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1. 发明授权

US07547292B2 Needleless syringe 有权
标题翻译：无针注射器
公开(公告)号：US07547292B2
公开(公告)日：2009-06-16
申请号：US10466076
申请日：2002-01-11
申请人： Colin David Sheldrake , George Costigan , Brian John Bellhouse
发明人： Colin David Sheldrake , George Costigan , Brian John Bellhouse
IPC分类号： A61M5/30
CPC分类号： A61M5/3015 , A61M5/2053 , A61M5/3007 , A61M2005/005
摘要： A method of distributing particles in a flow of gas and a needleless syringe for use in the needleless injection of particles into the skin or mucosa of a vertebrate subject are disclosed. The syringe includes a convergence which reduces pressure of the gas flowing in the gas flow path due to the Venturi effect such that particles initially located outside of the gas flow path are drawn into the gas flow path under the action of the reduced pressure and become entrained in the gas. An exit nozzle accelerates the particles so entrained. In another aspect of the invention, there is provided a method of creating a gas flow in a needleless syringe which comprises flowing gas through a first convergence into a chamber to form a transsonic gas jet in the chamber and passing the gas jet from the chamber into a second convergence and along the nozzle.
摘要翻译：公开了一种在气体和无针注射器中分配颗粒的方法，用于无脊椎动物注射到脊椎动物对象的皮肤或粘膜中。注射器包括会聚，其减少由于文丘里效应而在气体流动路径中流动的气体的压力，使得最初位于气体流动路径外部的颗粒在减压作用下被吸入气体流动路径并被夹带在气中。出口喷嘴加速如此夹带的颗粒。在本发明的另一方面，提供了一种在无针注射器中产生气流的方法，该方法包括将气体通过第一会聚流入腔室中，以在腔室中形成经络气体射流，并将气体射流从腔室送入沿着喷嘴的第二个会聚。

2. 发明授权

US11052204B2 Intranasal administration 有权
公开(公告)号：US11052204B2
公开(公告)日：2021-07-06
申请号：US14946389
申请日：2015-11-19
申请人： Per Gisle Djupesland , Ramy A. Mahmoud , Ole A Andreassen , Lars T. Westlye , Daniel S. Quintana , Knut T. Smerud , Colin David Sheldrake
发明人： Per Gisle Djupesland , Ramy A. Mahmoud , Ole A Andreassen , Lars T. Westlye , Daniel S. Quintana , Knut T. Smerud , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M15/00 , A61K38/22 , A61K38/28 , A61K38/095 , A61K9/00 , A61K38/08 , A61M29/00 , A61M11/00 , A61M31/00
摘要： A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.

3. 发明申请

US20160310683A1 Intranasal Administration 审中-公开
标题翻译：鼻内管理
公开(公告)号：US20160310683A1
公开(公告)日：2016-10-27
申请号：US14946389
申请日：2015-11-19
申请人： Per Gisle Djupesland , Ramy A. Mahmoud , Ole A Andreassen , Lars T. Westlye , Daniel S. Quintana , Knut T. Smerud , Colin David Sheldrake
发明人： Per Gisle Djupesland , Ramy A. Mahmoud , Ole A Andreassen , Lars T. Westlye , Daniel S. Quintana , Knut T. Smerud , Colin David Sheldrake
IPC分类号： A61M15/00 , A61K9/00 , A61K38/08 , A61M15/08 , A61M29/00
CPC分类号： A61M15/08 , A61K9/0043 , A61K38/08 , A61K38/095 , A61K38/22 , A61K38/28 , A61M11/00 , A61M15/0013 , A61M15/0021 , A61M15/009 , A61M15/0098 , A61M29/00 , A61M31/00 , A61M2202/04 , A61M2202/064 , A61M2210/0618
摘要： A delivery device for and method of modulating a condition relating to sodal cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.
摘要翻译：使用催产素，其非肽激动剂和/或其拮抗剂调节与人类受试者相关的Sodal认知和/或行为状况的递送装置和方法，包括：向受试者的第一鼻腔提供鼻梁; 并且提供供应单元，其通过鼻梁将小于24IU的催产素，其非肽激动剂和/或其拮抗剂施用于由三叉神经支配的鼻塞后部的上部区域。

4. 发明授权

US08590530B2 Nasal delivery devices 有权
标题翻译：鼻输送装置
公开(公告)号：US08590530B2
公开(公告)日：2013-11-26
申请号：US13471146
申请日：2012-05-14
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M11/00
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置。

5. 发明申请

US20130098362A1 Nasal Delivery Devices 有权
标题翻译：鼻输送装置
公开(公告)号：US20130098362A1
公开(公告)日：2013-04-25
申请号：US13471146
申请日：2012-05-14
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M15/00
CPC分类号： A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置。

6. 发明授权

US09010325B2 Nasal delivery devices 有权
标题翻译：鼻输送装置
公开(公告)号：US09010325B2
公开(公告)日：2015-04-21
申请号：US12516404
申请日：2007-11-28
申请人： Per Gisle Djupesland , Colin David Sheldrake , Simon Smith , Rachel Striebig , Andy Pidgeon , Tom St. Quintin
发明人： Per Gisle Djupesland , Colin David Sheldrake , Simon Smith , Rachel Striebig , Andy Pidgeon , Tom St. Quintin
IPC分类号： A61M15/08 , A62B7/00 , B65D83/06 , A61M15/00 , A61M16/10
CPC分类号： A61M15/08 , A61M15/0018 , A61M15/0021 , A61M15/0026 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0043 , A61M15/0081 , A61M15/0098 , A61M16/1045 , A61M2202/064 , A61M2205/0222 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly (3) including a mouthpiece unit (9) which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit (5) which includes a nosepiece and contains a container containing particulate substance.
摘要翻译：一种用于将颗粒物质递送到受试者的鼻气道的鼻输送装置和方法，所述输送装置包括：主体组件（3），其包括接口单元（9），所述接口单元包括用于使用呼气的受试者的接口管，以及物质供应单元，其流体地连接到所述接口单元并且可致动以提供用于递送到所述对象的鼻气道的颗粒物质; 其特征在于，所述主体部件构造为容纳包含喷嘴的可更换喷嘴单元（5），并且容纳含有微粒物质的容器。

7. 发明授权

US08899229B2 Powder delivery devices 有权
标题翻译：送粉装置
公开(公告)号：US08899229B2
公开(公告)日：2014-12-02
申请号：US11816984
申请日：2006-02-23
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M15/00 , A61M16/12 , A61M16/10 , A61M16/00
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0086 , A61M15/0098 , A61M16/0066 , A61M16/105 , A61M16/1075 , A61M16/127 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/07 , A61M2205/076 , A61M2205/3606 , A61M2205/3673 , A61M2205/8218 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
摘要翻译：一种用于将物质输送到受试者的鼻腔的鼻输送装置，所述输送装置包括：物质供应单元，用于将待递送到物体的剂量的物质供应到受试者的鼻腔，所述物质供应单元包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与物质供应单元的出口流体连通的鼻梁; 以及接口单元，其包括与所述物质供应单元的入口流体连通的接口管，并且使用中的被检体呼气，从而将容器从容器室中夹带并将其输送通过喷嘴，以及至少一个用于降低呼出气流的温度，以降低其绝对湿度。

8. 发明申请

US20090293873A1 POWDER DELIVERY DEVICES 有权
标题翻译：粉末递送装置
公开(公告)号：US20090293873A1
公开(公告)日：2009-12-03
申请号：US11816984
申请日：2006-02-23
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0086 , A61M15/0098 , A61M16/0066 , A61M16/105 , A61M16/1075 , A61M16/127 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/07 , A61M2205/076 , A61M2205/3606 , A61M2205/3673 , A61M2205/8218 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, she substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
摘要翻译：一种用于将物质输送到受试者的鼻腔的鼻输送装置，所述输送装置包括：物质供应单元，用于将待递送到物体的剂量的剂量提供给受试者的鼻腔，所述物质供应单元包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与物质供应单元的出口流体连通的鼻梁; 以及接口单元，其包括与所述物质供应单元的入口流体连通的接口管，并且使用中的被检体呼气，从而将容器从容器室中夹带并将其输送通过喷嘴，以及至少一个用于降低呼出气流的温度，以降低其绝对湿度。

9. 发明申请

US20080289629A1 Nasal Delivery Devices 审中-公开
标题翻译：鼻输送装置
公开(公告)号：US20080289629A1
公开(公告)日：2008-11-27
申请号：US11663099
申请日：2005-09-15
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08
CPC分类号： A61M15/002 , A61M15/0008 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置，该装置例如通过将容器设置在可更换容器的构件中，通过压敏阀其通常关闭容器室和接口之间的流体连接，以及容器室上游的温度调节器。

10. 发明申请

US20160331916A1 Intranasal Administration 审中-公开
标题翻译：鼻内管理
公开(公告)号：US20160331916A1
公开(公告)日：2016-11-17
申请号：US14946442
申请日：2015-11-19
申请人： Per Gisle Djupesland , Colin David Sheldrake
发明人： Per Gisle Djupesland , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M11/00 , A61M15/00 , A61M31/00 , A61M29/00
CPC分类号： A61M15/08 , A61K9/0043 , A61K38/08 , A61K38/095 , A61K38/22 , A61K38/28 , A61M11/00 , A61M15/0013 , A61M15/0021 , A61M15/009 , A61M15/0098 , A61M29/00 , A61M31/00 , A61M2202/04 , A61M2202/064 , A61M2210/0618
摘要： A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.
摘要翻译：一种用于将物质输送到受试者的鼻腔的鼻梁，所述鼻梁包括主体部分，所述主体部分包括限定通过其的流动通道的基部，以及在所述基部的远端处的突起，其至少部分地提供尖端并赋予矢状方向的刚性，这使得尖端能够在鼻阀的上部区域打开肉质组织，从而扩大鼻阀的开放区域，并且在横向方向上的柔性在垂直于鼻腔矢状面，其有利于将尖端插入到鼻阀中。

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