专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006012504A3 COMPOUNDS AND METHODS FOR TREATMENT OF THROMBOSIS 审中-公开
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：WO2006012504A3
公开(公告)日：2006-05-18
申请号：PCT/US2005026022
申请日：2005-07-22
申请人： DAIAMED INC , DENG HONGFENG , LIN JIAN , GUO ZIHONG , MEYERS HAROLD V , ABDEL-MEGUID SHERIN S , BABINE ROBERT E
发明人： DENG HONGFENG , LIN JIAN , GUO ZIHONG , MEYERS HAROLD V , ABDEL-MEGUID SHERIN S , BABINE ROBERT E
IPC分类号： C07D209/42 , A61K31/40 , A61P7/02 , C07D401/14 , C07D405/12 , C07D471/04
CPC分类号： C07D471/04 , C07D209/42 , C07D401/14 , C07D405/12
摘要： The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.
摘要翻译：本发明提供了用于治疗血栓栓塞障碍的化合物，药物组合物和方法，例如动脉血管栓塞性疾病，静脉心血管血栓栓塞障碍或心脏腔室中的血栓栓塞性疾病。

2. 发明申请

WO2006108039A3 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：WO2006108039A3
公开(公告)日：2007-04-26
申请号：PCT/US2006012665
申请日：2006-04-04
申请人： DAIAMED INC , BANNISTER THOMAS , CELATKA CASSANDRA , CHANDRAKUMAR NIZAL S , DENG HONGFENG , GUO ZIHONG , JIN LEI , LAZAROVA TSVETELINA , LIN JIAN , MOE SCOTT T , NAGAFUJI PAMELA , NAVIA MANUEL , RIPKA AMY , RYNKIEWICZ MICHAEL J , SPEAR KERRY L , STRICKLER JAMES E , XIE ROGER
发明人： BANNISTER THOMAS , CELATKA CASSANDRA , CHANDRAKUMAR NIZAL S , DENG HONGFENG , GUO ZIHONG , JIN LEI , LAZAROVA TSVETELINA , LIN JIAN , MOE SCOTT T , NAGAFUJI PAMELA , NAVIA MANUEL , RIPKA AMY , RYNKIEWICZ MICHAEL J , SPEAR KERRY L , STRICKLER JAMES E , XIE ROGER
IPC分类号： C07D205/08 , A61K31/397 , A61P7/02 , A61P11/02 , C07D227/087
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure of formula (1), wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd' are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor Vila, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有式（1）结构的化合物，其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述，并且其可用作类胰蛋白酶，凝血酶的抑制剂，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

3. 发明申请

WO2007130072A2 LIGHT TRANSMISSION SYSTEM FOR PHOTOREACTIVE THERAPY 审中-公开
标题翻译：用于光敏治疗的光传输系统
公开(公告)号：WO2007130072A2
公开(公告)日：2007-11-15
申请号：PCT/US2006018570
申请日：2006-05-15
申请人： LIGHT SCIENCES ONCOLOGY INC , CHEN JAMES C , DALY STEVEN ROSS , GUO ZIHONG , KELTNER LLEW , STORM JEFFREY ROBIN
发明人： CHEN JAMES C , DALY STEVEN ROSS , GUO ZIHONG , KELTNER LLEW , STORM JEFFREY ROBIN
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，用于向患者内的靶细胞透射光。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程地编程，以允许用户灵活地为特定患者或病症定制治疗。防止重复使用的功能之一是控制模块缺少对电源进行充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

4. 发明申请

WO2004082736A3 LIGHT GENERATING DEVICE TO INTRAVASCULAR USE 审中-公开
标题翻译：光生成装置用于静脉内使用
公开(公告)号：WO2004082736A3
公开(公告)日：2005-10-27
申请号：PCT/US2004007563
申请日：2004-03-12
申请人： LIGHT SCIENCES CORP , BURWELL PHILLIP , GUO ZIHONG , MATSON JENNIFER , DALY STEVEN , SHINE DAVID , LICHTTENEGGER GARY , BISHOP JEAN , YEO NICK , NARCISO HUGH
发明人： BURWELL PHILLIP , GUO ZIHONG , MATSON JENNIFER , DALY STEVEN , SHINE DAVID , LICHTTENEGGER GARY , BISHOP JEAN , YEO NICK
IPC分类号： A61B18/22 , A61M20060101 , A61N1/00 , A61N5/00 , A61N5/06 , A61N5/10
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气球来中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

5. 发明申请

WO2004043925A3 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS 审中-公开
标题翻译： 3-取代的6-ARYL作为C5A受体的配体
公开(公告)号：WO2004043925A3
公开(公告)日：2004-08-05
申请号：PCT/US0335694
申请日：2003-11-07
申请人： NEUROGEN CORP , HUTCHISON ALAN , YUAN JUN , LEE KYUNGAE , MAYNARD GEORGE , CHENARD BERTRAND L , LIU NIAN , GUO QIN , GUO ZIHONG , HRNCIAR PETER
发明人： HUTCHISON ALAN , YUAN JUN , LEE KYUNGAE , MAYNARD GEORGE , CHENARD BERTRAND L , LIU NIAN , GUO QIN , GUO ZIHONG , HRNCIAR PETER
IPC分类号： A61P9/00 , A61P29/00 , C07B61/00 , C07D213/30 , C07D213/38 , C07D213/42 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4439 , A61K31/444 , C07D213/40 , C07D401/14 , C07D417/06
CPC分类号： C07D213/30 , C07B2200/05 , C07D213/38 , C07D213/42 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C40B40/00
摘要： 3-substituted-6-aryl pyridines of Formula (I) are provided: Formula (I) wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.
摘要翻译：提供式（I）的3-取代-6-芳基吡啶：式（I）其中R 1，R 2，R 3，R 8，R 9，A和Ar如本文所定义。这些化合物是C5a受体的配体。优选的式（I）化合物以高亲和力结合C5a受体，并在C5a受体上呈现中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。此外，本发明提供标记的3-取代-6-芳基吡啶，其可用作C5a受体定位的探针。

6. 发明申请

WO2008086376A3 THERAPEUTIC DEVICES FOR THE TREATMENT OF VARICOSITY 审中-公开
标题翻译：用于治疗病变的治疗设备
公开(公告)号：WO2008086376A3
公开(公告)日：2008-10-09
申请号：PCT/US2008050545
申请日：2008-01-08
申请人： LIGHT SCIENCES ONCOLOGY INC , GUO ZIHONG , YEO NICHOLAS , BURWELL PHIL , CESPEDES IGNACIO , WATTERS WADE
发明人： GUO ZIHONG , YEO NICHOLAS , BURWELL PHIL , CESPEDES IGNACIO , WATTERS WADE
IPC分类号： A61N5/06
CPC分类号： A61B18/24 , A61N5/0601 , A61N5/062 , A61N2005/0652 , A61N2005/0659 , A61N2005/0662
摘要： The present invention provides methods and devices for treating varicosities, including varicose veins, by administering therapeutic energy. In one embodiment, energy is delivered to the interior of a vessel using a catheter containing an energy emitting source, thereby causing ablation of the vessel without damage to surrounding tissue. The methods of the invention may further include the use of a photosensitizer that binds to the interior of the vessel wall or a chromophore, both of which generate localized thermal damage to the interior vessel wall without harming surrounding tissue. In another embodiment, the present invention provides less invasive methods of treating varicosities, which include introducing a heat-activated glue, photosensitizer solution, or heatable liquid into a vessel being treated and administering light from an external source sufficient to activate the glue to close the vessel, activate the photosensitizer to damage the vessel, or heat the liquid to damage the vessel.
摘要翻译：本发明提供了通过施用治疗能量来治疗静脉曲张的方法和装置，包括静脉曲张。在一个实施例中，使用包含能量发射源的导管将能量输送到容器的内部，由此引起容器的消融而不损坏周围的组织。本发明的方法还可以包括使用光敏剂，其结合血管壁或发色团的内部，两者都会对内部血管壁产生局部热损伤而不伤害周围组织。在另一个实施方案中，本发明提供了治疗静脉曲张的侵入性较差的方法，其包括将热活化胶，光敏剂溶液或可加热液体引入正在治疗的血管中，并从外部来源施加足以激活胶水的光以封闭容器，激活光敏剂以损坏容器，或加热液体以损坏容器。

7. 发明申请

WO2005004704A3 LIGHT GENERATING DEVICE THAT SELF CENTERS WITHIN A LUMEN TO RENDER PHOTODYNAMIC THERAPY 审中-公开
标题翻译：自发中心在灯光照射光发射治疗的光生成装置
公开(公告)号：WO2005004704A3
公开(公告)日：2005-11-03
申请号：PCT/US2004023451
申请日：2004-07-08
申请人： LIGHT SCIENCES CORP , CHEN JAMES , GUO ZIHONG , LICHTTENEGGERE GARY , SHINE DAVID , BURWELL PHILLIP
发明人： CHEN JAMES , GUO ZIHONG , LICHTTENEGGERE GARY , SHINE DAVID , BURWELL PHILLIP
IPC分类号： A61B20060101 , A61N5/06 , A61N5/067 , A61N5/10 , F21S2/00
CPC分类号： A61N5/0601 , A61M2025/1047 , A61N5/062 , A61N2005/0652 , A61N2005/1003
摘要： A light generating device (1) for illuminating tissue adjacent to a body lumen while a distal end (5) of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen (4B) has a port adjacent to an array of light sources(10) , to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering (45) member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.
摘要翻译：一种用于在所述装置的远端（5）位于所述内腔中心的情况下照射邻近体腔的组织的光产生装置（1），以进行光动力学治疗。该装置可以封闭或移动体液，而不使用气球。在一个实施例中，冲洗腔（4B）具有与光源阵列（10）相邻的端口，以移位否则可能吸收光的体液。另一个实施例采用在第一位置和第二位置之间移动的定心（45）构件。定心构件将装置居中在内腔中，并且优选地由形状记忆材料形成。在另一个实施例中，该装置包括可独立定位的外护套和内部构件，使得定心构件能够选择性地定位。定心构件可以是非多孔的，使得定心构件也阻塞流体流动。

8. 发明专利

CA2648522A1 SUBSTITUTED AZETIDINONES 未知
公开(公告)号：CA2648522A1
公开(公告)日：2006-10-12
申请号：CA2648522
申请日：2006-04-04
申请人： DAIAMED INC
发明人： GUO ZIHONG , LAZAROVA TSVETELINA , JIN LEI , RIPKA AMY , DENG HONGFENG , RYNKIEWICZ MICHAEL J , SPEAR KERRY L , STRICKLER JAMES E , CHANDRAKUMAR NIZAL S , CELATKA CASSANDRA , NAVIA MANUEL , BANNISTER THOMAS , NAGAFUJI PAMELA , MOE SCOTT T , XIE ROGER , LIN JIAN
IPC分类号： C07D205/08 , A61K31/397 , A61P7/02 , A61P11/02 , C07D227/087
摘要： Compounds are provided which have the structure of formula (1), wherein A, B , C, D, m, Y, Ra, Rc, Rd, and Rd' are as described herein, and which are usefu l as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor Vila, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

9. 发明公开

EP1871741A4 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的氮杂环丁酮
公开(公告)号：EP1871741A4
公开(公告)日：2012-01-11
申请号：EP06749333
申请日：2006-04-04
申请人： DAIAMED INC
发明人： BANNISTER THOMAS , CELATKA CASSANDRA , CHANDRAKUMAR NIZAL S , DENG HONGFENG , GUO ZIHONG , JIN LEI , LAZAROVA TSVETELINA , LIN JIAN , MOE SCOTT T , NAGAFUJI PAMELA , NAVIA MANUEL , RIPKA AMY , RYNKIEWICZ MICHAEL J , SPEAR KERRY L , STRICKLER JAMES E , XIE ROGER
IPC分类号： C07D205/08 , A61K31/397 , A61P7/02 , A61P11/02 , C07D227/087 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/14
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式