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1. 发明申请

US20090053316A1 NANOCLUSTERS FOR DELIVERY OF THERAPEUTICS 审中-公开
标题翻译：用于输送治疗药物的纳米科学家
公开(公告)号：US20090053316A1
公开(公告)日：2009-02-26
申请号：US12261907
申请日：2008-10-30
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： A61K9/14 , A61K31/4422 , A61K31/4545 , A61K31/496
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/1688 , A61K9/5153 , A61K9/5192 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.
摘要翻译：本发明公开了一种纳米颗粒，其包含多个纳米颗粒，其中纳米颗粒可以响应于环境提示而分散。还公开了一种预防，治疗或诊断受试者的疾病或病症的方法，包括施用治疗有效量的包含本发明的纳米簇的组合物。

2. 发明授权

US07993749B2 Nanoparticles comprising a nanoparticle template and a polymer shell having an amide side chain, and method of making thereof 有权
标题翻译：包含纳米颗粒模板和具有酰胺侧链的聚合物壳的纳米颗粒及其制备方法
公开(公告)号：US07993749B2
公开(公告)日：2011-08-09
申请号：US11893846
申请日：2007-08-17
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： B32B5/16 , C08F2/10
CPC分类号： A61K31/7052 , A61K9/0019 , A61K9/1688 , A61K9/5115 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K38/00 , A61K47/6923 , A61K47/6925 , A61K49/1803 , A61K49/1824 , B82Y5/00 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contains an acid-labile ketal facilitated stable etching of silica nanoparticle templates using sodium hydroxide and recovery of PNVF nanocapsules. The formamido side group of PNVF was then hydrolyzed by extended exposure to sodium hydroxide to produce polyvinylamine (“PVAm”) nanocapsules. PNVF and PVAm nanoparticles are also synthesized that form nanogels with optional active ingredients.
摘要翻译：通过N-二甲基甲酰胺与二氧化硅纳米粒子表面的任选的活性成分自由基聚合合成了酸不稳定的聚（N-乙烯基甲酰胺）（“PNVF”）纳米胶囊。在含有酸不稳定缩酮的新型交联剂存在下的聚合有助于使用氢氧化钠稳定蚀刻二氧化硅纳米颗粒模板并回收PNVF纳米胶囊。然后通过长时间暴露于氢氧化钠水解PNVF的甲酰侧基以产生聚乙烯胺（“PVAm”）纳米胶囊。还合成PNVF和PVAm纳米颗粒，其形成具有任选的活性成分的纳米凝胶。

3. 发明授权

US07651770B2 Nanoclusters for delivery of therapeutics 有权
标题翻译：用于递送治疗剂的纳米簇
公开(公告)号：US07651770B2
公开(公告)日：2010-01-26
申请号：US11610986
申请日：2006-12-14
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： B32B5/16
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/1688 , A61K9/5153 , A61K9/5192 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.
摘要翻译：本发明公开了一种纳米颗粒，其包含多个纳米颗粒，其中纳米颗粒可以响应于环境提示而分散。还公开了一种预防，治疗或诊断受试者的疾病或病症的方法，包括施用治疗有效量的包含本发明的纳米簇的组合物。

4. 发明授权

US08906392B2 Nanocluster compositions and methods 有权
标题翻译：纳米簇组合物和方法
公开(公告)号：US08906392B2
公开(公告)日：2014-12-09
申请号：US12954509
申请日：2010-11-24
申请人： Cory J. Berkland , Lianjun Shi , Nashwa El Gendy , Carl Plumley , Mark Bailey
发明人： Cory J. Berkland , Lianjun Shi , Nashwa El Gendy , Carl Plumley , Mark Bailey
IPC分类号： A61K9/00 , A61K9/16 , B82Y30/00 , A61K9/51 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/1688 , A61K9/5115 , A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K31/196 , A61K31/337 , A61K31/4422 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/58 , A61K38/28 , A61K38/38 , A61M11/001 , A61M15/0021 , A61M15/0065 , A61M15/009 , A61M15/08 , A61M2202/064 , B82Y30/00
摘要： Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of the nanoparticles contact adjacent nanoparticles, the nanoparticles comprise an active ingredient, and the nanocluster has a mass median aerodynamic diameter of from about 0.25 μm to about 20 μm.
摘要翻译：组合物，制备方法和使用纳米团簇的方法，其中纳米团簇包含具有纳米颗粒核心的多个纳米颗粒，其纳米颗粒的表面与纳米颗粒接触，纳米颗粒包含活性成分，纳米团簇具有质量中等空气动力学直径为约0.25μm至约20μm。

5. 发明申请

US20110287262A1 NANOPARTICLES, NANOCAPSULES AND NANOGELS 有权
标题翻译：纳米粒子，纳米粒子和纳米粒子
公开(公告)号：US20110287262A1
公开(公告)日：2011-11-24
申请号：US13198544
申请日：2011-08-04
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： B32B5/16 , A61K38/43 , A61P43/00 , C08F122/38 , C08J9/26 , C08F265/10 , C07C233/36 , A61K49/12 , C08F8/12 , B82Y15/00 , B82Y40/00
CPC分类号： A61K31/7052 , A61K9/0019 , A61K9/1688 , A61K9/5115 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K38/00 , A61K47/6923 , A61K47/6925 , A61K49/1803 , A61K49/1824 , B82Y5/00 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contains an acid-labile ketal facilitated stable etching of silica nanoparticle templates using sodium hydroxide and recovery of PNVF nanocapsules. The formamido side group of PNVF was then hydrolyzed by extended exposure to sodium hydroxide to produce polyvinylamine (“PVAm”) nanocapsules. PNVF and PVAm nanoparticles are also synthesized that form nanogels with optional active ingredients.
摘要翻译：通过N-二甲基甲酰胺与二氧化硅纳米粒子表面的任选的活性成分自由基聚合合成了酸不稳定的聚（N-乙烯基甲酰胺）（“PNVF”）纳米胶囊。在含有酸不稳定缩酮的新型交联剂存在下的聚合有助于使用氢氧化钠稳定蚀刻二氧化硅纳米颗粒模板并回收PNVF纳米胶囊。然后通过长时间暴露于氢氧化钠水解PNVF的甲酰侧基以产生聚乙烯胺（“PVAm”）纳米胶囊。还合成PNVF和PVAm纳米颗粒，其形成具有任选的活性成分的纳米凝胶。

6. 发明申请

US20090081295A1 NANOCLUSTERS FOR DELIVERY OF THERAPEUTICS 审中-公开
公开(公告)号：US20090081295A1
公开(公告)日：2009-03-26
申请号：US12261873
申请日：2008-10-30
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： A61K9/10
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/1688 , A61K9/5153 , A61K9/5192 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.

7. 发明授权

US08512862B2 Polyvinyl formamide (PNVF) and polyvinyl amine (PVAm)nanoparticles, nanocapsules and nanogels 有权
标题翻译：聚乙烯酰胺（PNVF）和聚乙烯胺（PVAm）纳米颗粒，纳米胶囊和纳米凝胶
公开(公告)号：US08512862B2
公开(公告)日：2013-08-20
申请号：US13198544
申请日：2011-08-04
申请人： Cory J. Berkland , Lianjun Shi
发明人： Cory J. Berkland , Lianjun Shi
IPC分类号： B32B5/16 , C08F218/06
CPC分类号： A61K31/7052 , A61K9/0019 , A61K9/1688 , A61K9/5115 , A61K9/5138 , A61K9/5153 , A61K9/5192 , A61K38/00 , A61K47/6923 , A61K47/6925 , A61K49/1803 , A61K49/1824 , B82Y5/00 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contains an acid-labile ketal facilitated stable etching of silica nanoparticle templates using sodium hydroxide and recovery of PNVF nanocapsules. The formamido side group of PNVF was then hydrolyzed by extended exposure to sodium hydroxide to produce polyvinylamine (“PVAm”) nanocapsules. PNVF and PVAm nanoparticles are also synthesized that form nanogels with optional active ingredients.
摘要翻译：通过N-二甲基甲酰胺与二氧化硅纳米粒子表面的任选的活性成分自由基聚合合成了酸不稳定的聚（N-乙烯基甲酰胺）（“PNVF”）纳米胶囊。在含有酸不稳定缩酮的新型交联剂存在下的聚合有助于使用氢氧化钠稳定蚀刻二氧化硅纳米颗粒模板并回收PNVF纳米胶囊。然后通过长时间暴露于氢氧化钠水解PNVF的甲酰侧基以产生聚乙烯胺（“PVAm”）纳米胶囊。还合成PNVF和PVAm纳米颗粒，其形成具有任选的活性成分的纳米凝胶。

8. 发明申请

US20110223203A1 NANOCLUSTER COMPOSITIONS AND METHODS 有权
标题翻译：纳米粒子组合物和方法
公开(公告)号：US20110223203A1
公开(公告)日：2011-09-15
申请号：US12954509
申请日：2010-11-24
申请人： Cory J. Berkland , Lianjun Shi , Nashwa El Gendy , Carl Plumley , Mark Bailey
发明人： Cory J. Berkland , Lianjun Shi , Nashwa El Gendy , Carl Plumley , Mark Bailey
IPC分类号： A61K9/00 , A61K39/00 , A61K31/713 , A61K31/58 , A61K38/04 , A61K31/437 , A61K31/135 , A61K51/00 , A61K31/439 , A61K31/195 , A61P11/00 , A61P9/00 , A61P21/00 , A61P19/00 , A61P35/00
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/1647 , A61K9/1688 , A61K9/5115 , A61K9/5123 , A61K9/5153 , A61K9/5192 , A61K31/196 , A61K31/337 , A61K31/4422 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/58 , A61K38/28 , A61K38/38 , A61M11/001 , A61M15/0021 , A61M15/0065 , A61M15/009 , A61M15/08 , A61M2202/064 , B82Y30/00
摘要： Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of the nanoparticles contact adjacent nanoparticles, the nanoparticles comprise an active ingredient, and the nanocluster has a mass median aerodynamic diameter of from about 0.25 μm to about 20 μm.
摘要翻译：组合物，制备方法和使用纳米团簇的方法，其中纳米团簇包含具有纳米颗粒核心的多个纳米颗粒，其纳米颗粒的表面与纳米颗粒接触，纳米颗粒包含活性成分，纳米团簇具有质量中等空气动力学直径为约0.25μm至约20μm。

9. 发明申请

US20070172653A1 NANOCLUSTERS FOR DELIVERY OF THERAPEUTICS 有权
标题翻译：用于输送治疗药物的纳米科学家
公开(公告)号：US20070172653A1
公开(公告)日：2007-07-26
申请号：US11610986
申请日：2006-12-14
申请人： Cory Berkland , Lianjun Shi
发明人： Cory Berkland , Lianjun Shi
IPC分类号： B32B5/16 , B32B9/00
CPC分类号： A61K9/5115 , A61K9/0019 , A61K9/1688 , A61K9/5153 , A61K9/5192 , B82Y30/00 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： The present invention discloses a nano-cluster that includes a plurality of nano-particles, wherein the nano-particles can disperse in response to an environmental cue. Also disclosed is a method of preventing, treating, or diagnosing a disease or condition in a subject comprising administering a therapeutically effective amount of a composition comprising nano-clusters of the present invention.
摘要翻译：本发明公开了一种纳米颗粒，其包含多个纳米颗粒，其中纳米颗粒可以响应于环境提示而分散。还公开了一种预防，治疗或诊断受试者的疾病或病症的方法，包括施用治疗有效量的包含本发明的纳米簇的组合物。

10. 发明申请

US20070004890A1 N-vinylformamide derivatives, polymers formed therefrom and synthesis thereof 审中-公开
标题翻译： N-乙烯基甲酰胺衍生物，由其形成的聚合物及其合成
公开(公告)号：US20070004890A1
公开(公告)日：2007-01-04
申请号：US11519631
申请日：2006-09-12
申请人： Eric Beckman , Toby Chapman , Lianjun Shi
发明人： Eric Beckman , Toby Chapman , Lianjun Shi
IPC分类号： C08F12/28
CPC分类号： C07C233/03 , C07C233/13 , C07D209/48 , C08F26/02
摘要： A method of synthesizing a compound having the formula: comprising the step of: reacting a N-vinylformamide salt having the formula with a compound having the formula XRR1; wherein X is Br, Cl or I, M is an alkali metal or an alkali earth metal, R1 is a C0-C25 alkylene group, a C0-C25 fluroalkylene group or a C0-C25 perfluoro alkylene group, R2 is H, provided R1 is not absent, an alkyl group, a fluroalkyl group, a perfluoroalkyl group, an aryl group, a hydroxy group, a polyether group, a heterocyclic group of 5 or 6 atoms wherein at least one of the atoms is not a carbon and is N, O, or S, —OR3, wherein, R3 is an alkyl group, a fluoroalkyl group, a perfluoroalkyl group, or an aryl group, —C(O)R4, —C(O)OR4, —OC(O)R4, wherein R4 is an H, an alkyl group, a fluoroalkyl group, a perfluoroalkyl group, or an aryl group, a phthalimide group or NR5R5 wherein R5 and R5 are independently H, —C(O)R4, an alkyl, a fluoroalkyl group, a perfluoroalkyl group or an aryl group.
摘要翻译：一种合成具有下式的化合物的方法：包括以下步骤：使具有下式的N-乙烯基甲酰胺与具有式XRR 1的化合物反应; 其中X是Br，Cl或I，M是碱金属或碱土金属，R 1是C 0 -C 25亚烷基，C 0 -C 25氟代亚烷基或C 0 -C 25全氟亚烷基基团R 2是H，条件是R 1不存在，烷基，氟烷基，全氟烷基，芳基，羟基，聚醚基团，5或6个原子的杂环基，其中至少一个原子不是碳并且是N，O或S，-OR 3，其中，R 3， SUP>是烷基，氟烷基，全氟烷基或芳基，-C（O）R 4，-C（O）OR 4， -OC（O）R 4，其中R 4是H，烷基，氟烷基，全氟烷基或芳基，邻苯二甲酰亚胺基或其中R 5和R 5独立地为H，-C（O）R SUP 烷基，氟代烷基，全氟烷基或芳基。

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