专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100093811A1 HIV PROTEASE INHIBITORS 审中-公开
标题翻译：艾滋病病毒蛋白酶抑制剂
公开(公告)号：US20100093811A1
公开(公告)日：2010-04-15
申请号：US12523200
申请日：2008-09-22
申请人： Craig A. Coburn , Joseph P. Vacca , Hemaka A. Rajapakse , Kristen L.G. Jones , Philippe Nantermet , James C. Barrow , Keith P. Moore , Steven S. Sharik , Cory Theberge , Abbas M. Walji
发明人： Craig A. Coburn , Joseph P. Vacca , Hemaka A. Rajapakse , Kristen L.G. Jones , Philippe Nantermet , James C. Barrow , Keith P. Moore , Steven S. Sharik , Cory Theberge , Abbas M. Walji
IPC分类号： A61K31/44 , C07C311/15 , A61K31/18 , C07C271/06 , A61K31/27 , C07D277/62 , A61K31/426 , C07D213/55 , A61P31/18
CPC分类号： C07C311/41 , C07C311/18 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2603/32 , C07D213/30 , C07D277/64
摘要： Compounds of Formula I are disclosed: (I), wherein XA, k, R1, R2, R3, R4, R5, R5A, R6, R6A, R7 and R8 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be metabolized in vivo to HIV protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：公开了式I的化合物：其中XA，k，R1，R2，R3，R4，R5，R5A，R6，R6A，R7和R8如本文所定义。式I所包括的化合物包括可以在体内代谢为HIV蛋白酶抑制剂的HIV蛋白酶抑制剂和其它化合物的化合物。化合物及其药学上可接受的盐可用于预防或治疗HIV感染以及预防，治疗或延迟艾滋病的发病。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

2. 发明申请

US20160317543A1 SPIROCYCLIC HETERCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 有权
标题翻译：作为艾滋病毒整合抑制剂的螺旋体异构体化合物有用
公开(公告)号：US20160317543A1
公开(公告)日：2016-11-03
申请号：US15105376
申请日：2014-12-17
申请人： Thomas H. Graham , Wensheng Liu , Tao Yu , Yonglian Zhang , Sherman T. Waddell , John S. Wai , Paul J. Coleman , John M. Sanders , Mark W. Embrey , Abbas M. Walji , Ronald Dale Ferguson, II , Christine Ng Di Marco , Thomas G. Steele , Lihong Hu , Xuanjia Peng
发明人： Thomas H. Graham , Wensheng Liu , Tao Yu , Yonglian Zhang , Sherman T. Waddell , John S. Wai , Paul J. Coleman , John M. Sanders , Mark W. Embrey , Abbas M. Walji , Ronald Dale Ferguson, II , Christine Ng Di Marco , Thomas G. Steele , Lihong Hu , Xuanjia Peng
IPC分类号： A61K31/53 , A61K45/06 , C07D471/22 , A61K31/675 , C07D491/20 , A61K31/55 , A61K31/499 , C07F9/6561 , C07D471/20 , C07D495/20
CPC分类号： A61K31/53 , A61K31/427 , A61K31/499 , A61K31/513 , A61K31/52 , A61K31/55 , A61K31/675 , A61K45/06 , C07D471/20 , C07D471/22 , C07D475/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D495/20 , C07F9/65616 , A61K2300/00
摘要： The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R11 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
摘要翻译：本发明涉及式（I）的螺环杂环化合物及其药学上可接受的盐，其中A，B，X，Y，R 1，R 2和R 11如本文所定义。本发明还涉及包含至少一种螺环杂环化合物的组合物，以及使用螺环杂环化合物治疗或预防受试者中HIV感染的方法。

3. 发明申请

US20130012526A1 OXAZOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH 有权
公开(公告)号：US20130012526A1
公开(公告)日：2013-01-10
申请号：US13635286
申请日：2011-04-18
申请人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
发明人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
IPC分类号： C07D413/12 , C07D413/14 , A61K31/4545 , A61K31/444 , A61K31/422 , C07D473/32 , A61K31/52 , C07D413/04 , A61P19/02 , A61P29/00 , A61P25/00 , A61P25/06 , A61P25/20 , A61P25/28 , A61P25/16 , A61K31/4439
CPC分类号： C07D263/46 , C07D413/12 , C07D413/14
摘要： The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

4. 发明授权

US09073879B2 Oxazole derivatives useful as modulators of FAAH 有权
公开(公告)号：US09073879B2
公开(公告)日：2015-07-07
申请号：US13635286
申请日：2011-04-18
申请人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
发明人： Philippe G. Nantermet , Zhi-Qiang Yang , Constantine Kreatsoulas , Abbas M. Walji , Hong Zhu
IPC分类号： C07D413/12 , C07D413/14 , C07D263/46 , A61K31/4545 , A61K31/444 , A61K31/422 , C07D473/32 , A61K31/52 , C07D413/04 , A61P19/02 , A61P29/00 , A61P25/00 , A61P25/06 , A61P25/20 , A61P25/28 , A61P25/16 , A61K31/4439
CPC分类号： C07D263/46 , C07D413/12 , C07D413/14
摘要： The present invention is directed to certain Oxazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer Disease, and Parkinson's Disease.

5. 发明授权

US07700798B1 Erogorgiaene congeners and methods and intermediates useful in the preparation of same 失效
标题翻译：嗜曙红同系物及其制备方法和中间体
公开(公告)号：US07700798B1
公开(公告)日：2010-04-20
申请号：US11449143
申请日：2006-06-08
申请人： Huw M. L. Davies , Abbas M. Walji
发明人： Huw M. L. Davies , Abbas M. Walji
IPC分类号： C07C69/76
CPC分类号： C07C67/303 , C07C29/147 , C07C67/343 , C07C67/347 , C07C2602/10 , C07C2603/97 , C07C33/34 , C07C69/616 , C07C69/618 , C07C69/753
摘要： Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R23 and R24 are independently selected from hydrogen, an alkyl, aryl, alkoxy, hydroxy, or amino group, and a halogen atom or wherein R23 and R24, taken together with the carbon atom to which they are bound, form a ring; wherein R25 is hydrogen, an alkyl, aryl, alkoxy, hydroxy, or O-silyl group or a halogen atom; wherein Z, taken together with the carbons to which it is bonded, forms a 5-12 membered ring; and wherein Y is an electron withdrawing group. These compounds can be used to prepare erogorgiaene congeners, such as erogorgiaene, pseudopterosin A, helioporin E, pseudopteroxazole, colombiasin A, elisapoterosin B, elisabethadione, p-benzoquinone natural products, ileabethin, sinulobtain B, sinulobtain C, and sinulobtain D.
摘要翻译：公开了具有下式的化合物：其中R21是烷基，芳基，烷氧基，羟基或氨基或卤素原子; 其中R2是氢或烷基，芳基，烷氧基或氨基; 其中R 23和R 24独立地选自氢，烷基，芳基，烷氧基，羟基或氨基，和卤素原子，或者R 23和R 24与它们所结合的碳原子一起形成环; 其中R 25是氢，烷基，芳基，烷氧基，羟基或O-甲硅烷基或卤素原子; 其中Z与与其键合的碳一起形成5-12元环; 并且其中Y是吸电子基团。这些化合物可用于制备胡萝卜素同系物，如胡萝卜素，假翅目蛋白A，日莲花素E，假opter azole唑，哥伦布菌素A，依替泊沙星B，伊马替丁，对苯醌天然产物，ileabethin，sinulobtain B，sinulobtain C和sinulobtain D.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式