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1. 发明申请

WO2015024992A3 TREATMENT OF ASTHMA 审中-公开
公开(公告)号：WO2015024992A3
公开(公告)日：2015-02-26
申请号：PCT/EP2014/067812
申请日：2014-08-21
申请人： CYTOS BIOTECHNOLOGY AG
发明人： ITIN, Christian , LASSEN, Cheryl , SAUDAN, Philippe
IPC分类号： A61K31/573 , A61K31/711 , A61K31/715 , A61P11/06 , A61K31/06
摘要： The application is related to compositions and methods for the treatment of asthma.

2. 发明申请

WO2006045796A2 GASTRIC INHIBITORY POLYPEPTIDE (GIP) ANTIGEN ARRAYS AND USES THEREOF 审中-公开
标题翻译：胃肠抑制多肽（GIP）抗原阵列及其用途
公开(公告)号：WO2006045796A2
公开(公告)日：2006-05-04
申请号：PCT/EP2005/055529
申请日：2005-10-25
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , FULURIJA, Alma , SAUDAN, Philippe
发明人： BACHMANN, Martin , FULURIJA, Alma , SAUDAN, Philippe
CPC分类号： C07K16/26 , A61K39/00 , A61K47/646 , A61K47/6901 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2317/34 , C12N7/00 , C12N2730/10122 , C12N2730/10123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia , a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a GIP protein or a GIP fragment linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of obesity and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是分别与VLP连接的GIP蛋白或GIP片段。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗肥胖症，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

3. 发明申请

WO2004053137A2 METHOD FOR PROTEIN PRODUCTION 审中-公开
标题翻译：蛋白质生产方法
公开(公告)号：WO2004053137A2
公开(公告)日：2004-06-24
申请号：PCT/CH2003/000810
申请日：2003-12-10
申请人： CYTOS BIOTECHNOLOGY AG , SAUDAN, Philippe , HENNECKE, Frank , BACHMANN, Martin, F. , STERN, Dorothee, M.
发明人： SAUDAN, Philippe , HENNECKE, Frank , BACHMANN, Martin, F. , STERN, Dorothee, M.
IPC分类号： C12N15/85
CPC分类号： C12N15/86 , A01K2267/01 , C07K14/505 , C12N15/85 , C12N15/8509 , C12N2710/16643 , C12N2800/108 , C12N2840/20
摘要： The present invention relates to the field of gene expression technology and the production of recombinant polypeptides and/or untranslated RNA molecules in host cells. In particular, the invention provides a method for the production of recombinant polypeptides and/or untranslated RNA molecules in host cells allowing the production of high amounts of those molecules in a very short time and with a high degree of reproducibility, in particular with respect to a, preferably, pre-defined standard and, thus, making the present invention particularly attractive for the production of proteins for clinical use and the production under Good Manufacturing Practice (GMP).
摘要翻译：本发明涉及基因表达技术领域和宿主细胞中重组多肽和/或非翻译RNA分子的产生。特别地，本发明提供了用于在宿主细胞中生产重组多肽和/或非翻译RNA分子的方法，其允许在非常短的时间内产生大量的这些分子并具有高度的再现性，特别是关于 a，优选预定义的标准，因此使得本发明对于临床使用的蛋白质的生产和良好生产规范（GMP）下的生产特别有吸引力。

4. 发明申请

WO2006134125A1 ANTIGEN CONJUGATES AND USES THEREOF 审中-公开
标题翻译：抗原结合及其用途
公开(公告)号：WO2006134125A1
公开(公告)日：2006-12-21
申请号：PCT/EP2006/063198
申请日：2006-06-14
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
发明人： BACHMANN, Martin , TISSOT, Alain , JEGERLEHNER, Andrea , SAUDAN, Philippe , ZOU, Yu , SCHMITZ, Nicole , HUBER, Adrian , MARTIN, Stephen , HINTON, Heather
IPC分类号： A61K39/12 , C12N15/12 , C12N15/48 , C12N15/52
CPC分类号： A61K39/21 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/622 , A61K2039/627 , A61K2039/64 , C07K2319/70 , C12N2740/16211 , C12N2740/16234 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen of the invention, wherein said antigen of the invention is CCR5 of the invention, gastrin of the invention, CXCR4 of the invention, CETP of the invention or C5a of the invention. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of diseases in which the antigen of the invention mediates, or contributes to the condition, particularly for the treatment of AIDS, gastrointestinal cancers, coronary heart diseases or inflammatory diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供包含连接至本发明的至少一种抗原的病毒样颗粒（VLP）的组合物，其中本发明的所述抗原是本发明的CCR5，本发明的胃泌素，本发明的CXCR4，本发明的CETP或 C5a。本发明还提供了一种制备该组合物的方法。本发明的组合物可用于疫苗的生产，特别是用于治疗其中本发明的抗原介导或有助于该疾病的疾病，特别是用于治疗AIDS，胃肠癌，冠心病或炎性疾病。此外，本发明的组合物诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

5. 发明申请

WO2005005644A1 GENE EXPRESSION SYSTEM 审中-公开
标题翻译：基因表达系统
公开(公告)号：WO2005005644A1
公开(公告)日：2005-01-20
申请号：PCT/EP2004/007556
申请日：2004-07-09
申请人： CYTOS BIOTECHNOLOGY AG , IVANOVA, Lidia , SAUDAN, Philippe
发明人： IVANOVA, Lidia , SAUDAN, Philippe
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , C07K14/005 , C07K2319/30 , C12N2710/16222 , C12N2800/108 , C12N2830/42 , C12N2830/46 , C12N2840/20
摘要： The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one origin of replication, and at least one replication initiation factor, cells comprising these, processes for their propagation, and their use, in particular for the high level expression of proteins which can be used as medicaments.
摘要翻译：本发明涉及核酸分子，特别涉及包含至少一种目的基因，至少一种支架/基质附着区域（S / MAR），至少一种复制起点和至少一种复制起始因子的载体，包含它们的细胞，它们的繁殖过程及其用途，特别是可用作药物的蛋白质的高水平表达。

6. 发明申请

WO2004096272A3 METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADIPONECTIN AND ITS RECEPTOR 审中-公开
公开(公告)号：WO2004096272A3
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004473
申请日：2004-04-28
申请人： CYTOS BIOTECHNOLOGY AG , SAUDAN, Philippe , BACHMANN, Martin
发明人： SAUDAN, Philippe , BACHMANN, Martin
IPC分类号： G01N33/566
摘要： The invention is directed to methods for identifying agents that mimic or modulate the interaction between adiponectin and its receptor. In particular, the invention is directed to methods for mimicking or modulating the adiponectin-T-cadherin interaction in order to treat diseases and disorders associated with a deficiency or overabundance of adiponectin. Such diseases include, e.g., obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease and atherosclerosis. The invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin.

7. 发明申请

WO2010125202A1 INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：流感嗜血红蛋白组合物及其用途
公开(公告)号：WO2010125202A1
公开(公告)日：2010-11-04
申请号：PCT/EP2010/055944
申请日：2010-04-30
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
发明人： BACHMANN, Martin , JEGERLEHNER, Andrea , SAUDAN, Philippe
IPC分类号： A61K47/48 , A61P39/00
CPC分类号： A61K47/6901 , A61K47/646
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions, vaccine compositions and pharmaceutical compositions for the treatment, amelioration and / or prevention of influenza. The compositions, vaccine compositions and pharmaceutical compositions of the invention comprise a virus-like particle of an RNA bacteriophage and at least one antigen, wherein said at least one antigen is an ectodomain of an influenza virus hemagglutinin protein or a fragment of said ectodomain of an influenza virus hemagglutinin protein. When administered to an animal, preferably to a human, said compositions, vaccine compositions and pharmaceutical compositions efficiently induce immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against influenza virus. Thus, the invention further provides methods of treating, ameliorating and / or preventing influenza virus infection.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供用于治疗，改善和/或预防流感的组合物，疫苗组合物和药物组合物。本发明的组合物，疫苗组合物和药物组合物包含RNA噬菌体和至少一种抗原的病毒样颗粒，其中所述至少一种抗原是流感病毒血凝素蛋白的胞外域或所述胞外域的片段流感病毒血凝素蛋白。当施用于动物，优选给人时，所述组合物，疫苗组合物和药物组合物有效诱导免疫应答，特别是抗体应答，其中通常且优选地，所述抗体应答针对流感病毒。因此，本发明还提供了治疗，改善和/或预防流感病毒感染的方法。

8. 发明申请

WO2007039458A2 HIV PEPTIDE CONJUGATES AND USES THEREOF 审中-公开
标题翻译： HIV肽缀合物及其用途
公开(公告)号：WO2007039458A2
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066526
申请日：2006-09-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
发明人： BACHMANN, Martin , SAUDAN, Philippe , JEGERLEHNER, Andrea , RÖHN, Till Alexander , JENNINGS, Gary
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/5258 , C12N2740/16122 , C12N2740/16134 , C12N2795/18123
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is HIV gpl60 peptide. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and treatment of diseases. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.
摘要翻译：本发明属于医学，公共卫生，免疫学，分子生物学和病毒学领域。本发明提供了包含与至少一种抗原连接的病毒样颗粒（VLP）的组合物，其中所述抗原是HIV gp160肽。本发明还提供了一种生产该组合物的方法。本发明的组合物可用于生产疫苗，特别是用于预防和治疗疾病。而且，本发明的组合物诱导有效的免疫应答，特别是抗体应答。

9. 发明申请

WO2004018506A2 GENE EXPRESSION SYSTEM 审中-公开
标题翻译：基因表达系统
公开(公告)号：WO2004018506A2
公开(公告)日：2004-03-04
申请号：PCT/EP2003/009291
申请日：2003-08-21
申请人： CYTOS BIOTECHNOLOGY AG , IVANOVA, Lidia , RENNER, Wolfgang, A. , SAUDAN, Philippe
发明人： IVANOVA, Lidia , RENNER, Wolfgang, A. , SAUDAN, Philippe
IPC分类号： C07K14/18
CPC分类号： C12N15/86 , A61K48/00 , C12N15/85 , C12N2710/16243 , C12N2800/108 , C12N2840/20
摘要： The present invention relates to compositions and methods that allow the production of polypeptides and untranslated RNA molecules in host cells. More specifically, the invention provides nucleic acid molecules, expression systems, recombinant host cells, methods and kits, which enable the production and/or isolation and/or purification of polypeptides and untranslated RNA molecules. The compositions and methods of the invention can be applied in a regulatable expression system that is transiently transfected into mammalian host cells.
摘要翻译：本发明涉及允许在宿主细胞中产生多肽和非翻译RNA分子的组合物和方法。更具体地说，本发明提供了能够产生和/或分离和/或纯化多肽和非翻译RNA分子的核酸分子，表达系统，重组宿主细胞，方法和试剂盒。本发明的组合物和方法可以应用于瞬时转染到哺乳动物宿主细胞中的可调节表达系统。

10. 发明申请

WO2006045849A1 T-CADHERIN ANTIGEN ARRAYS AND USES THEREOF 审中-公开
标题翻译： T-CADHERIN抗原阵列及其用途
公开(公告)号：WO2006045849A1
公开(公告)日：2006-05-04
申请号：PCT/EP2005/055668
申请日：2005-10-31
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN, Martin , SAUDAN, Philippe , TISSOT, Alain , DIETMEIER, Klaus
发明人： BACHMANN, Martin , SAUDAN, Philippe , TISSOT, Alain , DIETMEIER, Klaus
IPC分类号： A61K39/00 , A61K39/385 , C07K14/705 , C07K16/28
CPC分类号： A61K39/385 , A61K47/6901 , A61K2039/6075 , A61K2039/627
摘要： The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The present invention provides, inter alia, a composition comprising a virus-like particle (VLP) and at least one antigen, wherein said antigen is a T- cadherin domain protein, a combination of any T-cadherin domain proteins, a T-cadherin domain fragment or a combination of any T-cadherin domain fragments, linked to the VLP respectively. The invention also provides a method for producing the aforesaid composition. The compositions of this invention are useful in the production of vaccines, in particular, for the prevention and/or treatment of T-cadherin related disease, and hereby, in particular, by inducing efficient immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。本发明尤其提供包含病毒样颗粒（VLP）和至少一种抗原的组合物，其中所述抗原是T-钙粘蛋白结构域蛋白，任何T-cadherin结构域蛋白，T-钙粘蛋白结构域片段或与VLP分别连接的任何T-cadherin结构域片段的组合。本发明还提供了一种制备上述组合物的方法。本发明的组合物可用于疫苗的制备，特别是用于预防和/或治疗T-钙粘蛋白相关疾病，特别是通过诱导有效的免疫应答，特别是抗体应答。此外，本发明的组合物特别可用于在指定的上下文中有效诱导自身特异性免疫应答。

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