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1. 发明申请

US20070005084A1 Minimally invasive coring vein harvester 有权
标题翻译：微创取芯静脉收割机
公开(公告)号：US20070005084A1
公开(公告)日：2007-01-04
申请号：US11155533
申请日：2005-06-16
申请人： Cynthia Clague , Michael Hobday , Raymond Usher , Roderick Briscoe , Katherine Jolly , Ana Buhr , Christopher Olig , Eric Meyer , Steven Christian , Tom Daigle , Robert Reetz , Jeffrey Sandstrom , James Keogh , Matthew Bonner , Scott Jahns
发明人： Cynthia Clague , Michael Hobday , Raymond Usher , Roderick Briscoe , Katherine Jolly , Ana Buhr , Christopher Olig , Eric Meyer , Steven Christian , Tom Daigle , Robert Reetz , Jeffrey Sandstrom , James Keogh , Matthew Bonner , Scott Jahns
IPC分类号： A61B17/22
CPC分类号： A61B17/22 , A61B17/00008 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B2017/00557 , A61B2017/00778 , A61B2017/22062 , A61B2017/22068
摘要： The invention provides a system and method for harvesting a vessel section. The system comprises a vessel support member, a handle, and a tubular cutting device. The vessel support member is introduced into the vessel section to be harvested. The tubular cutting device may comprise an outer tubular member or an outer and an inner tubular member. The outer tubular member carries at least one cutting element. The tubular member or members are advanced over the vessel section and vessel support member to core out the vessel section and tissue adjoining the vessel section.
摘要翻译：本发明提供了一种收集血管部分的系统和方法。该系统包括容器支撑构件，手柄和管状切割装置。将容器支撑构件引入待收获的容器部分。管状切割装置可以包括外部管状构件或外部管状构件和内部管状构件。外部管状构件承载至少一个切割元件。管状构件在容器部分和容器支撑构件上前进，以将与容器部分相邻的容器部分和组织芯出。

2. 发明申请

US20070043397A1 Cardiac mapping instrument with shapeable electrode 审中-公开
标题翻译：具有可塑电极的心脏测绘仪
公开(公告)号：US20070043397A1
公开(公告)日：2007-02-22
申请号：US11586112
申请日：2006-10-25
申请人： Jon Ocel , Roderick Briscoe , David Francischelli , Scott Jahns , James Keogh , Katherine Jolly , Matthew Bonner
发明人： Jon Ocel , Roderick Briscoe , David Francischelli , Scott Jahns , James Keogh , Katherine Jolly , Matthew Bonner
IPC分类号： A61N1/362
CPC分类号： A61B5/042 , A61B5/7475 , A61B18/14 , A61B2017/2927 , A61B2018/1472 , A61N1/056
摘要： An instrument including an elongated shaft and a non-conductive handle is disclosed. The shaft defines a proximal section and a distal section. The distal section forms an electrically conductive tip. Further, the shaft is adapted to be transitionable from a straight state to a first bent state. The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. The instrument is useful for epicardial pacing and/or mapping of the heart for temporary pacing on a beating heart, for optimizing the placement of ventricular leads for the treatment of patients with congestive heart failure and ventricular dysynchrony and/or for use in surgical ablation procedures.
摘要翻译：公开了一种包括细长轴和非导电手柄的仪器。轴限定近端部分和远端部分。远侧部分形成导电尖端。此外，轴适于从直状态转变到第一弯曲状态。轴能够独立地保持与直线状态和第一弯曲状态相关联的不同形状。手柄刚性地联接到轴的近端部分。该仪器可用于心脏起搏和/或心脏在心脏跳动中临时起搏的作用，以优化用于治疗患有充血性心力衰竭和心室异常不适和/或用于外科手术切除手术的患者的心室导线的位置。

3. 发明申请

US20050209564A1 Devices and methods for interstitial injection of biologic agents into tissue 有权
标题翻译：将生物制剂间插注入组织的装置和方法
公开(公告)号：US20050209564A1
公开(公告)日：2005-09-22
申请号：US11000798
申请日：2004-11-30
申请人： Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , Raymond Usher , James Keogh , Scott Jahns , Victor Chen
发明人： Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , Raymond Usher , James Keogh , Scott Jahns , Victor Chen
IPC分类号： A61B17/00 , A61B17/20 , A61B17/28 , A61B17/30 , A61B17/34 , A61M5/00
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00243 , A61B2017/00247 , A61B2017/2926 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M25/0084
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译：将生物制剂注入组织的装置和方法。设备具有细长轴和远端注射头，用于将针驱动到组织中，并通过针将药剂注射到组织中。沿着轴引导的纵向力可以转换成针驱动力。一些装置提供可控的可变针穿透深度。设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。其他装置包括用于驱动和缩回针的可充气构件。还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

4. 发明申请

US20060041243A1 Devices and methods for interstitial injection of biologic agents into tissue 有权
标题翻译：将生物制剂间插注入组织的装置和方法
公开(公告)号：US20060041243A1
公开(公告)日：2006-02-23
申请号：US11159752
申请日：2005-06-23
申请人： Asha Nayak , Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , James Keogh , Raymond Usher , Scott Jahns , Victor Chen
发明人： Asha Nayak , Matthew Bonner , Paul Rothstein , Prasanga Hiniduma-Lokuge , James Keogh , Raymond Usher , Scott Jahns , Victor Chen
IPC分类号： A61F2/04 , A61M31/00
CPC分类号： A61B17/205 , A61B17/00491 , A61B17/0206 , A61B17/3478 , A61B2017/00247 , A61B2017/0243 , A61B2017/2936 , A61B2017/2939 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61M5/32 , A61M25/0084
摘要： The current invention discloses a method for treating infracted/ischemic injury to a myocardium by injecting a substance into the myocardium. The injected substance helps to prevent negative adaptive remodeling by providing mechanical reinforcement or mechanical reinforcement combined with biological therapy. A number of substances for injection are disclosed, including multi component substances such as platelet gel, and other substances. The substances disclosed may contain additives to augment/enhance the desired effects of the injection. The invention also discloses devices used to inject the substances. The devices can include means for ensuring needles do not penetrate beyond a desired depth into the myocardium. The devices can also include needles having multiple lumens such that the components of the platelet gel will be combined at the injection site and begin polymerization in the myocardium.
摘要翻译：本发明公开了一种通过将物质注入心肌来治疗心肌缺血/缺血损伤的方法。注射的物质通过提供结合生物治疗的机械加强或机械增强物有助于防止负性适应性重塑。公开了许多注射用物质，包括多成分物质如血小板凝胶和其他物质。所公开的物质可以含有增加/增强注射效果的添加剂。本发明还公开了用于注入物质的装置。该装置可以包括用于确保针不超过心肌内的所需深度的装置。该装置还可以包括具有多个内腔的针，使得血小板凝胶的组分将在注射部位组合并开始在心肌中聚合。

5. 发明申请

US20070049863A1 Devices and methods for interstitial injection of biologic agents into tissue 有权
标题翻译：将生物制剂间插注入组织的装置和方法
公开(公告)号：US20070049863A1
公开(公告)日：2007-03-01
申请号：US11545197
申请日：2006-10-10
申请人： Scott Jahns , Gary Oehme , Matthew Bonner , James Keogh
发明人： Scott Jahns , Gary Oehme , Matthew Bonner , James Keogh
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00247 , A61B2017/00876 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M5/32 , A61M2025/0086 , A61M2025/0087
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for transversely driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force transverse to the shaft. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译：将生物制剂注入组织的装置和方法。设备具有细长的轴和远端注射头，用于将针横向驱动到组织中，并通过针将药剂注射到组织中。沿着轴引导的纵向力可以平移到与轴垂直的针驱动力。一些装置提供可控的可变针穿透深度。设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。其他装置包括用于驱动和缩回针的可充气构件。还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

6. 发明申请

US20050261673A1 Methods and apparatus for accessing and stabilizing an area of the heart 审中-公开
标题翻译：获取和稳定心脏区域的方法和装置
公开(公告)号：US20050261673A1
公开(公告)日：2005-11-24
申请号：US11172287
申请日：2005-06-30
申请人： Matthew Bonner , Raymond Usher , Victor Chen , James Keogh
发明人： Matthew Bonner , Raymond Usher , Victor Chen , James Keogh
IPC分类号： A61B18/14 , A61B19/00 , A61B19/02 , A61B19/08 , A61B19/10 , A61M1/00 , A61B18/18
CPC分类号： A61B18/1485 , A61B17/0401 , A61B18/1402 , A61B46/00 , A61B46/23 , A61B50/20 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2017/0243 , A61B2017/06052 , A61B2017/306 , A61B2018/00291 , A61B2090/306 , A61B2090/3614 , A61B2218/007 , A61M1/008
摘要： A tubular suction tool for accessing an anatomic surface or anatomic space and particularly the pericardium to access pericardial space and the epicardial surface of the heart to implant cardiac leads in a minimally invasive manner are disclosed. The suction tool incorporates a suction pad concave wall defining a suction cavity, a plurality of suction ports arrayed about the concave wall, and a suction lumen, to form a bleb of tissue into the suction cavity when suction is applied. The suction cavity extends along one side of the suction pad, so that the suction pad and suction cavity can be applied tangentially against a tissue site. The suction tool can incorporate light emission and video imaging of tissue adjacent the suction pad. A working lumen terminating in a working lumen port into the suction cavity enables introduction of tools, cardiac leads, and other instruments, cells, drugs or materials into or through the tissue bleb drawn into the suction cavity.
摘要翻译：公开了一种用于进入解剖表面或解剖空间的管状抽吸工具，特别是用于进入心包的心包以心脏心外膜表面以微创方式植入心脏引线。抽吸工具包括限定吸入腔的吸盘凹壁，围绕凹壁排列的多个吸入口和吸入腔，以在施加抽吸时形成吸入腔中的组织泡。吸入腔沿吸盘的一侧延伸，使得吸力垫和抽吸腔可以相对于组织部位切向施加。吸入工具可以包含邻近吸盘的组织的发光和视频成像。终止在吸入腔中的工作管腔端口的工作腔使得可以将工具，心脏引线以及其它器械，细胞，药物或材料引入到吸入腔中或穿过组织气泡中的吸入腔中。

7. 发明申请

US20100023004A1 SYSTEMS AND METHODS FOR CARDIAC TISSUE ELECTROPORATION ABLATION 有权
标题翻译：用于心脏组织电泳消融的系统和方法
公开(公告)号：US20100023004A1
公开(公告)日：2010-01-28
申请号：US12331004
申请日：2008-12-09
申请人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
发明人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2018/00291 , A61B2018/00351 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00738 , A61B2018/00839 , A61B2018/00875 , A61B2018/122 , A61B2218/002 , A61B2218/007
摘要： Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.
摘要翻译：心脏电穿孔消融系统和方法，其中递送脉冲的高电压能量以诱导心脏组织细胞的电穿孔，随后细胞破裂。在一些实施方案中，所递送的能量是双相的，循环时间不超过500微秒。

8. 发明申请

US20050273129A1 Anatomical space access tools and methods 审中-公开
标题翻译：解剖空间访问工具和方法
公开(公告)号：US20050273129A1
公开(公告)日：2005-12-08
申请号：US11111466
申请日：2005-04-21
申请人： Koen Michels , Nicolaas Lokhoff , Matthew Bonner
发明人： Koen Michels , Nicolaas Lokhoff , Matthew Bonner
IPC分类号： A61B17/00 , A61B17/30 , A61B17/34
CPC分类号： A61B17/3423 , A61B17/3415 , A61B2017/00247 , A61B2017/00561 , A61B2017/306 , A61B2017/3486 , A61B2017/3488 , A61B2018/00392
摘要： Medical devices and methods for accessing an anatomical space of the body and particularly for penetrating the epicardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner employing suction are disclosed. The distal end of a tubular access sleeve having a sleeve wall surrounding a sleeve access lumen and extending between a sleeve proximal end and a sleeve distal end having a plurality of suction ports arrayed around the sleeve access lumen distal end opening is applied against an outer tissue layer. Suction is applied through the plurality of suction ports to a plurality of portions of the outer tissue layer. A perforation instrument is introduced through the sleeve access lumen to perforate the outer tissue layer to form an access perforation into the anatomic space while the applied suction stabilizes the outer tissue layer, whereby further treatment drugs and devices can be introduced into the anatomic space.
摘要翻译：公开了用于访问身体的解剖空间，特别是用于穿透心外膜以采用抽吸的微创方式进入心包空间和心外膜表面的医疗装置和方法。管状进入套管的远端具有围绕套管进入腔并且在套筒近端和套筒远端之间延伸的套筒壁，其具有围绕套筒入口腔远端开口排列的多个吸入口，抵靠外部组织层。通过多个抽吸端口将吸力施加到外部组织层的多个部分。通过套管进入腔引入穿孔器械以使外部组织层穿孔，以在被施加的吸力稳定外部组织层时形成进入解剖空间的通路穿孔，从而可以将进一步的治疗药物和装置引入解剖空间。

9. 发明授权

US09642555B2 Subcutaneous lead guidance 有权
公开(公告)号：US09642555B2
公开(公告)日：2017-05-09
申请号：US12503298
申请日：2009-07-15
申请人： Matthew Bonner , Kenneth Gardeski , Bruce R. Mehdizadeh , Roger Christopherson , Michael R. Neidert
发明人： Matthew Bonner , Kenneth Gardeski , Bruce R. Mehdizadeh , Roger Christopherson , Michael R. Neidert
IPC分类号： A61B5/05 , A61B5/06 , A61B5/053 , A61M25/02 , A61B17/00 , A61M25/01 , A61B34/20
CPC分类号： A61B5/06 , A61B5/0538 , A61B5/061 , A61B5/062 , A61B5/065 , A61B5/067 , A61B34/20 , A61B2017/00243 , A61B2034/2051 , A61B2034/2072 , A61M25/0194 , A61M25/02 , A61M2025/0166 , A61M2025/026
摘要： An apparatus for subcutaneous lead guidance includes a flexible guide strap, a navigation catheter and a tunneling tool. The guide strap includes an upper layer having a plurality of retainer formations and a substrate attachable on a patient's skin extending between an incision and a target site. The navigation catheter is coupled to the upper layer via the retainer formations from a first end to a second end of the guide strap. The navigation catheter includes a plurality of position sensors for generating a subcutaneous navigation volume between the incision and the target site when the navigation catheter is coupled to a navigation system. The tunneling tool has a distal portion with a leading end and at least one position sensor on the distal portion for viewing digital representation of the distal portion in relation to the navigation volume on a display coupled to the navigation system.

10. 发明授权

US08221411B2 Systems and methods for cardiac tissue electroporation ablation 有权
标题翻译：心脏组织电穿孔消融的系统和方法
公开(公告)号：US08221411B2
公开(公告)日：2012-07-17
申请号：US12331004
申请日：2008-12-09
申请人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
发明人： David Francischelli , Mark Stewart , Jinback Hong , Vladimir Nikolski , Cushing Hamlen , Daniel Cheek , Matthew Bonner
IPC分类号： A61B18/18
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2018/00291 , A61B2018/00351 , A61B2018/00613 , A61B2018/00642 , A61B2018/00702 , A61B2018/00738 , A61B2018/00839 , A61B2018/00875 , A61B2018/122 , A61B2218/002 , A61B2218/007
摘要： Cardiac electroporation ablation systems and methods in which pulsed, high voltage energy is delivered to induce electroporation of cells of cardiac tissue followed by cell rupturing. In some embodiments, the delivered energy is biphasic, having a cycle time of not more than 500 microseconds.
摘要翻译：心脏电穿孔消融系统和方法，其中递送脉冲的高电压能量以诱导心脏组织细胞的电穿孔，随后细胞破裂。在一些实施方案中，所递送的能量是双相的，循环时间不超过500微秒。

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