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1. 发明申请

US20050009067A1 Expression profile of pancreatic cancer 审中-公开
标题翻译：胰腺癌的表达谱
公开(公告)号：US20050009067A1
公开(公告)日：2005-01-13
申请号：US10848259
申请日：2004-05-18
申请人： Craig Logsdon , Samir Hanash , Diane Simeone
发明人： Craig Logsdon , Samir Hanash , Diane Simeone
IPC分类号： A61B20060101 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： G01N33/57438 , G01N33/507 , G01N33/5082
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with pancreatic cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of pancreatic cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供了与胰腺癌相关的基因表达谱。使用本发明的方法鉴定为癌症标志物的基因可用于胰腺癌的诊断和表征。此外，这些基因为癌症药物筛选和治疗应用提供了靶标。

2. 发明申请

US20110201517A1 AUTOANTIGEN BIOMARKERS FOR EARLY DIAGNOSIS OF LUNG ADENOCARCINOMA 审中-公开
标题翻译：用于早期诊断肺腺癌的自动生物标记
公开(公告)号：US20110201517A1
公开(公告)日：2011-08-18
申请号：US13032402
申请日：2011-02-22
申请人： John Kolman , Samir Hanash , Brad Love , Alexei Krasnoselsky , Charles Kooperberg , Ji Qiu
发明人： John Kolman , Samir Hanash , Brad Love , Alexei Krasnoselsky , Charles Kooperberg , Ji Qiu
IPC分类号： C40B30/04 , G01N33/574 , C40B40/10 , G01N33/566
CPC分类号： G01N33/57423 , G01N33/564
摘要： Provided herein are novel panels of biomarkers for the detection and diagnosis of lung adenocarcinoma, and methods and kits for detecting these biomarkers in samples of individuals suspected of having the disease. Also provided are methods of monitoring the progression of lung adenocarcinoma and methods of monitoring the efficacy of a treatment.
摘要翻译：本文提供了用于肺腺癌的检测和诊断的生物标志物的新颖小组，以及用于在怀疑患有该疾病的个体的样品中检测这些生物标志物的方法和试剂盒。还提供了监测肺腺癌进展的方法和监测治疗功效的方法。

3. 发明申请

US20070003972A1 Detection and treatment of cancers of the lung 审中-公开
公开(公告)号：US20070003972A1
公开(公告)日：2007-01-04
申请号：US11517659
申请日：2006-09-08
申请人： Samir Hanash , Franck Brichory
发明人： Samir Hanash , Franck Brichory
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57423 , A61K39/0011 , A61K2039/55522 , C07K14/47 , C07K16/3023 , G01N33/564
摘要： The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.

4. 发明申请

US20090047689A1 AUTOANTIGEN BIOMARKERS FOR EARLY DIAGNOSIS OF LUNG ADENOCARCINOMA 审中-公开
标题翻译：用于早期诊断肺腺癌的自动生物标记
公开(公告)号：US20090047689A1
公开(公告)日：2009-02-19
申请号：US12143288
申请日：2008-06-20
申请人： John Kolman , Samir Hanash , Brad Love , Alexei Krasnoselsky , Charles Kooperberg , Ji Qiu
发明人： John Kolman , Samir Hanash , Brad Love , Alexei Krasnoselsky , Charles Kooperberg , Ji Qiu
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , G01N33/564
摘要： Provided herein are novel panels of biomarkers for the detection and diagnosis of lung adenocarcinoma, and methods and kits for detecting these biomarkers in samples of individuals suspected of having the disease. Also provided are methods of monitoring the progression of lung adenocarcinoma and methods of monitoring the efficacy of a treatment.
摘要翻译：本文提供了用于肺腺癌的检测和诊断的生物标志物的新颖小组，以及用于在怀疑患有该疾病的个体的样品中检测这些生物标志物的方法和试剂盒。还提供了监测肺腺癌进展的方法和监测治疗功效的方法。

5. 发明申请

US20050095249A1 Protein markers for lung cancer and use thereof 审中-公开
标题翻译：用于肺癌的蛋白质标记物及其用途
公开(公告)号：US20050095249A1
公开(公告)日：2005-05-05
申请号：US10461424
申请日：2003-06-16
申请人： Samir Hanash
发明人： Samir Hanash
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/08 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N15/09 , C12P21/08 , C12R1/19 , G01N33/574 , C12Q1/68 , C07K14/705 , C07K16/30
CPC分类号： G01N33/57423 , A61K2039/505 , C07K14/47 , G01N33/57488
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from lung tumors, reveals proteins which are different in different types of tumors and in control tissues.
摘要翻译：基于来自肺肿瘤组织的蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在不同类型的肿瘤和对照组织中不同的蛋白质。

6. 发明申请

US20100055704A1 EXPRESSION PROFILE OF THYROID CANCER 有权
标题翻译：甲状腺癌的表达谱
公开(公告)号：US20100055704A1
公开(公告)日：2010-03-04
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanash , Yuri Nikiforov , Dafydd G. Thomas
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanash , Yuri Nikiforov , Dafydd G. Thomas
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供与甲状腺癌相关的基因表达谱。使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。此外，这些基因为癌症药物筛选和治疗应用提供了靶标。

7. 发明申请

US20070148713A1 Protein markers for esophageal cancer 审中-公开
标题翻译：食管癌蛋白标志物
公开(公告)号：US20070148713A1
公开(公告)日：2007-06-28
申请号：US11549050
申请日：2006-10-12
申请人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
发明人： Samir Hanash , David Beer , Rork Kuick , Robert Hinderer
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N33/57407
摘要： Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.
摘要翻译：来自食管肿瘤组织中蛋白质的载体两性电泳（CA）和固定化pH梯度（IPG）的2-D凝胶的计算机化分析揭示了在肿瘤和对照组织中不同的蛋白质。

8. 发明申请

US20070037227A1 ANNEXIN PROTEINS AND AUTOANTIBODIES AS SERUM MARKERS FOR CANCER 失效
标题翻译：作为癌症血清标记的新生蛋白和自身抗体
公开(公告)号：US20070037227A1
公开(公告)日：2007-02-15
申请号：US11425528
申请日：2006-06-21
申请人： Samir Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
发明人： Samir Hanash , David Misek , Robert Hinderer , David Beer , Franck Brichory
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , A61K39/0011 , G01N33/57423 , G01N33/57484 , G01N2333/4718 , G01N2800/52
摘要： The present invention relates to screening methods for diagnosis, prognosis, or susceptibility to cancer in a subject by means of detecting the presence of serum autoantibodies to specific annexin protein antigens in sera from subjects. The present invention also provides screening methods for diagnosis and prognosis of cancer in a subject by means of detecting increased expression levels of annexin proteins in biological samples of the subject. The method of the invention can also be used to identify subjects at risk for developing cancer. The method of the invention involves the use of subject derived biological samples to determine the occurrence and level of expression of annexin proteins or expression of annexin derived peptides or antigens, and/or the occurrence and level of circulating autoantibodies to specific annexin protein antigens. The present invention further provides for kits for carrying out the above described screening methods. Such kits can be used to screen subjects for increased levels of annexin proteins, or for the detection of autoantibodies to annexin proteins, as a diagnostic, predictive or prognostic indicator of cancer.
摘要翻译：本发明涉及通过检测来自受试者的血清中特异性膜联蛋白抗原的血清自身抗体的存在而在受试者中诊断，预后或易感性的筛选方法。本发明还提供了通过检测受试者生物样品中膜联蛋白的增加的表达水平来检测受试者中癌症的诊断和预后的筛选方法。本发明的方法还可以用于鉴定患有癌症风险的受试者。本发明的方法涉及使用受试者衍生的生物样品来确定膜联蛋白的表达的发生和水平或膜联蛋白衍生的肽或抗原的表达，和/或对特定的膜联蛋白抗原的循环自身抗体的发生和水平。本发明还提供了用于实施上述筛选方法的试剂盒。这样的试剂盒可用于筛选受试者增加的膜联蛋白水平，或用于检测对膜联蛋白的自身抗体，作为癌症的诊断性，预测性或预后指标。

9. 发明申请

US20050079560A1 Detection and treatment of cancers of the colon 有权
标题翻译：检测和治疗结肠癌
公开(公告)号：US20050079560A1
公开(公告)日：2005-04-14
申请号：US10844216
申请日：2004-05-12
申请人： Myeong Nam , Juan Madoz-Gurpide , Hong Wang , David Misek , Samir Hanash
发明人： Myeong Nam , Juan Madoz-Gurpide , Hong Wang , David Misek , Samir Hanash
IPC分类号： A61K35/12 , C07K5/00 , C07K16/00 , C12N20060101 , C12P19/34 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： G01N33/574 , G01N33/57419
摘要： The present invention relates to compositions and methods for cancer therapies and diagnostics, including but not limited to, cancer markers. In particular, the present invention provides tumor antigens associated with specific cancers and diagnostic assays for the detection of such antigens and associated autoantibodies as indicative of the presence of specific cancers. The present invention further provides cancer immunotherapy utilizing the tumor antigens of the present invention.
摘要翻译：本发明涉及用于癌症治疗和诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供了与特异性癌症相关的肿瘤抗原和用于检测这些抗原和相关的自身抗体的诊断测定法，以指示特定癌症的存在。本发明进一步提供利用本发明的肿瘤抗原的癌症免疫疗法。

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