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1. 发明申请

US20090299420A1 METHOD AND APPARATUS FOR CRYOTHERAPY AND PACING PRECONDITIONING 审中-公开
标题翻译：方法和装置用于结冰和皮肤预处理
公开(公告)号：US20090299420A1
公开(公告)日：2009-12-03
申请号：US12474448
申请日：2009-05-29
申请人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
发明人： Allan C. Shuros , Craig Stolen , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
IPC分类号： A61B18/02 , A61N1/362
CPC分类号： A61N1/06 , A61B18/02 , A61B2017/22002 , A61B2018/0022 , A61B2018/0212 , A61B2018/0243 , A61F2/958 , A61N1/362
摘要： A method and apparatus are described for delivering myocardial pacing and cryotherapy in conjunction with a coronary revascularization procedure using one catheter/stent system. In one embodiment, a balloon-stent delivery platform incorporates pacing electrode(s) on or near the distal tip for myocardial pacing.
摘要翻译：描述了一种用于使用一个导管/支架系统与冠状动脉血运重建术一起递送心肌起搏和冷冻治疗的方法和装置。在一个实施例中，球囊支架递送平台包括用于心肌起搏的远侧末端上或附近的起搏电极。

2. 发明申请

US20090318749A1 METHOD AND APPARATUS FOR PACING AND INTERMITTENT ISCHEMIA 审中-公开
标题翻译：方法和装置用于切割和间歇性间断
公开(公告)号：US20090318749A1
公开(公告)日：2009-12-24
申请号：US12484822
申请日：2009-06-15
申请人： Craig Stolen , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
发明人： Craig Stolen , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Eric A. Mokelke
IPC分类号： A61M1/12 , A61N1/365
CPC分类号： A61N1/056 , A61B5/02028 , A61B5/0215 , A61B5/026 , A61F2/95 , A61N1/3625 , A61N1/3627 , A61N1/36514 , A61N1/36564 , A61N1/36571
摘要： A system delivers multiple enhanced therapies to limit myocardial damage post-revascularization. The system includes a catheter that incorporates features for delivering cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy. In one embodiment, a method for delivering cardiac protection therapies to a heart is provided. One or more catheters are provided having a balloon, at least one pacing electrode and at least one hemodynamic sensor. Cardiac protection pacing therapy (CPPT) and intermittent ischemia therapy are concurrently delivered using the one or more catheters. The pacing and ischemia are adapted to protect the heart from ischemic and reperfusion injuries. The delivery of the CPPT and the intermittent ischemia are controlled using a closed-loop system monitoring a signal sensed by the at least one hemodynamic sensor.
摘要翻译：系统提供多种增强疗法以限制血运重建后的心肌损伤。该系统包括导管，其包括用于递送心脏保护起搏治疗（CPPT）和间歇性缺血治疗的特征。在一个实施方案中，提供了将心脏保护治疗递送至心脏的方法。提供一个或多个导管，其具有球囊，至少一个起搏电极和至少一个血流动力学传感器。使用一个或多个导管同时输送心脏保护起搏治疗（CPPT）和间歇性缺血治疗。起搏和缺血适应于保护心脏免于缺血和再灌注损伤。 CPPT的传送和间歇性缺血通过监视由至少一个血流动力学传感器感测到的信号的闭环系统来控制。

3. 发明授权

US08412326B2 Pacemaker with vagal surge monitoring and response 有权
标题翻译：起搏器与迷走神经浪涌监测和反应
公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
申请人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译：起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。

4. 发明申请

US20110106197A1 PACEMAKER WITH VAGAL SURGE MONITORING AND RESPONSE 有权
标题翻译：具有VAGAL SURGE监测和响应的PACEMAKER
公开(公告)号：US20110106197A1
公开(公告)日：2011-05-05
申请号：US12709867
申请日：2010-02-22
申请人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
发明人： Shantha Arcot-Krishnamurthy , Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译：起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。

5. 发明申请

US20090318984A1 EXTERNAL PACEMAKER WITH AUTOMATIC CARDIOPROTECTIVE PACING PROTOCOL 审中-公开
标题翻译：具有自动保护性氯化物协议的外部手套
公开(公告)号：US20090318984A1
公开(公告)日：2009-12-24
申请号：US12484811
申请日：2009-06-15
申请人： Eric A. Mokelke , Allan C. Shuros , Shantha Arcot-Krishnamurthy
发明人： Eric A. Mokelke , Allan C. Shuros , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B2017/22001 , A61B2017/22051 , A61N1/025 , A61N1/056 , A61N1/3625 , A61N1/3627 , A61N1/3706 , A61N1/37241 , A61N1/37264 , G06F19/3481 , G16H40/63
摘要： A pacing system includes a pacemaker and a pacing protocol module externally attached to the pacemaker. The pacing protocol module stores the pacing protocol. The pacemaker controls delivery of pacing pulses by automatically executing the pacing protocol. In one embodiment, the pacing protocol is a cardioprotective pacing protocol for preventing and/or reducing cardiac injury associated with myocardial infarction (MI) and revascularization procedure. The pacing pulses are generated from the pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure.
摘要翻译：起搏系统包括外部连接到起搏器的起搏器和起搏协议模块。起搏协议模块存储起搏协议。起搏器通过自动执行起搏协议来控制起搏脉冲的传递。在一个实施方案中，起搏方案是用于预防和/或减少与心肌梗塞（MI）和血运重建术相关的心脏损伤的心脏保护起搏方案。起搏脉冲从心脏起搏器产生，并通过一个或多个在血运重建过程中并入一个或多个经皮腔内血管介入（PTVI）装置的起搏电极输送。

6. 发明授权

US08942819B2 Automatic neural stimulation titration sweep 有权
标题翻译：自动神经刺激滴定扫描
公开(公告)号：US08942819B2
公开(公告)日：2015-01-27
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译：各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。神经刺激输出电路被配置为递送神经刺激。控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。控制器被配置为与传感器电路通信。存储器具有存储在其中的指令，由控制器电路可操作。说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数刺激并提供理想的安全余量以防止对神经组织的损伤。

7. 发明申请

US20110313488A1 AUTOMATIC NEURAL STIMULATION TITRATION SWEEP 有权
标题翻译：自动神经刺激ATION ATION
公开(公告)号：US20110313488A1
公开(公告)日：2011-12-22
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译：各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。神经刺激输出电路被配置为递送神经刺激。控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。控制器被配置为与传感器电路通信。存储器具有存储在其中的指令，可由控制器电路操作。说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数刺激并提供理想的安全余量以防止对神经组织的损伤。

8. 发明申请

US20100056858A1 PACING SYSTEM FOR USE DURING CARDIAC CATHETERIZATION OR SURGERY 审中-公开
标题翻译：在心脏导管或手术期间使用的PACING系统
公开(公告)号：US20100056858A1
公开(公告)日：2010-03-04
申请号：US12547316
申请日：2009-08-25
申请人： Eric A. Mokelke , Allan C. Shuros
发明人： Eric A. Mokelke , Allan C. Shuros
IPC分类号： A61N1/36 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/3207 , A61B2017/0243 , A61B2017/22001 , A61B2017/308 , A61B2090/3784 , A61N1/056 , A61N1/08 , A61N1/3625 , G16H40/63
摘要： Cardioprotective pacing is applied to prevent and/or reduce cardiac injury associated with cardiac catheterization or surgery. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto one or more devices used in the cardiac catheterization or surgery. The pacemaker controls the delivery of the pacing pulses by executing a cardioprotective pacing protocol. In one embodiment, the one or more pacing electrodes are incorporated onto an intravascular ultrasound (IVUS) catheter. In another embodiment, the one or more pacing electrodes are incorporated onto one or more cardiac surgical instruments such as a heart stabilizer and a sternal retractor.
摘要翻译：应用心脏保护起搏来预防和/或减少与心脏导管插入术或手术相关的心脏损伤。起搏脉冲从起搏器产生并通过一个或多个起搏电极输送，该起搏电极并入到用于心脏导管插入术或手术中的一个或多个装置上。起搏器通过执行心脏保护起搏协议来控制起搏脉冲的输送。在一个实施例中，将一个或多个起搏电极并入到血管内超声（IVUS）导管中。在另一个实施例中，将一个或多个起搏电极并入一个或多个心脏外科器械，例如心脏稳定器和胸骨牵开器。

9. 发明申请

US20100249860A1 EXTERNAL CARDIAC STIMULATION PATCH 审中-公开
标题翻译：外部心脏刺激贴
公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译：外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

10. 发明授权

US08219192B2 Method and apparatus for transcutaneous cardioprotective pacing 有权
标题翻译：用于经皮心脏保护起搏的方法和装置
公开(公告)号：US08219192B2
公开(公告)日：2012-07-10
申请号：US12496504
申请日：2009-07-01
申请人： Allan C. Shuros , Eric A. Mokelke
发明人： Allan C. Shuros , Eric A. Mokelke
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/046 , A61N1/3625 , A61N1/39
摘要： A transcutaneous cardiac stimulation system delivers pacing pulses according to a cardioprotective pacing protocol. The pacing pulses are delivered through body-surface electrodes attached onto a patient. The cardioprotective pacing protocol specifies pacing parameters selected to augment cardiac stress on the patient's myocardium to a level effecting cardioprotection against ischemic and reperfusion injuries.
摘要翻译：经皮心脏刺激系统根据心脏保护起搏方案提供起搏脉冲。起搏脉冲通过附着在患者身上的体表电极传递。心脏保护起搏方案规定了选择的起搏参数，以增加患者心肌的心脏应激，达到对缺血再灌注损伤的心脏保护作用。

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