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1. 发明专利

AU1271799A Methods for preventing and treating bacterial infections using cellulose acetatephthalate or hydroxypropyl methylcellulose phthalate excipients 未知
公开(公告)号：AU1271799A
公开(公告)日：1999-05-10
申请号：AU1271799
申请日：1998-10-21
申请人： DEBNATH ASIM KUMAR , DOW GORDON JAY , JIANG SHIBO , NEURATH ALEXANDER ROBERT , NEW YORK BLOOD CENTER INC , STRICK NATHAN
发明人： NEURATH ALEXANDER ROBERT , JIANG SHIBO , DEBNATH ASIM KUMAR , STRICK NATHAN , DOW GORDON JAY
IPC分类号： A61K9/06 , A61K9/107 , A61K9/14 , A61K31/717 , A61K47/02 , A61K47/10 , A61K47/32 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A01F25/02 , A01F25/08
摘要： A method for decreasing the frequency of transmission of human immunodeficiency virus or herpesviruses or for preventing the transmission of or treating a sexually transmitted bacterial infection by administering to a human an anti-human immunodeficiency virus amount or an anti-herpesvirus amount or an anti-bacterial amount of cellulose acetate phthalate (CAP) or hydroxypropyl methylcellulose phthalate (HPMCP), such as in micronized form, or a combination thereof, either alone or in combination with a pharmaceutically acceptable carrier or diluent. The CAP and/or HPMCP may be employed as a suspension of micronized particles and may further contain a water miscible, non-solvent for CAP or HPMCP, such as glycerol.

2. 发明公开

EP1030547A4 METHODS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS USING CELLULOSE ACETATE PHTHALATE OR HYDROXYPROPYL METHYLCELLULOSE PHTHALATE EXCIPIENTS 有权
标题翻译：方法预防和治疗中使用或CELLULOSEACETATPHTHALAT-HYDROXYPROPPYLMETHYLCELLULOSETRÄGERSTOFFEN细菌感染
公开(公告)号：EP1030547A4
公开(公告)日：2002-11-06
申请号：EP98956122
申请日：1998-10-21
申请人： NEW YORK BLOOD CT INC , NEURATH ALEXANDER ROBERT , JIANG SHIBO , DEBNATH ASIM KUMAR , STRICK NATHAN , DOW GORDON J
发明人： NEURATH ALEXANDER ROBERT , JIANG SHIBO , DEBNATH ASIM KUMAR , STRICK NATHAN , DOW GORDON JAY
IPC分类号： A61K9/06 , A61K9/107 , A61K9/14 , A61K31/717 , A61K47/02 , A61K47/10 , A61K47/32 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A01F25/02 , A01F25/08 , A61K31/715
CPC分类号： A61K9/14 , A61K31/717

3. 发明专利

AT284675T 未知
公开(公告)号：AT284675T
公开(公告)日：2005-01-15
申请号：AT98956122
申请日：1998-10-21
申请人： NEW YORK BLOOD CT INC , NEURATH ALEXANDER ROBERT , JIANG SHIBO , DEBNATH ASIM KUMAR , STRICK NATHAN , DOW GORDON J
发明人： NEURATH ALEXANDER ROBERT , JIANG SHIBO , DEBNATH ASIM KUMAR , STRICK NATHAN , DOW GORDON JAY
IPC分类号： A61K9/06 , A61K9/107 , A61K9/14 , A61K31/717 , A61K47/02 , A61K47/10 , A61K47/32 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61K31/715
摘要： A method for decreasing the frequency of transmission of human immunodeficiency virus or herpesviruses or for preventing the transmission of or treating a sexually transmitted bacterial infection by administering to a human an anti-human immunodeficiency virus amount or an anti-herpesvirus amount or an anti-bacterial amount of cellulose acetate phthalate (CAP) or hydroxypropyl methylcellulose phthalate (HPMCP), such as in micronized form, or a combination thereof, either alone or in combination with a pharmaceutically acceptable carrier or diluent. The CAP and/or HPMCP may be employed as a suspension of micronized particles and may further contain a water miscible, non-solvent for CAP or HPMCP, such as glycerol.

4. 发明申请

WO2004047730A2 COMPOUNDS FOR INHIBITION OF HIV INFECTION BY BLOCKING HIV ENTRY 审中-公开
标题翻译：通过阻止艾滋病毒入侵来抑制艾滋病毒感染的化合物
公开(公告)号：WO2004047730A2
公开(公告)日：2004-06-10
申请号：PCT/US0336359
申请日：2003-11-12
申请人： NEW YORK BLOOD CT INC , JIANG SHIBO , DEBNATH ASIM KUMAR
发明人： JIANG SHIBO , DEBNATH ASIM KUMAR
IPC分类号： A61K20060101 , A61K31/40 , C07D207/30 , C07D207/32 , C07D207/327 , C07D413/04 , C07D417/04 , A61K
CPC分类号： C07D207/327
摘要： A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC50 values
摘要翻译：鉴定了一组通过阻断HIV进入而抑制HIV复制的化合物。两种代表性的化合物（称为NB-2和NB-64）抑制HIV复制（p24产生），IC50值<0.5 mug / ml。证明NB-2和NB-64是通过靶向HIV gp41的HIV进入抑制因子，因为：1）它们抑制HIV介导的细胞融合; 2）只有当病毒加入不到1小时后，才能抑制HIV复制; 3）它们不阻断gp120-CD4结合; 4）它们没有与共受体CXCR4相互作用，因为它们不能阻断抗CXCR4抗体结合CXCR4表达细胞; 5）它们阻断了使用构象特异性Mab NC-1通过夹心酶联免疫吸附测定（ELISA）检测到的gp41核心的形成; 6）它们抑制荧光天然 - 聚丙烯酰胺凝胶电泳（FN-PAGE）显示的gp41六螺旋束的形成; 和7）它们阻断了肽肽与肽IQN17模拟的gp41卷曲螺旋结构域内的疏水空穴的结合。这些结果表明NB-2和NB-64可能与疏水腔相互作用并阻断融合活性gp41卷曲螺旋结构域的形成，导致HIV-1介导的膜融合和病毒进入的抑制。

5. 发明申请

WO2006138118B1 ANTI-VIRAL COMPOSITIONS COMPRISING HETEROCYCLIC SUBSTITUTED PHENYL FURANS AND RELATED COMPOUNDS 审中-公开
标题翻译：包含杂环取代苯基呋喃的抗病毒组合物及相关化合物
公开(公告)号：WO2006138118B1
公开(公告)日：2007-09-20
申请号：PCT/US2006021993
申请日：2006-06-06
申请人： NEW YORK BLOOD CT INC , JIANG SHIBO , DEBNATH ASIM KUMAR , LU HONG
发明人： JIANG SHIBO , DEBNATH ASIM KUMAR , LU HONG
IPC分类号： A61K31/53 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/501
CPC分类号： A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/53
摘要： A group of compounds that inhibit HIV replication by blocking HIV entry was identified. One representative compound, designated NB-206, and its analogs inhibited HIV replication (p24 production) with IC50 values at nanomolar levels. It was proved that NB-206 and its analogs are HIV entry inhibitors by targeting the HIV gp41 since: 1) they inhibited HIV-mediated cell fusion; 2) they inhibited HIV replication only when they were added to the cells less than one hour after virus addition; 3) they blocked the formation of the gp41 core that is detected by sandwich enzyme linked immunosorbent assay (ELISA) using a conformation- specific MAb NC-I; and 4) they inhibited the formation of the gp41 six-helix bundle revealed by fluorescence native-polyacrylamide gel electrophoresis (FN-PAGE) . These results suggested that NB-206 and its analogs may interact with the hydrophobic cavity and block the formation of the fusion- active gp41 coiled coil domain, resulting in inhibition of HIV-I mediated membrane fusion and virus entry.
摘要翻译：确定了一组通过阻止HIV进入来抑制HIV复制的化合物。一种名为NB-206的代表性化合物及其类似物抑制HIV复制（p24产生），IC 50值在纳摩尔水平。已经证明NB-206及其类似物是通过靶向HIV gp41的HIV进入抑制剂，因为：1）它们抑制HIV介导的细胞融合; 2）只有当病毒添加后不到1小时才加入到细胞中时，它们就抑制HIV复制; 3）它们阻断了使用构象特异性MAb NC-1通过夹心酶联免疫吸附测定（ELISA）检测到的gp41核心的形成; 和4）它们抑制荧光天然聚丙烯酰胺凝胶电泳（FN-PAGE）显示的gp41六螺旋束的形成。这些结果表明NB-206及其类似物可能与疏水空腔相互作用并阻断融合活性gp41卷曲螺旋结构域的形成，导致抑制HIV-1介导的膜融合和病毒进入。

6. 发明申请

WO2006138118A2 ANTI-VIRAL COMPOSITIONS COMPRISING HETEROCYCLIC SUBSTITUTED PHENYL FURANS AND RELATED COMPOUNDS 审中-公开
标题翻译：包含杂环取代的苯甲酸和相关化合物的抗病毒组合物
公开(公告)号：WO2006138118A2
公开(公告)日：2006-12-28
申请号：PCT/US2006021993
申请日：2006-06-06
申请人： NEW YORK BLOOD CT INC , JIANG SHIBO , DEBNATH ASIM KUMAR , LU HONG
发明人： JIANG SHIBO , DEBNATH ASIM KUMAR , LU HONG
IPC分类号： A61K31/53 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/501
CPC分类号： A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/53
摘要： A group of compounds that inhibit HIV replication by blocking HIV entry was identified. One representative compound, designated NB-206, and its analogs inhibited HIV replication (p24 production) with IC50 values at nanomolar levels. It was proved that NB-206 and its analogs are HIV entry inhibitors by targeting the HIV gp41 since: 1) they inhibited HIV-mediated cell fusion; 2) they inhibited HIV replication only when they were added to the cells less than one hour after virus addition; 3) they blocked the formation of the gp41 core that is detected by sandwich enzyme linked immunosorbent assay (ELISA) using a conformation- specific MAb NC-I; and 4) they inhibited the formation of the gp41 six-helix bundle revealed by fluorescence native-polyacrylamide gel electrophoresis (FN-PAGE) . These results suggested that NB-206 and its analogs may interact with the hydrophobic cavity and block the formation of the fusion- active gp41 coiled coil domain, resulting in inhibition of HIV-I mediated membrane fusion and virus entry.
摘要翻译：鉴定了一组通过阻断HIV进入而抑制HIV复制的化合物。一个代表性的化合物，称为NB-206及其类似物，其抑制HIV复制（p24产生），IC50值为纳摩尔水平。证实NB-206及其类似物是通过靶向HIV gp41的HIV进入抑制因子，因为：1）它们抑制HIV介导的细胞融合; 2）只有当病毒加入不到1小时后，才能抑制HIV复制; 3）它们阻断了使用构象特异性MAb NC-1通过夹心酶联免疫吸附测定（ELISA）检测到的gp41核心的形成; 和4）它们抑制由荧光天然 - 聚丙烯酰胺凝胶电泳（FN-PAGE）显示的gp41六螺旋束的形成。这些结果表明，NB-206及其类似物可能与疏水腔相互作用并阻断融合活性gp41卷曲螺旋结构域的形成，导致HIV-1介导的膜融合和病毒进入的抑制。

7. 发明专利

JP2013216693A Small-molecule inhibitor of assembly and maturation of retrovirus 审中-公开
标题翻译：组装的小分子抑制剂和逆转录酶的成熟
公开(公告)号：JP2013216693A
公开(公告)日：2013-10-24
申请号：JP2013153344
申请日：2013-07-24
申请人： New York Blood Center Inc , ニューヨークブラッドセンター, インコーポレイテッド
发明人： DEBNATH ASIM KUMAR , ZHANG HONGTAO , CURRELI FRANCESCA
IPC分类号： A61K31/437 , A61K31/17 , A61K31/496 , A61K31/5377 , A61K38/22 , A61K39/395 , A61K45/00 , A61P31/18 , A61P43/00
CPC分类号： A61K31/4709 , A61K31/437
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition containing a pharmaceutically effective amount of the compound represented by the formula I, pharmaceutically acceptable salt thereof, or ester.SOLUTION: Disclosed is a chemical substance that breaks up the assembly and maturation of retrovirus. To be more specific, provided are a small molecule compound capable of breaking up the formation and maturation of virus particles and a method of using the small molecule for treatment of HIV-1 infection. This system and method target also at a method for breaking up the assembly and replication of HIV-1. These methods may include an intracellular administration of a pharmaceutically effective amount of the compound represented by the formula I or formula II, pharmaceutically acceptable salt thereof, or ester.
摘要翻译：要解决的问题：提供含有药学有效量的式I化合物，其药学上可接受的盐或酯的药物组合物。解决方案：公开了分解逆转录病毒的组装和成熟的化学物质。更具体地说，提供能够破坏病毒颗粒的形成和成熟的小分子化合物以及使用该小分子治疗HIV-1感染的方法。该系统和方法的目标也是分解HIV-1的组装和复制的方法。这些方法可以包括药学上有效量的由式I或式II表示的化合物，其药学上可接受的盐或酯的细胞内施用。

8. 发明专利

IL211111A Use of small molecule inhibitors in the manufacture of a medicament for treating hiv assembly and maturation 未知
公开(公告)号：IL211111A
公开(公告)日：2014-05-28
申请号：IL21111111
申请日：2011-02-07
申请人： NEW YORK BLOOD CT INC , DEBNATH ASIM KUMAR , ZHANG HONGTAO , CURRELI FRANCESCA
发明人： DEBNATH ASIM KUMAR , ZHANG HONGTAO , CURRELI FRANCESCA
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101

9. 发明专利

IL228831A Small molecule inhibitors of retroviral assembly and maturation 未知
公开(公告)号：IL228831A
公开(公告)日：2014-06-30
申请号：IL22883113
申请日：2013-10-10
申请人： NEW YORK BLOOD CT INC , DEBNATH ASIM KUMAR , ZHANG HONGTAO , CURRELI FRANCESCA
发明人： DEBNATH ASIM KUMAR , ZHANG HONGTAO , CURRELI FRANCESCA
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101

10. 发明专利

CA3152002A1 INHIBITORS OF ZIKA VIRUS INFECTION 未知
公开(公告)号：CA3152002A1
公开(公告)日：2021-02-25
申请号：CA3152002
申请日：2020-08-20
申请人： NEW YORK BLOOD CENTER INC
发明人： DU LANYING , DEBNATH ASIM KUMAR , JIANG SHIBO , GAO YANING
IPC分类号： A61K31/7048 , A61P31/12 , A61P31/14
摘要： The present specification provides methods of treatment of flavivirus infection, such as Zika or dengue virus infection, by administration of gossypol, a gossypol derivative, digitonin, or conessine. These compounds may be used alone, in combination with each other, or in combination with curcumin or bortezomib.

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