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1. 发明授权

US11759552B2 Regulation/modification of stent contact surface for polymer free drug coating 有权
公开(公告)号：US11759552B2
公开(公告)日：2023-09-19
申请号：US15899436
申请日：2018-02-20
申请人： Cook Medical Technologies LLC
发明人： John Neilan , David Murray , James Butler
IPC分类号： A61L31/08 , A61L31/16 , A61L31/02 , A61L27/04 , A61L27/30 , A61L27/54 , B05D3/12 , A61F2/915 , A61F2/90
CPC分类号： A61L31/084 , A61L27/04 , A61L27/303 , A61L27/54 , A61L31/022 , A61L31/16 , B05D3/12 , A61F2/90 , A61F2/915 , A61L2300/416 , A61L2400/18 , A61L2420/02
摘要： There is disclosed a method of improving the reliability of coating an implantable medical device, such as a stent, with bioactive material in the absence of a carrier material such as a matrix or polymer layer. The method involves cleaning volatile components from the exposed surfaces of the medical device, removing carbon deposits and then applying a uniform carbon layer in a controlled environment. The deliberately applied carbon layer masks impurities of the underlying native oxide layer and leads to more uniform bioactive material coating not only a over the surfaces of a single medical device but also from device to device within a batch and between batches of devices. This improves production as well as optimising the amount and release of drug on the medical device without the need for a carrier material.

2. 发明授权

US10369030B2 Woven stent device and manufacturing method 有权
公开(公告)号：US10369030B2
公开(公告)日：2019-08-06
申请号：US15992472
申请日：2018-05-30
申请人： Cook Medical Technologies LLC
发明人： Gerard Thomas Treacy , Don Frawley , John Neilan
IPC分类号： A61F2/88 , A61F2/90
摘要： A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.

3. 发明申请

US20190161854A1 MEDICAL DEVICE WITH PLASMA MODIFIED OXIDE LAYER AND METHOD OF FORMING SUCH A DEVICE 审中-公开
公开(公告)号：US20190161854A1
公开(公告)日：2019-05-30
申请号：US16200870
申请日：2018-11-27
申请人： Cook Medical Technologies LLC
发明人： John Neilan , David Murray , James Butler
IPC分类号： C23C16/02 , H01J37/32 , C23C16/50 , C23C16/40 , A61L31/08 , A61L31/16 , A61L31/02 , A61F2/82
摘要： A method of modifying a surface of a medical device for implantation or disposition inside a patient is described. The medical device comprises a structure having at least one surface. The method includes the steps of: placing the medical device into a plasma chamber substantially free from contaminants and substantially sealing the plasma chamber from the atmosphere; removing at least an outermost layer of any oxide layer from the at least one surface of the structure by a plasma oxide-removal process, whilst maintaining the plasma chamber under seal from the atmosphere; and subsequently forming a new oxide layer at the least one surface of the structure by introducing at least one gas into the plasma chamber, whilst maintaining the plasma chamber under seal from the atmosphere. A medical device including a bulk material and an oxide layer disposed over at least one surface of the medical device. The oxide layer is substantially pure and free from contaminants.

4. 发明申请

US20180271682A1 WOVEN STENT DEVICE AND MANUFACTURING METHOD 审中-公开
公开(公告)号：US20180271682A1
公开(公告)日：2018-09-27
申请号：US15992472
申请日：2018-05-30
申请人： Cook Medical Technologies LLC
发明人： Gerard Thomas Treacy , Don Frawley , John Neilan
IPC分类号： A61F2/88 , A61F2/90
CPC分类号： A61F2/88 , A61F2/90 , A61F2220/0075 , A61F2230/0054 , A61F2240/001 , A61F2250/0098
摘要： A stent and method for treating an end of a pre-woven stent is provided. The method includes providing a pre-woven stent including a plurality of sharp ends. A pair of wire portions that extend in opposite helical directions around the stent are bent and woven into the stent to define a pair of overlapping crown portions. When the wires are woven into the stent a double weave portion of the stent is defined. The wires can be cut to define tail portions that are removed from the stent, leaving a single crown portion. The sharp ends can be alternatively treated by curving the ends to define rounded looped ends.

5. 发明申请

US20180161121A1 RADIOPAQUE COMPOSITE WIRE FOR MEDICAL APPLICATIONS AND METHOD OF MAKING A RADIOPAQUE COMPOSITE WIRE 审中-公开
公开(公告)号：US20180161121A1
公开(公告)日：2018-06-14
申请号：US15837203
申请日：2017-12-11
申请人： Cook Medical Technologies LLC
发明人： James Butler , Melissa Lonn , Keith R. Milner , John Neilan
IPC分类号： A61B90/00 , C22F1/16 , B32B15/01 , C22F1/10 , B21C1/02 , A61B17/22 , A61B17/221 , A61B17/34 , A61C7/20 , A61F2/01 , A61F2/07 , A61B17/00 , A61F2/86 , A61M25/00
CPC分类号： A61B90/39 , A61B17/0057 , A61B17/1214 , A61B17/22031 , A61B17/221 , A61B17/3415 , A61B2017/00358 , A61B2017/00526 , A61B2017/00831 , A61B2017/00867 , A61B2090/3966 , A61C7/20 , A61C2201/005 , A61C2201/007 , A61F2/013 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2002/016 , A61F2240/001 , A61F2250/0098 , A61L29/123 , A61L29/18 , A61L31/124 , A61L31/18 , A61M25/0012 , A61M25/005 , A61M25/0108 , A61M2025/0063 , A61M2025/09108 , A61M2025/09133 , A61M2025/09141 , A61M2025/09166 , B21C1/02 , B21C23/22 , B32B15/01 , C22C19/03 , C22F1/10 , C22F1/16
摘要： A radiopaque composite wire for medical applications has a core comprising a rare earth metal, an outer layer comprising a nickel-titanium alloy disposed over the core, and a controlled diffusion zone between the core and the outer layer. The controlled diffusion zone includes at least one compound phase comprising (a) the rare earth metal and (b) nickel and/or titanium.

6. 发明授权

US09592142B2 Inner catheter arrangement for a self-expanding medical device delivery system 有权
标题翻译：用于自扩张医疗装置输送系统的内导管装置
公开(公告)号：US09592142B2
公开(公告)日：2017-03-14
申请号：US14180064
申请日：2014-02-13
申请人： Cook Medical Technologies LLC
发明人： Conor M. Dillon , John Neilan , Brent A. Mayle , James C. Merk , Dean R. Puckett , Tiffani L. Cannon , Darin Voorhies
IPC分类号： A61F2/966
CPC分类号： A61F2/966 , Y10T29/49874
摘要： A delivery system for a self-expanding medical device is provided. The delivery system includes an outer sheath that radially restrains the medical device. First and second inner catheters are disposed within the outer sheath. The first inner catheter is a composite structure with a closed coil wire covered by a polymer outer layer. The second inner catheter is disposed within the closed coil wire but is not attached to the closed coil wire.
摘要翻译：提供了一种用于自扩张医疗装置的输送系统。输送系统包括径向限制医疗装置的外护套。第一和第二内导管设置在外护套内。第一内导管是具有由聚合物外层覆盖的闭合线圈线的复合结构。第二内导管设置在闭合线圈线内，但未附接到闭合线圈线。

7. 发明申请

US20160331405A1 ENDOSCOPIC NEEDLE STYLET WITH ENHANCED-FLEXIBILITY LENGTHS 审中-公开
标题翻译：具增强灵活性长度的内窥镜针刺
公开(公告)号：US20160331405A1
公开(公告)日：2016-11-17
申请号：US15146178
申请日：2016-05-04
申请人： Cook Medical Technologies LLC
发明人： Fionán Keady , John Neilan , James Butler , Shay Joseph Lavelle
IPC分类号： A61B17/34 , A61B8/12
CPC分类号： A61B17/3478 , A61B8/12 , A61B10/04 , A61B2010/045 , A61B2017/00867 , A61B2017/3413
摘要： A single-wire stylet may be constructed as an elongate single-wire, memory-metal alloy body with a generally cylindrical body profile, extending distally from a proximal end terminus, where embodiments include a polymeric distal tip member fixedly attached directly at a distal end of the single-wire body. At least one lengthwise portion of the single-wire body is at least partially in martensitic phase at operating temperatures at and below about 37° C. Where present, the polymeric distal tip member has a generally cylindrical body profile circumferentially bounded by an outer circumference substantially equal to or greater than that of the metal body. The polymeric distal tip member may be overmolded upon a distal-end tip length of an elongate single-wire, memory-metal alloy stylet body, where the distal end and/or discrete intermediate distal-portion length(s) that include martensitic-phase alloy and any polymeric member have greater flexibility than a proximal-most length of the alloy stylet body.
摘要翻译：单线探针可以被构造为具有大致圆柱形主体轮廓的细长单丝记忆金属合金体，其从近端终端向远侧延伸，其中实施例包括直接固定在远端的单线体。单丝主体的至少一个纵向部分在马氏体相中至少部分地处于等于或低于约37℃的操作温度。在存在的情况下，聚合物远侧末端构件具有大致圆柱形的主体轮廓，其外周基本上包围等于或大于金属体的厚度。聚合物远侧末端构件可以在细长单丝，记忆 - 金属合金探针体的远端尖端长度上包覆成型，其中远端和/或离散的中间远端部分长度包括马氏体相合金和任何聚合物构件具有比最近的长度的合金探针体更大的柔性。

8. 发明授权

US09468546B2 Inner catheter arrangement for a self-expanding medical device delivery system 有权
公开(公告)号：US09468546B2
公开(公告)日：2016-10-18
申请号：US14180064
申请日：2014-02-13
申请人： Cook Medical Technologies LLC
发明人： Conor M. Dillon , John Neilan
IPC分类号： A61F2/966
摘要： A delivery system for a self-expanding medical device is provided. The delivery system includes an outer sheath that radially restrains the medical device. First and second inner catheters are disposed within the outer sheath. The first inner catheter is a composite structure with a closed coil wire covered by a polymer outer layer. The second inner catheter is disposed within the closed coil wire but is not attached to the closed coil wire.

9. 发明申请

US20150099995A1 WIRE-EMBEDDED POLYMER-BODY NEEDLE 有权
标题翻译：电线嵌入式聚合物体针
公开(公告)号：US20150099995A1
公开(公告)日：2015-04-09
申请号：US14492984
申请日：2014-09-22
申请人： Cook Medical Technologies LLC
发明人： Michael S. Clancy , John Neilan , Darach McGrath
IPC分类号： A61M5/32 , A61B10/04 , A61M5/158 , A61B10/02
CPC分类号： A61M5/3286 , A61B10/0233 , A61B10/04 , A61B17/3478 , A61B2010/045 , A61B2090/3925 , A61M5/158 , A61M2205/0266
摘要： A medical needle including an elongate tubular body having an outer wall defining at least one longitudinal lumen is provided. The at least one longitudinal lumen may be configured to provide access for at least one of a wire guide, a therapeutic tool, a diagnostic tool, a medicament, and/or contrast fluid. The body may be configured with sufficient length and flexibility to be extended out of and operated through a working channel of a surgical endoscope. The body further includes one or more wires embedded in, and secured substantially immovably relative to, the outer wall. A distal end of the body includes a needle tip configured with at least one sharpened surface configured to penetrate into body tissue.
摘要翻译：提供了包括具有限定至少一个纵向内腔的外壁的细长管状体的医疗针。所述至少一个纵向内腔可以被配置为为线引导件，治疗工具，诊断工具，药物和/或对比流体中的至少一个提供通路。身体可以构造成具有足够的长度和柔性，以延伸出并通过手术内窥镜的工作通道操作。身体还包括一个或多个线，其相对于外壁嵌入并基本上不可移动地固定。主体的远端包括配置有至少一个被锐化的表面的针头，构造成穿透身体组织。

10. 发明申请

US20130289711A1 Anti-Aspiration Valve 有权
标题翻译：防吸气阀
公开(公告)号：US20130289711A1
公开(公告)日：2013-10-31
申请号：US13794010
申请日：2013-03-11
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： Alison Liddy , John Neilan , Michael Ryan , Gerard Treacy
IPC分类号： A61F2/06
CPC分类号： A61F2/04 , A61F2/06 , A61F2/07 , A61F2/2412 , A61F2/2415 , A61F2002/044 , A61F2230/0069 , A61F2250/0069
摘要： A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.
摘要翻译：提供了一种用于制造用于控制通过体腔流动的假体的假体和方法。假体包括具有近端部分，远侧部分和延伸穿过其中的内腔的主体，并且还包括可操作地连接到身体的瓣膜。阀具有远端，其包括阀腔表面的第一部分和表面的彼此接触并形成封闭构造的密封件的第二部分。阀的远端形成为使得阀腔的表面的第一部分和第二部分彼此接触，并且远端构造成响应于大于大气压力的压力而打开。

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