专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5082835A Novel steroid diols, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译：新型甾体糊剂，含有它们的药物组合物及其制备方法
公开(公告)号：US5082835A
公开(公告)日：1992-01-21
申请号：US491683
申请日：1990-03-09
申请人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
发明人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
IPC分类号： A61K31/57 , A61P29/00 , C07J5/00 , C07J13/00
CPC分类号： C07J5/0092 , C07J13/005
摘要： The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group; and represents a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

2. 发明授权

US5053404A Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same 失效
标题翻译：新型甾体衍生物，含有它们的药物组合物及其制备方法
公开(公告)号：US5053404A
公开(公告)日：1991-10-01
申请号：US491682
申请日：1990-03-09
申请人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
发明人： Csaba Molnar , Gyorgy Hajos , Laszlo Szporny , Jozsef Toth , Arpad Kiraly , Anna Boor nee Mezei , Janos Csorgei , Kristina Szekely , Lilla Forgacs , Gyorgy Fekete , Bulcsu Herenyi , Sandor Holly , Jozsef Szunyog
IPC分类号： A61K31/58 , A61P29/00 , C07J7/00 , C07J71/00
CPC分类号： C07J71/0031 , C07J7/008
摘要： The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group;R.sup.1 and R.sup.2, which are the same or different, stand for hydrogen or a C.sub.1-4 alkyl group; or one of R.sup.1 and R.sup.2 is hydrogen and the other is phenyl group; or R.sup.1 and R.sup.2 together form a C.sub.4-5 alkylene group;means a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

3. 发明授权

US4456601A 3-Chloro-pregnane derivatives and a process for the preparation thereof 失效
标题翻译： 3-氯 - 孕烷衍生物及其制备方法
公开(公告)号：US4456601A
公开(公告)日：1984-06-26
申请号：US434335
申请日：1982-10-14
申请人： Jozsef Toth , Gyorgy Hajos , Gyorgy Fekete , Istvan Horvath , Laszlo Szporny , Anna Boor nee Mezei , Peter Aranyi , Aniko Naray , Sandor Gorog , Sandor Holly , Csaba Molnar
发明人： Jozsef Toth , Gyorgy Hajos , Gyorgy Fekete , Istvan Horvath , Laszlo Szporny , Anna Boor nee Mezei , Peter Aranyi , Aniko Naray , Sandor Gorog , Sandor Holly , Csaba Molnar
IPC分类号： C07J5/00 , A61K31/58 , A61P29/00 , C07J71/00 , A61K31/56
CPC分类号： C07J71/0031
摘要： New .DELTA..sup.1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, andY and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen,are prepared by reacting a .DELTA..sup.1,4 -3-oxo-pregnane derivative of the general formula (II), ##STR2## wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyleneiminium salt of the general formula (III), ##STR3## wherein A.sup.(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydrolysis.The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.
摘要翻译：通式（I），其中X是氢原子，乙酰基或氯代乙酰基的新的具有通式（I）的1,3,5-三氯 - 孕烷衍生物，Y和Z代表氢原子或卤素原子，条件是它们中的至少一个不是氢，通过使通式（II）的DELTA 1,4-3-氧代 - 孕烷衍生物，其中X' 与乙酰基或氯乙酰基，Y和Z如上所定义，与通式（III）的氯亚甲基亚胺鎓盐，其中A（ - ）是形成盐的阴离子，在非质子传递溶剂在叔碱存在下，如果需要，使所得产物水解。通式（I）的化合物发挥消炎作用，可用于治疗炎症的治疗。

4. 发明授权

US4368160A Process for preparing 17.alpha.-hydroxy-pregn-4-en-3,20-dione derivatives 失效
标题翻译：制备17α-羟基孕甾-4-en-3,20-二酮衍生物的方法
公开(公告)号：US4368160A
公开(公告)日：1983-01-11
申请号：US365015
申请日：1982-04-02
申请人： Anna Boor nee Mezei , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Fastner , Sandor Holly
发明人： Anna Boor nee Mezei , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Fastner , Sandor Holly
IPC分类号： C07J5/00 , A61K31/57 , B01J23/06 , B01J31/04 , C07B61/00 , C07J1/00 , C07J7/00
CPC分类号： C07J1/0048 , C07J1/0096 , C07J7/0045
摘要： The invention relates to a novel process for the preparation of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond between the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.
摘要翻译：本发明涉及一种制备式I的孕烷衍生物的新方法，其中R1代表甲基或乙基，R2代表氢原子或甲基，X是氢原子或甲酰基或乙酰基，并且由点和连续线表示的键表示两个相邻碳原子之间的单键或双键。根据本发明，将式II的三氟乙酸酯，其中R 1和R 2如上定义，在催化量的汞盐存在下，在偶极子质子中与甲酸或乙酸反应，游离或碱性溶剂。代替X的甲酰基或乙酰基可以以本身已知的方式分离。该过程提供了一种新颖有利的方法来建立皮质激素的孕烷侧链特征。

5. 发明授权

US4764613A 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine and a process for preparing same 失效
标题翻译： 2,6-二（氯甲氧基 - 羰氧基甲基）吡啶及其制备方法
公开(公告)号：US4764613A
公开(公告)日：1988-08-16
申请号：US88875
申请日：1987-08-24
申请人： Jozsef Toth , Mate Kovatsits , Laszlo Csutoras , Gabor Szabo , Sandor Gorog , Ferenc Trischler , Sandor Holly , Erzsebet Francsics , Bela Losonczi , Gabor Havasi
发明人： Jozsef Toth , Mate Kovatsits , Laszlo Csutoras , Gabor Szabo , Sandor Gorog , Ferenc Trischler , Sandor Holly , Erzsebet Francsics , Bela Losonczi , Gabor Havasi
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P9/10 , A61P29/00 , C07D213/28 , C07D213/30 , C07D213/55
CPC分类号： C07D213/30
摘要： The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs.According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.
摘要翻译：本发明涉及式（I）的新型2,6-双（氯甲氧基 - 羰基氧基甲基）吡啶（I）以及制备该化合物的方法，该方法是制备抗动脉粥样硬化的2,6-双）羟甲基）吡啶双（N-甲基氨基甲酸酯）（吡啶基氨基甲酸酯）等药物。根据本发明，式（I）化合物通过式（II）的2,6-二羟甲基吡啶与式（III）的氯甲酸酯反应来制备，（III）在极性 - 非质子，水不混溶的有机溶剂中，在约-30℃至+ 10℃的碱性物质存在下

6. 发明授权

US4482494A Process for preparing 17.alpha.-hydroxy-pregn-4-en-3,20-dione 失效
标题翻译：制备17α-羟基孕甾-4-en-3,20-二酮的方法
公开(公告)号：US4482494A
公开(公告)日：1984-11-13
申请号：US435494
申请日：1982-10-20
申请人： Anna Boor , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Feistner , Sandor Holly
发明人： Anna Boor , Jozsef Toth , Tamas Szen , Laszlo Gabor , Piroska Major nee Feistner , Sandor Holly
IPC分类号： C07J1/00 , C07J7/00 , C07J5/00
CPC分类号： C07J1/0096 , C07J1/0048 , C07J7/0045
摘要： The invention relates to a novel process for the preparations of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond beween the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.
摘要翻译：本发明涉及制备式I的孕烷衍生物的新方法，其中R1代表甲基或乙基，R2代表氢原子或甲基，X是氢原子或甲酰基或乙酰基，并且由点和连续线表示的键代表在两个相邻碳原子之间的单键或双键。根据本发明，将式II的三氟乙酸酯，其中R 1和R 2如上定义，在催化量的汞盐存在下，在偶极子质子中与甲酸或乙酸反应，游离或碱性溶剂。代替X的甲酰基或乙酰基可以以本身已知的方式分离。该过程提供了一种新颖有利的方法来建立皮质激素的孕烷侧链特征。

7. 发明申请

US20080236380A1 Firearm with a Pressure Accumulator 审中-公开
标题翻译：带有压力蓄能器的火器
公开(公告)号：US20080236380A1
公开(公告)日：2008-10-02
申请号：US11908589
申请日：2006-03-16
申请人： Jozsef Toth , Istvan Attila Levai , Istvan Balazs
发明人： Jozsef Toth , Istvan Attila Levai , Istvan Balazs
IPC分类号： F41A5/26 , F41A3/94 , F41A3/62
CPC分类号： F41A3/62 , F41A3/94
摘要： The firearm with pressure accumulator (5) having increased battering charge (3) and barrel (1) length has a piston (43) sliding in the accumulator housing (41) fixed to the breech (6) and springs (38, 38, 40) supporting the piston. To create a pneumatic spring (17) an annular brake chamber (44) is provided. The battering charge is arranged in the bolt body (31) located in the breech and has a neck (7) with an opening (9) facing towards the barrel to direct propellant gas to the barrel. This structure can be adapted to any size of the firearms, e.g. sharpshooter rifles with range of 4 to 6 kilometres, sky sweepers with an amplitude of 30 to 35 kilometres to combat targets by homing missiles as well as intercontinental missiles with a range of 500 to 1000 kilometres.
摘要翻译：带有压力蓄能器（5）的具有增加的电击充电（3）和枪管（1）长度的枪具具有在蓄能器壳体（41）中滑动的活塞（43），所述活塞（43）固定到后膛（6）和弹簧（38,38,40 ）支撑活塞。为了创建气动弹簧（17），提供环形制动室（44）。殴打装料设置在位于后膛中的螺栓体（31）中，并具有一个颈部（7），其中开口（9）面向枪管，以将推进剂气体引导到枪管。这种结构可适用于任何大小的火器，例如， 4至6公里的狙击手步枪，扫射机幅度为30至35公里，通过导弹导弹和500至1000公里的洲际导弹作战目标。

8. 发明授权

US5744629A Process for manufacturing methylene-bis (dibutyl-dithiocarbamate) with ASTM colour less than 2 失效
标题翻译：制造亚甲基双（二丁基 - 二硫代氨基甲酸盐）的方法，ASTM颜色小于2
公开(公告)号：US5744629A
公开(公告)日：1998-04-28
申请号：US595286
申请日：1996-02-02
申请人： Bela Jover , Janos Forstner , Jozsef Petro , Szabolcs Szoboszlay , Imre Fekete , Karoly Csergo , Gyula Sztreharszki , Gyula Raksi , Janos Kiss , Ferenc Miko , Jeno Baladincz , Jozsef Toth
发明人： Bela Jover , Janos Forstner , Jozsef Petro , Szabolcs Szoboszlay , Imre Fekete , Karoly Csergo , Gyula Sztreharszki , Gyula Raksi , Janos Kiss , Ferenc Miko , Jeno Baladincz , Jozsef Toth
IPC分类号： C07C271/12 , C07C333/20 , C10M135/18 , C07C57/04
CPC分类号： C07C333/20 , C10M135/18 , C10M2219/066
摘要： The invention relates to improved manufacture of methylene bis-(dibutyl-dithiocarbamate) with ASTM coulour less than 2, by reacting aqueous solutions of dibutyl amine and sodium hydroxide with carbon disulfide, treating the obtained reaction product with methylene dichloride, followed by vacuum stripping, phase separation and filtration of the precipitated sodium chloride. According to the invention, during reaction with carbon disulfide the temperature of the mixture is kept at or below 15.degree. C. and the vacuum stripping is performed in two steps, first between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa, then phase separation is carried out at a temperature between 35.degree. C. and 50.degree. C., followed by stripping the separated organic phase in vacuum also at a temperature between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa.
摘要翻译：本发明涉及通过使二丁基胺和氢氧化钠的水溶液与二硫化碳反应，用二氯甲烷二氯化物处理所得反应产物，然后真空汽提，改进了ASTM库仑小于2的二（二丁基二硫代氨基甲酸）亚甲基酯的制备，沉淀氯化钠的相分离和过滤。根据本发明，在与二硫化碳反应期间，将混合物的温度保持在15℃或低于15℃，真空汽提分两步进行，首先在45℃至100℃之间， 5-50kPa，然后在35℃至50℃的温度下进行相分离，然后在45℃至100℃的温度下真空除去分离的有机相，并在压力为5-50 kPa。

9. 发明授权

US4250774A Self-adjusting powder distributor 失效
标题翻译：自调粉分配器
公开(公告)号：US4250774A
公开(公告)日：1981-02-17
申请号：US8191
申请日：1979-01-31
申请人： Istvan Kraxner , Antal Sebok , Janos Steiner , Jozsef Toth
发明人： Istvan Kraxner , Antal Sebok , Janos Steiner , Jozsef Toth
IPC分类号： F27B7/20 , F27B15/00 , F27B7/02
CPC分类号： F27B7/2016
摘要： A self-adjusting powder distributor--which is particularly intended for use with alumina calcination apparatus--comprises a casing with a permeable partition, a plurality of outlets, and means for introducing preheated hydrate above the partition and fluidizing air therebelow. The fluidized hydrate withdraws through outlets of the casing for further treatment or partly as final product. The casing is provided with means by which the amounts and mutual ratios of the withdrawing material can be adjusted according to preselected values by altering the cross-sectional flow area or the level of the outlets.
摘要翻译：特别适用于氧化铝煅烧装置的自调整粉末分配器包括具有可渗透分隔件的壳体，多个出口，以及用于在分隔件上方引入预热的水合物并在其周围流化空气的装置。流化的水合物通过套管的出口退出以进一步处理或部分作为最终产品。壳体设置有可以通过改变横截面流动面积或出口水平根据预先选择的值来调节抽出材料的量和相互比例的装置。

10. 发明授权

US5075473A Process for the preparation of aluminum oxide carboxylate polymers containing at most two percent by weight of ester 失效
标题翻译：制备含二氧化铈羧酸酯聚合物的方法，以二酯重量百分比计
公开(公告)号：US5075473A
公开(公告)日：1991-12-24
申请号：US521048
申请日：1990-05-03
申请人： Istvan Kantor , Ferenc Denes , Janos Kis , Janos Auer , Lajos Peterfy , L. Peter Farkas , .ANG.ntal Matravolgyi , Jozsef Horvath , Jozsef Toth
发明人： Istvan Kantor , Ferenc Denes , Janos Kis , Janos Auer , Lajos Peterfy , L. Peter Farkas , .ANG.ntal Matravolgyi , Jozsef Horvath , Jozsef Toth
IPC分类号： C07C29/00 , C07C31/00 , C08G59/62 , C08G79/10 , C09K3/00 , C10M119/30
CPC分类号： C10M119/30 , C08G79/10 , C09K3/00 , C10M2227/09
摘要： The invention relates to a novel process for the preparation of aluminum oxide carboxylate polymers containing at most 2% by weight of ester by reacting an aluminum alkoxide of the general formula Al(OR).sub.3, wherein R stands for a C.sub.2-5 alkyl group, dissolved in an aromatic or aliphatic hydrocarbon with a solution of a C.sub.8-22 aliphatic or alicyclic monocarboxylic acid or carboxylic acid mixture and water in a C.sub.2-5 alkanol and removing the alkanol(s).The process according to the invention comprises introducing the solution of the aluminum alkoxide to a tube reactor having a 10 to 200 length/diameter ratio at a temperature exceeding by 15.degree.to 50.degree.C. the boiling point of the higher boiling alkanol among that corresponding to the alkanol component of aluminum alkoxide and that used as solvent; then feeding in the alkanolic solution containing the monocarboxylic acid and water, wherein the aluminum/monocarboxylic acid mole ratio is at least 10:1 and the aluminum/water mole ratio is at least 10:1; removing the alkanol formed in the reaction; returning the reaction mixture into the tube reactor; repeating this operation until the mono-carboxylic acid/aluminum mole ratio reaches 0.95 to 1.05 and the water/aluminum mole ratio reaches 0.9 to 1.0; and then making the product obtained free from alkanol.
摘要翻译：本发明涉及通过使通式为Al（OR）3的烷氧基铝反应其中R代表C 2-5烷基的方法制备含有至多2重量％酯的氧化铝羧酸盐聚合物的新方法，用C8-22脂族或脂环族单羧酸或羧酸混合物和水溶解在C 2-5链烷醇中并除去链烷醇的芳族或脂族烃中。根据本发明的方法包括在超过15℃至50℃的温度下将烷醇铝溶液引入具有10至200个长度/直径比的管式反应器中，其中相应的沸点高的烷醇的沸点用作醇溶剂的烷醇成分; 然后进料含有一元羧酸和水的链烷醇溶液，其中铝/一元羧酸摩尔比为至少10:1，铝/水摩尔比为至少10:1; 除去反应中形成的链烷醇; 将反应混合物返回到管式反应器中; 重复该操作直到单羧酸/铝摩尔比达到0.95至1.05，水/铝摩尔比达到0.9至1.0; 然后使得到的产物不含链烷醇。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式