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1. 发明申请

WO2007138227A1 DISPOSITIF MICROFLUIDIQUE AVEC MATERIAU DE VOLUME VARIABLE 审中-公开
标题翻译：具有可变体积材料的微流体装置
公开(公告)号：WO2007138227A1
公开(公告)日：2007-12-06
申请号：PCT/FR2007/051346
申请日：2007-05-29
申请人： DEBIOTECH SA , VALLET, Véronique , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique , SCHNEEBERGER, Niklaus
发明人： VALLET, Véronique , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique , SCHNEEBERGER, Niklaus
IPC分类号： B01L3/00 , B81C1/00
CPC分类号： F16K99/0003 , B01J19/0093 , B01J2219/00783 , B01J2219/00984 , B01L3/502738 , B01L2200/12 , B01L2300/0874 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F16K99/0001 , F16K99/0036 , F16K99/0046 , F16K99/0065 , F16K2099/0074 , F16K2099/0084 , Y10T137/2191 , Y10T137/2196 , Y10T137/2213 , Y10T137/2224
摘要： L'invention concerne un dispositif microfluidique comprenant au moins une première plaque (112) formant le substrat et présentant au moins une perforation (113) et, de chaque côté de cette première plaque (112), en au moins plusieurs emplacements, un matériau apte à délimiter des portions de canaux, ledit matériau étant formé, en au moins un de ces emplacements, d'un matériau activable (114, 116) pouvant faire varier son volume par activation, ledit matériau étant agencé auxdits emplacements selon une disposition qui permet, lors d'une première phase et par activation d'au moins un emplacement constitué dudit matériau activable, la transformation depuis une première configuration vers une deuxième configuration, ce par quoi est modifié un réseau tridimensionnel qui correspond, dans la deuxième configuration et selon le choix du ou des emplacements qui sont activés dans ladite première phase, à différents parcours de liquide présentant plusieurs portions de canaux (117, 119) parallèles au plan de la première plaque (112), situées dans des plans décalés, au moins de chaque côté de cette première plaque (11), et entre lesquelles se situe au moins une desdites perforations (113).
摘要翻译：本发明涉及一种微流体装置，其包括形成基底的至少一个第一板（112）并且具有至少一个穿孔（113），并且在至少几个位置处在所述第一板（112）的任一侧上，用于限定的材料所述材料在所述位置中的至少一个中包括能够通过激活而改变其体积的可活化材料，所述材料基于这样的布置被布置在所述位置处，所述布置使得能够在第一阶段期间和在激活由所述可激活材料组成的至少一个位置，其从第一配置到第二配置的变换，修改在第二配置中对应的三维网络并且依赖于在第一阶段被激活的所选择的位置到具有平行于第一板（112）的平面的多个通道部分（117,119）的液体的不同路径位于偏移平面中，至少在其上所述第一板（1112）的侧面，其间位于所述穿孔（113）中的至少一个。

2. 发明申请

WO2007060635A3 SYSTEM TO MEASURE BLOOD COAGULATION RELATED PARAMETERS 审中-公开
公开(公告)号：WO2007060635A3
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054432
申请日：2006-11-24
申请人： DEBIOTECH S.A. , PIVETEAU, Laurent-Dominique , VALLET, Véronique , NEFTEL, Frédéric , METREF, Lynda , BLANC, Nicolas
发明人： PIVETEAU, Laurent-Dominique , VALLET, Véronique , NEFTEL, Frédéric , METREF, Lynda , BLANC, Nicolas
IPC分类号： F15C5/00 , B01L3/00 , F04B19/00 , G01N33/49
摘要： System to measure blood coagulation related parameters comprising one first channel (6) adapted to contain a blood sample; said system containing, at least partially, an expandable material which is able to increase its volume when activated by an exciting source; said system furthermore comprising several excitable regions distributed close to said first channel (6), in such a way that, when one of said excitable region is activated, said expandable material increases to such an extend that the channel cross section is reduced to a location situated at or near to said excitable region.

3. 发明申请

WO2008018024A2 POROUS COATING INCORPORATING FLUID RESERVOIRS 审中-公开
标题翻译：多孔涂料包含流体储存
公开(公告)号：WO2008018024A2
公开(公告)日：2008-02-14
申请号：PCT/IB2007/053115
申请日：2007-08-07
申请人： DEBIOTECH S.A. , HOFMANN, Heinrich , PIVETEAU, Laurent-Dominique , NEFTEL, Frédéric
发明人： HOFMANN, Heinrich , PIVETEAU, Laurent-Dominique , NEFTEL, Frédéric
CPC分类号： A61L31/146 , A61F2250/0068 , A61K9/0024 , A61L27/54 , A61L27/56 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2400/12
摘要： Porous coating for the controlled release of fluids such as drugs comprising a porous structure with internal reservoirs and passages, said reservoirs communicating with the external environment through said passages, in such a way that a fluid can move between the reservoirs and the external environment, characterized by the fact that for at least a group of said passages, each passage contains a restricting element which partially restricts the passage cross section.
摘要翻译：用于控制释放流体的多孔涂层，例如包含具有内部储存器和通道的多孔结构的药物，所述储存器通过所述通道与外部环境连通，使得流体可以在储存器和外部环境之间移动，其特征在于通过对于至少一组所述通道，每个通道包含部分地限制通道横截面的限制元件。

4. 发明申请

WO2007060636A3 MICROFLUIDIC SYSTEM 审中-公开
公开(公告)号：WO2007060636A3
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054433
申请日：2006-11-24
申请人： BONSENS AB , GRISS, Patrick , SAMEL, Björn , STEMME, Göran , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
发明人： GRISS, Patrick , SAMEL, Björn , STEMME, Göran , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
IPC分类号： F15C5/00 , B01L3/00 , F04B19/00
摘要： Microfluidic system (1, 2, 10, 11, 16) comprising a first portion (3, 4, 24, 25) and a second portion (5-7), said first portion (3, 4) comprising a material which is able to change its volume when activated by an exciting factor, characterized by the fact that said first portion (3, 4) and said second portion (5-7) define a zone (3-7) which, when said first portion (3,4) is not yet activated by said exciting factor, shows a first topography devoid of any fluidic pathway and which, after activation by said exciting factor, shows a second topography (9, 14) which is adapted to contain at least one fluidic pathway, said microfluidic system furthermore comprising a tight cover surface (20) situated above said first portion (3, 4) and said second portion (5-7).

5. 发明申请

WO2007148240A2 ANISOTROPIC NANOPOROUS COATING 审中-公开
标题翻译：各向异性纳米涂料
公开(公告)号：WO2007148240A2
公开(公告)日：2007-12-27
申请号：PCT/IB2007/051869
申请日：2007-05-16
申请人： DEBIOTECH S.A. , PIVETEAU, Laurent-Dominique , HOFMANN, Heinrich , NEFTEL, Frédéric
发明人： PIVETEAU, Laurent-Dominique , HOFMANN, Heinrich , NEFTEL, Frédéric
IPC分类号： A61F2/82
CPC分类号： A61M31/002 , A61B17/68 , A61C8/0004 , A61C8/0013 , A61C8/0015 , A61C2008/0046 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61L27/28 , A61L27/56 , A61L31/08 , A61L31/146 , A61L2400/12 , Y10T428/24942 , Y10T428/249979
摘要： The present invention relates to a process for fabricating a porous coatings with controlled structure in the micro and nano-size domain. In particular, but not exclusively, it relates to a process for fabricating coatings with an anisotropic pore size distribution and to coatings obtained using such coatings. It describes in particular the use of ink-jet method to deposit in a controlled way such coatings. It also relates to porous coatings with controlled structure in the micro and nano-size domain. The coating has a thickness between 10 nanometres and 10 millimetres and its porosity is created in such a way that the pore size distribution is anisotropic. It finally describes objects covered with this coating.
摘要翻译：本发明涉及一种在微米级和纳米尺寸域中制造具有受控结构的多孔涂层的方法。特别地但并不排他地涉及一种制备具有各向异性孔径分布的涂层以及使用这种涂层获得的涂层的方法。它特别描述了使用喷墨方法以受控的方式沉积这样的涂层。它还涉及在微尺寸和纳米尺寸域中具有受控结构的多孔涂层。涂层的厚度在10纳米到10毫米之间，其孔隙度是以孔径分布是各向异性的方式产生的。最后描述了这种涂层所覆盖的物体。

6. 发明申请

WO2007031972A1 REINFORCED POROUS COATING 审中-公开
标题翻译：增强多孔涂层
公开(公告)号：WO2007031972A1
公开(公告)日：2007-03-22
申请号：PCT/IB2006/053327
申请日：2006-09-15
申请人： DEBIOTECH S.A. , AXIS BIODENTAL S.A. , HOFMANN, Heinrich , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
发明人： HOFMANN, Heinrich , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
IPC分类号： A61L27/28 , A61L31/08
CPC分类号： A61L27/28 , A61L27/54 , A61L27/56 , A61L31/08 , A61L31/146 , A61L31/16 , A61L2300/00 , Y10T428/249978
摘要： The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps : - providing a support having a surface, - depositing on said surface one mono-layer of temporary particles, - depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, - eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment, - applying a coating fixation step, characterized by the fact that said temporary particles are deposited on said surface in such a way that, after particle deposition, more than 50 % of the temporary particles are in contact with a maximum of two adjacent particles and otherwise are separated by an empty space. The invention also concerns a coating and an object which can be obtained with this process.
摘要翻译：本发明涉及一种用于制造具有微米或纳米尺寸结构的多孔涂层的方法，其特征在于以下步骤： - 提供具有表面的支撑体， - 在所述表面上沉积一个单层临时颗粒 - 在所述临时颗粒上沉积涂层，使得所述涂层的厚度小于颗粒直径， - 消除所述临时颗粒，从而获得多孔涂层，所述涂层的孔对应于先前由临时颗粒占据的空间颗粒和至少一部分与外部环境相通的孔， - 施加涂层固定步骤，其特征在于所述临时颗粒沉积在所述表面上，使得在颗粒沉积之后，超过50％临时颗粒与最多两个相邻的颗粒接触，否则由空的空间分开。本发明还涉及可以用该方法获得的涂层和物体。

7. 发明申请

WO2007031968A3 POROUS COATING LOADED WITH A LIQUID OR A SOLID SUBSTANCE 审中-公开
公开(公告)号：WO2007031968A3
公开(公告)日：2007-03-22
申请号：PCT/IB2006/053323
申请日：2006-09-15
申请人： DEBIOTECH S.A. , AXIS BIODENTAL S.A. , HOFMANN, Heinrich , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
发明人： HOFMANN, Heinrich , NEFTEL, Frédéric , PIVETEAU, Laurent-Dominique
IPC分类号： A61L27/28 , A61K31/08
摘要： The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps : - providing a support having a surface, - depositing on said surface one mono-layer of temporary particles, - depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, - eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment, - applying a coating fixation step, characterized by the fact that it furthermore comprise a filling step where said pores are at least partially filled with a liquid or solid substance. The invention also concerns a coating and an object which can be obtained with this process.

8. 发明申请

WO2010136848A1 CONTROLLING THE POROSITY IN AN ANISOTROPIC COATING 审中-公开
标题翻译：控制各向异性涂层中的孔隙度
公开(公告)号：WO2010136848A1
公开(公告)日：2010-12-02
申请号：PCT/IB2009/052206
申请日：2009-05-26
申请人： DEBIOTECH S.A. , TOURVIEILLE, Arnaud , HOFMANN, Heinrich , PIVETEAU, Laurent-Dominique
发明人： TOURVIEILLE, Arnaud , HOFMANN, Heinrich , PIVETEAU, Laurent-Dominique
IPC分类号： B05D7/00
CPC分类号： B05D1/32 , B05D3/0254 , B05D3/06 , B05D5/08 , B05D7/534 , Y10T428/249979
摘要： The present invention relates to a process for fabricating a porous coatings with controlled structure in the micro and nano-size domain. In particular, but not exclusively, it relates to a process for fabricating coatings with an anisotropic pore size distribution and to coatings obtained using such coatings. It describes in particular the use of ink-jet method to deposit in a controlled way such coatings. It also relates to porous coatings with controlled structure in the micro and nano-size domain. The coating has a thickness between 10 nanometres and 10 millimetres and its porosity is created in such a way that the pore size distribution is anisotropic. It finally describes objects covered with this coating.
摘要翻译：本发明涉及一种在微纳米尺寸领域制造具有受控结构的多孔涂层的方法。特别地但并不排他地涉及一种制备具有各向异性孔径分布的涂层以及使用这种涂层获得的涂层的方法。它特别描述了使用喷墨方法以受控的方式沉积这样的涂层。它还涉及在微尺寸和纳米尺寸域中具有受控结构的多孔涂层。涂层的厚度在10纳米到10毫米之间，其孔隙度是以孔径分布是各向异性的方式产生的。最后描述了这种涂层所覆盖的物体。

9. 发明申请

WO2011007196A1 MECHANICALLY STABLE COATING 审中-公开
标题翻译：机械稳定涂料
公开(公告)号：WO2011007196A1
公开(公告)日：2011-01-20
申请号：PCT/IB2009/053055
申请日：2009-07-14
申请人： DEBIOTECH S.A. , TOURVIEILLE DE LABROUHE, Arnaud , PIVETEAU, Laurent-Dominique , HOFMANN, Heinrich
发明人： TOURVIEILLE DE LABROUHE, Arnaud , PIVETEAU, Laurent-Dominique , HOFMANN, Heinrich
IPC分类号： C23C24/00 , C23C26/00 , A61L27/28
CPC分类号： C23C24/00 , A61L27/28 , A61L27/50 , A61L31/08 , A61L31/14 , A61L2400/12 , C23C26/00 , Y10T428/24372 , Y10T428/24413
摘要： Element comprising a substrate and a nanoporous adherent coating made of at least one layer, said layer being in adherent contact with said substrate and comprising separate domains of nanoparticles, each of said domains having an average diameter between 1 and 1000 nm and being separated from its neighbor domains on the major part of its circumference by an average distance equal or less to its diameter.
摘要翻译：元件包括基材和由至少一层制成的纳米多孔粘附涂层，所述层与所述基底粘合接触，并且包括纳米颗粒的分开的结构域，每个所述结构域的平均直径在1至1000nm之间并与其分离其周长的主要部分的平均距离等于或小于其直径。

10. 发明申请

WO2011076537A1 SOLUBLE MICRONEEDLE 审中-公开
标题翻译：可溶性麦克风
公开(公告)号：WO2011076537A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/068710
申请日：2010-12-02
申请人： DEBIOTECH S.A. , MEFTI, Selma , CACHEMAILLE, Astrid , PIVETEAU, Laurent-Dominique , LEMAIRE, Pierre
发明人： MEFTI, Selma , CACHEMAILLE, Astrid , PIVETEAU, Laurent-Dominique , LEMAIRE, Pierre
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： Microneedle comprising a distal part made of a soluble material, characterized by the fact that said distal part comprises a skeleton.
摘要翻译：微针包括由可溶性材料制成的远端部分，其特征在于所述远端部分包括骨架。

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