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1. 发明授权

US07750128B2 Modified Fc molecules 有权
公开(公告)号：US07750128B2
公开(公告)日：2010-07-06
申请号：US12221417
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

2. 发明授权

US07662931B2 Modified Fc molecules 有权
公开(公告)号：US07662931B2
公开(公告)日：2010-02-16
申请号：US12221418
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

3. 发明授权

US07655765B2 Modified Fc molecules 有权
标题翻译：修饰的Fc分子
公开(公告)号：US07655765B2
公开(公告)日：2010-02-02
申请号：US12221421
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.
摘要翻译：本发明涉及物质的组合物，例如但不限于经修饰的抗体，其中一种或多种生物活性肽掺入到免疫球蛋白Fc结构域的非末端结构域的环区中。

4. 发明授权

US07442778B2 Modified Fc molecules 有权
标题翻译：修饰的Fc分子
公开(公告)号：US07442778B2
公开(公告)日：2008-10-28
申请号：US11234731
申请日：2005-09-23
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , C07H21/02
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns molecules and a process in which one or more biologically active peptides are incorporated into an Fc domain. In this invention, pharmacologically active compounds may be prepared by a process comprising (a) selecting at least one peptide that modulates the activity of a protein of interest; and (b) preparing a pharmacologic agent comprising an amino acid sequence of the selected peptide in a loop region of an Fc domain. This process may be employed to modify an Fc domain that is already linked through an N- or C-terminus or sidechain to a peptide or to a polypeptide (e.g., etanercept). This process may also be employed to modify an Fc domain that is part of an antibody (e.g., adalimumab, epratuzumab, infliximab, Herceptin®, and the like). In this way, different molecules can be produced that have additional functionalities, such as a binding domain to a different epitope or an additional binding domain to the precursor molecule's existing epitope. The peptide can be selected, for example, by phage display, E. coli display, ribosome display, RNA-peptide screening, yeast-based screening, chemical-peptide screening, rational design, or protein structural analysis.
摘要翻译：本发明涉及分子和一种或多种生物活性肽并入Fc结构域的方法。在本发明中，药理学活性化合物可以通过以下方法制备：（a）选择至少一种调节目的蛋白质活性的肽; 和（b）在Fc结构域的环区中制备包含所选肽的氨基酸序列的药理学试剂。该方法可以用于修饰已经通过N-或C-末端或侧链连接到肽或多肽（例如依那西普）的Fc结构域。该方法也可用于修饰作为抗体一部分的Fc结构域（例如阿达木单抗，依普珠单抗，英夫利昔单抗，赫赛汀等）。以这种方式，可以产生具有额外功能的不同分子，例如与不同表位的结合结构域或与前体分子存在的表位的附加结合结构域。肽可以例如通过噬菌体展示，大肠杆菌展示，核糖体展示，RNA-肽筛选，酵母筛选，化学肽筛选，合理设计或蛋白质结构分析来选择。

5. 发明申请

US20090041768A1 Modified Fc molecules 有权
公开(公告)号：US20090041768A1
公开(公告)日：2009-02-12
申请号：US12221414
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： A61K39/395 , C07K16/46 , A61P3/10
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

6. 发明申请

US20090022744A1 Modified Fc molecules 有权
公开(公告)号：US20090022744A1
公开(公告)日：2009-01-22
申请号：US12221412
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

7. 发明授权

US07750127B2 Modified Fc molecules 有权
公开(公告)号：US07750127B2
公开(公告)日：2010-07-06
申请号：US12221413
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

8. 发明授权

US07655764B2 Modified Fc molecules 有权
公开(公告)号：US07655764B2
公开(公告)日：2010-02-02
申请号：US12221412
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

9. 发明申请

US20090286964A1 Modified Fc molecules 有权
标题翻译：修饰的Fc分子
公开(公告)号：US20090286964A1
公开(公告)日：2009-11-19
申请号：US12221417
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K19/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.
摘要翻译：本发明涉及物质的组合物，例如但不限于经修饰的抗体，其中一种或多种生物活性肽掺入到免疫球蛋白Fc结构域的非末端结构域的环区中。

10. 发明授权

US07645861B2 Modified Fc molecules 有权
公开(公告)号：US07645861B2
公开(公告)日：2010-01-12
申请号：US12221414
申请日：2008-08-01
申请人： Colin Gegg , Fei Xiong , Karen C. Sitney
发明人： Colin Gegg , Fei Xiong , Karen C. Sitney
IPC分类号： C07K16/00 , A61K38/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2318/10 , C07K2319/30
摘要： The present invention concerns compositions of matter, for example, but not limited to, modified antibodies, in which one or more biologically active peptides are incorporated into a loop region of a non-terminal domain of an immunoglobulin Fc domain.

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