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1. 发明授权

US06451802B1 S-oxide lipid lowering compounds 失效
标题翻译： S-氧化物降脂化合物
公开(公告)号：US06451802B1
公开(公告)日：2002-09-17
申请号：US09857838
申请日：2001-06-08
申请人： Cornelus Gerardus Maria Janssen , Peter Walter Maria Roevens , Jozef Bertha August Thijssen
发明人： Cornelus Gerardus Maria Janssen , Peter Walter Maria Roevens , Jozef Bertha August Thijssen
IPC分类号： A61K31496
CPC分类号： C07D405/14 , C07D417/14
摘要： The present invention relates to compounds of formula (I) the N-oxides, the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts, wherein n is 1 or 2, R1 is hydrogen, C1-6alkyl or halo; R2 is hydrogen or halo; R3 is C1-8alkyl or C3-6cycloalkyl; Hetis an optionally substituted triazole, imidazole, or thiazole; and —A—B— is a bivalent radical of formula —CH═CH—, —N═CH—, —CH═N—, wherein optionally one of the hydrogen atoms is replaced by C1-4alkyl; having apolipoprotein B inhibiting activity and concomitant lipid lowering activity. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating disorders caused by an excess of very low density lipoproteins (VLDL) or low density lipoproteins (LDL), and especially disorders caused by the cholesterol associated with said VLDL and LDL, such as, for example, hyperlipidemia, obesitas or atherosclerosis.
摘要翻译：本发明涉及式（I）化合物的N-氧化物，其立体化学异构形式和药学上可接受的酸加成盐，其中n为1或2，R 1为氢，C 1-6烷基或卤素; R2是氢或卤素; R3是C1-8烷基或C3-6环烷基; Hetis是任选取代的三唑，咪唑或噻唑; 并且-A-B-是式-CH = CH-，-N = CH-，-CH = N-的二价基团，其中任选地一个氢原子被C 1-4烷基取代; 具有载脂蛋白B抑制活性和伴随的降脂活性。公开了用于制备所述产品的方法，包含所述产品的制剂及其作为药物的用途，特别是用于治疗由过量非常低密度脂蛋白（VLDL）或低密度脂蛋白（LDL）引起的疾病，特别是由与所述VLDL和LDL相关的胆固醇，例如高脂血症，肥胖或动脉粥样硬化。

2. 发明申请

US20110269747A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS 有权
标题翻译：有益于脂肪降低剂的多元醇
公开(公告)号：US20110269747A1
公开(公告)日：2011-11-03
申请号：US13181624
申请日：2011-07-13
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/495 , C07D211/34 , C07D401/12 , C07D211/32 , C07D243/08 , C07D211/58 , C07D409/12 , C07D405/12 , A61K31/451 , A61K31/496 , A61K31/4545 , A61K31/5513 , A61P3/06 , A61P3/04 , A61P3/10 , A61P9/10 , A61P7/00 , A61P1/18 , A61P9/00 , C07D241/04
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译：式（I）的聚芳基酰胺化合物可用作降脂剂。

3. 发明申请

US20110112111A1 DRUG COMBINATIONS COMPRISING A DGAT INHIBITOR AND A PPAR-AGONIST 有权
标题翻译：包含DGAT抑制剂和PPAR-AGONIST的药物组合
公开(公告)号：US20110112111A1
公开(公告)日：2011-05-12
申请号：US12993491
申请日：2009-06-03
申请人： Joannes Theodorus Maria Linders , Peter Walter Maria Roevens , Brian Joel Hrupka
发明人： Joannes Theodorus Maria Linders , Peter Walter Maria Roevens , Brian Joel Hrupka
IPC分类号： A61K31/496 , C07D403/10 , C07D403/14 , A61P3/04 , A61P9/04 , A61P9/10 , A61P3/10 , A61P3/06 , A61P17/06 , A61P17/10 , A61P9/12 , A61P35/00 , A61P25/28
CPC分类号： A61K45/06 , A61K31/216 , A61K31/496 , C07D295/192 , A61K2300/00
摘要： The present invention relates to combinations of a DGAT inhibitor and a peroxisome proliferator-activator receptor (PPAR) agonist or a prodrug thereof. The invention further relates to methods for preparing such combinations, pharmaceutical compositions comprising said combinations as well as the use as a medicament of said combinations.The present invention also relates to novel DGAT inhibitors. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicament of said compounds.
摘要翻译：本发明涉及DGAT抑制剂和过氧化物酶体增殖物激活受体（PPAR）激动剂或其前药的组合。本发明还涉及制备这种组合的方法，包含所述组合的药物组合物以及作为所述组合的药物的用途。本发明还涉及新型DGAT抑制剂。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及用作所述化合物的药物的用途。

4. 发明申请

US20100190789A1 PIPERIDINE/PIPERAZINE DERIVATIVES 有权
公开(公告)号：US20100190789A1
公开(公告)日：2010-07-29
申请号：US12663013
申请日：2008-06-06
申请人： Jean-Pierre Andre Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J.M De Waepenaert , Peter Walter Maria Roevens , Gustaaf Maria Boeckx , Peter Vladimirivich Davidenko
发明人： Jean-Pierre Andre Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J.M De Waepenaert , Peter Walter Maria Roevens , Gustaaf Maria Boeckx , Peter Vladimirivich Davidenko
IPC分类号： A61K31/5377 , C07D241/04 , A61K31/495 , C07D401/12 , A61K31/496 , C07D403/10 , C07D405/12 , C07D403/12 , C07D413/12 , C07D211/34 , A61K31/451 , A61P3/04 , A61P3/06 , A61P3/10 , A61P1/16
CPC分类号： C07D295/205 , C07D207/09 , C07D211/26 , C07D211/38 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/18 , C07D295/192 , C07D295/21 , C07D295/215 , C07D295/24 , C07D295/26 , C07D307/52 , C07D307/79 , C07D309/04 , C07D317/58 , C07D333/24
摘要： The invention relates to a DGAT inhibitor of formula (I): including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —C(═O)—; —O—C(═O)—; C(═O)—C(═O)—; —NRx—C(═O)—; —Z1—C(O)—; —Z1—NRx—C(═O)—; —C(═O)—Z1—; —NRx—C(═O)—Z1—; —S(═O)p-; —C(═S)—; —NRx—C(═S)—; —Z1—C(═S)—; —Z1—NRx—C(═S)—; —C(═S)—Z1-; NRx—C(═S)—Z—; Y represents NRx—C(=0)-Z2—; —NRx—C(=0)-Z2—NRy—; —NRx—C(=0)-Z 2—NRy—C(=0)—; —NRx—C(=0)-Z2—NRy—C(=0)-; O—; —NRx—C(=0)-Z2-0-; —NRx—C(=0)-Z2-0-C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-0-; —NRx—C(═O)—O—Z2—O—C(═O)—; —NRx—C(═O)—Z2—C(═O)—NRy—; —NRx—C(═O)—Z2—NRy—C(=0)-NRy—; —C(═O)—Z2—; —C(═O)—Z2—O—; —C(=0)-NRx—Z2—; —C(=0)-NRx—Z2-0-; —C(=0)-NRx—Z2—C(=0)-0-; —C(=0)-NRx—Z2-0-C(=0)-; —C(=0)-NRx—Z2—NRy—; —C(=0)—NRx—Z2—NRy—C(=0)-; —C(=0)-NRx—Z2—NRy—C(=0)-0-; R1 represents C1-12alkyl optionally substituted with cyano, C1-4alkyloxy, C1-4alkyl-oxyC1-4alkyloxy, C3-6Cycloalkyl or aryl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; adamantanyl; aryl1; aryl1C1-6alkyl; Het1; or Het1C1-6alkyl; provided that when Y represents —NRx—C(═O)—Z2—; —NRx—C(=0)-Z2—NRy; —NRx—C(═O)—Z2—C(═O)—NRy—; —C(═O)—Z2—; —NRx—C(=0)-Z2—NRy—C(=0)—NRy—; —C(═O)—NR—Z2—; —C(═O)—NR—O—Z2—; or —C(=0)-NRx—Z2—NRy—; then R1 may also represent hydrogen; R2 represents hydrogen, C1-12alkyl, C2-6alkenyl or R3; provided that if X represents —O—C(═O)—; the R2 O represents R3; and provided that (A) is excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.

5. 发明授权

US07169796B2 Polyarylcarboxamides useful as lipid lowering agents 有权
标题翻译：可用作降脂剂的聚芳酰胺酰胺
公开(公告)号：US07169796B2
公开(公告)日：2007-01-30
申请号：US11029956
申请日：2005-01-05
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/445 , C07D211/14 , C07D401/10
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula I) are useful as lipid lowering agents.
摘要翻译：式I）的聚芳酰基甲酰胺化合物可用作降脂剂。

6. 发明授权

US06878724B2 Polyarylcarboxamides useful as lipid lowering agents 有权
标题翻译：可用作降脂剂的聚芳酰胺酰胺
公开(公告)号：US06878724B2
公开(公告)日：2005-04-12
申请号：US10363665
申请日：2001-08-27
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： C07D243/08 , A61K31/4409 , A61K31/445 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/551 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/14 , C07D211/26 , C07D211/34 , C07D211/70 , C07D211/82 , C07D213/40 , C07D213/55 , C07D213/56 , C07D295/14 , C07D295/15 , C07D307/54 , C07D333/24 , C07D401/12 , A61K31/451 , C07D211/28 , C07D211/32
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I): are useful as lipid lowering agents.
摘要翻译：式（I）的聚芳酰基甲酰胺化合物：可用作降脂剂。

7. 发明授权

US08981094B2 Piperidine/piperazine derivatives 有权
公开(公告)号：US08981094B2
公开(公告)日：2015-03-17
申请号：US12663013
申请日：2008-06-06
申请人： Jean-Pierre André Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J. M. De Waepenaert , Peter Walter Maria Roevens , Gustaaf Maria Boeckx , Petr Vladimirivich Davidenko
发明人： Jean-Pierre André Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J. M. De Waepenaert , Peter Walter Maria Roevens , Gustaaf Maria Boeckx , Petr Vladimirivich Davidenko
IPC分类号： C07D211/00 , C07D241/04 , C07D295/00 , C07D401/00 , C07D403/00 , C07D295/205 , C07D207/09 , C07D211/26 , C07D211/38 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/18 , C07D295/192 , C07D295/21 , C07D295/215 , C07D295/24 , C07D295/26 , C07D307/52 , C07D307/79 , C07D309/04 , C07D317/58 , C07D333/24
CPC分类号： C07D295/205 , C07D207/09 , C07D211/26 , C07D211/38 , C07D213/40 , C07D213/56 , C07D213/61 , C07D213/75 , C07D233/18 , C07D295/192 , C07D295/21 , C07D295/215 , C07D295/24 , C07D295/26 , C07D307/52 , C07D307/79 , C07D309/04 , C07D317/58 , C07D333/24
摘要： The invention relates to a DGAT inhibitor of formula (I): including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —C(═O)—; —O—C(═O)—; C(═O)—C(═O)—; —NRx—C(═O)—; —Z1—C(O)—; —Z1—NRx—C(═O)—; —C(═O)—Z1—; —NRx—C(═O)—Z1—; —S(═O)p-; —C(═S)—; —NRx—C(═S)—; —Z1—C(═S)—; —Z1—NRx—C(═S)—; —C(═S)—Z1-; —NRx—C(═S)—Z—; Y represents NRx—C(=0)-Z2—; —NRx—C(=0)-Z2—NRy—; —NRx—C(=0)-Z2—NRy—C(=0)-; —NRx—C(=0)-Z2—NRy—C(=0)-O—; —NRx—C(=0)-Z2-0-; —NRx—C(=0)-Z2-0-C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-; —NRx—C(=0)-0-Z2—C(=0)-0-; —NRx—C(═O)—O—Z2—O—C(═O)—; —NRx—C(═O)—Z2—C(═O)—NRy—; —NRx—C(═O)—Z2—NRy—C(=0)-NRy—; —C(═O)—Z2—; —C(═O)—Z2—O—; —C(=0)-NRx—Z2—; —C(=0)-NRx—Z2-0-; —C(=0)-NRx—Z2—C(=0)-0-; —C(=0)-NRx—Z2-0-C(=0)-; —C(=0)-NRx—Z2—NRy—; —C(=0)-NRx—Z2—NRy—C(=0)-; —C(=0)-NRx—Z2—NRy—C(=0)-0-; R1 represents C1-12alkyl optionally substituted with cyano, C1-4alkyloxy, C1-4alkyl-oxyC1-4alkyloxy, C3-6Cycloalkyl or aryl; C2-6alkenyl; C2-6alkynyl; C3-6cycloalkyl; adamantanyl; aryl1; aryl1C1-6alkyl; Het1; or Het1C1-6alkyl; provided that when Y represents —NRX—C(═O)—Z2—; —NRx—C(=0)-Z2—NRy; —NRX—C(═O)—Z2—C(═O)—NRy—; —C(═O)—Z2—; —NRx—C(=0)-Z2—NRy—C(=0)-NRy—; —C(═O)—NRX—Z2—; —C(═O)—NRX—O—Z2—; or —C(=0)-NRx—Z2—NRy—; then R1 may also represent hydrogen; R2 represents hydrogen, C1-12alkyl, C2-6alkenyl or R3; provided that if X represents —O—C(═O)—; the R2 represents R3; and provided that (A) is excluded; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine of said compounds.

8. 发明授权

US07816360B2 MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles 有权
标题翻译： MTP抑制芳基哌啶或被5元杂环取代的哌嗪
公开(公告)号：US07816360B2
公开(公告)日：2010-10-19
申请号：US12341567
申请日：2008-12-22
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
IPC分类号： A61K31/496 , A61K31/454 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D487/04 , C07D233/74 , C07D249/12
CPC分类号： C07D233/54 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
摘要翻译：本发明涉及用具有apoB分泌/ MTP抑制活性和伴随的降脂活性的某些5-元杂环取代的新的芳基哌啶或哌嗪化合物。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗动脉粥样硬化，胰腺炎，肥胖症，高甘油三酯血症，高胆固醇血症，高脂血症，糖尿病和II型糖尿病的药物的用途。

9. 发明授权

US07504400B2 MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles 有权
标题翻译：用5元杂环取代的MTP抑制芳基哌啶或哌嗪
公开(公告)号：US07504400B2
公开(公告)日：2009-03-17
申请号：US10589515
申请日：2005-03-07
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
IPC分类号： A61K31/496 , A61K31/454 , C07D295/15 , C07D401/04 , C07D401/10 , C07D401/12 , C07D417/121
CPC分类号： C07D233/54 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
摘要翻译：本发明涉及用具有apoB分泌/ MTP抑制活性和伴随的降脂活性的某些5-元杂环取代的新的芳基哌啶或哌嗪化合物。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗动脉粥样硬化，胰腺炎，肥胖症，高甘油三酯血症，高胆固醇血症，高脂血症，糖尿病和II型糖尿病的药物的用途。

10. 发明授权

US08946228B2 Piperidine/piperazine derivatives 有权
标题翻译：哌啶/哌嗪衍生物
公开(公告)号：US08946228B2
公开(公告)日：2015-02-03
申请号：US12663011
申请日：2008-06-06
申请人： Jean-Pierre André Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J. M. De Waepenaert , Peter Walter Maria Roevens , Petr Vladimirivich Davidenko
发明人： Jean-Pierre André Marc Bongartz , Joannes Theodorus Maria Linders , Lieven Meerpoel , Guy Rosalia Eugeen Van Lommen , Erwin Coesemans , Mirielle Braeken , Christophe Francis Robert Nestor Buyck , Monique Jenny Marie Berwaer , Katharina Antonia Germania J. M. De Waepenaert , Peter Walter Maria Roevens , Petr Vladimirivich Davidenko
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00 , A61K31/451 , A61K31/495 , C07D207/323 , C07D211/26 , C07D231/12 , C07D233/54 , C07D233/64 , C07D235/18 , C07D249/08 , C07D257/04 , C07D263/34 , C07D277/56 , C07D279/02 , C07D279/12 , C07D295/20 , C07D307/54 , C07D319/18 , C07D401/12 , C07D417/12 , C07D417/14
CPC分类号： A61K31/4523 , A61K31/451 , A61K31/454 , A61K31/495 , A61K31/496 , C07D207/277 , C07D207/323 , C07D211/26 , C07D211/60 , C07D231/12 , C07D233/54 , C07D233/64 , C07D235/18 , C07D249/08 , C07D257/04 , C07D263/34 , C07D277/56 , C07D279/02 , C07D279/12 , C07D295/20 , C07D295/205 , C07D295/21 , C07D295/215 , C07D307/54 , C07D319/18 , C07D401/12 , C07D417/12 , C07D417/14
摘要： The invention relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof, and methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use as a medicine, as a DGAT inhibitor, of said compounds.
摘要翻译：本发明涉及式（I）的DGAT抑制剂，包括其任何立体化学异构形式，其N-氧化物，其药学上可接受的盐或其溶剂合物，以及制备这些化合物的方法，包含所述化合物的药物组合物作为所述化合物作为DGAT抑制剂的药物使用。

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