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1. 发明申请

US20040073164A1 Medical device including improved expandable balloon 有权
标题翻译：医疗装置包括改进的可膨胀气囊
公开(公告)号：US20040073164A1
公开(公告)日：2004-04-15
申请号：US10463749
申请日：2003-06-16
申请人： Cook Incorporated , Sabin Corporation
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , David R. Lessard , David A. Drewes JR. , Maggie A.Z. Hupcey
IPC分类号： A61M029/00 , A61M031/00 , A61M037/00
CPC分类号： C08G69/48 , A61L29/06 , C08F283/04 , C08L77/00 , C08F218/16
摘要： A medical device (10) includes a catheter shaft (11) including inner and outer catheter shafts (12 and 14), and an expandable balloon (18) carried by the catheter shaft (11). The balloon (18) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon (18) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.
摘要翻译：医疗装置（10）包括导管轴（11），其包括内导管轴和外导管轴（12和14）和由导管轴（11）承载的可膨胀气囊（18）。球囊（18）由聚酰胺弹性体和至少一种另外的交联反应物的照射交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。照射通过暴露于电子束或紫外线，X射线或γ射线进行，优选以约0.5至约20兆拉德的总注量。选择交联反应物的量以避免在制备气囊（18）的过程中形成胶凝，并且选择交联剂的量和照射注量以使球囊具有强度通常大约等于仅通过照射获得的能量。

2. 发明申请

US20030195490A1 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US20030195490A1
公开(公告)日：2003-10-16
申请号：US09848742
申请日：2001-05-03
申请人： Cook Incorporated
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, JR. , David R. Lessard , Maggie A.Z. Hupcey
IPC分类号： A61M029/00 , B29C045/00
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：包括导管轴（ 111 ）的医疗装置（ 110 ）和具有变化的硬度的一体且连续形成的部分（ 108 ），以及可选地包括可扩展气球（ 18,118 ）。整体和连续形成的部分（ 108 ）和气球（ 18,118 ）中的一个或两个由照射交联或可交联的混合物聚酰胺弹性体和至少一种另外的交联反应物。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

3. 发明申请

US20040073284A1 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US20040073284A1
公开(公告)日：2004-04-15
申请号：US10618977
申请日：2003-07-14
申请人： Cook Incorporated , MED Institute, Inc. , WILLIAM COOK EUROPE ApS
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F002/06
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

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