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    • 1. 发明申请
    • MODIFIED TOXINS
    • 改性毒素
    • US20090221500A1
    • 2009-09-03
    • US12335297
    • 2008-12-15
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • A61K38/16C07K14/00
    • C07K14/34A61K38/00C07K2319/035
    • The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.
    • 本申请涉及具有降低的免疫原性并降低与血管内皮细胞或血管内皮细胞结合的修饰毒素的组合物,从而降低血管渗漏综合征的发生率。 还提供了来自修饰的白喉毒素的多肽毒素体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基中。 另一方面涉及来自修饰的白喉毒素的多肽毒候球体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基和未修饰的天然白喉毒素的至少一个VLS基序的至少一个氨基酸残基 。 另一方面涉及融合蛋白,其包含修饰的白喉毒素和作为细胞结合部分的非白喉毒素片段。 另一方面涉及使用修饰的白喉毒素治疗恶性疾病或非恶性疾病。
    • 2. 发明授权
    • Modified toxins
    • 改良毒素
    • US08470314B2
    • 2013-06-25
    • US12335297
    • 2008-12-15
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • A61K39/00
    • C07K14/34A61K38/00C07K2319/035
    • The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.
    • 本申请涉及具有降低的免疫原性并降低与血管内皮细胞或血管内皮细胞结合的修饰毒素的组合物,从而降低血管渗漏综合征的发生率。 还提供了来自修饰的白喉毒素的多肽毒素体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基中。 另一方面涉及来自修饰的白喉毒素的多肽毒候球体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基和未修饰的天然白喉毒素的至少一个VLS基序的至少一个氨基酸残基 。 另一方面涉及融合蛋白,其包含修饰的白喉毒素和作为细胞结合部分的非白喉毒素片段。 另一方面涉及使用修饰的白喉毒素治疗恶性疾病或非恶性疾病。
    • 3. 发明授权
    • Modified toxins
    • 改良毒素
    • US08252897B2
    • 2012-08-28
    • US12143469
    • 2008-06-20
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • Claude Geoffrey DavisDeepshikha DattaMatthew Paul BakerAlyson Jane RustSimon Keen
    • A61K39/02C07K16/46
    • C07K14/34A61K38/16A61K39/0011A61K39/39A61K47/6415A61K47/642A61K2039/5156A61K2039/55533A61K2039/55544
    • The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.
    • 本申请涉及具有降低的免疫原性并降低与血管内皮细胞或血管内皮细胞结合的修饰毒素的组合物,从而降低血管渗漏综合征的发生率。 还提供了来自修饰的白喉毒素的多肽毒素体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基中。 另一方面涉及来自修饰的白喉毒素的多肽毒候球体,其中修饰在至少一个T细胞表位的至少一个氨基酸残基和未修饰的天然白喉毒素的至少一个VLS基序的至少一个氨基酸残基 。 另一方面涉及融合蛋白,其包含修饰的白喉毒素和作为细胞结合部分的非白喉毒素片段。 另一方面涉及使用修饰的白喉毒素治疗恶性疾病或非恶性疾病。