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1. 发明申请

US20110256183A1 Hydrogels with network defects enhanced by nanoparticle incorporation 有权
标题翻译：通过纳米颗粒掺入增强网络缺陷的水凝胶
公开(公告)号：US20110256183A1
公开(公告)日：2011-10-20
申请号：US13065030
申请日：2011-03-11
申请人： Curtis W. Frank , Won Jae Lee , Nam-Joon Cho , Jeffrey S. Glenn
发明人： Curtis W. Frank , Won Jae Lee , Nam-Joon Cho , Jeffrey S. Glenn
IPC分类号： A61K9/00 , A61K35/407 , A61P1/16 , C12N5/071 , A61K35/12 , B82Y5/00
CPC分类号： B82Y5/00 , A61K9/5184 , A61K35/12 , A61K38/00 , C12N5/0671 , C12N2533/30 , C12N2533/40 , Y10S977/773 , Y10S977/915 , Y10S977/923
摘要： Compositions and methods are provided for the manufacture and use of hydrogels with increased permeability to macromolecules with minimum loss of matrix mechanical strength and prepolymer viscosity for patternability. The hydrogels of the invention are formed from a prepolymer, which is polymerized in the presence of hydrophobic nanoparticles. In some embodiments of the invention cells are present during polymerization, and are encapsulated by the hydrogel. A high interfacial energy between the hydrophobic substrate and the aqueous polymerizing solution disrupts the hydrogel network structure, leading to network defects that increase permeability without loss of patternability.
摘要翻译：提供了组合物和方法，用于制造和使用具有增加的大分子渗透性的水凝胶，同时基质机械强度和预聚物粘度对图案性的损失最小。本发明的水凝胶由预聚物形成，预聚物在疏水性纳米颗粒存在下聚合。在本发明的一些实施方案中，细胞在聚合期间存在，并被水凝胶包封。疏水性底物和水性聚合溶液之间的高界面能量破坏了水凝胶网络结构，从而导致网络缺陷，从而增加渗透性而不损失图案性。

2. 发明授权

US08852614B2 Hydrogels with network defects enhanced by nanoparticle incorporation 有权
标题翻译：通过纳米颗粒掺入增强网络缺陷的水凝胶
公开(公告)号：US08852614B2
公开(公告)日：2014-10-07
申请号：US13065030
申请日：2011-03-11
申请人： Curtis W. Frank , Won Jae Lee , Nam-Joon Cho , Jeffrey S. Glenn
发明人： Curtis W. Frank , Won Jae Lee , Nam-Joon Cho , Jeffrey S. Glenn
IPC分类号： A61K9/00 , A01N63/00 , C12N5/02 , C12N5/071 , A61K35/12 , B82Y5/00 , A61K9/51 , A61K38/00
CPC分类号： B82Y5/00 , A61K9/5184 , A61K35/12 , A61K38/00 , C12N5/0671 , C12N2533/30 , C12N2533/40 , Y10S977/773 , Y10S977/915 , Y10S977/923
摘要： Compositions and methods are provided for the manufacture and use of hydrogels with increased permeability to macromolecules with minimum loss of matrix mechanical strength and prepolymer viscosity for patternability. The hydrogels of the invention are formed from a prepolymer, which is polymerized in the presence of hydrophobic nanoparticles. In some embodiments of the invention cells are present during polymerization, and are encapsulated by the hydrogel. A high interfacial energy between the hydrophobic substrate and the aqueous polymerizing solution disrupts the hydrogel network structure, leading to network defects that increase permeability without loss of patternability.
摘要翻译：提供了组合物和方法，用于制造和使用具有增加的大分子渗透性的水凝胶，同时基质机械强度和预聚物粘度对图案性的损失最小。本发明的水凝胶由预聚物形成，预聚物在疏水性纳米颗粒存在下聚合。在本发明的一些实施方案中，细胞在聚合期间存在，并被水凝胶包封。疏水性底物和水性聚合溶液之间的高界面能量破坏了水凝胶网络结构，从而导致网络缺陷，从而增加渗透性而不损失图案性。

3. 发明授权

US08211712B2 Method of fabricating lipid bilayer membranes on solid supports 失效
标题翻译：在固体支持物上制备脂质双层膜的方法
公开(公告)号：US08211712B2
公开(公告)日：2012-07-03
申请号：US11887669
申请日：2006-03-29
申请人： Nam-Joon Cho , Curtis W. Frank , Jeffrey S. Glenn , Kwang Ho Cheong
发明人： Nam-Joon Cho , Curtis W. Frank , Jeffrey S. Glenn , Kwang Ho Cheong
IPC分类号： G01N33/543
CPC分类号： G01N33/533 , B82Y5/00 , G01N33/554 , Y10T428/31678
摘要： The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support. Next, the lipid vesicles are destabilized by adding an amphipathic peptide solution to the lipid vesicle solution. This destabilization leads to production of a planar lipid bilayer on the solid support. The present invention also provides a supported planar lipid bilayer, where the planar lipid bilayer is made of naturally occurring lipids and the solid support is made of unmodified gold or titanium oxide. Preferably, the supported planar lipid bilayer is continuous. The planar lipid bilayer may be made of any naturally occurring lipid or mixture of lipids, including, but not limited to phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinsitol, cardiolipin, cholesterol, and sphingomyelin.
摘要翻译：本发明提供了一种在固体支持物上制备平面脂双层的方法。使用该方法，首先将脂质囊泡溶液沉积在固体支持物上。接下来，通过向脂质囊泡溶液中加入两亲肽溶液使脂质囊泡不稳定。这种不稳定性导致在固体支持物上产生平面脂双层。本发明还提供了一种支撑的平面脂质双层，其中平面脂质双层由天然存在的脂质制成，并且固体支持物由未改性的金或氧化钛制成。优选地，支撑的平面脂质双层是连续的。平面脂质双层可以由任何天然存在的脂质或脂质混合物制成，包括但不限于磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰胰岛素，心磷脂，胆固醇和鞘磷脂。

4. 发明申请

US20110217265A1 Screening for Inhibitors of HCV Amphipathic Helix (AH) Function 审中-公开
标题翻译：筛选HCV两性螺旋（AH）功能的抑制剂
公开(公告)号：US20110217265A1
公开(公告)日：2011-09-08
申请号：US13119245
申请日：2009-09-23
申请人： Jeffrey S. Glenn , Nam-Joon Cho , Wenjin Yang
发明人： Jeffrey S. Glenn , Nam-Joon Cho , Wenjin Yang
IPC分类号： A61K31/4965 , A61K31/497 , A61K31/7064 , A61K38/21 , A61P31/14 , C40B30/10 , C40B30/00 , G01B11/02
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent.
摘要翻译：提供筛选方法用于鉴定HCV两亲性螺旋（AH）功能的药理学抑制剂，该抑制剂可用于预防和治疗HCV感染。还提供了可用于抑制病毒复制的化合物。本发明的方法基于意想不到的发现，即AH的存在，例如， HCV多肽的AH引起囊泡表观直径的增加。本发明的方法提供了将AH肽添加到脂质囊泡中，例如以高通量形式加入; 该添加可以在不存在或存在候选药理剂的情况下进行。测量明显囊泡大小的变化，并与对照样品进行比较。囊泡大小或聚集的增加表明存在AH功能; 并且缺乏增加表明AH功能不存在或已被测试者抑制。

5. 发明授权

US08728793B2 Amphipathic alpha-helical peptide compositions as antiviral agents 有权
标题翻译：两亲性α-螺旋肽组合物作为抗病毒剂
公开(公告)号：US08728793B2
公开(公告)日：2014-05-20
申请号：US12172796
申请日：2008-07-14
申请人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
发明人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
IPC分类号： C12N7/04 , C12N7/08 , A61K39/29
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起含脂质囊泡如包膜病毒破坏的能力的方法和组合物。

6. 发明申请

US20090263670A1 Method of Fabricating Lipid Bilayer Membranes on Solid Supports 失效
标题翻译：在固体支持物上制备脂质双层膜的方法
公开(公告)号：US20090263670A1
公开(公告)日：2009-10-22
申请号：US11887669
申请日：2006-03-29
申请人： Nam-Joon Cho , Curtis W. Frank
发明人： Nam-Joon Cho , Curtis W. Frank
IPC分类号： B32B15/04 , B05D3/10 , C07C51/42
CPC分类号： G01N33/533 , B82Y5/00 , G01N33/554 , Y10T428/31678
摘要： The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support. Next, the lipid vesicles are destabilized by adding an amphipathic peptide solution to the lipid vesicle solution. This destabilization leads to production of a planar lipid bilayer on the solid support. The present invention also provides a supported planar lipid bilayer, where the planar lipid bilayer is made of naturally occurring lipids and the solid support is made of unmodified gold or titanium oxide. Preferably, the supported planar lipid bilayer is continuous. The planar lipid bilayer may be made of any naturally occurring lipid or mixture of lipids, including, but not limited to phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinsitol, cardiolipin, cholesterol, and sphingomyelin.
摘要翻译：本发明提供了一种在固体支持物上制备平面脂双层的方法。使用该方法，首先将脂质囊泡溶液沉积在固体支持物上。接下来，通过向脂质囊泡溶液中加入两亲肽溶液使脂质囊泡不稳定。这种不稳定性导致在固体支持物上产生平面脂双层。本发明还提供了一种支撑的平面脂质双层，其中平面脂质双层由天然存在的脂质制成，并且固体支持物由未改性的金或氧化钛制成。优选地，支撑的平面脂质双层是连续的。平面脂质双层可以由任何天然存在的脂质或脂质混合物制成，包括但不限于磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰胰岛素，心磷脂，胆固醇和鞘磷脂。

7. 发明申请

US20090105151A1 AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS 有权
公开(公告)号：US20090105151A1
公开(公告)日：2009-04-23
申请号：US12172796
申请日：2008-07-14
申请人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
发明人： Jeffrey Glenn , Nam-Joon Cho , Curtis W. Frank , Kwang Ho Cheong
IPC分类号： A61K38/10 , C12N7/00 , A01N1/02
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-containing vesicles, such as enveloped viruses, in a size-dependent manner.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起含脂质囊泡如包膜病毒破坏的能力的方法和组合物。

8. 发明申请

US20110262565A1 PIP-2 Inhibition-Based Antiviral and Anti-Hyperlipidemic Therapies 审中-公开
标题翻译： PIP-2抑制型抗病毒和抗高脂血症治疗
公开(公告)号：US20110262565A1
公开(公告)日：2011-10-27
申请号：US12994414
申请日：2009-05-29
申请人： Jeffrey S. Glenn , Phillip S. Pang , Nam-Joon Cho , Choongho Lee
发明人： Jeffrey S. Glenn , Phillip S. Pang , Nam-Joon Cho , Choongho Lee
IPC分类号： A61K33/00 , A61K31/7036 , A61P31/12 , G01N33/53
CPC分类号： G01N33/92 , A61K31/7036 , A61K45/06 , C12Q1/18
摘要： Interaction of a specific viral domain with phosphatidylinositol 4,5-bisphosphate (PIP 2) is shown to mediate viral replication. Basic Amino Acid PIP-2 Pincer (BAAPP) domains are described herein, including, without limitation, NS5A protein of HCV, NS4B protein of HCV, poliovirus, and rhinovirus.
摘要翻译：特异性病毒结构域与磷脂酰肌醇4,5-二磷酸酯（PIP 2）的相互作用显示可介导病毒复制。本文描述了碱性氨基酸PIP-2蒎烯（BAAPP）结构域，包括但不限于HCV的NS5A蛋白，HCV的NS4B蛋白，脊髓灰质炎病毒和鼻病毒。

9. 发明授权

US08387410B2 Air cooling type chiller 有权
标题翻译：风冷式冷水机
公开(公告)号：US08387410B2
公开(公告)日：2013-03-05
申请号：US12725606
申请日：2010-03-17
申请人： Nam-Joon Cho , Gi-Seop Lee , Bon-Chang Hwang , Jong-Ho Hong
发明人： Nam-Joon Cho , Gi-Seop Lee , Bon-Chang Hwang , Jong-Ho Hong
IPC分类号： F25D17/06
CPC分类号： F28B1/06 , F25B39/04 , F25B2400/06 , F25D23/003 , F25D2323/0021 , F28B11/00 , F28F2009/222
摘要： An air-cooling type chiller is provided. The chiller may include a plurality of fans, and an intermediate device provided between adjacent fans of the plurality of fans. When one of the fans is disabled, air is not drawn in through the disabled fan due to the intermediate device, but instead may pass through a condenser, thereby minimizing degradation in condensing efficiency. The intermediate device may be formed as an auxiliary condenser so that any air drawn in through a disabled fan passes through the auxiliary condenser, also minimizing impact on condensing efficiency.
摘要翻译：提供了一种空冷式冷水机组。冷却器可以包括多个风扇，以及设置在多个风扇的相邻风扇之间的中间装置。当其中一个风扇被禁用时，由于中间装置，空气不会通过残余风扇吸入，而是可以通过冷凝器，从而最大限度地降低冷凝效率。中间装置可以形成为辅助冷凝器，使得通过残余风扇吸入的任何空气通过辅助冷凝器，同时也减小对冷凝效率的影响。

10. 发明申请

US20100114718A1 Function-Based Embedded Advertising in Software 审中-公开
标题翻译：基于功能的嵌入式广告在软件中
公开(公告)号：US20100114718A1
公开(公告)日：2010-05-06
申请号：US12264179
申请日：2008-11-03
申请人： Nam-Joon Cho
发明人： Nam-Joon Cho
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0276 , G06Q30/02
摘要： A computer-implemented method executes a function of a software application that includes a plurality of functions. Respective functions of the plurality of functions correspond to respective commands of a plurality of commands associated with the software application. In the method, a respective command of the plurality of commands is received. In response to the received respective command, an advertisement is displayed and the respective function corresponding to the received respective command is performed
摘要翻译：计算机实现的方法执行包括多个功能的软件应用的功能。多个功能的相应功能对应于与软件应用相关联的多个命令的相应命令。在该方法中，接收多个命令的相应命令。响应于所接收的相应命令，显示广告，并且执行与所接收的相应命令相对应的各个功能

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