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1. 发明授权

US07972786B2 Detection and analysis of influenza virus 有权
标题翻译：检测和分析流感病毒
公开(公告)号：US07972786B2
公开(公告)日：2011-07-05
申请号：US11822536
申请日：2007-07-06
申请人： Cristina Hartshorn , Kenneth E. Pierce , Arthur Henry Reis, Jr. , John E. Rice , J. Aquiles Sanchez , Lawrence J. Wangh
发明人： Cristina Hartshorn , Kenneth E. Pierce , Arthur Henry Reis, Jr. , John E. Rice , J. Aquiles Sanchez , Lawrence J. Wangh
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/701
摘要： An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using any suitable nucleic acid amplification technique. Related kits and methods are also described.
摘要翻译：包含多于一个引物对和多于一个检测探针的测定法，对应于每个引物对的低拷贝数合成扩增子。该测定可以使用任何合适的核酸扩增技术检测和区分流感病毒的各种亚型和菌株。还描述了相关的试剂盒和方法。

2. 发明申请

US20110311971A1 RT-LATE-PCR 审中-公开
公开(公告)号：US20110311971A1
公开(公告)日：2011-12-22
申请号：US13103649
申请日：2011-05-09
申请人： Cristina Hartshorn , Kenneth E. Pierce , Arthur Henry Reis, JR. , John E. Rice , J. Aquiles Sanchez , Lawrence J. Wangh
发明人： Cristina Hartshorn , Kenneth E. Pierce , Arthur Henry Reis, JR. , John E. Rice , J. Aquiles Sanchez , Lawrence J. Wangh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701
摘要： An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using any suitable nucleic acid amplification technique. Related kits and methods are also described.
摘要翻译：包含多于一个引物对和多于一个检测探针的测定法，对应于每个引物对的低拷贝数合成扩增子。该测定可以使用任何合适的核酸扩增技术检测和区分流感病毒的各种亚型和菌株。还描述了相关的试剂盒和方法。

3. 发明授权

US09745624B2 Methods for sequential DNA amplification and sequencing 有权
公开(公告)号：US09745624B2
公开(公告)日：2017-08-29
申请号：US13564528
申请日：2012-08-01
申请人： Lawrence J. Wangh , John E. Rice , J. Aquiles Sanchez , Kenneth E. Pierce , Jesse Salk , Arthur H. Reis , Cristina Hartshorn
发明人： Lawrence J. Wangh , John E. Rice , J. Aquiles Sanchez , Kenneth E. Pierce , Jesse Salk , Arthur H. Reis , Cristina Hartshorn
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6844 , C12Q1/6851 , C12Q1/6876 , C12Q2600/156 , C12Q2600/16 , C12Q2545/114 , C12Q2531/107 , C12Q2527/107 , C12Q2561/113
摘要： Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non-symmetric PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled mismatch-tolerant probes permits analysis of complex targets. Sequencing sample preparation methods following LATE-PCR amplifications reduce complexity and permit “single-tube” processing.

4. 发明授权

US09850529B2 Compositions and methods for nucleic acid based diagnostic assays for variable sequence targets 有权
公开(公告)号：US09850529B2
公开(公告)日：2017-12-26
申请号：US13821287
申请日：2011-09-08
申请人： Kenneth E. Pierce , John E. Rice , Lawrence J. Wangh
发明人： Kenneth E. Pierce , John E. Rice , Lawrence J. Wangh
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q2531/107 , C12Q2537/143 , C12Q2561/113
摘要： The present invention relates to compositions and methods for nucleic acid based diagnostic assays. In particular, the present invention provides primers for asymmetric PCR and other amplification modalities. In some embodiments, the present invention provides multiple primers for amplification of related nucleic acid targets in a single reaction.

5. 发明申请

US20130203626A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID BASED DIAGNOSTIC ASSAYS FOR VARIABLE SEQUENCE TARGETS 有权
标题翻译：用于可变序列目标的基于核酸的诊断测定的组合物和方法
公开(公告)号：US20130203626A1
公开(公告)日：2013-08-08
申请号：US13821287
申请日：2011-09-08
申请人： Kenneth E. Pierce , John E. Rice , Lawrence J. Wangh
发明人： Kenneth E. Pierce , John E. Rice , Lawrence J. Wangh
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q2531/107 , C12Q2537/143 , C12Q2561/113
摘要： The present invention relates to compositions and methods for nucleic acid based diagnostic assays. In particular, the present invention provides primers for asymmetric PCR and other amplification modalities. In some embodiments, the present invention provides multiple primers for amplification of related nucleic acid targets in a single reaction.
摘要翻译：本发明涉及基于核酸的诊断测定的组合物和方法。特别地，本发明提供了用于不对称PCR和其它扩增方式的引物。在一些实施方案中，本发明提供用于在单个反应中扩增相关核酸靶的多个引物。

6. 发明授权

US4572340A Safety lock vehicle transmission 失效
标题翻译：安全锁车辆传动
公开(公告)号：US4572340A
公开(公告)日：1986-02-25
申请号：US496546
申请日：1983-05-20
申请人： Kenneth E. Pierce
发明人： Kenneth E. Pierce
IPC分类号： B60K20/00 , B60T11/10 , F16H61/22 , B60K41/26 , F16D41/24
CPC分类号： F16H61/22 , B60T11/103 , B60W10/10 , B60W10/18
摘要： A device to prevent the gears of an automotive vehicle from being shifted from forward, reverse or neutral to another position unless the brakes are firmly applied. The transmission includes a gear shift actuator that is rotatable between forward, neutral and reverse positions, and fixed to this actuator is a lever having an axially projecting fin on one side of the free end. Pivoted on a supporting frame is a steel bar having notches in one edge that are shaped and positioned to engage the fin on the lever whenever the lever is in any one of its three operating positions. A spring bears against the bar to urge the notched edge toward the fin of the lever, so that the bar normally engages and locks the lever. A hydraulic cylinder has its piston rod attached to the bar, and the cylinder is connected to the hydraulic braking system of the vehicle, so that when the brakes are applied, the cylinder acts to disengage the bar from the lever. Thus, the transmission can only be shifted into or out of gear while the brakes are applied.
摘要翻译：一种用于防止机动车辆的齿轮不被向前，反向或中立移动到另一位置的装置，除非制动器被牢固地施加。变速器包括可在前进位置，中立位置和后退位置之间转动的换档致动器，并且固定到该致动器的杠杆具有在自由端的一侧上的轴向突出的翅片。在支撑框架上设置的钢筋是在一个边缘上具有凹口的钢筋，只要杠杆处于其三个操作位置中的任何一个中，该钢筋的形状和定位成与杆上的翅片接合。弹簧靠在杆上以将切口的边缘推向杆的翅片，使得杆通常接合并锁定杆。液压缸具有连接到杆的活塞杆，并且气缸连接到车辆的液压制动系统，使得当制动器被施加时，气缸用于使杆与杆脱离。因此，当制动器被施加时，变速器只能移入或移出齿轮。

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