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1. 发明授权

US08556921B2 Method of using an aortic dissection septal cutting tool 有权
标题翻译：使用主动脉夹层隔膜切割工具的方法
公开(公告)号：US08556921B2
公开(公告)日：2013-10-15
申请号：US12944623
申请日：2010-11-11
申请人： Cody L. Bliss , Edward H. Cully , Michael D. Dake , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdish Patel , David M. Williams , William P. Witort
发明人： Cody L. Bliss , Edward H. Cully , Michael D. Dake , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdish Patel , David M. Williams , William P. Witort
IPC分类号： A61B17/22
CPC分类号： A61B18/18 , A61B17/320016 , A61B17/3201 , A61B17/32075 , A61B18/1492 , A61B2017/00778 , A61B2017/22052 , A61B2017/22069
摘要： The present invention relates to methods of using medical cutting tools for treating aortic septal dissections.
摘要翻译：本发明涉及使用医疗切割工具治疗主动脉间隔解剖的方法。

2. 发明申请

US20110144672A1 METHOD OF USING AN AORTIC DISSECTION SEPTAL CUTTING TOOL 有权
标题翻译：使用离子切割的方法切割工具
公开(公告)号：US20110144672A1
公开(公告)日：2011-06-16
申请号：US12944623
申请日：2010-11-11
申请人： Cody L. Bliss , Edward H. Cully , Michael D. Dake , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdis Patel , David M. Williams , William P. Witort
发明人： Cody L. Bliss , Edward H. Cully , Michael D. Dake , Joel M. Greene , Joshua J. Lovekamp , Michael C. Nilson , Himanshu Jagdis Patel , David M. Williams , William P. Witort
IPC分类号： A61B17/22
CPC分类号： A61B18/18 , A61B17/320016 , A61B17/3201 , A61B17/32075 , A61B18/1492 , A61B2017/00778 , A61B2017/22052 , A61B2017/22069
摘要： The present invention relates to methods of using medical cutting tools for treating aortic septal dissections.
摘要翻译：本发明涉及使用医疗切割工具治疗主动脉间隔解剖的方法。

3. 发明授权

US09314328B2 Branched stent graft device and deployment 有权
标题翻译：支架移植装置和部署
公开(公告)号：US09314328B2
公开(公告)日：2016-04-19
申请号：US13584650
申请日：2012-08-13
申请人： Michael D. Dake , Joshua J. Lovekamp , Michael C. Nilson , Edward E. Shaw
发明人： Michael D. Dake , Joshua J. Lovekamp , Michael C. Nilson , Edward E. Shaw
IPC分类号： A61F2/07 , A61F2/954 , A61F2/06 , A61F2/90
CPC分类号： A61F2/07 , A61F2/844 , A61F2/90 , A61F2/954 , A61F2002/061 , A61F2002/065 , A61F2002/067 , F04C2270/0421
摘要： A device for treating disease along a main vessel and at least one branch vessel extending from the main vessel includes a branch member for deployment in the branch vessel, the branch member having a branch lumen; and a main body for deployment in the main vessel. The main body has a generally tubular wall extending generally longitudinally between opposite first and second ends. The wall has an internal surface defining a main lumen and an opposite outer surface. The wall has a recessed portion that is recessed relative to the outer surface of the wall and positioned between the first and second ends of the main body. The main body has an opening formed in the recessed portion of the wall for receiving the branch member therethrough such that the branch lumen is in fluid communication with the main lumen.
摘要翻译：用于沿着主容器处理疾病的装置和从主容器延伸的至少一个分支容器包括用于展开在分支容器中的分支构件，该分支构件具有分支内腔; 以及用于在主船舶中部署的主体。主体具有在相对的第一和第二端之间大致纵向延伸的大致管状壁。壁具有限定主腔和相对外表面的内表面。壁具有相对于壁的外表面凹入并位于主体的第一和第二端之间的凹部。主体具有形成在壁的凹部中的开口，用于接收分支构件，使得分支腔与主腔流体连通。

4. 发明申请

US20130211506A1 BRANCHED STENT GRAFT DEVICE AND DEPLOYMENT 有权
标题翻译：分支支架装置和部署
公开(公告)号：US20130211506A1
公开(公告)日：2013-08-15
申请号：US13584650
申请日：2012-08-13
申请人： Michael D. Dake , Joshua J. Lovekamp , Michael C. Nilson , Edward E. Shaw
发明人： Michael D. Dake , Joshua J. Lovekamp , Michael C. Nilson , Edward E. Shaw
IPC分类号： A61F2/07 , A61F2/954
CPC分类号： A61F2/07 , A61F2/844 , A61F2/90 , A61F2/954 , A61F2002/061 , A61F2002/065 , A61F2002/067 , F04C2270/0421
摘要： A device for treating disease along a main vessel and at least one branch vessel extending from the main vessel includes a branch member for deployment in the branch vessel, the branch member having a branch lumen; and a main body for deployment in the main vessel. The main body has a generally tubular wall extending generally longitudinally between opposite first and second ends. The wall has an internal surface defining a main lumen and an opposite outer surface. The wall has a recessed portion that is recessed relative to the outer surface of the wall and positioned between the first and second ends of the main body. The main body has an opening formed in the recessed portion of the wall for receiving the branch member therethrough such that the branch lumen is in fluid communication with the main lumen.
摘要翻译：用于沿着主容器处理疾病的装置和从主容器延伸的至少一个分支容器包括用于展开在分支容器中的分支构件，该分支构件具有分支内腔; 以及用于在主船舶中部署的主体。主体具有在相对的第一和第二端之间大致纵向延伸的大致管状壁。壁具有限定主腔和相对外表面的内表面。壁具有相对于壁的外表面凹入并位于主体的第一和第二端之间的凹部。主体具有形成在壁的凹部中的开口，用于接收分支构件，使得分支腔与主腔流体连通。

5. 发明授权

US08962548B2 Multi-component biological transport systems 有权
公开(公告)号：US08962548B2
公开(公告)日：2015-02-24
申请号：US10591485
申请日：2005-03-03
申请人： Jacob M. Waugh , Michael D. Dake
发明人： Jacob M. Waugh , Michael D. Dake
IPC分类号： A61K49/14 , A61K47/48 , A61K9/00 , A61K47/34 , A61K49/00 , A61K49/12 , B82Y5/00 , A61K38/00
摘要： Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, including nucleic acids and therapeutic proteins including insulin, larger therapeutic proteins such as botulinum toxin and other biologically active agents such as a therapeutic protein which does not therapeutically alter blood glucose levels, a therapeutic nucleic acid-based agent, a non-protein non-nucleic acid therapeutic agent such as an antifungal agent or alternately an agent for immunization. The compositions can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

6. 发明授权

US08022179B2 Compositions and methods for topical application and transdermal delivery of an oligopeptide 有权
标题翻译：用于局部应用和透皮递送寡肽的组合物和方法
公开(公告)号：US08022179B2
公开(公告)日：2011-09-20
申请号：US11368198
申请日：2006-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K38/08 , A61K38/10 , A61K31/74 , A61K39/08 , C07K4/00
CPC分类号： A61K9/7023 , A61K8/64 , A61K38/08 , A61Q7/00 , A61Q15/00 , C07K14/33
摘要： The invention relates to the transdermal application of oligopeptides for reducing synaptic transmission in tissues of an animal. In one aspect, this invention relates to compositions comprising an oligopeptide and optionally a carrier comprising a positively charged “backbone” having positively charged branching or “efficiency” groups, as described herein. Most preferably the positively charged carrier is a long-chain positively charged polypeptide or a positively charged nonpeptidyl polymer, for example, a polyalkyleneimine. The invention further relates methods for producing a biologic effect of reducing synaptic transmission in a tissue by topically applying an effective amount of such a composition, preferably to the skin, of a subject or patient in need of such treatment. This invention also provides kits for preparing or formulating a composition that comprises the oligopeptide and optionally a carrier, as well as such additional items that are needed to produce a usable formulation, or a premix that may in turn be used to produce such a formulation.
摘要翻译：本发明涉及用于减少动物组织中突触传递的寡肽的透皮应用。一方面，本发明涉及包含寡肽和任选的载体的组合物，其包含具有带正电荷的支化或“效率”基团的带正电荷的“骨架”，如本文所述。最优选地，带正电荷的载体是长链带正电荷的多肽或带正电荷的非肽基聚合物，例如聚亚烷基亚胺。本发明还涉及用于通过局部施用有效量的这种组合物，优选给予需要这种治疗的受试者或患者的皮肤来产生减少组织中突触传递的生物学效应的方法。本发明还提供用于制备或配制包含寡肽和任选的载体的组合物的试剂盒，以及产生可用制剂所需的其它物质，或可以依次用于制备这种制剂的预混物。

7. 发明授权

US06302906B1 System for delivering a prosthesis 有权
标题翻译：用于输送假体的系统
公开(公告)号：US06302906B1
公开(公告)日：2001-10-16
申请号：US09313593
申请日：1999-05-18
申请人： George Goicoechea , Claude Mialhe , John Hudson , Andrew H. Cragg , Michael D. Dake
发明人： George Goicoechea , Claude Mialhe , John Hudson , Andrew H. Cragg , Michael D. Dake
IPC分类号： A61F200
CPC分类号： A61F2/852 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2002/8486 , A61F2210/0019 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2240/001 , A61F2250/0098 , A61M25/0662 , Y10S623/903 , Y10T29/49826
摘要： An introducer for delivering into the vasculature a straight or bifurcated stent or prosthesis; a method for delivering into the vasculature a straight or bifurcated stent or prosthesis; a method of treating and angeological disease using a bifurcated stent; an endoluminal stent having perpendicular hoop members, each hoop member formed of wire in a sinuous configuration, at least some of juxtaposed apices in neighboring hoops being secured to one another, such stents also forming axially aligned segments in straight stents, and segments of bifurcated stents in particular embodiments. Certain embodiments of such stents also include barbs, fabric covering and radiopaque markers.
摘要翻译：用于将脉管系统输送到直立或分叉的支架或假体的导引器; 将血管系统输送到直立或分叉的支架或假体的方法; 使用分叉支架治疗和发病的方法; 具有垂直环箍构件的腔内支架，每个环形构件由线形成为弯曲构型，相邻箍中的至少一些并置的顶点彼此固定，这种支架还在直立支架中形成轴向对齐的区段，以及分叉支架的段在特定实施例中。这种支架的某些实施例还包括倒钩，织物覆盖和不透射线的标记。

8. 发明授权

US5693083A Thoracic graft and delivery catheter 失效
标题翻译：胸腔移植和输送导管
公开(公告)号：US5693083A
公开(公告)日：1997-12-02
申请号：US358067
申请日：1994-12-15
申请人： Steve G. Baker , Michael D. Dake , David C. Dillow , Arnold Escano
发明人： Steve G. Baker , Michael D. Dake , David C. Dillow , Arnold Escano
IPC分类号： A61B17/11 , A61F2/00 , A61F2/04 , A61F2/82 , A61F2/06
CPC分类号： A61F2/07 , A61B17/11 , A61F2/04 , A61F2/82 , A61F2/95 , A61F2/958 , A61F2/966 , A61M25/10 , A61F2/848 , A61F2/89 , A61F2002/075 , A61F2002/3008 , A61F2002/30451 , A61F2002/8486 , A61F2002/9511 , A61F2002/9517 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2250/0098 , A61M2025/1068
摘要： A delivery catheter having an inner catheter assembly, an inferior capsule catheter, and a capsule jacket assembly for use in deploying a graft having a compressible and expandable attachment systems in the thoracic region of an aorta. The graft is comprised of a tubular member having superior and inferior ends, each having an attachment system with wall engaging members secured thereto and is crimped along its midsection to resist kinking and elongation. The delivery catheter includes an inferior capsule assembly for releasably retaining the inferior attachment system of the graft and a superior capsule assembly for releasably retaining the superior attachment system of the graft as well as a releasing system for maintaining the attachment systems in a compressed configuration and for facilitating expansion of the attachment systems. The delivery catheter also includes an anti-elongation wire attached to the inner catheter assembly to prevent stretching of the delivery catheter during deployment of the graft within the aorta. Upon removing the attachment systems from the capsule, the releasing system functions to allow the attachment systems to assume their expanded configuration and engage the walls of the aorta. The graft and attachment systems remain in the vessel after the delivery catheter is withdrawn.
摘要翻译：具有内导管组件，下胶囊导管和胶囊护套组件的输送导管，其用于部署具有在主动脉的胸部区域中的可压缩和可扩张的附接系统的移植物。移植物由具有上端和下端的管状构件组成，每个管状构件具有固定到其上的壁接合构件的附接系统，并沿其中部卷曲以抵抗扭结和伸长。递送导管包括用于可释放地保持移植物的下部附接系统的下部胶囊组件和用于可释放地保持移植物的上部附接系统的上部胶囊组件以及用于将附着系统保持在压缩构型中的释放系统，并且促进附件系统的扩展。递送导管还包括附接到内导管组件的抗延伸丝，以防止在将主动脉内的移植物展开期间伸出导管。在从胶囊中取出附接系统时，释放系统的作用是允许附接系统呈现它们的扩张构型并且接合主动脉的壁。输送导管拔出后，移植物和附着系统保留在血管内。

9. 发明授权

US08398997B2 Compositions and methods for topical application and transdermal delivery of botulinum toxins 有权
标题翻译：用于局部应用和经皮递送肉毒杆菌毒素的组合物和方法
公开(公告)号：US08398997B2
公开(公告)日：2013-03-19
申请号：US10591732
申请日：2005-03-03
申请人： Michael D. Dake , Jacob M. Waugh
发明人： Michael D. Dake , Jacob M. Waugh
IPC分类号： A61K39/08 , A61K45/00 , A61K39/02 , A61K31/74 , A61K39/00 , A61K33/32 , A01N59/16
CPC分类号： A61Q19/08 , A61K8/64 , A61K9/0014 , A61K47/34 , A61K47/42 , A61K47/645 , Y02A50/469
摘要： A composition for topical application of a botulinum toxin (including botulinum toxin derivatives) comprises a botulinum toxin and a carrier comprising a polymeric backbone comprising a long-chain polypeptide or nonpeptidyl polymer having attached positively charged branching or “efficiency” groups. The invention also relates to methods for reducing muscle paralysis and other conditions that may be treated with a botulinum toxin, particularly paralysis of subcutaneous, and most particularly, facial, muscles, by topically applying an effective amount of the botulinum toxin and carrier, in conjunction, to the subject's skin or epithelium. Kits for administration are also described.
摘要翻译：用于局部施用肉毒杆菌毒素（包括肉毒杆菌毒素衍生物）的组合物包含肉毒毒素和包含聚合物主链的载体，所述载体包含长链多肽或具有带正电荷的支化或效率基团的非肽基聚合物。本发明还涉及通过局部施用有效量的肉毒杆菌毒素和载体，减少肌肉麻痹和其它可用肉毒杆菌毒素治疗的病症，特别是皮下，尤其是面部肌肉麻痹的方法。，对受试者的皮肤或上皮。还描述了用于给药的试剂盒。

10. 发明授权

US08192482B2 Endoluminal stent 有权
标题翻译：腔内支架
公开(公告)号：US08192482B2
公开(公告)日：2012-06-05
申请号：US09977826
申请日：2001-10-15
申请人： George Goicoechea , John Hudson , Andrew H. Cragg , Claude Mialhe , Michael D. Dake
发明人： George Goicoechea , John Hudson , Andrew H. Cragg , Claude Mialhe , Michael D. Dake
IPC分类号： A61F2/06
CPC分类号： A61F2/852 , A61F2/07 , A61F2/82 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/828 , A61F2002/8486 , A61F2210/0019 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/0066 , A61F2220/0075 , A61F2230/0067 , A61F2240/001 , A61F2250/0098 , A61M25/0662 , Y10S623/903 , Y10T29/49826
摘要： A stent is provided comprising a plurality of hoops aligned along a common axis, wherein each of the hoops is oriented in a plane substantially perpendicular to the longitudinal axis of the stent. Each of the hoops includes a plurality of elongate elements joined to one another and forming apices that point in a direction along the axis of the stent. The stent also comprises means for securing an apex of one hoop to a juxtaposed apex of a neighboring hoop.
摘要翻译：提供一种支架，其包括沿公共轴线对准的多个环，其中每个箍在基本上垂直于支架的纵向轴线的平面中取向。每个箍包括彼此连接的多个细长元件，并形成沿着支架的轴线的方向指向的顶点。支架还包括用于将一个环的顶点固定到相邻箍的并置顶点的装置。

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