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    • 1. 发明申请
    • Artificial valve prosthesis with improved flow dynamics
    • 具有改善流动动力学的人造瓣膜假体
    • US20040260389A1
    • 2004-12-23
    • US10828716
    • 2004-08-30
    • Cook Incorporated
    • Brian C. CaseJacob A. FlagleAndrew K. HoffaDarin G. SchaefferMichael L. Garrison
    • A61F002/06
    • A61F2/2418A61F2/2475A61F2002/068A61F2220/0008A61F2220/0016A61F2230/0054A61F2230/0076A61F2230/0078A61F2230/008A61F2250/0037A61F2250/0039
    • An expandable venous valve having a support structure that configured to enlarge the area adjacent to the valve structure such that the flow patterns of retrograde flow are modified in a way that facilitates the flushing of the pockets at the base of the valve area to prevent stagnation of bodily fluid, which in the venous system, can lead to thrombus formation. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame section or the support frame can comprise an expanded-diameter intermediate or proximal section that forms an artificial sinus adjacent the valve structure. In another group of embodiments, the attachment pathway between opposing leaflets and the support frame and/or vessel wall comprises a proximal portion that places the leaflets in extended contact with one another and a distal portion forms a large angle with respect to the adjacent walls such that a large pocket is created at the base of the leaflets. In one embodiment, the attachment pathway extends distally along a pair of substantially parallel longitudinal attachment struts to create an extended leaflet contact area, then angles circumferentially and distally from the former along distal attachment struts to define the bottom edge of the leaflets.
    • 一种可膨胀静脉瓣,其具有支撑结构,该支撑结构被配置为扩大邻近阀结构的区域,使逆行流的流动模式以便于冲洗瓣膜区域底部的口袋的方式进行改变,以防止滞留 在静脉系统中的体液可导致血栓形成。 扩大的口袋区域可以通过在两个支撑框架部分之间的容器壁的无支撑部分中形成邻近阀结构的人造窦来形成,或者支撑框架可以包括形成邻近瓣膜的人造窦的扩张直径的中间或近端部分 结构体。 在另一组实施例中,相对的小叶与支撑框架和/或血管壁之间的附接通路包括将小叶彼此延伸接触的近端部分,并且远侧部分相对于相邻壁形成大角度, 在传单的底部创造了一个大口袋。 在一个实施例中,附接通道沿着一对基本上平行的纵向连接支柱向远侧延伸以产生延伸的小叶接触区域,然后沿着远侧连接支柱周向地和远端地从前者角度定位以限定传单的底部边缘。
    • 2. 发明申请
    • Prosthesis adapted for placement under external imaging
    • 假体适应放置在外部成像
    • US20040167619A1
    • 2004-08-26
    • US10787307
    • 2004-02-26
    • Cook Incorporated
    • Brian C. CaseJacob A. FlagleMichael L. GarrisonAndrew K. HoffaRay Leonard II
    • A61F002/06
    • A61F2/2475A61B90/39A61F2/2418A61F2230/0026A61F2230/0095A61F2250/0098
    • A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.
    • 一种具有可成像结构的可扩张假体,其包括可由外部(例如,射线照相或超声)成像系统在视觉上区分的一个或多个元件,所述结构围绕与假体的结构特征对应的第一轴定位,所述第一轴构造成执行 特定于该轴的特定功能。 可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。 在一个实施例中,假体包括静脉瓣,其包括可成像元件或结构,例如一对不透射线的标记,其限定瓣膜结构的孔,使得孔可以在成像下具有特定解剖特征,例如 以将孔与容器的长轴对准。 在另一个实施例中,可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征(例如分支血管开口)定向。 本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。
    • 4. 发明申请
    • Medical device delivery system
    • 医疗器械输送系统
    • US20030144670A1
    • 2003-07-31
    • US10307141
    • 2002-11-27
    • Cook Incorporated
    • Dusan PavcnikChristopher G. DixonJacob A. FlagleMike GarrisonAndrew K. HoffaRay Leonard IIBrian C. Case
    • A61F011/00
    • A61F2/2436A61F2/95A61F2002/011A61F2002/9517
    • A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with a sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment. The inner member is preferably radiolucent underlying the device for contrast with radiopaque markers (43) of the device. The inner member preferably includes a flat portion (35) extending from the device-containing portion to the proximal end (22) to form a passageway or lumen (21) with the delivery catheter to transmit hydrating fluid to a device such as a valve containing lyophilized tissue requiring hydration immediately prior to patient implantation.
    • 一种用于将诸如静脉瓣的医疗装置(30)植入患者脉管系统的输送系统(10)。 递送系统包括具有与其远端(14)相邻的装置容纳部分(15)的输送导管(11)和延伸穿过导管并超出其远端的内部构件(16)到无创伤 远端尖端部分(17)在导管远端的前方。 内部构件在包含装置的区域中延伸通过医疗装置,包括具有足够大的直径的近端部分(18),以防止在展开期间导管缩回时装置的纵向移动, 远端导管末端部署期间。 内部构件优选地是设备下方的射线可透以与装置的不透射线标记(43)形成对比。 内部构件优选地包括从装置容纳部分延伸到近端(22)的平坦部分(35),以与输送导管形成通道或内腔(21),以将保湿流体传送到装置,例如包含 在患者植入前立即需要水合的冻干组织。