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1. 发明授权

US09650745B2 Oil-in-water emulsions 有权
公开(公告)号：US09650745B2
公开(公告)日：2017-05-16
申请号：US14116577
申请日：2012-05-09
申请人： Claudius Kormann , Wolfgang Gaschler , Christian Holtze
发明人： Claudius Kormann , Wolfgang Gaschler , Christian Holtze
IPC分类号： B01D19/04 , D21H21/12 , D21C3/28
CPC分类号： D21H21/12 , B01D19/0404 , D21C3/28
摘要： The invention relates to oil-in-water emulsions based on fatty alcohols and mono- or diesters of glycerol and the use thereof as antifoams or deaerators for aqueous compositions. The oil phase of the emulsions according to the invention consists to at least 95% by weight of the following constituents: a) 40 to 95% by weight, based on the total weight of the oil phase, of a mixture of at least two alcohols as component A, consisting of: a1) at least one alkanol having 12 to 30 carbon atoms as component A1, a2) at least one mono- or diester of glycerol with at least one fatty acid having 14 to 24 carbon atoms as component A2; b) 0.1 to 10% by weight, based on the total weight of the oil phase, of at least one further component B, which is selected from esters of C12-C36-alkanecarboxylic acids with polyglycerol, amides of C12-C36-alkanecarboxylic acids with alkylenediamines or oligoalkyleneamines, and esters of C12-C36-alkanecarboxylic acids with C12-C36-alkanols, and mixtures thereof, c) 4.9 to 50% by weight, based on the total weight of the oil phase, of at least one further component C, which is selected from organic substances which are liquid at 50° C. and 1013 mbar, at atmospheric pressure have a boiling point above 200° C., and at 25° C. and 1013 mbar have a solubility in water of less than 0.1 g/l.

2. 发明申请

US20140107229A1 OIL-IN-WATER EMULSIONS 有权
标题翻译：水包油乳液
公开(公告)号：US20140107229A1
公开(公告)日：2014-04-17
申请号：US14116577
申请日：2012-05-09
申请人： Claudius Kormann , Wolfgang Gaschler , Christian Holtze
发明人： Claudius Kormann , Wolfgang Gaschler , Christian Holtze
IPC分类号： D21H21/12
CPC分类号： D21H21/12 , B01D19/0404 , D21C3/28
摘要： The invention relates to oil-in-water emulsions based on fatty alcohols and mono- or diesters of glycerol and the use thereof as antifoams or deaerators for aqueous compositions. The oil phase of the emulsions according to the invention consists to at least 95% by weight of the following constituents: a) 40 to 95% by weight, based on the total weight of the oil phase, of a mixture of at least two alcohols as component A, consisting of: a1) at least one alkanol having 12 to 30 carbon atoms as component A1, a2) at least one mono- or diester of glycerol with at least one fatty acid having 14 to 24 carbon atoms as component A2; b) 0.1 to 10% by weight, based on the total weight of the oil phase, of at least one further component B, which is selected from esters of C12-C36-alkanecarboxylic acids with polyglycerol, amides of C12-C36-alkanecarboxylic acids with alkylenediamines or oligoalkyleneamines, and esters of C12-C36-alkanecarboxylic acids with C12-C36-alkanols, and mixtures thereof, c) 4.9 to 50% by weight, based on the total weight of the oil phase, of at least one further component C, which is selected from organic substances which are liquid at 50° C. and 1013 mbar, at atmospheric pressure have a boiling point above 200° C., and at 25° C. and 1013 mbar have a solubility in water of less than 0.1 g/l.
摘要翻译：本发明涉及基于脂肪醇和甘油单酯或二酯的水包油乳液及其作为水性组合物的消泡剂或脱气剂的用途。根据本发明的乳液的油相是至少95重量％的以下组分：a）40至95重量％，基于油相的总重量，至少两种醇的混合物作为组分A，由以下组成：a1）至少一种具有12-30个碳原子的链烷醇作为组分A1，a2）至少一种甘油与至少一种具有14-24个碳原子的脂肪酸作为组分A2的单酯或二酯; b）0.1至10重量％，基于油相的总重量，至少一种另外的组分B，其选自C12-C36-烷烃羧酸与聚甘油的酯，C12-C36-烷烃羧酸的酰胺具有亚烷基二胺或低聚亚烷基胺，以及C 12 -C 36 - 链烷羧酸与C 12 -C 36 - 链烷醇的酯及其混合物，c）基于油相的总重量为4.9至50重量％的至少一种其它组分选自在大气压下为50℃和1013毫巴液体的有机物质的C的沸点高于200℃，在25℃和1013毫巴下在水中的溶解度小于 0.1g / l。

3. 发明申请

US20110229545A1 MELT EMULSIFICATION 审中-公开
公开(公告)号：US20110229545A1
公开(公告)日：2011-09-22
申请号：US13049957
申请日：2011-03-17
申请人： Ho Cheung Shum , Bingjie Sun , David A. Weitz , Christian Holtze
发明人： Ho Cheung Shum , Bingjie Sun , David A. Weitz , Christian Holtze
IPC分类号： A01N25/08 , A01P15/00 , A61K9/54 , B82Y5/00
CPC分类号： B01J13/0086 , B01F3/0807 , B01F13/0062 , B01F2005/0034 , B01J13/04 , C09B67/0009 , C09B67/0097 , G01N2015/1413
摘要： The present invention generally relates to colloidal systems, which may include colloidal particles and/or other types of particles. One aspect of the invention is generally directed to a system comprising fluidic droplets that can be at least partially solidified, e.g., to form colloidal particles. In some embodiments, particles comprising an at least partially solid outer phase encapsulating an inner phase are formed. The inner phase may be any phase, e.g., a solid, a liquid, or a gas. In some cases, solidifying at least a portion of the outer phase of the droplets to form particles may increase the stability of the particles and/or the colloidal system containing the particles. In one set of embodiments, melting or liquefying the outer phase of the particles (for example, by heating the particle to a temperature above a threshold temperature) can allow release of an agent contained within the inner phase, and/or allow the inner phase to coalesce with a phase external to the particles. The melting temperature of the outer phase can be controlled in some embodiments such that the outer phase will melt above a predetermined temperature. In some embodiments, the particles may be formed to be essentially free of an auxiliary stabilizing agent. In some embodiments, an agent may be encapsulated within a particle with relatively high efficiency. Other aspects of the invention are generally directed to methods of making and using such colloidal systems, e.g., containing such particles, kits involving such colloidal systems, or the like.
摘要翻译：本发明一般涉及胶体体系，其可以包括胶体颗粒和/或其它类型的颗粒。本发明的一个方面通常涉及包含流体液滴的系统，其可以至少部分地固化，例如形成胶体颗粒。在一些实施方案中，形成包含至少部分固体外层的包封内相的颗粒。内相可以是任何相，例如固体，液体或气体。在一些情况下，固化液滴的外相的至少一部分以形成颗粒可以增加颗粒和/或含有颗粒的胶体体系的稳定性。在一组实施方案中，熔化或液化颗粒的外相（例如，通过将颗粒加热到高于阈值温度的温度）可以允许包含在内相内的试剂的释放和/或允许内相以颗粒外部的相合并。在一些实施方案中，可以控制外相的熔融温度，使得外相将在预定温度以上熔化。在一些实施方案中，颗粒可以形成为基本上不含辅助稳定剂。在一些实施方案中，试剂可以以相对高的效率封装在颗粒内。本发明的其它方面通常涉及制备和使用这种胶体体系的方法，例如含有这种颗粒，涉及这种胶体系的试剂盒等。

4. 发明申请

US20100239824A1 Metal Oxide Coating On Surfaces 有权
标题翻译：表面金属氧化物涂层
公开(公告)号：US20100239824A1
公开(公告)日：2010-09-23
申请号：US12733086
申请日：2008-08-07
申请人： David A. Weitz , Christian Holtze , Abate R. Adam , Daeyeon Lee , Thao Do
发明人： David A. Weitz , Christian Holtze , Abate R. Adam , Daeyeon Lee , Thao Do
IPC分类号： B32B3/10 , B05D5/00 , B01J19/00 , G01N33/00
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the re-active PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfluidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
摘要翻译：本发明提供一种在PDMS表面上涂覆金属氧化物的方法。该方法包括制备含有溶胶 - 凝胶前体的混合物，使混合物反应以形成预转化的溶胶 - 凝胶前体，其中预转化的溶胶 - 凝胶前体不扩散到PDMS中并且不是凝胶形式，反应性PDMS表面，将预转化的溶胶 - 凝胶前体施加到反应性PDMS表面上，将预转化的溶胶 - 凝胶前体结合到再活性PDMS表面，并将结合的预转化的溶胶 - 凝胶前体转化为金属氧化物以形成金属氧化物涂在PDMS表面上。本发明还提供一种PDMS微流体装置，其中微流体装置的一个或多个通道设置有仅在一个或多个通道的表面上共价结合的金属氧化物涂层。

5. 发明授权

US09238206B2 Control of emulsions, including multiple emulsions 有权
标题翻译：控制乳液，包括多重乳液
公开(公告)号：US09238206B2
公开(公告)日：2016-01-19
申请号：US13477636
申请日：2012-05-22
申请人： Assaf Rotem , David A. Weitz , Adam R. Abate , Christian Holtze
发明人： Assaf Rotem , David A. Weitz , Adam R. Abate , Christian Holtze
IPC分类号： B01F13/00 , B01F3/08
CPC分类号： B01F3/0811 , B01F3/0807 , B01F13/0062 , B01F13/0084 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to double and other multiple emulsions. Certain aspects of the present invention are generally directed to the creation of double emulsions and other multiple emulsions at a common junction of microfluidic channels. In some cases, the microfluidic channels at the common junction may have substantially the same hydrophobicity. In one set of embodiments, a device may include a common junction of six or more channels, where a first fluid flows through one channel, a second fluid flows through two channels, and a third or carrying fluid flows through two more channels, such that a double emulsion of a first droplet of the first fluid, contained in a second droplet of the second fluid, contained by the carrying fluid, flows away from the common junction through a sixth channel.
摘要翻译：本发明一般涉及乳液，更具体地说涉及双重和其它多重乳液。本发明的某些方面通常涉及在微流体通道的共同连接处产生双重乳液和其它多重乳液。在一些情况下，共同连接处的微流体通道可具有基本上相同的疏水性。在一组实施例中，装置可以包括六个或更多个通道的公共接头，其中第一流体流过一个通道，第二流体流过两个通道，并且第三或承载流体流过两个以上通道，使得包含在第二流体的第二液滴中的第一流体的第一液滴的双重乳液由携带流体包含，通过第六通道从公共接头流出。

6. 发明授权

US08802027B2 Surfaces, including microfluidic channels, with controlled wetting properties 有权
标题翻译：表面，包括微流体通道，具有受控的润湿性能
公开(公告)号：US08802027B2
公开(公告)日：2014-08-12
申请号：US12935203
申请日：2009-02-11
申请人： Adam R. Abate , Amber T. Krummel , Christian Holtze , David A. Weitz
发明人： Adam R. Abate , Amber T. Krummel , Christian Holtze , David A. Weitz
IPC分类号： B01L99/00
CPC分类号： F16L9/14 , B01F3/0807 , B01F13/0062 , B01J2219/00619 , B01J2219/00635 , B01J2219/00637 , B01L3/502707 , B81B2201/058 , B81B2203/0338 , B81C1/00206
摘要： The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions.
摘要翻译：本发明一般涉及涂料，包括光活性涂料。在本发明的一些方面，提供可以形成为微流体通道上的涂层的溶胶 - 凝胶。在一些情况下，溶胶 - 凝胶的一个或多个部分可以反应以改变其疏水性。例如，在一组实施例中，溶胶 - 凝胶的一部分可以暴露于光，例如紫外光，其可以用于在溶胶 - 凝胶中诱导改变其疏水性的化学反应。在一组实施方案中，溶胶 - 凝胶可以包括光引发剂，其在暴露于光时产生自由基。任选地，光引发剂可以与溶胶 - 凝胶内的硅烷或其它材料缀合。这样生成的基团可以用于在溶胶 - 凝胶的表面上发生聚合反应，从而改变表面的疏水性。在一些情况下，例如通过控制曝光（例如，使用掩模），各种部分可能反应或未反应。微流体通道内的这样处理的表面可用于多种应用中，例如在产生诸如多重乳液的乳液中。

7. 发明申请

US20120167410A1 SPRAY DRYING TECHNIQUES 审中-公开
标题翻译：喷雾干燥技术
公开(公告)号：US20120167410A1
公开(公告)日：2012-07-05
申请号：US13330793
申请日：2011-12-20
申请人： Adam R. Abate , Julian W.P. Thiele , David A. Weitz , Christian Holtze , Maike Windbergs
发明人： Adam R. Abate , Julian W.P. Thiele , David A. Weitz , Christian Holtze , Maike Windbergs
IPC分类号： F26B21/00 , F26B3/02
CPC分类号： B01D1/18 , A61K31/58 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfluidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.
摘要翻译：本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。在一些方面，使用含有一种或多种通道或微流体通道的制品在喷雾干燥之前混合一种或多种流体。在流体通过喷嘴或其它开口排出到喷雾干燥器的干燥区域之前，混合可能发生。在一组实施例中，例如，第一流体暴露于第二流体，然后在通过喷嘴排出之前将流体暴露于空气或其它气体。在某些情况下，第一流体可以含有在暴露于第二流体时可能沉淀的溶解物质; 这样的沉淀可以在通过喷嘴或其他开口排出之前立即发生，从而导致作为喷雾干燥过程的一部分的受控沉淀。

8. 发明申请

US20120199226A1 MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
标题翻译：使用连接产生多种乳液
公开(公告)号：US20120199226A1
公开(公告)日：2012-08-09
申请号：US13390584
申请日：2010-09-01
申请人： David A. Weitz , Mark Romanowsky , Christian Holtze
发明人： David A. Weitz , Mark Romanowsky , Christian Holtze
IPC分类号： F17D1/00
CPC分类号： B01F13/0084 , B01F3/0807 , B01F2003/0838 , Y10T137/0318 , Y10T137/87571
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.
摘要翻译：本发明一般涉及乳剂，更具体地说涉及多重乳液。在一个方面，使用多个通道（例如微流体通道）形成多个乳液，其在共同的交叉处相遇。在一些实施例中，可以在单个公共交叉点处产生多个乳液，与需要多个通道交叉点以产生多个乳液的其它现有技术系统不同。例如，在一组实施例中，三个，四个或更多个微流体通道可以在共同的交叉点相交，其中两个或三个用作入口，一个用作出口。在一些实施例中，第一流体通道可以是相对疏水的，而第二流体通道是相对亲水的。根据应用，第三通道（如果存在）可以是相对亲水或疏水的。出口通道可以是疏水的，亲水的，或者可以包括至少一个相对亲水的部分和至少一个相对亲水的部分。通过控制流体通过通道的亲水和疏水部分的流动，由于进入公共交叉点的流体之间的相互作用，可能在公共交叉点附近产生多个乳液。在其它实施方案中，可以使用不同的亲水或疏水通道图案。本发明的其它方面通常涉及制造和使用这种系统的方法，涉及这种系统的试剂盒，使用这种系统产生的乳液等。

9. 发明授权

US09012390B2 Fluorocarbon emulsion stabilizing surfactants 有权
标题翻译：氟碳乳液稳定表面活性剂
公开(公告)号：US09012390B2
公开(公告)日：2015-04-21
申请号：US12310048
申请日：2007-08-07
申请人： Christian Holtze , David A. Weitz , John Brian Hutchison
发明人： Christian Holtze , David A. Weitz , John Brian Hutchison
IPC分类号： C12P17/14 , B01F17/00 , C08G65/00
CPC分类号： B01F17/005 , B01F17/0035 , C08G65/007 , C08G65/332 , C08G65/337 , C08G81/00 , C08G2650/48 , C08L71/00 , C08L2201/52 , C08L2205/05
摘要： Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions. In another embodiment, aqueous droplets are stabilized in a fluorocarbon phase at least in part by the electrostatic attraction of two oppositely charged or polar components, one of which is at least partially soluble in the dispersed phase, the other at least partially soluble in the continuous phase. One component may provide collodial stability of the emulsion, and the other may prevent the adsorption of biomolecules at the interface between a component and the discontinous phase. Advantageously, surfactants and surfactant combinations of the invention may provide sufficient stabilization against coalescence of droplets, without interfering with processes that can be carried out inside the droplets.
摘要翻译：提出了用于稳定氟离子连续相中的水或碳氢化合物液滴的表面活性剂（如含氟表面活性剂）。在一些实施方案中，含氟表面活性剂包括可溶于氟亲核（例如，碳氟化合物）连续相的荧光尾部和可溶于水相或亲油（例如烃）相的头团。可以选择荧光尾巴和头组的组合，以便产生具有合适几何形状的表面活性剂，以在连续的氟亲水相中形成具有分散水性或亲油相的稳定的反相乳液液滴。在一些实施方案中，头基优选是非离子型的，并且可以防止或限制分子在表面活性剂与不连续相之间的界面处的吸附。这种构型可以使液滴例如用作某些化学和/或生物反应的反应位点。在另一个实施方案中，水性液滴至少部分地通过两个相反电荷或极性组分的静电吸引而稳定在碳氟化合物相中，其中之一至少部分地可溶于分散相，另一个至少部分可溶于连续的相。一种组分可以提供乳液的胶体稳定性，另一种可以防止生物分子在组分和不连续相之间的界面处的吸附。有利地，本发明的表面活性剂和表面活性剂组合可以提供足够的稳定性以防止液滴的聚结，而不干扰可在液滴内进行的方法。

10. 发明授权

US08883291B2 Metal oxide coating on surfaces 有权
标题翻译：表面金属氧化物涂层
公开(公告)号：US08883291B2
公开(公告)日：2014-11-11
申请号：US12733086
申请日：2008-08-07
申请人： David A. Weitz , Christian Holtze , Adam R. Abate , Daeyeon Lee , Thao Do
发明人： David A. Weitz , Christian Holtze , Adam R. Abate , Daeyeon Lee , Thao Do
IPC分类号： B32B3/20 , B32B3/30 , B32B3/00 , C23C18/12 , C03C1/00
CPC分类号： C23C18/1295 , C03C1/008 , C23C18/1216 , C23C18/1233 , C23C18/1254 , Y10T428/2457 , Y10T428/24612 , Y10T428/24744
摘要： The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the re-active PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfluidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
摘要翻译：本发明提供一种在PDMS表面上涂覆金属氧化物的方法。该方法包括制备含有溶胶 - 凝胶前体的混合物，使混合物反应以形成预转化的溶胶 - 凝胶前体，其中预转化的溶胶 - 凝胶前体不扩散到PDMS中并且不是凝胶形式，反应性PDMS表面，将预转化的溶胶 - 凝胶前体施加到反应性PDMS表面上，将预转化的溶胶 - 凝胶前体结合到再活性PDMS表面，并将结合的预转化的溶胶 - 凝胶前体转化为金属氧化物以形成金属氧化物涂在PDMS表面上。本发明还提供一种PDMS微流体装置，其中微流体装置的一个或多个通道设置有仅在一个或多个通道的表面上共价结合的金属氧化物涂层。

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