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1. 发明授权

US5792624A Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof 失效
标题翻译： Dirofilaria和onchocerca幼虫L3半胱氨酸蛋白酶蛋白及其用途
公开(公告)号：US5792624A
公开(公告)日：1998-08-11
申请号：US482282
申请日：1995-06-07
申请人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank , Jennifer K. Richer
发明人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank , Jennifer K. Richer
IPC分类号： A61K38/00 , A61K39/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N9/64 , G01N33/50 , G01N33/53 , G01N33/569 , C12P21/06 , C12N15/00 , C12P21/04
CPC分类号： G01N33/5091 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , C12N9/641 , G01N33/5008 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译：本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

2. 发明授权

US06419923B1 Filariid nematode cysteine protease proteins, and uses thereof 失效
标题翻译：丝状线虫半胱氨酸蛋白酶蛋白及其用途
公开(公告)号：US06419923B1
公开(公告)日：2002-07-16
申请号：US08768619
申请日：1996-12-18
申请人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
发明人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
IPC分类号： A61K3846
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译：本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

3. 发明授权

US06365392B1 Filariid nematode cysteine protease nucleic acid molecules and uses thereof 失效
标题翻译：丝状线虫半胱氨酸蛋白酶核酸分子及其用途
公开(公告)号：US06365392B1
公开(公告)日：2002-04-02
申请号：US09005298
申请日：1998-01-09
申请人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
发明人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
IPC分类号： C12N701
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K2039/51 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/6402 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/422
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译：本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

4. 发明授权

US5795768A Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof 失效
标题翻译：丝状线虫半胱氨酸蛋白酶蛋白，核酸分子及其用途
公开(公告)号：US5795768A
公开(公告)日：1998-08-18
申请号：US486036
申请日：1995-06-07
申请人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
发明人： Cynthia Ann Tripp , Nancy Wisnewski , Robert B. Grieve , Glenn R. Frank
IPC分类号： C12N15/09 , A61K35/68 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P33/00 , C07K14/435 , C07K16/18 , C07K16/40 , C12N7/00 , C12N9/64 , C12N15/57 , C12Q1/37 , G01N33/50 , G01N33/53 , G01N33/569 , C12N1/20
CPC分类号： C12N9/641 , A61K39/0003 , C07K14/4354 , C07K16/18 , C07K16/40 , C12N9/6402 , G01N33/5008 , G01N33/5091 , G01N33/5308 , G01N33/56905 , A61K2039/51 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N2799/021 , G01N2333/4353 , G01N2333/95 , G01N2333/96402
摘要： The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
摘要翻译：本发明提供丝状线虫半胱氨酸蛋白酶蛋白; 丝丝虫线虫半胱氨酸蛋白酶核酸分子，特别是id ia is is is val val val val val val val ysteine;;;;;;;;;;;;;;;;;;;; 针对这种蛋白质产生的抗体，以及抑制丝状线虫半胱氨酸蛋白酶活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和/或抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

5. 发明授权

US06673916B1 Compositions of parasitic helminth PLA2 nucleic acid molecules and uses thereof 失效
标题翻译：寄生蠕虫PLA2核酸分子的组成及其用途
公开(公告)号：US06673916B1
公开(公告)日：2004-01-06
申请号：US09391270
申请日：1999-09-07
申请人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
发明人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
IPC分类号： C07H2104
CPC分类号： G01N33/502 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K39/39533 , C07K14/4354 , C07K16/18 , C07K16/40 , C07K2319/00 , C12N9/641 , C12N2799/021 , G01N33/5008 , G01N33/5308 , G01N33/56905 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , A61K2300/00
摘要： The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫PLA2蛋白; 包括寄生虫的PLA2核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制寄生蠕虫磷脂酶A2活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。本发明还包括含有这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

6. 发明授权

US06391569B1 Method to detect Dirofilaria immitis infection 失效
标题翻译：检测疟原虫感染的方法
公开(公告)号：US06391569B1
公开(公告)日：2002-05-21
申请号：US08715628
申请日：1996-09-18
申请人： Robert B. Grieve , Glenn R. Frank , Roy R. Mondesire , James P. Porter , Nancy Wisnewski
发明人： Robert B. Grieve , Glenn R. Frank , Roy R. Mondesire , James P. Porter , Nancy Wisnewski
IPC分类号： G01N3353
CPC分类号： C07K14/4354 , G01N33/569 , G01N2333/4353
摘要： The present invention includes a method to detect D. immitis infection in a host animal using a D. immitis Di33 protein to detect anti-D. immitis Di33 antibodies in a bodily fluid of the animal. Also included is a method to detect D. immitis infection in a host animal using a D. immitis anti-Di33 protein to detect Di33 proteins in a bodily fluid of the animal. The present invention also relates to D. immitis detection kits that include either a Di33 protein or an anti-Di33 antibody; such kits also include a composition to detect an immunocomplex between the anti-Di33 antibody and D. immitis Di33 protein. The present invention also includes Di33 proteins, nucleic acid molecules encoding such proteins, as well as recombinant molecules and recombinant cells comprising such nucleic acid molecules, and anti-Di33 antibodies. Also included are methods to produce such proteins, nucleic acid molecules and antibodies.
摘要翻译：本发明包括使用D.Imitmiti Di33蛋白检测宿主动物中的D. immitis感染以检测抗-D的方法。 immitis Di33抗体在动物的体液中。还包括在宿主动物中使用D.emmitis抗-Di33蛋白检测动物体内的Di33蛋白的方法。本发明还涉及包含Di33蛋白或抗-Di33抗体的D.IMIITIS检测试剂盒; 这样的试剂盒还包括用于检测抗Di33抗体和D.Imitmiti Di33蛋白之间的免疫复合物的组合物。本发明还包括Di33蛋白，编码这种蛋白质的核酸分子，以及重组分子和包含这种核酸分子的重组细胞和抗Di33抗体。还包括产生这种蛋白质，核酸分子和抗体的方法。

7. 发明授权

US6099843A Parasitic helminth PLA2 proteins 失效
标题翻译：寄生虫丝虫PLA2蛋白
公开(公告)号：US6099843A
公开(公告)日：2000-08-08
申请号：US483474
申请日：1995-06-07
申请人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
发明人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
IPC分类号： A61K39/00 , A61K39/02 , A61P33/02 , C07K14/44 , C12N15/30
CPC分类号： C12N9/18 , A61K39/0003 , A61K2039/5256 , A61K2039/552 , C12N2710/16743 , C12N2770/36143
摘要： The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A.sub.2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫PLA2蛋白; 包括寄生虫的PLA2核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制寄生蠕虫磷脂酶A2活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

8. 发明授权

US6060281A Parasitic helminth PLA2 proteins and nucleic acid molecules 失效
标题翻译：寄生虫蠕虫PLA2蛋白和核酸分子
公开(公告)号：US6060281A
公开(公告)日：2000-05-09
申请号：US482304
申请日：1995-06-07
申请人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
发明人： Robert B. Grieve , Glenn R. Frank , Nancy Wisnewski
IPC分类号： C07K14/435 , C12N15/30 , A61K39/00 , A61K39/002 , C07K14/44
CPC分类号： C07K14/4354 , C12N2799/021
摘要： The present invention relates to parasitic helminth PLA2 proteins; to parasitic helminth PLA2 nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit parasitic helminth phospholipase A.sub.2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫PLA2蛋白; 包括寄生虫的PLA2核酸分子，包括编码这些蛋白质的那些; 针对这种蛋白质产生的抗体; 以及抑制寄生蠕虫磷脂酶A2活性的化合物。本发明还包括获得这种蛋白质，核酸分子，抗体和抑制剂的方法。本发明还包括含有这些蛋白质，核酸分子，抗体和/或抑制剂的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

9. 发明授权

US06207158B1 Parasitic helminth macrophage migration inhibitory factor proteins, nucleic acid molecules, and uses thereof 失效
标题翻译：寄生虫蠕虫巨噬细胞迁移抑制因子蛋白质，核酸分子及其用途
公开(公告)号：US06207158B1
公开(公告)日：2001-03-27
申请号：US08906480
申请日：1997-08-05
申请人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Kevin S. Brandt , Nancy Wisnewski
IPC分类号： A61K3900
CPC分类号： H01G9/055 , C07K14/52 , C07K2319/00 , Y10S435/975
摘要： The present invention relates to parasitic helminth macrophage migration inhibitory factor (MIF) proteins; to parasitic helminth MIF nucleic acid molecules, including those that encode such MIF proteins; to antibodies raised against such MIF proteins; and to compounds that inhibit parasitic helminth MIF activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫巨噬细胞迁移抑制因子（MIF）蛋白; 包括那些编码这种MIF蛋白的MIF核酸分子，针对这种MIF蛋白产生的抗体; 以及抑制寄生蠕虫MIF活性的化合物。本发明还包括获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制性化合物的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

10. 发明授权

US5789194A Parasitic helminth venom allergen antigen 5-like genes and proteins 失效
标题翻译：寄生蠕虫毒液变应原抗原5样基因和蛋白质
公开(公告)号：US5789194A
公开(公告)日：1998-08-04
申请号：US450944
申请日：1995-05-23
申请人： Cynthia Ann Tripp , Nancy Wisnewski
发明人： Cynthia Ann Tripp , Nancy Wisnewski
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P33/00 , C07K14/435 , C07K14/44 , C07K16/18 , C07K16/20 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N7/00 , C12P21/02 , C12P21/00 , C07H21/04 , C07K1/00
CPC分类号： C07K16/18 , C07K14/4354 , A61K38/00 , A61K39/00
摘要： The present invention relates to parasitic helminth venom allergen antigen 5-like proteins; to parasitic helminth venom allergen antigen 5-like nucleic acid molecules, including those that encode such proteins; and to antibodies raised against such proteins. The present invention also includes methods to obtain such proteins, nucleic acid molecules and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules and/or antibodies, as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
摘要翻译：本发明涉及寄生蠕虫毒液变应原抗原5样蛋白; 对寄生蠕虫毒素变应原抗原5样核酸分子，包括编码这些蛋白质的那些; 以及针对这种蛋白质产生的抗体。本发明还包括获得这些蛋白质，核酸分子和抗体的方法。本发明还包括包含这些蛋白质，核酸分子和/或抗体的治疗组合物，以及这些治疗组合物用于保护动物免受寄生蠕虫引起的疾病的用途。

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