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1. 发明申请

WO2008157790A3 PULSED LASERS IN FREQUENCY DOMAIN DIFFUSE OPTICAL TOMOGRAPHY AND SPECTROSCOPY 审中-公开
标题翻译：频率范围内的脉冲激光光学光学和光谱学
公开(公告)号：WO2008157790A3
公开(公告)日：2009-02-26
申请号：PCT/US2008067741
申请日：2008-06-20
申请人： DARTMOUTH COLLEGE , JIANG SHUDONG , POGUE BRIAN WILLIAM , WANG JIA , PAULSEN KEITH D
发明人： JIANG SHUDONG , POGUE BRIAN WILLIAM , WANG JIA , PAULSEN KEITH D
IPC分类号： G01N21/47
CPC分类号： G01N21/4795 , A61B5/0073
摘要： A diffuse optical tomography system incorporating a a mode- locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection signal may be heterodyne shifted to lower frequencies to allow easy and accurate measurement of phase and amplitude. Embodiments incorporating wavelength-swept, tunable, lasers and embodiments using broadband photonic fiber lasers with spectrally-sensitive detectors are described.
摘要翻译：包含锁模可调激光器的漫射光学断层扫描系统产生可用于以高空间和光谱分辨率询问组织的脉冲光。检测信号可以是外差偏移到较低频率，以便容易且准确地测量相位和振幅。描述了使用具有光谱敏感检测器的宽带光子激光器的波长扫描，可调谐，激光器和实施例的实施例。

2. 发明申请

WO2006116672A3 SYSTEMS AND METHODS FOR TOMOGRAPHIC IMAGE RECONSTRUCTION 审中-公开
标题翻译：用于图像图像重构的系统和方法
公开(公告)号：WO2006116672A3
公开(公告)日：2007-02-22
申请号：PCT/US2006016210
申请日：2006-04-27
申请人： DARTMOUTH COLLEGE , POGUE BRIAN WILLIAM , PIAO DAQING , PAULSEN KEITH D , JIANG SHUDONG , DEHGHANI HAMID , XU HENG , SPRINGETT ROGER , SRINIVASAN SUBHA
发明人： POGUE BRIAN WILLIAM , PIAO DAQING , PAULSEN KEITH D , JIANG SHUDONG , DEHGHANI HAMID , XU HENG , SPRINGETT ROGER , SRINIVASAN SUBHA
IPC分类号： A61B5/00
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0091 , A61B5/4312 , A61B5/7239 , G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/10 , G01J3/2803 , G01N2021/1787
摘要： Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the mammalian tissue is collected at a plurality of reception points. Collected light from each reception point is separated according to its wavelength, and received by a photodetector to produce path attenuation signals representing attenuation along paths between the source locations and the reception points. An image construction system generates a tomographic image of the mammalian tissue from the path attenuation signals. One embodiment of an optical imaging system includes an optical coherence tomography-near infrared probe. The systems and methods may utilize a spectral derivative approach that provides insensitivity to the boundary and boundary artifacts in the signal, thereby improving the quality of the reconstructed images.
摘要翻译：描述了从多个源提供多个不同波长的光的光学层析成像系统。系统将光引入哺乳动物组织，并且在多个接收点收集来自哺乳动物组织的光。来自每个接收点的收集的光根据其波长被分离，并由光电检测器接收以产生表示沿着源位置和接收点之间的路径衰减的路径衰减信号。图像构造系统从路径衰减信号生成哺乳动物组织的断层图像。光学成像系统的一个实施例包括光学相干断层摄影近红外探测器。系统和方法可以利用对信号中的边界和边界伪像提供不敏感性的光谱导数方法，从而提高重建图像的质量。

3. 发明专利

CA2855874A1 INCREASING TUMOR OXYGENATION FOR DIAGNOSTIC ASSESSMENTS 未知
公开(公告)号：CA2855874A1
公开(公告)日：2016-01-04
申请号：CA2855874
申请日：2014-07-04
申请人： JIANG SHUDONG , FISHER JOSEPH
发明人： JIANG SHUDONG , FISHER JOSEPH
IPC分类号： A61B5/145 , A61M16/00
摘要： A method of assessing the susceptibility of a breast tumor to a reduction in hypoxia, comprising delivering controlled amounts of oxygen and carbon dioxide to attain a starting end tidal concentration of oxygen (PetO2) which lies in the range of 350 to 450 mm Hg and a starting end tidal concentration of carbon dioxide (PetCO2) which lies in the range of 42 to 55 mm of Hg: incrementally increasing or decreasing the end tidal of at least one of oxygen and carbon dioxide wherein at least one increment is maintained for at least as long as the time required to obtain a surrogate measure of tumor oxygenation reflecting at least an increase or decrease in oxygenation of the tumor relative to a previously measured surrogate value of tumor oxygenation in at least one region of the breast tumor, wherein at least one of -- the starting PetO2and an incremental increase or decrease in PetO2--, is in the range of approximately 375 to approximately 425 mm of Hg, and wherein at least one of -- the starting PetCO2 and an incremental increase or decrease in PetCO2-- is in the range of approximately 42 to approximately 50 mm of Hg; and obtaining at least one surrogate measure of tumor oxygenation after incrementally increasing or decreasing the end tidal of at least one of oxygen and carbon dioxide for comparison to a previously measured surrogate value of tumor oxygenation, with respect to at least one region of the breast tumor.

4. 发明专利

AU2016253948A1 Cherenkov imaging systems and methods for determining radiation dose 未知
公开(公告)号：AU2016253948A1
公开(公告)日：2017-11-23
申请号：AU2016253948
申请日：2016-04-27
申请人： DARTMOUTH COLLEGE
发明人： ZHANG RONGXIAO , POGUE BRIAN WILLIAM , GLASER ADAM K , GLADSTONE DAVID J , JARVIS LESLEY A , ANDREOZZI JACQUELINE M , JIANG SHUDONG , DAVIS SCOTT CHRISTIAN , AXELSSON JOHAN JAKOB
IPC分类号： A61N5/00 , A61N5/01 , A61N5/06 , A61N5/10
摘要： A Cherenkov imaging system for determining surface radiation dose for a subject undergoing radiation therapy includes (a) a first camera for capturing a Cherenkov image of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, (b) a second camera for capturing a reflectance image of reflectance of optical illumination off the surface region, and (c) a correction module for correcting the Cherenkov image based upon the reflectance image to form a corrected Cherenkov image that indicates radiation dose for the surface region. A Cherenkov imaging method for determining surface radiation dose for a subject, undergoing radiation therapy includes correcting a Cherenkov image, of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, using a reflectance image of visible light reflected by the surface region, to form a corrected Cherenkov image that indicates radiation dose for the surface region.

5. 发明专利

CA3022122A1 CHERENKOV IMAGING SYSTEMS AND METHODS FOR DETERMINING RADIATION DOSE 未知
公开(公告)号：CA3022122A1
公开(公告)日：2016-11-03
申请号：CA3022122
申请日：2016-04-27
申请人： DARTMOUTH COLLEGE
发明人： ZHANG RONGXIAO , POGUE BRIAN WILLIAM , GLASER ADAM K , GLADSTONE DAVID J , JARVIS LESLEY A , ANDREOZZI JACQUELINE M , JIANG SHUDONG , DAVIS SCOTT CHRISTIAN , AXELSSON JOHAN JAKOB
IPC分类号： A61N5/00 , A61N5/01 , A61N5/06 , A61N5/10
摘要： A Cherenkov imaging system for determining surface radiation dose for a subject undergoing radiation therapy includes (a) a first camera for capturing a Cherenkov image of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, (b) a second camera for capturing a reflectance image of reflectance of optical illumination off the surface region, and (c) a correction module for correcting the Cherenkov image based upon the reflectance image to form a corrected Cherenkov image that indicates radiation dose for the surface region. A Cherenkov imaging method for determining surface radiation dose for a subject, undergoing radiation therapy includes correcting a Cherenkov image, of Cherenkov radiation from a surface region of the subject undergoing Cherenkov-radiation-inducing radiation therapy, using a reflectance image of visible light reflected by the surface region, to form a corrected Cherenkov image that indicates radiation dose for the surface region.

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