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    • 5. 发明授权
    • N-Substituted amino pyridines and derivatives thereof
    • N-取代的氨基吡啶及其衍生物
    • US4035375A
    • 1977-07-12
    • US686330
    • 1976-05-14
    • Paul G. GassmanGordon D. Gruetzmacher
    • Paul G. GassmanGordon D. Gruetzmacher
    • C07C209/68C07D213/73C07D213/38C07D417/06
    • C07D213/73C07C209/68
    • Preparing ortho-substituted anilines by reacting an N-chloroaniline with a non-carbonylic di-hydrocarbon sulfide to form an azasulfonium chloride, reacting the azasulfonium chloride with a strong base to form an aniline substituted in the 2-position with a hydrocarbon-S-hydrocarbyl thio-ether group. The ortho-substituted thio-ether compounds can be reduced with a de-sulfurizing reducing agent such as Raney nickel or the like to form the orthoalkylated aniline. The analine may be an amino-pyridine. The azasulfonium salt and thio-ether intermediate products can be isolated and recovered. If desired, the thio-ether compounds can be reduced to form ortho-alkylated aniline products which are useful as intermediates for a wide variety of purposes, including their uses in making dyes, herbicides, and the like.
    • 通过使N-氯苯胺与非羰基二烃硫化物反应制备邻位取代的苯胺,形成氮杂锍氯化物,使氮杂锍氯化物与强碱反应,形成2-位取代的苯胺与烃-S- 烃基硫代醚基团。 邻位取代的硫醚化合物可以用脱硫还原剂如阮内镍等还原,以形成原烷基化苯胺。 分析物可以是氨基 - 吡啶。 可以分离和回收氮杂锍盐和硫代醚中间产物。 如果需要,可以将硫代醚化合物还原形成邻烷基化苯胺产物,其可用作各种目的的中间体,包括其在制备染料,除草剂等中的用途。