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1. 发明专利

JP2009179798A Bioabsorbable block copolymer 有权
标题翻译：生物可降解共聚物
公开(公告)号：JP2009179798A
公开(公告)日：2009-08-13
申请号：JP2009016030
申请日：2009-01-27
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： BENNETT STEVEN L
IPC分类号： C08G18/65 , A61B17/12 , A61B17/58 , A61L17/00 , A61L31/00 , C08G18/72
CPC分类号： A61L31/148 , A61B17/06166 , A61B17/0643 , A61B17/68 , A61B17/846 , A61B2017/00004 , A61B2017/00889 , A61L17/10 , A61L27/16 , A61L27/58 , A61L31/048 , C08F283/006 , C08F290/067 , C08G18/3819 , C08G18/4825 , C08G18/771 , C08G2230/00 , C08L53/00 , C08L2666/02
摘要： PROBLEM TO BE SOLVED: To prepare a bioabsorbable synthetic block copolymer having hard and soft segments. SOLUTION: The bioabsorbable polyurethane block copolymer is formed by the reaction of a diisocyanate such as lysine ethyl ester diisocyanate with a mixture of (i) an aromatic amide or an amino acid derivative and absorbable elastomeric polymer derived from the reaction of (ii) polyether glycol and/or dialkylene glycol with a cyclic bioabsorbable monomer such as trimethylene carbonate, caprolactone, or dioxanone. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：制备具有硬链段和软链段的生物可吸收合成嵌段共聚物。生物可吸收聚氨酯嵌段共聚物通过二异氰酸酯如赖氨酸乙酯二异氰酸酯与（i）芳族酰胺或氨基酸衍生物的混合物和衍生自（ii）的反应的可吸收弹性体聚合物的反应形成）聚醚二醇和/或二亚烷基二醇与环状生物可吸收单体如三亚甲基碳酸酯，己内酯或二恶烷酮。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010227564A Low-swelling biocompatible hydrogel 审中-公开
标题翻译：低沸点生物降解水凝胶
公开(公告)号：JP2010227564A
公开(公告)日：2010-10-14
申请号：JP2010065269
申请日：2010-03-19
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： BENNETT STEVEN L
IPC分类号： A61L27/00 , A61L29/00 , A61M25/00
CPC分类号： A61L27/52 , A61L27/18 , A61L27/58 , C08L71/02
摘要： PROBLEM TO BE SOLVED: To provide a system to increase sphincter muscles. SOLUTION: The system includes a catheter assembly comprising catheter. The catheter is connected to a syringe in the proximal end of the catheter, and it is connected to a tissue puncture needle in the distal end of the catheter. The catheter is constituted so that it is introduced into a patient. The needle is constituted so that it punctures a sphincteral outer surface, and it is constituted so that it advances by a certain distance into the sphincter muscle. The catheter assembly is constituted so that it introduces a first synthetic precursor possessing a first functional group and a second synthetic precursor into the sphincter muscle. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种增加括约肌的系统。解决方案：该系统包括包括导管的导管组件。导管连接到导管近端的注射器，并且其连接到导管远端的组织穿刺针。导管构成为将其导入患者体内。该针被构造成使得其穿刺一个括约肌外表面，并且构成为使其前进一定距离进入括约肌。构造导管组件，使得其将含有第一官能团和第二合成前体的第一合成前体引入括约肌。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2008212683A Low-swelling biocompatible hydrogels 审中-公开
标题翻译：低挥发性生物降解水
公开(公告)号：JP2008212683A
公开(公告)日：2008-09-18
申请号：JP2008050012
申请日：2008-02-29
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： SAWHNEY AMARPREET S , BENNETT STEVEN L
IPC分类号： A61L27/00
CPC分类号： A61L27/18 , A61K47/183 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2430/38 , C08G65/33324 , C08G2210/00
摘要： PROBLEM TO BE SOLVED: To provide low-swelling biocompatible hydrogel not exhibiting a high degree of swelling, and a method and kit relating thereto. SOLUTION: This invention provides a kit for forming a low-swelling biodegradable hydrogel by in situ polymerization that is adherent to tissue inside a vertebral column and substantially exterior to a theca in the vertebral column. This invention also provides a composition which comprises a first synthetic precursor possessing first functional groups; and a second synthetic precursor comprising a multi-armed precursor possessing a core and from about 3 to about 12 arms, the arms each comprising polyethylene glycol having a molecular weight from about 250 to about 5,000 and possessing second functional groups at the ends thereof, wherein the first functional groups crosslink with the second functional groups thereby forming a hydrogel which swells from about -50% to about 50%. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供不显示高度溶胀的低溶胀生物相容性水凝胶，以及与其相关的方法和试剂盒。解决方案：本发明提供了一种用于通过原位聚合形成低溶胀生物可降解水凝胶的试剂盒，其粘附于脊柱内的组织，并且基本上位于椎体柱的外侧。本发明还提供一种组合物，其包含具有第一官能团的第一合成前体; 该第二合成前体包含具有核心和约3至约12个臂的多臂前体，所述臂各自包含分子量为约250至约5,000的聚乙二醇，并且在其末端具有第二官能团，其中第一官能团与第二官能团交联，从而形成从约-50％至约50％膨胀的水凝胶。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2011189134A MITIGATING THROMBUS FORMATION ON MEDICAL DEVICE BY INFLUENCING pH MICROENVIRONMENT NEAR SURFACE 审中-公开
标题翻译：通过影响pH微环境在表面上缓解医疗器械上的血栓形成
公开(公告)号：JP2011189134A
公开(公告)日：2011-09-29
申请号：JP2011057228
申请日：2011-03-15
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： OHRI RACHIT , BLASKOVICH PHILLIP , BENNETT STEVEN L , TRAMONTANO VALENTINO
IPC分类号： A61M25/00 , A61F2/82 , A61L33/00 , A61M1/14 , A61M25/01 , A61N1/39
CPC分类号： A61L33/064 , A61L31/10 , A61L31/14 , A61L33/068
摘要： PROBLEM TO BE SOLVED: To provide improved materials and treatment methods for implants, which avoid thrombus formation. SOLUTION: A medical device includes: at least one substrate possessing a surface; and a functionality on at least a portion of the surface, wherein the functionality modulates a pH of a microenvironment near the surface of the medical device. In some embodiments, the functionality on at least a portion of the surface is influenced by a charged polymer. In some embodiments, the medical device is implantable. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为植入物提供改进的材料和治疗方法，避免血栓形成。解决方案：医疗装置包括：至少一个具有表面的基底; 以及在所述表面的至少一部分上的功能性，其中所述功能性调节所述医疗装置的表面附近的微环境的pH。在一些实施方案中，表面的至少一部分上的官能度受带电聚合物的影响。在一些实施例中，医疗装置是可植入的。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2010227563A Low-swelling biocompatible hydrogel 审中-公开
标题翻译：低沸点生物降解水凝胶
公开(公告)号：JP2010227563A
公开(公告)日：2010-10-14
申请号：JP2010063377
申请日：2010-03-18
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： BENNETT STEVEN L
IPC分类号： A61L26/00
CPC分类号： A61L27/52 , A61L27/18 , A61L27/58 , C08L71/02
摘要： PROBLEM TO BE SOLVED: To provide a low-swelling hydrogel. SOLUTION: A system includes: a first synthetic precursor having first functional groups and contacting the first precursor with tissue; and a second synthetic precursor including a multi-armed precursor having a core with from about 3 to about 12 pieces of arms, the arms each including a polyethylene glycol having a molecular weight from about 250 to about 5,000 and having second functional groups at the ends thereof, wherein the second precursor is made to contact the first precursor. The first functional groups crosslink with the second functional groups thereby forming a hydrogel which swells from about -50% to about 50%. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供低溶胀水凝胶。解决方案：一种系统包括：具有第一官能团并使第一前体与组织接触的第一合成前体; 该第二合成前体包括具有约3至约12个臂的芯的多臂前体，所述臂各自包含分子量为约250至约5,000的聚乙二醇，并且在末端具有第二官能团其中使第二前体与第一前体接触。第一官能团与第二官能团交联，从而形成从约-50％至约50％膨胀的水凝胶。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2009046473A Drug delivery device 有权
标题翻译：药物递送装置
公开(公告)号：JP2009046473A
公开(公告)日：2009-03-05
申请号：JP2008187933
申请日：2008-07-18
申请人： Confluent Surgical Inc , コンフルエントサージカル, インコーポレイテッド
发明人： BENNETT STEVEN L
IPC分类号： A61K47/30 , A61K9/00 , A61K45/00 , A61K45/06 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42
CPC分类号： A61K9/06 , C08L71/02 , C08L2203/02
摘要： PROBLEM TO BE SOLVED: To provide improved biocompatible crosslinked polymer, and to provide use thereof as a drug delivery device.
SOLUTION: A drug delivery device comprising a biocompatible crosslinked polymer hydrogel and at least one drug is provided. The biocompatible crosslinked polymer hydrogel comprises at least three drug release profiles comprising a first drug release profile of from about 0 days to about 10 days, a second drug release profile of from about 0 days to about 30 days, and a third drug release profile of from about 0 days to about 180 days.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供改进的生物相容性交联聚合物，并提供其作为药物递送装置的用途。提供了包含生物相容性交联聚合物水凝胶和至少一种药物的药物递送装置。生物相容性交联聚合物水凝胶包含至少三种药物释放曲线，其包含约0天至约10天的第一药物释放曲线，约0天至约30天的第二药物释放曲线，以及约0天至约30天的第三药物释放曲线从约0天到约180天。版权所有（C）2009，JPO＆INPIT

7. 发明专利

ES2546027T3 Dispositivo de liberación de fármaco 未知
公开(公告)号：ES2546027T3
公开(公告)日：2015-09-17
申请号：ES08252635
申请日：2008-08-06
申请人： CONFLUENT SURGICAL INC
发明人： BENNETT STEVEN L
IPC分类号： A61L31/10 , A61K9/06 , A61K47/34 , A61K47/42 , A61L27/00 , A61L31/14 , C08G81/00 , C08L71/00
摘要： Un dispositivo de liberación de fármaco, que comprende: un hidrogel polimérico reticulado biocompatible, que comprende una cadena principal; y al menos un fármaco incorporado en el hidrogel, en el que el dispositivo de liberación de fármaco comprende al menos tres perfiles de liberación de fármaco, en el que el al menos un fármaco que tiene el primer perfil de liberación de fármaco que corresponde a un tiempo de liberación de 0 días a 10 días está incorporado en el hidrogel polimérico reticulado sin unión, en el que el al menos un fármaco que tiene dicho segundo perfil de liberación de fármaco que corresponde a un tiempo de liberación de 0 días a 30 días está incorporado en el hidrogel polimérico reticulado por unión covalente mediante enlaces colgantes degradables, y en el que el al menos un fármaco que tiene dicho tercer perfil de liberación de fármaco que corresponde a una liberación de fármaco de 0 días a 180 días está incorporado en el hidrogel polimérico reticulado mediante incorporación en la cadena principal o por unión covalente al polímero reticulado mediante enlaces colgantes no degradables.

8. 发明专利

AU2011265375B2 Crosslinked polymers with the crosslinker as therapeutic for sustained release 未知
公开(公告)号：AU2011265375B2
公开(公告)日：2015-07-02
申请号：AU2011265375
申请日：2011-12-20
申请人： CONFLUENT SURGICAL INC
发明人： OHRI RACHIT , BLASKOVICH PHILIP , KENNEDY JOSHUA , BENNETT STEVEN L , DRISCOLL ARTHUR
IPC分类号： C08J3/24 , A61K47/34 , C08L71/00
摘要： CROSSLINKED POLYMERS WITH THE CROSSLINKER AS THERAPEUTIC FOR SUSTAINED RELEASE Abstract Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form. Amino Acid CvH DCC (10) C 0NIl OH NHS (20) 0 o 0 R, C NI-1 O N (30) 0

9. 发明专利

CA2692917A1 LOW-SWELLING BIOCOMPATIBLE HYDROGELS 未知
公开(公告)号：CA2692917A1
公开(公告)日：2010-09-27
申请号：CA2692917
申请日：2010-02-12
申请人： CONFLUENT SURGICAL INC
发明人： BENNETT STEVEN L
IPC分类号： A61K31/74 , A61K47/34 , A61L27/52 , C08J3/24 , C08L71/02
摘要： Some aspects of the present disclosure relate to methods for treating a tissue by forming a low-swelling biodegradable hydrogel in situ adherent to the tissue. In embodiments the hydrogel exhibits negative swelling, i.e., shrinking. Such treatments may be utilized to in cosmetic or reconstructive surgery, in sphincter augmentation, treating nerve inflammation, and the like.

10. 发明专利

CA2762228C CROSSLINKED POLYMERS WITH THE CROSSLINKER AS THERAPEUTIC FOR SUSTAINED RELEASE 未知
公开(公告)号：CA2762228C
公开(公告)日：2018-08-14
申请号：CA2762228
申请日：2011-12-15
申请人： CONFLUENT SURGICAL INC
发明人： OHRI RACHIT , BLASKOVICH PHILLIP , KENNEDY JOSHUA , BENNETT STEVEN L , DRISCOLL ARTHUR
IPC分类号： C08G65/329 , C08J3/24
摘要： Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.

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