta o ramificada, un radical alquilo que contiene de C2 a C4 en cadena recta o ramificada sustituido por hidroxi, alcoxi, alquiltio, aciloxi, amino, alquilamino, dialquilamino, alquil-carbamoyl-oxi, alcoxicarbonilamino, ureido o alquiureido, R2 es un radical -CO-R en el que R es un radical alquilo, un radical arilo, heterociclilo, bencilo o heterociclilmetilo,un radical -CO- Y-R4 para el que Y es un heteroátomo elegido entre -O-, -S-, -NH-, -Nalk- para el que alk es un radicalalquilo recto o ramificado que contiene de C1 a C4, y R4 se elige entre los radicales alquilo, arilo, aralquilo o heterociclilalquilo, que pueden sustituirse por uno o varios átomos de halógeno o radicales hidroxi, alquilo con C1 a C4en cadena recta o ramificada, alcoxi, alquiltio, acilamino alquiltio, alcoxicarbonilo o acilamino cuyos restos alquilocontienen de C1 a C4 en cadena recta o ramificada, u oxo, o que pueden sustituirse por un radical R5COO- en el que R5representa un radical alquilo, eventualmente sustituido por benciloxicarbonilamino, acilamino o por el resto de unaminoácido, o representa un heterociclo, o bien R2 es un radical alquilo que contiene de C2 a C4, sustituido por hidroxi, alcoxi, alquiltio, aciloxi, amino, alquilamino,dialquilamino cuyas partes alcohilo pueden formar con el átomo de nitrógeno al que están ligados, un heterociclo de 5 ó6 eslabones que contienen, eventualmente, otro heteroátomo elegido entre el oxígeno o el nitrógeno, o sustituido poralquil-carbamoyl-oxi, alcoxicarbonilamino, ureido o alquilureido, quedando entendido que dicho radical alquilo sustituidoestá en cadena recta o ramificada y contiene al menos 2 átomos de carbono entre el átomo de nitrógeno con R2 y el sustituyente; R3 es un radical alquilo que contiene de 1 a 4 átomos de carbono en cadena recta o ramificada,en sus formas R o S o sus mezclas, así como sus sales farmacéuticamente aceptables, cuando existen.

10. 发明专利

MA32125B1 Dérivés de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent 未知
公开(公告)号：MA32125B1
公开(公告)日：2011-03-01
申请号：MA33019
申请日：2010-07-15
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24
摘要： Esters dérivés de 2-amino-2-phényl-alkanol de formule générale (i) dans laquelle : r1 est h, alkyle 1 à 4c droit ou ramifié, alkyle 2 à 4c droit ou ramifié substitué par oh, alkoxy, alkylthio, acyloxy, nh2, alkylamino, dialkylamino, alkylcarbamoyloxy, alkoxycarbonylamino, uréido ou alkyluréido, r2 est un radical -co-r dans lequel r est h, alkyle, aryle, hétérocyclyle, benzyle ou hétérocyclylméthyle, ou bien r2 est un radical -co- y-r4 pour lequel y est -o-, -s-, -nh-, -naik- pour lequel alk est alkyle droit ou ramifié (1 à 4c), et r4 est alkyle, aryle, aralkyle ou hétérocyclylalkyle, pouvant être substitués par un ou plusieurs atomes d'halogène ou radicaux oh, alkyle (1 à 4c) droit ou ramifié, alkoxy, alkylthio, acylaminoalkylthio, alkoxycarbonyle ou acylamino (1 à 4c) droits ou ramifiés, ou oxo, ou pouvant être substitués par r5coo- dans lequel r5 est alkyle éventuellement substitué par benzyloxycarbonylamino, acylamino ou par le reste d'un aminoacide, ou représente un hétérocycle, ou bien r2 est alkyle (2 à 4c) substitué par oh, alkoxy, alkylthio, acyloxy, nh2, alkylamino, dialkylamino formant éventuellement avec l'atome d'azote auquel elles sont attachées, un hétérocycle à 5 ou 6 chaînons portant éventuellement un autre hétéroatome (o ou n), ou substitué par alkylcarbamoyloxy, alkoxycarbonylamino, uréido ou alkyluréido, étant entendu que ledit radical alkyle substitué droit ou ramifié, comporte au moins 2c entre >n-r2 et le substituant; et r3 est alkyle (1 à 4c) droit ou ramifié sauf mention spéciale, alkyle ou acyle sont droits ou ramifiés (1 à 7c), sous leurs formes r ou s ou leurs mélanges, ainsi que leurs sels pharmaceutiquement acceptables lorsqu'ils existent.

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