专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2017091673A8 BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF 审中-公开
标题翻译：双活性BROMODOMAIN抑制剂及其用途
公开(公告)号：WO2017091673A8
公开(公告)日：2017-06-01
申请号：PCT/US2016/063502
申请日：2016-11-23
申请人： DANA-FARBER CANCER INSTITUTE, INC.
发明人： QI, Jun , TANAKA, Minoru , ROBERTS, Justin, M. , BRADNER, James E.
IPC分类号： A61K31/5025 , C07D487/04
摘要： The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BDl and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.
摘要翻译：本发明提供了BET溴结构域的二价抑制剂，例如式（I），（II），（III），（IV），（V）和（VI）的化合物。一些含溴结构域蛋白（例如BRD4）具有包含多于一个溴结构域结合位点的串联溴结构域一级结构（例如，BRD4包含BD1和BD2）。本文提供的BET溴结构域的二价抑制剂可以通过有利的多价相互作用靶向溴结构域，因此可以治疗与含溴结构域的蛋白质相关的疾病或病症。本发明还提供了包含本发明化合物的药物组合物和试剂盒，以及使用本发明化合物的方法。

2. 发明申请

WO2017091673A2 BIVALENT BROMODOMAIN INHIBTORS AND USES THEREOF 审中-公开
标题翻译：双溴灭多威抑制剂及其用途
公开(公告)号：WO2017091673A2
公开(公告)日：2017-06-01
申请号：PCT/US2016/063502
申请日：2016-11-23
申请人： DANA-FARBER CANCER INSTITUTE, INC. , BRADNER, James, E.
发明人： BRADNER, James, E. , QI, Jun , TANAKA, Minoru , ROBERTS, Justin, M.
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： A61K31/551
摘要： The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BDl and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.
摘要翻译：本发明提供了BET溴结构域的二价抑制剂，例如式（I），（II），（III），（IV），（V）和（VI）的化合物。一些含溴结构域蛋白（例如BRD4）具有包含多于一个溴结构域结合位点的串联溴结构域一级结构（例如，BRD4包含BD1和BD2）。本文提供的BET溴结构域的二价抑制剂可以通过有利的多价相互作用靶向溴结构域，因此可以治疗与含溴结构域的蛋白质相关的疾病或病症。本发明还提供了包含本发明化合物的药物组合物和试剂盒，以及使用本发明化合物的方法。

3. 发明公开

EP3380100A2 BIVALENT BROMODOMAIN INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：EP3380100A2
公开(公告)日：2018-10-03
申请号：EP16869229.1
申请日：2016-11-23
申请人： Dana-Farber Cancer Institute, Inc.
发明人： BRADNER, James E. , QI, Jun , TANAKA, Minoru , ROBERTS, Justin, M.
IPC分类号： A61K31/5025 , C07D487/04
CPC分类号： C07D519/00 , A61K31/551 , A61P15/16 , Y02A50/463
摘要： The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases comprising the inventive compounds, as well as methods of using the inventive compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式