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1. 发明专利

JP2009003449A Extended wear ophthalmic lens 有权
标题翻译：延伸耐磨透镜
公开(公告)号：JP2009003449A
公开(公告)日：2009-01-08
申请号：JP2008152780
申请日：2008-06-11
申请人： Commonwealth Scientific & Industrial Research Organisation , Novartis Ag , コモンウェルスサイエンティフィックアンドインダストリアルリサーチオーガニゼイション , ノバルティスアクチエンゲゼルシャフト
发明人： NICOLSON PAUL CLEMENT , BARON RICHARD CARLTON , CHABRECEK PETER , COURT JOHN , DOMSCHKE ANGELIKA , GRIESSER HANS JOERG , HO ARTHUR , HOEPKEN JENS , LAYCOCK BRONWYN GLENICE , LIU QIN , LOHMANN DIETER , MEIJS GORDON FRANCIS , PAPASPILIOTOPOULOS ERIC , RIFFLE JUDY SMITH , SCHINDHELM KLAUS , SWEENEY DEBORAH , TERRY WILSON LEONARD JR , VOGT JUERGEN , WINTERTON LYNN COOK
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/38 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic lens, which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. SOLUTION: The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种眼用镜片，其适用于眼睛上至少一天的延长磨损期，而没有临床显着量的角膜肿胀并且没有实质的佩戴者不适。解决方案：透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼睛运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含量大分子单体和离子单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010020330A Extended wear ophthalmic lens 审中-公开
标题翻译：延伸耐磨透镜
公开(公告)号：JP2010020330A
公开(公告)日：2010-01-28
申请号：JP2009191836
申请日：2009-08-21
申请人： Commonwealth Scientific & Industrial Research Organisation , Novartis Ag , コモンウェルスサイエンティフィックアンドインダストリアルリサーチオーガニゼイション , ノバルティスアクチエンゲゼルシャフト
发明人： NICOLSON PAUL CLEMENT , BARON RICHARD CARLTON , CHABRECEK PETER , COURT JOHN , DOMSCHKE ANGELIKA , GRIESSER HANS JOERG , HO ARTHUR , HOEPKEN JENS , LAYCOCK BRONWYN GLENICE , LIU QIN , LOHMANN DIETER , MEIJS GORDON FRANCIS , PAPASPILIOTOPOULOS ERIC , RIFFLE JUDY SMITH , SCHINDHELM KLAUS , SWEENEY DEBORAH , TERRY WILSON LEONARD JR , VOGT JUERGEN , WINTERTON LYNN COOK
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F2/48 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/02 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08J7/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要： PROBLEM TO BE SOLVED: To provide an ophthalmic lens, which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. SOLUTION: The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种眼用镜片，其适用于眼睛的至少一天的延长磨损期，而没有临床显着量的角膜肿胀并且没有实质的佩戴者不适。解决方案：透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼睛运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含量大分子单体和离子单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2011141558A Extended wear ophthalmic lens 审中-公开
标题翻译：延伸耐磨透镜
公开(公告)号：JP2011141558A
公开(公告)日：2011-07-21
申请号：JP2011030444
申请日：2011-02-16
申请人： Commonwealth Scientific & Industrial Research Organisation , Novartis Ag , コモンウェルスサイエンティフィックアンドインダストリアルリサーチオーガニゼイション , ノバルティスアーゲー
发明人： NICOLSON PAUL CLEMENT , BARON RICHARD CARLTON , CHABRECEK PETER , COURT JOHN , DOMSCHKE ANGELIKA , GRIESSER HANS JOERG , HO ARTHUR , HOEPKEN JENS , LAYCOCK BRONWYN GLENICE , LIU QIN , LOHMANN DIETER , MEIJS GORDON FRANCIS , PAPASPILIOTOPOULOS ERIC , RIFFLE JUDY SMITH , SCHINDHELM KLAUS , SWEENEY DEBORAH , TERRY WILSON LEONARD JR , VOGT JUERGEN , WINTERTON LYNN COOK
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要： PROBLEM TO BE SOLVED: To provide a material of a contact lens that is sufficient to maintain corneal health and wearer comfort during long term wear.
SOLUTION: An ophthalmic lens has ophthalmically compatible inner and outer surfaces, the lens being suited to extended periods of wear in continuous, intimate contact with ocular tissue and ocular fluids. The lens comprises a polymeric material which has a high oxygen permeability and a high ion permeability. The polymeric material being formed from polymerizable materials comprises: at least one oxyperm polymerizable material and at least one ionoperm polymerizable material.The lens allows oxygen permeation in an amount sufficient to maintain corneal health and wearer comfort during a period of extended, continuous contact with ocular tissue and ocular fluids. The lens allows ion or water permeation in an amount sufficient to enable the lens to move on the eye such that corneal health is not substantially harmed and wearer comfort is acceptable during a period of extended, continuous contact with ocular tissue and ocular fluids.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供足以在长期磨损期间保持角膜健康和佩戴者舒适度的隐形眼镜的材料。解决方案：眼科镜片具有眼科学兼容的内表面和外表面，该镜片适合于与眼组织和眼液连续紧密接触的延长的磨损期。透镜包括具有高透氧性和高离子渗透性的聚合材料。由可聚合材料形成的聚合物材料包括：至少一种可熔融聚合材料和至少一种离子聚合材料。透镜允许氧气渗透量足以在与眼睛延伸，持续接触的时间段内保持角膜健康和佩戴者的舒适度组织和眼液。透镜允许离子或水渗透的量足以使透镜在眼睛上移动，使得角膜健康基本上不受伤害，并且佩戴者的舒适度在与眼组织和眼液的延长，持续接触的时期内是可接受的。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2003062059A Multilayered material 审中-公开
标题翻译：多层材料
公开(公告)号：JP2003062059A
公开(公告)日：2003-03-04
申请号：JP2002196950
申请日：2002-07-05
申请人： Commonwealth Scientific & Industrial Research Organization , Novartis Ag , コモンウェルスサイエンティフィックアンドインダストリアルリサーチオーガニゼーション , ノバルティスアクチエンゲゼルシャフト
发明人： CHATELIER RONALD CHRISTOPHER , DAI LIMING , GRIESSER HANS JOERG , LI SHENG , ZIENTEK PAUL , LOHMANN DIETER , CHABRECEK PETER
IPC分类号： A61L27/00 , A61L27/34 , C08L101/16 , G02B1/04 , G02C7/04
CPC分类号： G02B1/043 , A61L27/34 , C08L5/00
摘要： PROBLEM TO BE SOLVED: To provide a compound material for biomedical uses in which preservation of an aqueous layer is considerably improved and a method for producing a composite material from a material which has an adequate bulk property, but is not fit to keep an aqueous layer.
SOLUTION: This compound material constituted of a bulk material with one or more of wetting surface on which lasting layers of aqueous fluid are kept and a hydrophilic covering is especially used for a biomedical appliance, for example, an ophthalmological appliance and is suitable for contact lens. The hydrophilic covering is comprised of carbohydrates covalently bonding to a reacting group on the surface of the bulk material directly or through oligo-functional compound and the oligo-functional compound has functional group which react with the reacting group and the carbohydrate on the surface of the bulk material. It is characterized that the reacting group exist innately in the bulk material or bond to the surface of the bulk material by preparing the surface by plasma.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供一种用于生物医学用途的复合材料，其中水层的保存得到显着改善，以及由具有足够体积性但不适于保持水层的材料制备复合材料的方法。解决方案：这种复合材料由具有一个或多个润湿表面的水性流体的保持层和一个亲水性覆盖物构成的复合材料特别用于生物医学器具，例如眼科器具，并且适用于隐形眼镜。亲水性覆盖物由直接或通过低分子官能化合物共价结合到反应基团上的反应基团的碳水化合物组成，低官能化合物具有与反应基团和碳水化合物在表面上反应的官能团散装材料。其特征在于，通过用等离子体制备表面，反应基团本身存在于本体材料中或结合到本体材料的表面。

5. 发明专利

JP2000351862A NEUTRAL COATING FILM 失效
公开(公告)号：JP2000351862A
公开(公告)日：2000-12-19
申请号：JP2000119180
申请日：2000-04-20
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG
发明人： GRIESSER HANS JOERG , KINGSHOTT PETER
IPC分类号： G02C7/04 , C08J3/28 , C08J7/04
摘要： PROBLEM TO BE SOLVED: To obtain a composite material which has a wettable surface significantly made hardly susceptible to protein adsorption (staining) by forming, on the surface of a bulk material, a hydrophilic coating film which is covalently bonded to reactive groups on the surface and has pH-sensitive wettability- imparting groups partly modified with a neutralizing agent. SOLUTION: The composite material comprises a bulk material and a hydrophilic coating film. The film is covalently bonded, directly or indirectly through functional groups of an oligo-functional organic binding agent, to reactive groups on the surface of the bulk material and has many pH-sensitive wettability-imparting groups selected from among COOH, NH2, and SO3H groups, the pH-sensitive groups having been partly modified with a neutralizing agent selected from among organic acids and organic bases. Preferably, the reactive groups originally exist on the surface of the bulk material or are attached thereto by a plasma treatment. Preferably, the hydrophilic coating film is based on a polysaccharide or a (meth)acrylic acid (co)polymer.

6. 发明申请

WO0216974A3 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 审中-公开
标题翻译：表面修饰基板及其改性基板的工艺
公开(公告)号：WO0216974A3
公开(公告)日：2002-07-18
申请号：PCT/EP0109712
申请日：2001-08-22
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , COMMW SCIENT IND RES ORG , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯键式不饱和双键的双官能化合物共价结合到粘结层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

7. 发明申请

WO0029548A3 COUPLED PEPTIDES 审中-公开
标题翻译：偶联肽
公开(公告)号：WO0029548A3
公开(公告)日：2000-07-27
申请号：PCT/EP9908725
申请日：1999-11-12
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , COMMW SCIENT IND RES ORG , BEUMER GERRIT JAN , CHATELIER RONALD CHRISTOPHER , GRIESSER HANS JOERG , JOHNSON GRAHAM , MCLEAN KEITH MICHAEL
发明人： BEUMER GERRIT JAN , CHATELIER RONALD CHRISTOPHER , GRIESSER HANS JOERG , JOHNSON GRAHAM , MCLEAN KEITH MICHAEL
IPC分类号： C12N5/02 , A61L27/00 , C07K17/00 , C07K17/08 , C08G2/12 , C12N5/00
CPC分类号： C07K17/08 , C08G2/12 , C12N5/0068 , C12N2533/54
摘要： The present invention is directed to a process for coupling an adhesive glycoprotein to a surface of a bulk material comprising the following steps: a) a layer of a volatile aldehyde is deposited to the surface of the bulk material from a gas plasma atmosphere, b) the layer so formed on the bulk material is contacted with a cell-adhesive glycoprotein having amino groups, c) the coupling of the amino groups of the glycoprotein to the carbonyl groups of the deposited aldehyde layer is strenghthened by transforming the primarily formed -CH=N- bonds in the presence of a reducing agent into -CH2-NH-bonds; and to a cell growth material comprising a bulk material having at least one surface to which a cell adhesive glycoprotein having amino groups is coupled characterized in that said amino groups are covalently bonded to aldehyde groups of a layer of a volatile aldehyde, deposited to the surface of said bulk material from a gas plasma atmosphere, via first formed -CH=N- groups which have been transformed into -CH2-NH- groups in the presence of a reducing agent.
摘要翻译：本发明涉及一种将粘性糖蛋白与散装材料表面偶联的方法，包括以下步骤：a）从气体等离子体气氛中将一层挥发性醛沉积到散装材料的表面上，b）在大块材料上如此形成的层与具有氨基的细胞粘附糖蛋白接触，c）将糖蛋白的氨基与沉积的醛层的羰基的偶联通过转化初级形成的-CH = N-键在还原剂存在下形成-CH 2 -NH-键; 并且涉及包含具有至少一个表面的本体材料的细胞生长材料，具有氨基的细胞粘附性糖蛋白偶联到所述表面上，其特征在于所述氨基共价键合至沉积至表面的挥发性醛层的醛基通过在还原剂存在下已经转化成-CH 2 -NH-基团的第一次形成的-CH = N-基团从气体等离子体气氛中除去所述大块材料。

8. 发明申请

WO0216974A8 PROCESS FOR SURFACE MODIFYING SUBSTRATES AND MODIFIED SUBSTRATES RESULTING THEREFROM 审中-公开
标题翻译：表面修饰基板和改性基板的工艺
公开(公告)号：WO0216974A8
公开(公告)日：2004-04-08
申请号：PCT/EP0109712
申请日：2001-08-22
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , COMMW SCIENT IND RES ORG , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
发明人： QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN , CHABRECEK PETER , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER
IPC分类号： G02C7/04 , A61L27/34 , C08J7/04 , C08J7/16 , G02B1/04 , G02B1/14 , G02B1/10
CPC分类号： C08J7/16 , A61L27/34 , G02B1/043 , Y10T428/31511 , Y10T428/31663 , Y10T428/31667 , Y10T428/31909 , Y10T428/31928
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) applying to the material surface a tie layer comprising a polyionic material; (b) covalently binding a bifunctional compound comprising an ethylenically unsaturated double bond to the tie layer; and (c) graft polymerizing a hydrophilic monomer onto the compound comprising the ethylenically unsaturated double bond. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：本发明涉及一种涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加包含聚离子材料的粘结层; （b）将包含烯键式不饱和双键的双官能化合物共价结合到连接层上; 和（c）将亲水性单体接枝聚合到包含烯属不饱和双键的化合物上。通过本发明的方法可获得的涂覆制品具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的所需特性，因此可用于制造生物医学制品如眼科装置。

9. 发明申请

WO0130512A3 COATING PROCESS 审中-公开
标题翻译：涂层工艺
公开(公告)号：WO0130512A3
公开(公告)日：2001-12-27
申请号：PCT/EP0010529
申请日：2000-10-25
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG , PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER , CHABRECEK PETER
发明人： PASIC PAUL , GRIESSER HANS JOERG , KAMBOURIS PETER , CHABRECEK PETER
IPC分类号： G02C7/04 , A61L27/34 , B05D1/18 , B05D7/00 , C08J7/16 , C09D151/06 , G02B1/04 , G02B1/10
CPC分类号： B82Y30/00 , A61L27/34 , B05D1/185 , B05D7/00 , B82Y40/00 , C08J7/16 , G02B1/043
摘要： The invention relates to a process for coating a material surface, comprising the steps of: (a) covalently binding a compound comprising an ethylenically unsaturated double bond to the material surface; (b) polymerizing a monomer comprising a reactive or crosslinkable group on the surface and thereby providing a primary polymer coating comprising reactive or crosslinkable groups; (c) in case of a monomer comprising a reactive group in step (b) reacting the reactive groups of the primary coating with a further compound comprising an ethylenically unsaturated double bond and graft-polymerizing a hydrophilic monomer and optionally a co-monomer having a crosslinkable group onto the primary coating obtained according to step (b) and;(d) in case of crosslinkable groups being present in step (b) or (c) initiating crosslinking of said groups. The coated articles that are obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
摘要翻译：该方法包括以下步骤：（a）将包含烯属不饱和双键的化合物共价结合到材料表面; （b）在表面上聚合包含反应性或可交联基团的单体，从而提供包含反应性或可交联基团的初级聚合物涂层; （c）在步骤（b）中包含反应性基团的单体的情况下，使底涂层的反应性基团与另一种包含烯键式不饱和双键的化合物反应并接枝聚合亲水单体和任选的共聚单体，所述共聚单体具有（b）和（d）在步骤（b）或（c）中存在可交联基团的情况下，引发所述基团的交联。可通过本发明的方法获得的涂覆制品具有关于与基材的粘合性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此可用于制造生物医学制品如眼科装置。

10. 发明申请

WO9852620A3 COLLAGEN-LIKE POLYMERS WITH CELL BINDING ACTIVITY 审中-公开
标题翻译：具有细胞结合活性的胶原样聚合物
公开(公告)号：WO9852620A3
公开(公告)日：1999-02-25
申请号：PCT/EP9802857
申请日：1998-05-14
申请人： NOVARTIS AG , COMMW SCIENT IND RES ORG , STEELE JOHN GERARD , JOHNSON GRAHAM , GOODMAN MURRAY , GRIESSER HANS JOERG , MCLEAN KEITH MICHAEL , BEUMER GERRIT JAN
发明人： STEELE JOHN GERARD , JOHNSON GRAHAM , GOODMAN MURRAY , GRIESSER HANS JOERG , MCLEAN KEITH MICHAEL , BEUMER GERRIT JAN
IPC分类号： G01N33/544 , A61L27/00 , A61L27/22 , A61L27/34 , A61L31/04 , A61L31/10 , C12N5/06 , A61L
CPC分类号： A61L27/34 , A61L27/227 , A61L31/047 , A61L31/10 , C08L89/06 , C08L77/04
摘要： The invention is essentially directed to a biocompatible material comprising a bulk material which has covalently bound to a surface or surfaces thereof one or more biopolymer compounds, said biopolymer compounds comprising at least one peptoid residue. The biopolymer compounds are most preferably polymer compounds comprising the sequence of the formula (I): -(Gly-Pro-Nleu)(Y)-, wherein (y) denotes ≥9. Also disclosed is a method of binding biopolymer compounds to a bulk material, which biopolymer compounds comprise at least one peptoid residue, as well as primary amine groups, the method comprising the steps of: (a) providing aldehyde or carboxyl groups on a surface or surfaces of said bulk material; (b) reacting said primary amine groups with aldehyde or carboxyl groups to form covalent bonds.

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